Oral intake of phenylbutyrate with or without vitamin D3 upregulates the cathelicidin LL-37 in human macrophages: A dose finding study for treatment of tuberculosis

BMC Pulmonary Medicine

Volumn 13, Issue 1, 2013, Pages

  Mily, Akhirunnesa ^a   Rekha, Rokeya Sultana ^a,b   Kamal, S M Mostafa ^c   Akhtar, Evana ^a   Sarker, Protim ^a,b   Rahim, Zeaur ^a   Gudmundsson, Gudmundur H ^d   Agerberth, Birgitta ^b   Raqib, Rubhana ^a  

^a INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH   (Bangladesh)

^b KAROLINSKA INSTITUTE   (Sweden)

^c National Institute of Diseases of Chest and Hospital   (Bangladesh)

^d UNIVERSITY OF ICELAND   (Iceland)

Author keywords

Antimicrobial peptides; Innate immunity; Monocyte derived macrophages; Mycobacterium

Indexed keywords

4 PHENYLBUTYRIC ACID; ALANINE AMINOTRANSFERASE; ALBUMIN; ANTIMYCOBACTERIAL AGENT; CALCIFEDIOL; CALCITRIOL; CALCIUM; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; CREATININE;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANTIMICROBIAL ACTIVITY; ARTICLE; BLOOD SAMPLING; CELL CULTURE; CLINICAL ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; LYMPHOCYTE; MACROPHAGE; MALE; MONOCYTE DERIVED MACROPHAGE; MYCOBACTERIUM TUBERCULOSIS; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PILOT STUDY; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SUPERNATANT; TUBERCULOSIS; UPREGULATION; VITAMIN BLOOD LEVEL;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; ANTIMICROBIAL CATIONIC PEPTIDES; ANTINEOPLASTIC AGENTS; CALCIUM; CELLS, CULTURED; CHOLECALCIFEROL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; IMMUNITY, INNATE; MACROPHAGES; MALE; MIDDLE AGED; MYCOBACTERIUM TUBERCULOSIS; PHENYLBUTYRATES; RNA, MESSENGER; TUBERCULOSIS; UP-REGULATION; VITAMINS; YOUNG ADULT;

EID: 84876079791     PISSN: None     EISSN: 14712466     Source Type: Journal    
DOI: 10.1186/1471-2466-13-23     Document Type: Article

References (32)

