Novel agmatine dipeptide inhibitors against the West Nile virus NS2B/NS3 protease: A P3 and N-cap optimization study

European Journal of Medicinal Chemistry

Volumn 62, Issue , 2013, Pages 199-205

  Lim, Huichang Annie ^a   Ang, Melgious Jin Yan ^a   Joy, Joma ^a   Poulsen, Anders ^a   Wu, Wenshi ^a   Ching, Shi Chie ^a   Hill, Jeffrey ^a   Chia, Cheng San Brian ^a  

^a Agency for Science   (Singapore)

Author keywords

Agmatine; NS2B NS3; Peptide; Serine protease inhibitor; West Nile virus

Indexed keywords

AGMATINE DIPEPTIDE INHIBITOR; DIPEPTIDE DERIVATIVE; PEPTIDOMIMETIC AGENT; PROTEIN INHIBITOR; SERINE PROTEINASE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CONFORMATION; CRYSTAL STRUCTURE; DRUG INHIBITION; ENZYME BINDING; ENZYME INHIBITION; HYDROGEN BOND; MOLECULAR MODEL; NONHUMAN; PROCESS OPTIMIZATION; PROTEINASE INHIBITION; STEREOCHEMISTRY; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; WEST NILE FLAVIVIRUS; X RAY CRYSTALLOGRAPHY;

AGMATINE; CRYSTALLOGRAPHY, X-RAY; DIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEASE INHIBITORS; RNA HELICASES; SERINE ENDOPEPTIDASES; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS; WEST NILE VIRUS;

EID: 84875987992     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.12.043     Document Type: Article

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