-
1
-
-
79955921754
-
FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer
-
Trial about new therapeutic approach for pancreatic cancer
-
Conroy T, Desseigne F, Ychou M, et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med 2011;364(19):1817-25 . Trial about new therapeutic approach for pancreatic cancer.
-
(2011)
N Engl J Med
, vol.364
, Issue.19
, pp. 1817-1825
-
-
Conroy, T.1
Desseigne, F.2
Ychou, M.3
-
2
-
-
83355169753
-
Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: A phase I/II trial
-
Trial about new therapeutic approach for pancreatic cancer
-
Von Hoff DD, Ramanathan RK, Borad MJ, et al. Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial. J Clin Oncol 2011;29(34):4548-54 . Trial about new therapeutic approach for pancreatic cancer.
-
(2011)
J Clin Oncol
, vol.29
, Issue.34
, pp. 4548-4554
-
-
Von Hoff, D.D.1
Ramanathan, R.K.2
Borad, M.J.3
-
3
-
-
33746485766
-
Epidermal growth factor receptor targeting in cancer
-
Mendelsohn J, Baselga J. Epidermal growth factor receptor targeting in cancer. Semin Oncol 2006;33:369-85
-
(2006)
Semin Oncol
, vol.33
, pp. 369-385
-
-
Mendelsohn, J.1
Baselga, J.2
-
5
-
-
0041629450
-
Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer
-
Mendelsohn J, Baselga J. Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J Clin Oncol 2003;21:2787-99
-
(2003)
J Clin Oncol
, vol.21
, pp. 2787-2799
-
-
Mendelsohn, J.1
Baselga, J.2
-
6
-
-
0343620855
-
Enhanced expression of epidermal growth factor receptor correlates with alterations of chromosome 7 in human pancreatic cancer
-
Korc M, Meltzer P, Trent J. Enhanced expression of epidermal growth factor receptor correlates with alterations of chromosome 7 in human pancreatic cancer. Proc Natl Acad Sci USA 1986;83:5141-4
-
(1986)
Proc Natl Acad Sci USA
, vol.83
, pp. 5141-5144
-
-
Korc, M.1
Meltzer, P.2
Trent, J.3
-
7
-
-
0026020115
-
Transforming growth factor alpha and epidermal growth factor in human pancreatic cancer
-
Barton CM, Hall PA, Hughes CM, et al. Transforming growth factor alpha and epidermal growth factor in human pancreatic cancer. J Pathol 1991;163:111-16
-
(1991)
J Pathol
, vol.163
, pp. 111-116
-
-
Barton, C.M.1
Hall, P.A.2
Hughes, C.M.3
-
8
-
-
33745674902
-
Epidermal growth factor receptor tyrosine kinase inhibitors: Present and future role in gastrointestinal cancer treatment: A review
-
Arnold D, Peinert S, Voigt W, et al. Epidermal growth factor receptor tyrosine kinase inhibitors: present and future role in gastrointestinal cancer treatment: a review. Oncologist 2006;11:602-11
-
(2006)
Oncologist
, vol.11
, pp. 602-611
-
-
Arnold, D.1
Peinert, S.2
Voigt, W.3
-
9
-
-
18144409431
-
Epidermal growth factor receptor-related protein inhibits cell growth and induces apoptosis of bxpc3 pancreatic cancer cells
-
Zhang Y, Banerjee S, Wang ZW, et al. Epidermal growth factor receptor-related protein inhibits cell growth and induces apoptosis of bxpc3 pancreatic cancer cells. Cancer Res 2005;65:3877-82
-
(2005)
Cancer Res
, vol.65
, pp. 3877-3882
-
-
Zhang, Y.1
Banerjee, S.2
Wang, Z.W.3
-
10
-
-
6044241807
-
The correlation between cytoplasmic overexpression of epidermal growth factor receptor and tumor aggressiveness: Poor prognosis in patients with pancreatic ductal adenocarcinoma
-
Ueda S, Ogata S, Tsuda H, et al. The correlation between cytoplasmic overexpression of epidermal growth factor receptor and tumor aggressiveness: poor prognosis in patients with pancreatic ductal adenocarcinoma. Pancreas 2004;29:e1-8
-
(2004)
Pancreas
, vol.29
-
-
Ueda, S.1
Ogata, S.2
Tsuda, H.3
-
11
-
-
33746820175
-