1. Smith PE, Moss AR. Tuberculosis: pathogenesis, protection, and control, epidemiology of tuberculosis. Epidemiol Tuberc 1994, 1:47-60.
2. Parsons LM, Driscoll JR, Taber HW, Salfinger M. Drug resistance in tuberculosis. Infect Dis Clin North Am 1997, 11(4):905-928.
3. Bradford WZ, Daley CL. Multiple drug-resistant tuberculosis. Infect Dis Clin North Am 1998, 12(1):157-172.
4. Gandhi NR, Shah NS, Andrews JR, Vella V, Moll AP, Scott M, Weissman D, Marra C, Lalloo UG, Friedland GH. HIV coinfection in multidrug- and extensively drug-resistant tuberculosis results in high early mortality. Am J Respir Crit Care Med 2010, 181(1):80-86.
5. Wejse C, Gomes VF, Rabna P, Gustafson P, Aaby P, Lisse IM, Andersen PL, Glerup H, Sodemann M. Vitamin D as supplementary treatment for tuberculosis: a double-blind, randomized, placebo-controlled trial. Am J Respir Crit Care Med 2009, 179(9):843-850.
6. Martins M. Targeting the human macrophage with combinations of drugs and inhibitors of Ca2+ and K + transport to enhance the killing of intracellular multi-drug resistant Mycobacterium tuberculosis (MDR-TB)-a novel, patentable approach to limit the emergence of XDR-TB. Recent Pat Antiinfect Drug Discov 2011, 6(2):110-117.
7. Zasloff M. Antimicrobial peptides of multicellular organisms. Nature 2002, 415(6870):389-395.
8. Zaiou M, Gallo RL. Cathelicidins, essential gene-encoded mammalian antibiotics. J Mol Med (Berl) 2002, 80(9):549-561.
9. Ganz T. Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol 2003, 3(9):710-720.
10. Kai-Larsen Y, Agerberth B. The role of the multifunctional peptide LL-37 in host defense. Front Biosci 2008, 13:3760-3767.
11. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, Ochoa MT, Schauber J, Wu K, Meinken C. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 2006, 311(5768):1770-1773.
12. Liu PT, Stenger S, Tang DH, Modlin RL. Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin. J Immunol 2007, 179(4):2060-2063.
13. Salahuddin N, Ali F, Hasan Z, Rao N, Aqeel M, Mahmood F. Vitamin D accelerates clinical recovery from tuberculosis: results of the SUCCINCT study [supplementary cholecalciferol in recovery from tuberculosis]. A randomized, placebo-controlled, clinical trial of vitamin D supplementation in patients with pulmonary tuberculosis. BMC Infect Dis 2013, 13:22.
14. Martineau AR, Wilkinson RJ, Wilkinson KA, Newton SM, Kampmann B, Hall BM, Packe GE, Davidson RN, Eldridge SM, Maunsell ZJ. A single dose of vitamin D enhances immunity to mycobacteria. Am J Respir Crit Care Med 2007, 176(2):208-213.
15. Martineau AR, Timms PM, Bothamley GH, Hanifa Y, Islam K, Claxton AP, Packe GE, Moore-Gillon JC, Darmalingam M, Davidson RN. High-dose vitamin D(3) during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial. Lancet 2011, 377(9761):242-250.
16. Nnoaham KE, Clarke A. Low serum vitamin D levels and tuberculosis: a systematic review and meta-analysis. Int J Epidemiol 2008, 37(1):113-119.
17. Raqib R, Sarker P, Bergman P, Ara G, Lindh M, Sack DA, Nasirul Islam KM, Gudmundsson GH, Andersson J, Agerberth B. Improved outcome in shigellosis associated with butyrate induction of an endogenous peptide antibiotic. Proc Natl Acad Sci U S A 2006, 103(24):9178-9183.
18. Islam D, Bandholtz L, Nilsson J, Wigzell H, Christensson B, Agerberth B, Gudmundsson G. Downregulation of bactericidal peptides in enteric infections: a novel immune escape mechanism with bacterial DNA as a potential regulator. Nat Med 2001, 7(2):180-185.
19. Bergman P, Johansson L, Asp V, Plant L, Gudmundsson GH, Jonsson AB, Agerberth B. Neisseria gonorrhoeae downregulates expression of the human antimicrobial peptide LL-37. Cell Microbiol 2005, 7(7):1009-1017.
20. Sarker P, Ahmed S, Tiash S, Rekha RS, Stromberg R, Andersson J, Bergman P, Gudmundsson GH, Agerberth B, Raqib R. Phenylbutyrate counteracts Shigella mediated downregulation of cathelicidin in rabbit lung and intestinal epithelia: a potential therapeutic strategy. PLoS One 2011, 6(6):e20637.
21. Steinmann J, Halldorsson S, Agerberth B, Gudmundsson GH. Phenylbutyrate induces antimicrobial peptide expression. Antimicrob Agents Chemother 2009, 53(12):5127-5133.
22. Yoshio H, Tollin M, Gudmundsson GH, Lagercrantz H, Jornvall H, Marchini G, Agerberth B. Antimicrobial polypeptides of human vernix caseosa and amniotic fluid: implications for newborn innate defense. Pediatr Res 2003, 53(2):211-216.
23. Edfeldt K, Liu PT, Chun R, Fabri M, Schenk M, Wheelwright M, Keegan C, Krutzik SR, Adams JS, Hewison M. T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism. Proc Natl Acad Sci U S A 2010, 107(52):22593-22598.
24. Soliman MM, Ahmed MM, Salah-Eldin AE, Abdel-Aal AA. Butyrate regulates leptin expression through different signaling pathways in adipocytes. J Vet Sci 2011, 12(4):319-323.
25. de Haan JB, Gevers W, Parker MI. Effects of sodium butyrate on the synthesis and methylation of DNA in normal cells and their transformed counterparts. Cancer Res 1986, 46(2):713-716.
26. Soliman M, Kimura K, Ahmed M, Yamaji D, Matsushita Y, Okamatsu-Ogura Y, Makondo K, Saito M. Inverse regulation of leptin mRNA expression by short- and long-chain fatty acids in cultured bovine adipocytes. Domest Anim Endocrinol 2007, 33(4):400-409.
27. Kin NW, Chen Y, Stefanov EK, Gallo RL, Kearney JF. Cathelin-related antimicrobial peptide differentially regulates T- and B-cell function. Eur J Immunol 2011, 41(10):3006-3016.
28. Agerberth B, Charo J, Werr J, Olsson B, Idali F, Lindbom L, Kiessling R, Jornvall H, Wigzell H, Gudmundsson GH. The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations. Blood 2000, 96(9):3086-3093.
29. Ottenhoff TH, Kaufmann SH. Vaccines against tuberculosis: where are we and where do we need to go?. PLoS Pathog 2012, 8(5):e1002607.
30. Campbell GR, Spector SA. Autophagy induction by vitamin D inhibits both Mycobacterium tuberculosis and human immunodeficiency virus type 1. Autophagy 2012, 8(10):1523-1525.
31. Yuk JM, Shin DM, Lee HM, Yang CS, Jin HS, Kim KK, Lee ZW, Lee SH, Kim JM, Jo EK. Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin. Cell Host Microbe 2009, 6(3):231-243.
32. Lee JS, Lee GM. Effect of sodium butyrate on autophagy and apoptosis in Chinese hamster ovary cells. Biotechnol Prog 2012, 28(2):349-357.