메뉴 건너뛰기




Volumn 42, Issue 5, 2013, Pages 1674-1681

Scutellarin inhibits the growth and invasion of human tongue squamous carcinoma through the inhibition of matrix metalloproteinase-2 and -9 and αvβ6 integrin

Author keywords

v 6 integrin; Matrix metallo proteinase 9; Matrix metalloproteinase 2; Oral squamous cell carcinoma; Scutellarin

Indexed keywords

ALPHAVBETA6 INTEGRIN; COLLAGEN FIBER; GELATINASE A; GELATINASE B; MESSENGER RNA; SCUTELLARIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1;

EID: 84876003632     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2013.1873     Document Type: Article
Times cited : (47)

References (39)
  • 1
    • 67349154099 scopus 로고    scopus 로고
    • Oral squamous cell carcinoma overview
    • Scully C and Bagan J: Oral squamous cell carcinoma overview. Oral Oncol 45: 301-308, 2009.
    • (2009) Oral Oncol , vol.45 , pp. 301-308
    • Scully, C.1    Bagan, J.2
  • 2
    • 77950931419 scopus 로고    scopus 로고
    • Matrix metalloproteinases: Regulators of the tumor microenvironment
    • Kessenbrock K, Plaks V and Werb Z: Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 141: 52-67, 2010.
    • (2010) Cell , vol.141 , pp. 52-67
    • Kessenbrock, K.1    Plaks, V.2    Werb, Z.3
  • 3
    • 0034715896 scopus 로고    scopus 로고
    • Insights into extracellular matrix functions from mutant mouse models
    • Gustafsson E and Fassler R: Insights into extracellular matrix functions from mutant mouse models. Exp Cell Res 261: 52-68, 2000.
    • (2000) Exp Cell Res , vol.261 , pp. 52-68
    • Gustafsson, E.1    Fassler, R.2
  • 4
    • 0033018315 scopus 로고    scopus 로고
    • Matrix metalloproteinases and oral cancer
    • DOI 10.1016/S1368-8375(99)00004-4, PII S1368837599000044
    • Thomas GT, Lewis MP and Speight PM: Matrix metalloproteinases and oral cancer. Oral Oncol 35: 227-233, 1999. (Pubitemid 29148354)
    • (1999) Oral Oncology , vol.35 , Issue.3 , pp. 227-233
    • Thomas, G.T.1    Lewis, M.P.2    Speight, P.M.3
  • 5
    • 77957269498 scopus 로고    scopus 로고
    • Matrix metalloproteinases and their inhibitors: Correlation with invasion and metastasis in oral cancer
    • Singh RD, Haridas N, Patel JB, et al: Matrix metalloproteinases and their inhibitors: correlation with invasion and metastasis in oral cancer. Indian J Clin Biochem 25: 250-259, 2010.
    • (2010) Indian J Clin Biochem , vol.25 , pp. 250-259
    • Singh, R.D.1    Haridas, N.2    Patel, J.B.3
  • 6
    • 84867902476 scopus 로고    scopus 로고
    • Changes in the expression of MMP2, MMP9, and ColIV in stromal cells in oral squamous tongue cell carcinoma: Relationships and prognostic implications
    • Fan HX, Li HX, Chen D, Gao ZX and Zheng JH: Changes in the expression of MMP2, MMP9, and ColIV in stromal cells in oral squamous tongue cell carcinoma: relationships and prognostic implications. J Exp Clin Cancer Res 31: 90, 2012.
    • (2012) J Exp Clin Cancer Res , vol.31 , pp. 90
    • Fan, H.X.1    Li, H.X.2    Chen, D.3    Gao, Z.X.4    Zheng, J.H.5
  • 7
    • 14644405651 scopus 로고    scopus 로고
    • Expression and clinical significance of matrix metalloproteinase-2 and matrix metalloproteinase-9 in oral squamous cell carcinoma
    • DOI 10.1016/j.oraloncology.2004.08.013
    • De Vicente JC, Fresno MF, Villalain L, Vega JA and Hernandez Vallejo G: Expression and clinical significance of matrix metalloproteinase-2 and matrix metalloproteinase-9 in oral squamous cell carcinoma. Oral Oncol 41: 283-293, 2005. (Pubitemid 40311757)
    • (2005) Oral Oncology , vol.41 , Issue.3 , pp. 283-293
    • De Vicente, J.C.1    Fresno, M.F.2    Villalain, L.3    Vega, J.A.4    Hernandez Vallejo, G.5
  • 8
    • 0026770377 scopus 로고
    • Integrins: Versatility, modulation, and signaling in cell adhesion
    • Hynes RO: Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69: 11-25, 1992.