Epidermal growth factor receptor expression in pancreatic carcinoma using tissue microarray technique
-
Bloomston M, Bhardwaj A, Ellison EC, et al. Epidermal growth factor receptor expression in pancreatic carcinoma using tissue microarray technique. Dig Surg 2006;23:74-9
-
(2006)
Dig Surg
, vol.23
, pp. 74-79
-
-
Bloomston, M.1
Bhardwaj, A.2
Ellison, E.C.3
-
12
-
-
4143128359
-
Epidermal growth factor receptor expression in human pancreatic cancer: Significance for liver metastasis
-
Tobita K, Kijima H, Dowaki S, et al. Epidermal growth factor receptor expression in human pancreatic cancer: significance for liver metastasis. Int J Mol Med 2003;11:305-9
-
(2003)
Int J Mol Med
, vol.11
, pp. 305-309
-
-
Tobita, K.1
Kijima, H.2
Dowaki, S.3
-
13
-
-
33846220461
-
Epidermal growth factor receptor kinase domain mutations in esophageal and pancreatic adenocarcinomas
-
Kwak EL, Jankowski J, Thayer SP, et al. Epidermal growth factor receptor kinase domain mutations in esophageal and pancreatic adenocarcinomas. Clin Cancer Res 2006;12(14 Pt 1):4283-7
-
(2006)
Clin Cancer Res
, vol.12
, Issue.14 PART 1
, pp. 4283-4287
-
-
Kwak, E.L.1
Jankowski, J.2
Thayer, S.P.3
-
14
-
-
34247149803
-
Impact of epidermal growth factor receptor (EGFR) kinase mutations, EGFR gene amplifications, and KRAS mutations on survival of pancreatic adenocarcinoma
-
Lee J, Jang KT, Ki CS, et al. Impact of epidermal growth factor receptor (EGFR) kinase mutations, EGFR gene amplifications, and KRAS mutations on survival of pancreatic adenocarcinoma. Cancer 2007;109(8):1561-9
-
(2007)
Cancer
, vol.109
, Issue.8
, pp. 1561-1569
-
-
Lee, J.1
Jang, K.T.2
Ki, C.S.3
-
15
-
-
33947322389
-
Epidermal growth factor receptor (EGFR) is highly conserved in pancreatic cancer
-
Tzeng CW, Frolov A, Frolova N, et al. Epidermal growth factor receptor (EGFR) is highly conserved in pancreatic cancer. Surgery 2007;141(4):464-9
-
(2007)
Surgery
, vol.141
, Issue.4
, pp. 464-469
-
-
Tzeng, C.W.1
Frolov, A.2
Frolova, N.3
-
16
-
-
0029787957
-
An effect of k-ras gene mutation on epidermal growth factor receptor signal transduction in panc-1 pancreatic carcinoma cells
-
Watanabe M, Nobuta A, Tanaka J, et al. An effect of k-ras gene mutation on epidermal growth factor receptor signal transduction in panc-1 pancreatic carcinoma cells. Int J Cancer 1996;67:264-8
-
(1996)
Int J Cancer
, vol.67
, pp. 264-268
-
-
Watanabe, M.1
Nobuta, A.2
Tanaka, J.3
-
17
-
-
33744725273
-
Molecular analysis of the EGFRras- raf pathway in pancreatic ductal adenocarcinomas: Lack of mutations in the BRAF and EGFR genes
-
Immervoll H, Hoem D, Kugarajh K, et al. Molecular analysis of the EGFRras- raf pathway in pancreatic ductal adenocarcinomas: lack of mutations in the BRAF and EGFR genes. Virchows Arch 2006;448:788-96
-
(2006)
Virchows Arch
, vol.448
, pp. 788-796
-
-
Immervoll, H.1
Hoem, D.2
Kugarajh, K.3
-
18
-
-
34247149803
-
Impact of epidermal growth factor receptor (EGFR) kinase mutations, EGFR gene amplifications, and kras mutations on survival of pancreatic adenocarcinoma
-
Lee J, Jang KT, Ki CS, et al. Impact of epidermal growth factor receptor (EGFR) kinase mutations, EGFR gene amplifications, and kras mutations on survival of pancreatic adenocarcinoma. Cancer 2007;109:1561-9
-
(2007)
Cancer
, vol.109
, pp. 1561-1569
-
-
Lee, J.1
Jang, K.T.2
Ki, C.S.3
-
20
-
-
79956310674
-
Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: The OPUS study
-
Bokemeyer C, Bondarenko I, Hartmann JT, et al. Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study. Ann Oncol 2011;22(7):1535-46
-
(2011)
Ann Oncol
, vol.22
, Issue.7
