Peroxisome proliferator-activated receptor is involved in the regulation of lipid metabolism by ginseng

British Journal of Pharmacology

Volumn 138, Issue 7, 2003, Pages 1295-1302

  Yoon, Michung ^a   Lee, Hyunghee ^a   Jeong, Sunhyo ^a   Kim, Jung Jae ^b   Nicol, Christopher J ^c   Nam, Kung Woo ^b   Kim, Moonza ^a   Cho, Byung Goo ^d   Oh, Goo Taeg ^b  

^a Mokwon University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d Korea Ginseng Corporation   (South Korea)

Author keywords

Ginseng; Ginsenosides; Lipid metabolism; PPAR ; Wy14,643

Indexed keywords

GINSENG EXTRACT; GINSENOSIDE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PIRINIXIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FATTY ACID OXIDATION; GENE EXPRESSION REGULATION; GENE TARGETING; HYPERCHOLESTEROLEMIA; LIGAND BINDING; LIPID BLOOD LEVEL; LIPID METABOLISM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; REPORTER GENE;

ANIMALS; CELL LINE; CHOLESTEROL; CHOLESTEROL, HDL; DOSE-RESPONSE RELATIONSHIP, DRUG; GINSENOSIDES; LIPID METABOLISM; LIPIDS; LIVER; MALE; MICE; MICE, INBRED C57BL; MUTATION; PANAX; PYRIMIDINES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TIME FACTORS; TRANSCRIPTION FACTORS; TRIGLYCERIDES;

EID: 0038077329     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705169     Document Type: Article

References (39)