    • (1992) Cell , vol.69 , pp. 11-25
    • Hynes, R.O.1
  • 9
    • 0028978232 scopus 로고
    • Expression of the beta 6 integrin subunit in development, neoplasia and tissue repair suggests a role in epithelial remodeling
    • Breuss JM, Gallo J, De Lisser HM, et al: Expression of the beta 6 integrin subunit in development, neoplasia and tissue repair suggests a role in epithelial remodeling. J Cell Sci 108: 2241-2251, 1995.
    • (1995) J Cell Sci , vol.108 , pp. 2241-2251
    • Breuss, J.M.1    Gallo, J.2    De Lisser, H.M.3
  • 10
    • 70249086983 scopus 로고    scopus 로고
    • Defining the role of integrin alphavbeta6 in cancer
    • Bandyopadhyay A and Raghavan S: Defining the role of integrin alphavbeta6 in cancer. Curr Drug Targets 10: 645-652, 2009.
    • (2009) Curr Drug Targets , vol.10 , pp. 645-652
    • Bandyopadhyay, A.1    Raghavan, S.2
  • 12
    • 61449094945 scopus 로고    scopus 로고
    • The role of the integrin alpha v beta6 in regulating the epithelial to mesenchymal transition in oral cancer
    • Ramos DM, Dang D and Sadler S: The role of the integrin alpha v beta6 in regulating the epithelial to mesenchymal transition in oral cancer. Anticancer Res 29: 125-130, 2009.
    • (2009) Anticancer Res , vol.29 , pp. 125-130
    • Ramos, D.M.1    Dang, D.2    Sadler, S.3
  • 13
    • 0035354344 scopus 로고    scopus 로고
    • αVβ6 integrin promotes invasion of squamous carcinoma cells through up-regulation of matrix metalloproteinase-9
    • DOI 10.1002/1097-0215(20010601)92:5<641::AID-IJC1243>3.0.CO;2-P
    • Thomas GJ, Lewis MP, Hart IR, Marshall JF and Speight PM: AlphaVbeta6 integrin promotes invasion of squamous carcinoma cells through up-regulation of matrix metalloproteinase-9. Int J Cancer 92: 641-650, 2001. (Pubitemid 32385704)
    • (2001) International Journal of Cancer , vol.92 , Issue.5 , pp. 641-650
    • Thomas, G.J.1    Lewis, M.P.2    Hart, I.R.3    Marshall, J.F.4    Speight, P.M.5
  • 14
    • 43649083202 scopus 로고    scopus 로고
    • Integrin alpha v beta 6 mediates the potential for colon cancer cells to colonize in and metastasize to the liver
    • Yang GY, Xu KS, Pan ZQ, et al: Integrin alpha v beta 6 mediates the potential for colon cancer cells to colonize in and metastasize to the liver. Cancer Sci 99: 879-887, 2008.
    • (2008) Cancer Sci , vol.99 , pp. 879-887
    • Yang, G.Y.1    Xu, K.S.2    Pan, Z.Q.3
  • 16
    • 77951480423 scopus 로고    scopus 로고
    • Targeting anoikis resistance in prostate cancer metastasis
    • Sakamoto S and Kyprianou N: Targeting anoikis resistance in prostate cancer metastasis. Mol Aspects Med 31: 205-214, 2010.