, pp. 1535-1546
-
-
Bokemeyer, C.1
Bondarenko, I.2
Hartmann, J.T.3
-
21
-
-
63849088630
-
Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
-
Van Cutsem E, Kohne CH, Hitre E, et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 2009;360(14):1408-17
-
(2009)
N Engl J Med
, vol.360
, Issue.14
, pp. 1408-1417
-
-
Van Cutsem, E.1
Kohne, C.H.2
Hitre, E.3
-
22
-
-
32144433159
-
Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck
-
Bonner JA, Harari PM, Giralt J, et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 2006;354(6):567-78
-
(2006)
N Engl J Med
, vol.354
, Issue.6
, pp. 567-578
-
-
Bonner, J.A.1
Harari, P.M.2
Giralt, J.3
-
23
-
-
33144461661
-
Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/ recurrent head and neck cancer: An Eastern Cooperative Oncology Group study
-
Burtness B, Goldwasser MA, Flood W, et al. Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/ recurrent head and neck cancer: an Eastern Cooperative Oncology Group study. J Clin Oncol 2005;23:8646-54
-
(2005)
J Clin Oncol
, vol.23
, pp. 8646-8654
-
-
Burtness, B.1
Goldwasser, M.A.2
Flood, W.3
-
24
-
-
0031452314
-
Clinicopathological significance of epidermal growth factor and its receptor in human pancreatic cancer
-
Uegaki K, Nio Y, Inoue Y, et al. Clinicopathological significance of epidermal growth factor and its receptor in human pancreatic cancer. Anticancer Res 1997;17:3841-7
-
(1997)
Anticancer Res
, vol.17
, pp. 3841-3847
-
-
Uegaki, K.1
Nio, Y.2
Inoue, Y.3
-
25
-
-
18844473781
-
Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms
-
Bruns CJ, Harbison MT, Davis DW, et al. Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms. Clin Cancer Res 2000;6:1936-48
-
(2000)
Clin Cancer Res
, vol.6
, pp. 1936-1948
-
-
Bruns, C.J.1
Harbison, M.T.2
Davis, D.W.3
-
26
-
-
33846467633
-
Epidermal growth factor receptor inhibition strategies in pancreatic cancer: Past, Present and the Future
-
Cohenuram M, Saif MW. Epidermal growth factor receptor inhibition strategies in pancreatic cancer: past, Present and the Future. JOP J Pancreas (Online) 2007;8(1):4-15
-
(2007)
JOP J Pancreas (Online)
, vol.8
, Issue.1
, pp. 4-15
-
-
Cohenuram, M.1
Saif, M.W.2
-
27
-
-
4344590997
-
Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: A multicenter phase II trial
-
Xiong HQ, Rosenberg A, LoBuglio A, et al. Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: a multicenter phase II trial. J Clin Oncol 2004;22:2610-16
-
(2004)
J Clin Oncol
, vol.22
, pp. 2610-2616
-
-
Xiong, H.Q.1
Rosenberg, A.2
Lobuglio, A.3
-
28
-
-
37549027274
-
Cetuximab plus gemcitabine and cisplatin compared with gemcitabine and cisplatin alone in patients with advanced pancreatic cancer: A randomized, multicenter, phase II trial
-
Cascinu S, Berardi R, Labianca R, et al. Cetuximab plus gemcitabine and cisplatin compared with gemcitabine and cisplatin alone in patients with advanced pancreatic cancer: a randomized, multicenter, phase II trial. Lancet Oncol 2008;9:39-44
-
(2008)
Lancet Oncol
, vol.9
, pp. 39-44
-
-
Cascinu, S.1
Berardi, R.2
Labianca, R.3
-
29
-
-
63949086163
-
Cetuximab plus gemcitabine/ oxaliplatin (GEMOXCET) in 1st line metastatic pancreatic cancer. First results from a multicenter phase II study
-
Kullman F, Hollerbach S, Dollinger M, et al. Cetuximab plus gemcitabine/ oxaliplatin (GEMOXCET) in 1st line metastatic pancreatic cancer. First results from a multicenter phase II study. Br J Cancer 2009;100(7):1032-6
-
(2009)
Br J Cancer
, vol.100
, Issue.7
, pp. 1032-1036
-
-
Kullman, F.1
Hollerbach, S.2
Dollinger, M.3
-
30
-
-
77955914277
-
Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest Oncology Group-directed intergroup trial S0205
-
Philip PA, Benedetti J, Corless CL, et al. Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: southwest Oncology Group-directed intergroup trial S0205. J Clin Oncol 2010;28(22):3605-10
-
(2010)
J Clin Oncol
, vol.28
, Issue.22
, pp. 3605-3610
-
-
Philip, P.A.1
Benedetti, J.2
Corless, C.L.3
-
31
-
-
37449023725
-
Phase II trial of irinotecan/docetaxel for advanced pancreatic cancer with randomization between irinotecan/ docetaxel and irinotecan/docetaxel plus C225, a monoclonal antibody to the epidermal growth factor receptor (EGF-R)
-
abstract 4519
-
Burtness BA, Powell M, Berlin J, et al. Phase II trial of irinotecan/docetaxel for advanced pancreatic cancer with randomization between irinotecan/ docetaxel and irinotecan/docetaxel plus C225, a monoclonal antibody to the epidermal growth factor receptor (EGF-R). J Clin Oncol 2007;25(Suppl):abstract 4519
-
(2007)
J Clin Oncol
, vol.25
, Issue.SUPPL.
-
-
Burtness, B.A.1
Powell, M.2
Berlin, J.3
-
32
-
-
51149086367
-
Combined targeting of EGFR-dependent and VEGF-dependent pathways: Rationale, preclinical studies and clinical applications
-
Tortora G, Ciardiello F, Gasparini G. Combined targeting of EGFR-dependent and VEGF-dependent pathways: rationale, preclinical studies and clinical applications. Nat Clin Pract Oncol 2008;5(9):521-30
-
(2008)
Nat Clin Pract Oncol
, vol.5
, Issue.9
, pp. 521-530
-
-
Tortora, G.1
Ciardiello, F.2
Gasparini, G.3
-
33
-
-
38449087414
-
The role of the EGFR signaling in tumor microenvironment
-
De Luca A, Carotenuto A, Rachiglio A, et al. The role of the EGFR signaling in tumor microenvironment. J Cell Physiol 2008;214(3):559-67
-
(2008)
J Cell Physiol
, vol.214
, Issue.3
, pp. 559-567
-
-
De Luca, A.1
Carotenuto, A.2
Rachiglio, A.3
-
34
-
-
51749083205
-
Final analysis of a randomized phase II study of bevacizumab (B) and gemcitabine (G) plus cetuximab (C) or erlotinib (E) in patients (pts) with advanced pancreatic cancer (PC)
-
abstract 4502
-
Kindler HL, Gangadhar T, Karrison T, et al. Final analysis of a randomized phase II study of bevacizumab (B) and gemcitabine (G) plus cetuximab (C) or erlotinib (E) in patients (pts) with advanced pancreatic cancer (PC). J Clin Oncol 2008;26(Suppl):abstract 4502
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL.
-
-
Kindler, H.L.1
Gangadhar, T.2
Karrison, T.3
-
35
-
-
84866742346
-
A phase II randomized study of cetuximab and bevacizumab alone or in combination with gemcitabine as first-line therapy for metastatic pancreatic adenocarcinoma
-
Ko AH, Youssoufian H, Gurtler J, et al. A phase II randomized study of cetuximab and bevacizumab alone or in combination with gemcitabine as first-line therapy for metastatic pancreatic adenocarcinoma. Invest New Drugs 2012;30(4):1597-606
-
(2012)
Invest New Drugs
, vol.30
, Issue.4
, pp. 1597-1606
-
-
Ko, A.H.1
Youssoufian, H.2
Gurtler, J.3
-
36
-
-
4644335081
-
Targeting the epidermal growth factor receptor in radiotherapy: Radiobiological mechanisms, preclinical and clinical results
-
Baumann M, Krause M. Targeting the epidermal growth factor receptor in radiotherapy: radiobiological mechanisms, preclinical and clinical results. Radiother Oncol 2004;72:257-66
-
(2004)
Radiother Oncol
, vol.72
, pp. 257-266
-
-
Baumann, M.1
Krause, M.2
-
37
-
-
0037010091
-
Epidermal growth factor receptor-targeted therapy for pancreatic cancer
-
Xiong HQ, Abbruzzese JL. Epidermal growth factor receptor-targeted therapy for pancreatic cancer. Semin Oncol 2002;29(5 Suppl 14):31-7
-
(2002)
Semin Oncol