1. AOYAMA, T., PETERS, J.M., IRITANI, N., NAKAJIMA, T., FURIHATA, K., HASHIMOTO, T. & GONZALEZ, F.J. (1998). Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor α (PPARα). J. Biol. Chem., 273, 5678-5684.
2. ATTELE, A.S., WU, J.A. & YUAN, C.S. (1999). Ginseng pharmacology: multiple constituents and multiple actions. Biochem. Pharmacol., 58, 1685-1693.
3. AUWERX, J., SCHOONJANS, K., FRUCHART, J.C. & STAELS, B. (1996). Transcriptional control of triglyceride metabolism: fibrates and fatty acids change the expression of the LPL and apo C-III genes by activating the nuclear receptor PPAR. Atherosclerosis, 124(Suppl), S29-S37.
4. BANTHORPE, D.V. (1994). Terpenoids. In: Natural Products. ed. Mann, J. pp. 331-339. Essex: Longman Scientific and Technical.
5. CHUNG, E., LEE, K.Y., LEE, Y.J., LEE, Y.H. & LEE, S.K. (1998). Ginsenoside Rg1 down-regulates glucocorticoid receptor and displays synergistic effects with cAMP. Steroids, 63, 421-424.
6. COSTET, P., LEGENDRE, C., MORE, J., EDGAR, A., GALTIER, P. & PINEAU, T. (1998). Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis. J. Biol. Chem., 273, 29577-29585.
7. CUI, X., SAKAGUCHI, T., ISHIZUKA, D., TSUKADA, K. & HATAKEYAMA, K. (1998). Orally administered ginseng extract reduces serum total cholesterol and triglycerides that induce fatty liver in 66% hepatectomized rats. J. Int. Med. Res., 26, 181-187.
8. GILLIS, C.N. (1997). Panax ginseng pharmacology: a nitric oxide link? Biochem. Pharmacol., 54, 1-8.
9. HERTZ, R., BISHARA-SHIEBAN, J. & BAR-TANA (1995). Mode of action of peroxisome proliferators as hypolipidemic drugs. Suppression of apolipoprotein C-III. J. Biol. Chem., 270, 13470-13475.
10. HUANG, K.C. (1999). The Pharmacology of Chinese Herbs. Boca Raton, FL: CRC Press.
11. INOUE, M., WU, C.Z., DOU, D.Q., CHEN, Y.J. & OGIHARA, Y. (1999). Lipoprotein lipase activation by red ginseng saponins in hyperlipidemia model animals. Phytomedicine, 6, 257-265.
12. ISMAIL, M.F., GAD, M.Z. & HAMDY, M.A. (1999). Study of the hypolipidemic properties of pectin, garlic and ginseng in hypercholesterolemic rabbits. Pharmacol. Res., 39, 157-166.
13. KAKU, T., MIYATA, T., URUNO T., SAKO, I. & KINOSITA, Y. (1975). Chemico-pharmacological studies on saponins of Panax ginseng C. A. Meyer. I. Chemical part. Arzneimitted-Forschung, 25, 343-347.
14. KALDERON, B., HERTZ, R. & BAR-TANA, J. (1992). Tissue selective modulation of redox and phosphate potentials by beta, beta′-methyl-substituted hexadecanedioic acid. Endocrinology, 131, 1629-1635.
15. KENAROVA, B., NEYCHEV, H., HADJIIVANOVA, C. & PETKOV, V.D. (1990). Immunomodulating activity of ginsenoside Rg1 from Panax ginseng. Jpn. J. Pharmacol., 54, 447-454.
16. KIM, Y.S., KIM, D.S. & KIM, S.I. (1998). Ginsenoside Rh2 and Rh3 induce differentiation of HL-60 cells into granulocytes: modulation of protein kinase C isoforms during differentiation by ginsenoside Rh2. Int. J. Biochem. Cell Biol., 30, 327-338.
17. KROETZ, D.L., YOOK, P., COSTET, P., BIANCHI, P. & PINEAU, T. (1998). Peroxisome proliferator-activated receptor alpha controls the hepatic CYP4A induction adaptive response to starvation and diabetes. J. Biol. Chem., 273, 31581-31589.
18. LEE, Y.J., CHUNG, E., LEE, K.Y., LEE, Y.H., HUH, B. & LEE, S.K. (1997). Ginsenoside-Rg1, one of the major active molecules from Panax ginseng, is a functional ligand of glucocorticoid receptor. Mol. Cell. Endocrinol., 133, 135-140.
19. LEE, Y.K., DELL, H., DOWHAN, D.H., HADZOPOULOU-CLADARAS, M. & MOORE, D.D. (2000). The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression. Mol. Cell Biol., 20, 187-195.
20. LEMBERGER, T., DESVERGNE, B. & WAHLI, W. (1996). Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology. Annu. Rev. Cell Dev. Biol., 12, 335-363.
21. 2+ channels through a pertussis toxin-sensitive G protein. Proc. Natl. Acad. Sci. U.S.A., 92, 8739-8743.
22. ODASHIMA, S., OTA, T., KOHNO, H., MATSUDA, T., KITAGAWA, I., ABE, H. & ARICHI, S. (1985). Control of phenotypic expression of cultured B16 melanoma cells by plant glycosides. Cancer Res., 45, 2781-2784.
23. OTA, T., FUJIKAWA-YAMAMOTO, K., ZONG, Z.P., YAMAZAKI, M., ODASHIMA, S., KITAGAWA, I., ABE, H. & ARICHI, S. (1987). Plant-glycoside modulation of cell surface related to control of differentiation in cultured B16 melanoma cells. Cancer Res., 47, 3863-3867.
24. PETERS, J.M., HENNUYER, N., STAELS, B., FRUCHART, J.C., FIEVET, C., GONZALEZ, F.J. & AUWERX, J. (1997). Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice. J. Biol. Chem., 272, 27307-27312.
25. QURESHI, A.A., ABUIRMEILEH, N., DIN, Z.Z., AHMAD, Y., BURGER, W.C. & ELSON, C.E. (1983). Suppression of cholesterogenesis and reduction of LDL cholesterol by dietary ginseng and its fractions in chicken liver. Atherosclerosis, 48, 81-94.
26. RUSTAN, A.C., CHRISTIANSEN, E.N. & DREVOR, C.A. (1992). Serum lipids, hepatic glycerolipid metabolism and peroxisomal fatty acid oxidation in rats fed omega-3 and omega-6 fatty acids. Biochem. J., 283, 333-339.
27. SCHOONJANS, K., STAELS, B. & AUWERX, J. (1996). Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J. Lipid Res., 37, 907-925.
28. SEOL, W., HANSTEIN, B., BROWN, M. & MOORE, D.D. (1998). Inhibition of estrogen receptor action by the orphan receptor SHP (short heterodimer partner). Mol. Endocrinol., 12, 1551-1557.
29. SHIAU, A.K., BARSTAD, D., LORIA, P.M., CHENG, L., KUSHNER, P.J., AGARD, D.A. & GREENE, G.L. (1998). The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. Cell, 95, 927-937.
30. SHIBATA, S., TANAKA, O., SHOJI, J. & SAITO, H. (1985). Chemistry and pharmacology of Panax. In: Economic and Medicinal Plant Research. ed. Wagner, H., Hikino, H. & Farnsworth, N.R. Vol. 1. pp. 217-284. New York: Academic Press.
31. SINAL, C.J., YOON, M. & GONZALEZ, F.J. (2001). Antagonism of the actions of peroxisome proliferator activated receptor-alpha by bile acids. J. Biol. Chem., 276, 47154-47162.
32. SOLDATI, F. & STICHER, O. (1980). HPLC separation and quantitative determination of ginsenosides from Panax ginseng, Panax quinquefolium and from ginseng drug preparations. 2nd communication. Planta Med., 39, 348-357.
33. STAELS, B. & AUWERX, J. (1998). Regulation of apo A-I gene expression by fibrates. Atherosclerosis, 137(Suppl), S19-S23.
34. STAELS, B., DALLONGEVILLE, J., AUWERX, J., SCHOONJANS, K., LEITERSDORF, E. & FRUCHART, J.C. (1998). Mechanism of action of fibrates on lipid and lipoprotein metabolism. Circulation, 98, 2088-2093.
35. TSANG, D., YEUNG, H.W., TSO, W.W. & PECK, H. (1985). Ginseng saponins: influence on neurotransmitter uptake in rat brain synaptosomes. Planta Med., 3, 221-224.
36. VU-DAC, N., SCHOONJANS, K., KOSYKH, V., DALLONGEVILLE, J., FRUCHART, J.C., STAELS, B. & AUWERX, J. (1995). Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor. J. Clin. Invest., 96, 741-750.
37. WEN, T.C., YOSHIMURA, H., MATSUDA, S., LIM, J.H. & SAKANAKA, M. (1996). Ginseng root prevents learning disability and neuronal loss in gerbils with 5-minute forebrain ischemia. Acta Neuropathol. (Berl.)., 91, 15-22.
38. YAMAMOTO, M., UEMURA, T., NAKAMA, S., UEMIYA, M. & KUMAGAI, A. (1983). Serum HDL-cholesterol-increasing and fatty liver-improving actions of Panax ginseng in high cholesterol diet-fed rats with clinical effect on hyperlipidemia in man. Am. J. Chin. Med., 11, 96-101.
39. YAN, Z.H., KARAM, W.G., STAUDINGER, J.L., MEDVEDEV, A., GHANAYEM, B.I. & JETTEN, A.M. (1998). Regulation of peroxisome proliferator-activated receptor alpha-induced transactivation by the nuclear orphan receptor TAK1/TR4. J. Biol. Chem., 273, 10948-10957.