    • (2010) Mol Aspects Med , vol.31 , pp. 205-214
    • Sakamoto, S.1    Kyprianou, N.2
  • 17
    • 20944432774 scopus 로고    scopus 로고
    • Molecular pathogenesis of oral submucous fibrosis - A collagen metabolic disorder
    • DOI 10.1111/j.1600-0714.2005.00325.x
    • Rajalalitha P and Vali S: Molecular pathogenesis of oral submucous fibrosis - a collagen metabolic disorder. J Oral Pathol Med 34: 321-328, 2005. (Pubitemid 40868401)
    • (2005) Journal of Oral Pathology and Medicine , vol.34 , Issue.6 , pp. 321-328
    • Rajalalitha, P.1    Vali, S.2
  • 18
    • 36849058762 scopus 로고    scopus 로고
    • Deciphering AP-1 function in tumorigenesis: Fra-ternizing on target promoters
    • Verde P, Casalino L, Talotta F, Yaniv M and Weitzman JB: Deciphering AP-1 function in tumorigenesis: fra-ternizing on target promoters. Cell Cycle 6: 2633-2639, 2007. (Pubitemid 350224046)
    • (2007) Cell Cycle , vol.6 , Issue.21 , pp. 2633-2639
    • Verde, P.1    Casalino, L.2    Talotta, F.3    Yaniv, M.4    Weitzman, J.B.5
  • 19
    • 0034579141 scopus 로고    scopus 로고
    • Integrin-mediated signaling regulates AP-1 transcription factors and proliferation in osteoblasts
    • Cowles EA, Brailey LL and Gronowicz GA: Integrin-mediated signaling regulates AP-1 transcription factors and proliferation in osteoblasts. J Biomed Mater Res 52: 725-737, 2000.
    • (2000) J Biomed Mater Res , vol.52 , pp. 725-737
    • Cowles, E.A.1    Brailey, L.L.2    Gronowicz, G.A.3
  • 20
    • 77957756704 scopus 로고    scopus 로고
    • Fibronectin and vitronectin induce AP-1-mediated matrix metalloproteinase-9 expression through integrin alpha(5)beta(1)/alpha(v)beta(3)- dependent Akt, ERK and JNK signaling pathways in human umbilical vein endothelial cells
    • Jin YJ, Park I, Hong IK, et al: Fibronectin and vitronectin induce AP-1-mediated matrix metalloproteinase-9 expression through integrin alpha(5)beta(1)/alpha(v)beta(3)-dependent Akt, ERK and JNK signaling pathways in human umbilical vein endothelial cells. Cell Signal 23: 125-134, 2011.
    • (2011) Cell Signal , vol.23 , pp. 125-134
    • Jin, Y.J.1    Park, I.2    Hong, I.K.3
  • 21
    • 77952762498 scopus 로고    scopus 로고
    • AP-1 (Fra-1/c-Jun)-mediated induction of expression of matrix metalloproteinase-2 is required for 15S-hydroxyeicosa-tetraenoic acid-induced angiogenesis
    • Singh NK, Quyen DV, Kundumani-Sridharan V, Brooks PC and Rao GN: AP-1 (Fra-1/c-Jun)-mediated induction of expression of matrix metalloproteinase-2 is required for 15S-hydroxyeicosa-tetraenoic acid-induced angiogenesis. J Biol Chem 285: 16830-16843, 2010.
    • (2010) J Biol Chem , vol.285 , pp. 16830-16843
    • Singh, N.K.1    Quyen, D.V.2    Kundumani-Sridharan, V.3    Brooks, P.C.4    Rao, G.N.5
  • 22
    • 78149328322 scopus 로고    scopus 로고
    • Scutellarin inhibits cell migration by regulating production of alphavbeta6 integrin and E-cadherin in human tongue cancer cells
    • Li H, Huang D, Gao Z, et al: Scutellarin inhibits cell migration by regulating production of alphavbeta6 integrin and E-cadherin in human tongue cancer cells. Oncol Rep 24: 1153-1160, 2010.
