Inhibition of HCN channels within the periaqueductal gray attenuates neuropathic pain in rats

Behavioral Neuroscience

Volumn 127, Issue 2, 2013, Pages 325-329

  Du, Lu ^a   Wang, Shao Jun ^a   Cui, Jian ^a   He, Wen Juan ^a   Ruan, Huai Zhen ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

HCN channel; Neuropathic pain; Periaqueductal gray; ZD7288

Indexed keywords

4 (N ETHYL N PHENYLAMINO) 1,2 DIMETHYL 6 (METHYLAMINO)PYRIMIDINIUM CHLORIDE; CYCLIC NUCLEOTIDE GATED CHANNEL; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CATION CHANNEL 1; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CATION CHANNEL 2; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ALLODYNIA; ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DRUG DOSE COMPARISON; HYPERALGESIA; NERVE CELL EXCITABILITY; NERVE COMPRESSION; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PROTEIN EXPRESSION; RAT; UPREGULATION; WESTERN BLOTTING;

ANIMALS; CYCLIC NUCLEOTIDE-GATED CATION CHANNELS; HYPERALGESIA; NEURALGIA; PAIN MEASUREMENT; PERIAQUEDUCTAL GRAY; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84876034040     PISSN: 07357044     EISSN: 19390084     Source Type: Journal    
DOI: 10.1037/a0031893     Document Type: Article

References (24)

1. Bennett, G. J., & Xie, Y. K. (1988). A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain, 33, 87-107.
2. Chaplan, S. R., Bach, F. W., Pogrel, J. W., Chung, J. M., & Yaksh, T. L. (1994). Quantitative assessment of tactile allodynia in the rat paw. Journal of Neuroscience Methods, 53, 55-63.
3. Chaplan, S. R., Guo, H. Q., Lee, D. H., Luo, L., Liu, C., Kuei, C.,... Dubin, A. E. (2003). Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain. Journal of Neuroscience, 23, 1169- 1178.
4. Emery, E. C., Young, G. T., Berrocoso, E. M., Chen, L., & McNaughton, P. A. (2011, September 9). HCN2 ion channels play a central role in inflammatory and neuropathic pain. Science, 333, 1462-1466.
5. Emery, E. C., Young, G. T., & McNaughton, P. A. (2012). HCN2 ion channels: An emerging role as the pacemakers of pain. Trends in Pharmacological Sciences, 33, 456-463.
6. Gasparini, S., & DiFrancesco, D. (1997). Action of the hyperpolarizationactivated current (Ih) blocker ZD 7288 in hippocampal CA1 neurons. Pflugers Archiv. European Journal of Physiology, 435, 99-106.
7. Hargreaves, K., Dubner, R., Brown, F., Flores, C., & Joris, J. (1988). A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain, 32, 77-88.
8. Hong, S., & Wiley, J. W. (2005). Early painful diabetic neuropathy is associated with differential changes in the expression and function of vanilloid receptor 1. Journal of Biological Chemistry, 280, 618-627.
9. Jiang, Y. Q., Xing, G. G., Wang, S. L., Tu, H. Y., Chi, Y. N., Li, J.,... Wan, Y. (2008). Axonal accumulation of hyperpolarization-activated cyclic nucleotide-gated cation channels contributes to mechanical allodynia after peripheral nerve injury in rat. Pain, 137, 495-506.
10. Kim, S. J., Chung, W. H., Rhim, H., Eun, S. Y., Jung, S. J., & Kim, J. (2002). Postsynaptic action mechanism of somatostatin on the membrane excitability in spinal substantia gelatinosa neurons of juvenile rats. Neuroscience, 114, 1139-1148.
11. Lee, D. H., Chang, L., Sorkin, L. S., & Chaplan, S. R. (2005). Hyperpolarization-activated, cation-nonselective, cyclic nucleotidemodulated channel blockade alleviates mechanical allodynia and suppresses ectopic discharge in spinal nerve ligated rats. The Journal of Pain, 6, 417-424.
12. Luo, L., Chang, L., Brown, S. M., Ao, H., Lee, D. H., Higuera, E. S.,... Chaplan, S. R. (2007). Role of peripheral hyperpolarization-activated cyclic nucleotide-modulated channel pacemaker channels in acute and chronic pain models in the rat. Neuroscience, 144, 1477-1485.
13. Mellor, J., Nicoll, R. A., & Schmitz, D. (2002, January 4). Mediation of hippocampal mossy fiber long-term potentiation by presynaptic Ih channels. Science, 295, 143-147.
14. Monteggia, L. M., Eisch, A. J., Tang, M. D., Kaczmarek, L. K., & Nestler, E. J. (2000). Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brain. Brain Research. Molecular Brain Research, 81, 129-139.
15. Notomi, T., & Shigemoto, R. (2004). Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain. Journal of Comparative Neurology, 471, 241-276.
16. Palazzo, E., Guida, F., Gatta, L., Luongo, L., Boccella, S., Bellini, G.,... Maione, S. (2011). EP1 receptor within the ventrolateral periaqueductal grey controls thermonociception and rostral ventromedial medulla cell activity in healthy and neuropathic rat. Molecular Pain, 7, 82.
17. Papp, I., Szucs, P., Hollo, K., Erdelyi, F., Szabo, G., & Antal, M. (2006). Hyperpolarization-activated and cyclic nucleotide-gated cation channel subunit 2 ion channels modulate synaptic transmission from nociceptive primary afferents containing substance P to secondary sensory neurons in laminae I-IIo of the rodent spinal dorsal horn. European Journal of Neuroscience, 24, 1341-1352.
18. Postea, O., & Biel, M. (2011). Exploring HCN channels as novel drug targets. Nature Reviews. Drug Discovery, 10, 903-914.
19. Robinson, R. B., & Siegelbaum, S. A. (2003). Hyperpolarization-activated cation currents: From molecules to physiological function. Annual Review of Physiology, 65, 453-480.
20. Santoro, B., & Tibbs, G. R. (1999). The HCN gene family: Molecular basis of the hyperpolarization-activated pacemaker channels. Annals of the New York Academy of Sciences, 868, 741-764.
21. Sun, Q., Tu, H., Xing, G. G., Han, J. S., & Wan, Y. (2005). Ectopic discharges from injured nerve fibers are highly correlated with tactile allodynia only in early, but not late, stage in rats with spinal nerve ligation. Experimental Neurology, 191, 128-136.
22. Takasu, K., Ono, H., & Tanabe, M. (2010). Spinal hyperpolarization-activated cyclic nucleotide-gated cation channels at primary afferent terminals contribute to chronic pain. Pain, 151, 87-96.
23. Yao, H., Donnelly, D. F., Ma, C., & LaMotte, R. H. (2003). Upregulation of the hyperpolarization-activated cation current after chronic compression of the dorsal root ganglion. Journal of Neuroscience, 23, 2069- 2074.
24. Zimmermann, M. (1983). Ethical guidelines for investigations of experimental pain in conscious animals. Pain, 16, 109-110.