Synthesis and in vitro antiproliferative effect of novel quinoline-based potential anticancer agents

European Journal of Medicinal Chemistry

Volumn 63, Issue , 2013, Pages 826-832

  Arafa, Reem K ^a   Hegazy, Gehan H ^a   Piazza, Gary A ^b   Abadi, Ashraf H ^a,c  

^a CAIRO UNIVERSITY   (Egypt)

^b UNIVERSITY OF SOUTH ALABAMA   (United States)

^c German University in Cairo   (Egypt)

Author keywords

Antiproliferative agents; Cytotoxicity; HT29 human colon cancer cell line; MDA MB231 human breast cancer cell line; Quinolines

Indexed keywords

2 (5,7 DIBROMOQUINOLIN 8 YLOXY) 1 (3,5 DIMETHYL 1H PYRAZOL 1 YL)ETHANONE; 2 (5,7 DIBROMOQUINOLIN 8 YLOXY) N' (1 PHENYLETHYLIDENE)ACETOHYDRAZIDE; 2 (5,7 DIBROMOQUINOLIN 8 YLOXY)N'(4 CHLOROBENZYLIDENE)ACETOHYDRAZIDE; 2 (5,7 DIBROMOQUINOLIN 8 YLOXY)N'(4 HYDROXY 3 METHOXYBENZYLIDENE)ACETOHYDRAZIDE; 2 (5,7 DIBROMOQUINOLIN 8 YLOXY)N'(4 METHOXYBENZYLIDENE)ACETOHYDRAZIDE; 2 (5,7 DIBROMOQUINOLIN 8 YLOXY)N'(4 NITROBENZYLIDENE)ACETOHYDRAZIDE; 2 (5,7 DIBROMOQUINOLIN 8 YLOXY)N'[1 (4 NITROPHENYL)ETHYLIDENE]ACETOHYDRAZIDE; 2 [2 (5,7 DIBROMOQUINOLIN 8 YLOXY)ACETYL] 5 METHYL 1H PYRAZOL 3(2H)ONE; 2 [2 (5,7 DIBROMOQUINOLIN 8 YLOXY)ACETYL]N PHENYL HYDRAZINECARBOXAMIDE; 2 [2 (5,7 DIBROMOQUINOLIN 8 YLOXY)ACETYL]N PHENYL HYDRAZINETHIOCARBOX AMIDE; 2 [5,7 DIBROMOQUINOLIN 8 YLOXY)N'1 (4 BROMOPHENYL)ETHYLIDENE]ACETOHYDRAZIDE; 5 [(5,7 DIBROMOQUINOLIN 8 YLOXY)METHYL] 1,3,4 OXADIAZOLE 2 THIOL; 5 [(5,7 DIBROMOQUINOLIN 8 YLOXY)METHYL] 4 PHENYL 4H 1,2,4 TRIAZOL 3 OL; 5 [(5,7 DIBROMOQUINOLIN 8 YLOXY)METHYL] 4 PHENYL 4H 1,2,4 TRIAZOL 3 THIOL; 6 [2 (DIMETHYLAMINO)ETHYLAMINO] 3 HYDROXY 7H INDENO[2,1 C]QUINOLIN 7 ONE; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; DOFEQUIDAR; MT 477; N' BENZYLIDENE2 (5,7 DIBROMOQUINOLIN 8 YLOXY)ACETOHYDRAZIDE; N'(4 BROMOBENZYLIDENE) 2 (5,7 DIBROMOQUINOLIN 8 YLOXY)ACETOHYDRAZIDE; QUINOLINE DERIVATIVE; SCHIFF BASE; TOPOTECAN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL STRAIN HT29; CYTOTOXICITY TEST; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IC 50; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HT29 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MOLECULAR STRUCTURE; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84876006481     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.03.008     Document Type: Article

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