Korean red ginseng protects oxidative injury caused by lead poisoning

Journal of Ginseng Research

Volumn 34, Issue 2, 2010, Pages 132-137

  Park, Myoung Soo ^a   Cho, Eun Jung ^a   Lee, Sang Ki ^a   Lee, Eun Ji ^a   Lee, Dae Sik ^b   Lee, Kwon Ho ^b   Jeon, Byeong Hwa ^a  

^a Chungnam National University   (South Korea)

^b Joongbu University   (South Korea)

Author keywords

Blood lead concentration; Blood pressure; Glutathione; Korean red ginseng; Lead

Indexed keywords

ANIMALIA; PANAX GINSENG; RATTUS;

EID: 79951804442     PISSN: 12268453     EISSN: None     Source Type: Journal    
DOI: 10.5142/jgr.2010.34.2.132     Document Type: Article

References (24)

1. Harlan WR. The relationship of blood lead levels to blood pressure in the U. S. population. Environ Health Perspect 1988;78:9-13.
2. Sharp DS, Becker CE, Smith AH. Chronic low-level lead exposure. Its role in the pathogenesis of hypertension. Med Toxicol 1987;2:210-232. (Pubitemid 17092355)
3. Sharp DS, Osterloh J, Becker CE, Bernard B, Smith AH, Fisher JM, Syme SL, Holman BL, Johnston T. Blood pressure and blood lead concentration in bus drivers. Environ Health Perspect 1988;78:131-137.
4. Vaziri ND, Liang K, Ding Y. Increased nitric oxide inactivation by reactive oxygen species in lead-induced hypertension. Kidney Int 1999;56:1492-1498. (Pubitemid 29451255)
5. Gonick HC, Ding Y, Bondy SC, Ni Z, Vaziri ND. Leadinduced hypertension: interplay of nitric oxide and reactive oxygen species. Hypertension 1997;30:1487-1492. (Pubitemid 27528093)
6. Vaziri ND, Ding Y, Ni Z, Gonick HC. Altered nitric oxide metabolism and increased oxygen free radical activity in lead-induced hypertension: effect of lazaroid therapy. Kidney Int 1997;52:1042-1046. (Pubitemid 27435837)
7. Vaziri ND, Lin CY, Farmand F, Sindhu RK. Superoxide dismutase, catalase, glutathione peroxidase and NADPH oxidase in lead-induced hypertension. Kidney Int 2003;63:186-194. (Pubitemid 35463920)
8. Lee KH, Lee SK, Kim HS, Cho EJ, Joo HK, Lee EJ, Lee JY, Park MS, Chang SJ, Cho CH, et al. Overexpression of Ref-1 inhibits lead-induced endothelial cell death via the upregulation of catalase. Korean J Physiol Pharmacol 2009;13:431-436.
9. Patrick L. Lead toxicity part II: the role of free radical damage and the use of antioxidants in the pathology and treatment of lead toxicity. Altern Med Rev 2006;11:114-127. (Pubitemid 44050250)
10. Patrick L. Lead toxicity, a review of the literature. Part 1: Exposure, evaluation, and treatment. Altern Med Rev 2006;11:2-22.
11. Nam KY. Clinical applications and efficacy of Korean ginseng. J Ginseng Res 2002;26:111-131.
12. Kim EH, Rhee DK. Anti-oxidative properties of ginseng. J Ginseng Res 2009;33:1-7.
13. Kim CS, Park JB, Kim KJ, Chang SJ, Ryoo SW, Jeon BH. Effect of Korean red ginseng on cerebral blood flow and superoxide production. Acta Pharmacol Sin 2002;23:1152-1156. (Pubitemid 35470340)
14. Jeon BH, Kim CS, Park KS, Lee JW, Park JB, Kim KJ, Kim SH, Chang SJ, Nam KY. Effect of Korean red ginseng on the blood pressure in conscious hypertensive rats. Gen Pharmacol 2000;35:135-141. (Pubitemid 34017498)
15. Jeon BH, Kim CS, Kim HS, Park JB, Nam KY, Chang SJ. Effect of Korean red ginseng on blood pressure and nitric oxide production. Acta Pharmacol Sin 2000;21:1095-1100. (Pubitemid 32012716)
16. Han K, Shin IC, Choi KJ, Yun YP, Hong JT, Oh KW. Korean red ginseng water extract increases nitric oxide concentrations in exhaled breath. Nitric Oxide 2005;12:159-162. (Pubitemid 40439239)
17. Chang SJ, Suh JS, Jeon BH, Nam KY, Park HK. Vasorelaxing effect by protopanaxatriol and protopanaxadiol of Panax ginseng in the pig coronary artery. J Ginseng Res 1994;18:95-101.
18. Jovanovski E, Jenkins A, Dias AG, Peeva V, Sievenpiper J, Arnason JT, Rahelic D, Josse RG, Vuksan V. Effects of Korean red ginseng (Panax ginseng C. A. Mayer) and its isolated ginsenosides and polysaccharides on arterial stiffness in healthy individuals.. Am J Hypertens 2010;23:469-472.
19. Vupputuri S, He J, Muntner P, Bazzano LA, Whelton PK, Batuman V. Blood lead level is associated with elevated blood pressure in blacks. Hypertension 2003;41:463-468. (Pubitemid 36314617)
20. Courtois E, Marques M, Barrientos A, Casado S, Lopez-Farre A. Lead-induced downregulation of soluble guanylate cyclase in isolated rat aortic segments mediated by reactive oxygen species and cyclooxygenase-2. J Am Soc Nephrol 2003;14:1464-1470. (Pubitemid 36687047)
21. Centers for Disease Control and Prevention (CDC). Blood lead levels-United States, 1999-2002. MMWR Morb Mortal Wkly Rep 2005;54:513-516.
22. Kosnett MJ, Wedeen RP, Rothenberg SJ, Hipkins KL, Materna BL, Schwartz BS, Hu H, Woolf A. Recommendations for medical management of adult lead exposure. Environ Health Perspect 2007;115:463-471. (Pubitemid 46554448)
23. Gracia RC, Snodgrass WR. Lead toxicity and chelation therapy. Am J Health Syst Pharm 2007;64:45-53. (Pubitemid 46395707)
24. Lee JW, Do JH. Current studies on browning reaction products and acidic polysaccharide in Korean red ginseng. J Ginseng Res 2006;30:41-48.