    • (2010) Oncol Rep , vol.24 , pp. 1153-1160
    • Li, H.1    Huang, D.2    Gao, Z.3
  • 23
    • 0034755651 scopus 로고    scopus 로고
    • Collagen matrix in development and progression of experimentally induced respiratory neoplasms in the hamster
    • DOI 10.1080/019262301317226311
    • Laitakari J and Stenback F: Collagen matrix in development and progression of experimentally induced respiratory neoplasms in the hamster. Toxicol Pathol 29: 514-527, 2001. (Pubitemid 33031600)
    • (2001) Toxicologic Pathology , vol.29 , Issue.5 , pp. 514-527
    • Laitakari, J.1    Stenback, F.2
  • 24
    • 33846998658 scopus 로고    scopus 로고
    • Chemoprevention of Scutellaria bardata on human cancer cells and tumorigenesis in skin cancer
    • Suh SJ, Yoon JW, Lee TK, et al: Chemoprevention of Scutellaria bardata on human cancer cells and tumorigenesis in skin cancer. Phytother Res 21: 135-141, 2007.
    • (2007) Phytother Res , vol.21 , pp. 135-141
    • Suh, S.J.1    Yoon, J.W.2    Lee, T.K.3
  • 25
    • 27644445236 scopus 로고    scopus 로고
    • Inhibitory effects of a chemically standardized extract from Scutellaria barbata in human colon cancer cell lines, LoVo
    • DOI 10.1021/jf051506+
    • Goh D, Lee YH and Ong ES: Inhibitory effects of a chemically standardized extract from Scutellaria barbata in human colon cancer cell lines, LoVo. J Agric Food Chem 53: 8197-8204, 2005. (Pubitemid 41564626)
    • (2005) Journal of Agricultural and Food Chemistry , vol.53 , Issue.21 , pp. 8197-8204
    • Goh, D.1    Yian, H.L.2    Eng, S.O.3
  • 26
    • 70649114483 scopus 로고    scopus 로고
    • Selective fraction of Scutellaria baicalensis and its chemopreventive effects on MCF-7 human breast cancer cells
    • Wang CZ, Li XL, Wang QF, Mehendale SR and Yuan CS: Selective fraction of Scutellaria baicalensis and its chemopreventive effects on MCF-7 human breast cancer cells. Phytomedicine 17: 63-68, 2010.
    • (2010) Phytomedicine , vol.17 , pp. 63-68
    • Wang, C.Z.1    Li, X.L.2    Wang, Q.F.3    Mehendale, S.R.4    Yuan, C.S.5
  • 27
    • 84868365866 scopus 로고    scopus 로고
    • Novel function of scutellarin in inhibiting cell proliferation and inducing cell apoptosis of human Burkitt lymphoma Namalwa cells
    • Feng Y, Zhang S, Tu J, et al: Novel function of scutellarin in inhibiting cell proliferation and inducing cell apoptosis of human Burkitt lymphoma Namalwa cells. Leuk Lymphoma 53: 2456-2464, 2012.
    • (2012) Leuk Lymphoma , vol.53 , pp. 2456-2464
    • Feng, Y.1    Zhang, S.2    Tu, J.3
  • 28
    • 44349127209 scopus 로고    scopus 로고
    • Effects of scutellarin on apoptosis induced by cobalt chloride in PC12 cells
    • Wang LX, Zeng JP, Wei XB, Wang FW, Liu ZP and Zhang XM: Effects of scutellarin on apoptosis induced by cobalt chloride in PC12 cells. Chin J Physiol 50: 301-307, 2007.
    • (2007) Chin J Physiol , vol.50 , pp. 301-307
    • Wang, L.X.1    Zeng, J.P.2    Wei, X.B.3    Wang, F.W.4    Liu, Z.P.5    Zhang, X.M.6
  • 29
    • 68549130601 scopus 로고    scopus 로고
    • Scutellarin sensitizes drug-evoked colon cancer cell apoptosis through enhanced caspase-6 activation
    • Chan JY, Tan BK and Lee SC: Scutellarin sensitizes drug-evoked colon cancer cell apoptosis through enhanced caspase-6 activation. Anticancer Res 29: 3043-3047, 2009.