, vol.29
, Issue.5 SUPPL. 14
, pp. 31-37
-
-
Xiong, H.Q.1
Abbruzzese, J.L.2
-
38
-
-
0035868359
-
The relative role of ErbB1-4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells
-
Bowers G, Reardon D, Hewitt T, et al. The relative role of ErbB1-4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells. Oncogene 2001;20:1388-97
-
(2001)
Oncogene
, vol.20
, pp. 1388-1397
-
-
Bowers, G.1
Reardon, D.2
Hewitt, T.3
-
39
-
-
0030772168
-
Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation
-
Schmidt-Ullrich RK, Mikkelsen RB, Dent P, et al. Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation. Oncogene 1997;15:1191-7
-
(1997)
Oncogene
, vol.15
, pp. 1191-1197
-
-
Schmidt-Ullrich, R.K.1
Mikkelsen, R.B.2
Dent, P.3
-
40
-
-
0034084314
-
Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: Inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis
-
Huang SM, Harari PM. Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis. Clin Cancer Res 2000;6:2166-74
-
(2000)
Clin Cancer Res
, vol.6
, pp. 2166-2174
-
-
Huang, S.M.1
Harari, P.M.2
-
41
-
-
0037111274
-
Treatment of pancreatic cancer xenografts with Erbitux (IMC-C225) anti-EGFR antibody, gemcitabine, and radiation
-
Buchsbaum DJ, Bonner JA, Grizzle WE, et al. Treatment of pancreatic cancer xenografts with Erbitux (IMC-C225) anti-EGFR antibody, gemcitabine, and radiation. Int J Radiat Oncol Biol Phys 2002;54:1180-93
-
(2002)
Int J Radiat Oncol Biol Phys
, vol.54
, pp. 1180-1193
-
-
Buchsbaum, D.J.1
Bonner, J.A.2
Grizzle, W.E.3
-
42
-
-
67650867224
-
Final results of a phase II trial [PARCStudy ISRCTN 56652283] for patients with primary inoperable locally advanced pancreatic cancer combining intensity modulated radiotherapy (IMRT) with cetuximab and gemcitabine
-
abstract 4613
-
Munter M, Timke C, Abdollahi A, et al. Final results of a phase II trial [PARCStudy ISRCTN 56652283] for patients with primary inoperable locally advanced pancreatic cancer combining intensity modulated radiotherapy (IMRT) with cetuximab and gemcitabine. J Clin Oncol 2008;26(Suppl):abstract 4613
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL.
-
-
Munter, M.1
Timke, C.2
Abdollahi, A.3
-
43
-
-
0027412319
-
Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: A model of glioblastoma multiforme pathophysiology
-
Goldman CK, Kim J, Wong WL, et al. Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology. Mol Biol Cell 1993;4(1):121-33
-
(1993)
Mol Biol Cell
, vol.4
, Issue.1
, pp. 121-133
-
-
Goldman, C.K.1
Kim, J.2
Wong, W.L.3
-
44
-
-
0035045386
-
Epidermal growth factor modulates the expression of vascular endothelial growth factor in the human prostate
-
Ravindranath N, Wion D, Brachet P, et al. Epidermal growth factor modulates the expression of vascular endothelial growth factor in the human prostate. J Androl 2001;22:432-43
-
(2001)
J Androl
, vol.22
, pp. 432-443
-
-
Ravindranath, N.1
Wion, D.2
Brachet, P.3
-
45
-
-
40849147041
-
EGFR antagonists in cancer treatment
-
Ciardiello F, Tortora G. EGFR antagonists in cancer treatment. N Engl J Med 2008;358:1160-74
-
(2008)
N Engl J Med
, vol.358
, pp. 1160-1174
-
-
Ciardiello, F.1
Tortora, G.2
-
46
-
-
34249933404
-
Erlotinib improves survival when added to gemcitabine in patients with advances pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
-
Moore MJ, Goldstein D, Hamm J, et al. Erlotinib improves survival when added to gemcitabine in patients with advances pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2007;25(15):1960-6
-
(2007)
J Clin Oncol
, vol.25
, Issue.15
, pp. 1960-1966
-
-
Moore, M.J.1
Goldstein, D.2
Hamm, J.3
|