    • (2009) Anticancer Res , vol.29 , pp. 3043-3047
    • Chan, J.Y.1    Tan, B.K.2    Lee, S.C.3
  • 31
    • 0027535914 scopus 로고
    • Biology and biochemistry of proteinases in tumor invasion
    • Mignatti P and Rifkin DB: Biology and biochemistry of proteinases in tumor invasion. Physiol Rev 73: 161-195, 1993. (Pubitemid 23065437)
    • (1993) Physiological Reviews , vol.73 , Issue.1 , pp. 161-195
    • Mignatti, P.1    Rifkin, D.B.2
  • 32
  • 33
    • 0037509851 scopus 로고    scopus 로고
    • Matrix metalloproteinases in cancer
    • Itoh Y and Nagase H: Matrix metalloproteinases in cancer. Essays Biochem 38: 21-36, 2002. (Pubitemid 36589192)
    • (2002) Essays in Biochemistry , vol.38 , pp. 21-36
    • Itoh, Y.1    Nagase, H.2
  • 34
    • 34548262577 scopus 로고    scopus 로고
    • Clinical significance of MMP-2 and MMP-9 in patients with oral cancer
    • DOI 10.1002/hed.20561
    • Patel BP, Shah SV, Shukla SN, Shah PM and Patel PS: Clinical significance of MMP-2 and MMP-9 in patients with oral cancer. Head Neck 29: 564-572, 2007. (Pubitemid 47324773)
    • (2007) Head and Neck , vol.29 , Issue.6 , pp. 564-572
    • Patel, B.P.1    Shah, S.V.2    Shukla, S.N.3    Shah, P.M.4    Patel, P.S.5
  • 35
    • 79954989615 scopus 로고    scopus 로고
    • Regulation of transforming growth factor-beta1-dependent integrin beta6 expression by p38 mitogen-activated protein kinase in bile duct epithelial cells
    • Sullivan BP, Kassel KM, Manley S, Baker AK and Luyendyk JP: Regulation of transforming growth factor-beta1-dependent integrin beta6 expression by p38 mitogen-activated protein kinase in bile duct epithelial cells. J Pharmacol Exp Ther 337: 471-478, 2011.
    • (2011) J Pharmacol Exp Ther , vol.337 , pp. 471-478
    • Sullivan, B.P.1    Kassel, K.M.2    Manley, S.3    Baker, A.K.4    Luyendyk, J.P.5
  • 36
    • 22244438537 scopus 로고    scopus 로고
    • Tetraspanin CD9 induces MMP-2 expression by activating p38 MAPK, JNK and c-Jun pathways in human melanoma cells
    • Hong IK, Kim YM, Jeoung DI, Kim KC and Lee H: Tetraspanin CD9 induces MMP-2 expression by activating p38 MAPK, JNK and c-Jun pathways in human melanoma cells. Exp Mol Med 37: 230-239, 2005. (Pubitemid 40992739)
    • (2005) Experimental and Molecular Medicine , vol.37 , Issue.3 , pp. 230-239
    • Hong, I.-K.1    Kim, Y.-M.2    Jeoung, D.-I.I.3    Kim, K.-C.4    Lee, H.5
  • 38
    • 0034595439 scopus 로고    scopus 로고
    • The α2 and α5 integrin genes: Identification of transcription factors that regulate promoter activity in epidermal keratinocytes
    • DOI 10.1016/S0014-5793(00)01591-X, PII S001457930001591X
    • Corbi AL, Jensen UB and Watt FM: The alpha2 and alpha5 integrin genes: identification of transcription factors that regulate promoter activity in epidermal keratinocytes. FEBS Lett 474: 201-207, 2000. (Pubitemid 30330834)
    • (2000) FEBS Letters , vol.474 , Issue.2-3 , pp. 201-207
    • Corbi, A.L.1    Jensen, U.B.2    Watt, F.M.3
  • 39
    • 79957957063 scopus 로고    scopus 로고
    • Scutellarin promotes in vitro angiogenesis in human umbilical vein endothelial cells
    • Gao ZX, Huang DY, Li HX, et al: Scutellarin promotes in vitro angiogenesis in human umbilical vein endothelial cells. Biochem Biophys Res Commun 400: 151-156, 2010.
    • (2010) Biochem Biophys Res Commun , vol.400 , pp. 151-156
    • Gao, Z.X.1    Huang, D.Y.2    Li, H.X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.