-
1
-
-
29644444216
-
Azathioprine suppresses ezrin-radixin-moesin-dependent T cell-APC conjugation through inhibition of Vav guanosine exchange activity on rac proteins
-
Poppe D, Tiede I, Fritz G et al. Azathioprine suppresses ezrin-radixin-moesin-dependent T cell-APC conjugation through inhibition of Vav guanosine exchange activity on Rac proteins. J. Immunol. 176, 640-651 (2006). (Pubitemid 43023313)
-
(2006)
Journal of Immunology
, vol.176
, Issue.1
, pp. 640-651
-
-
Poppe, D.1
Tiede, I.2
Fritz, G.3
Becker, C.4
Bartsch, B.5
Wirtz, S.6
Strand, D.7
Tanaka, S.8
Galle, P.R.9
Bustelo, X.R.10
Neurath, M.F.11
-
2
-
-
0029134702
-
Azathioprine and 6-mercaptopurine in Crohn disease. A meta-analysis
-
Pearson DC, May GR, Fick GH et al. Azathioprine and 6-mercaptopurine in Crohn disease. A meta-analysis. Ann. Intern. Med. 123, 132-142 (1995).
-
(1995)
Ann. Intern. Med
, vol.123
, pp. 132-142
-
-
Pearson, D.C.1
May, G.R.2
Fick, G.H.3
-
3
-
-
50649110056
-
Thiopurine-induced myelotoxicity in patients with inflammatory bowel disease: A review
-
Gisbert JP, Gomollon F. Thiopurine-induced myelotoxicity in patients with inflammatory bowel disease: a review. Am. J. Gastroenterol. 103, 1783-1800 (2008).
-
(2008)
Am. J. Gastroenterol
, vol.103
, pp. 1783-1800
-
-
Gisbert, J.P.1
Gomollon, F.2
-
4
-
-
0033828949
-
Genetic polymorphism of thiopurine S-methyltransferase: Molecular mechanisms and clinical importance
-
Krynetski EY, Evans WE. Genetic polymorphism of thiopurine S-methyltransferase: molecular mechanisms and clinical importance. Pharmacology 61, 136-146 (2000).
-
(2000)
Pharmacology
, vol.61
, pp. 136-146
-
-
Krynetski, E.Y.1
Evans, W.E.2
-
5
-
-
79951809968
-
Clinical pharmacogenetics implementation consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing
-
Relling MV, Gardner EE, Sandborn WJ et al. Clinical pharmacogenetics implementation consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing. Clin. Pharmacol. Ther. 89, 387-391 (2011).
-
(2011)
Clin. Pharmacol. Ther
, vol.89
, pp. 387-391
-
-
Relling, M.V.1
Gardner, E.E.2
Sandborn, W.J.3
-
6
-
-
34247213437
-
Thiopurine methyltransferase activity in Spain: A study of 14,545 patients
-
DOI 10.1007/s10620-006-9119-z
-
Gisbert JP, Gomollon F, Cara C et al. Thiopurine methyltransferase activity in Spain: a study of 14,545 patients. Dig. Dis. Sci. 52, 1262-1269 (2007). (Pubitemid 46626159)
-
(2007)
Digestive Diseases and Sciences
, vol.52
, Issue.5
, pp. 1262-1269
-
-
Gisbert, J.P.1
Gomollon, F.2
Cara, C.3
Luna, M.4
Gonzalez-Lama, Y.5
Pajares, J.M.6
Mate, J.7
Guijarro, L.G.8
-
7
-
-
0034093057
-
Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy
-
Colombel J, Ferrari N, Debuysere H et al. Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy. Gastroenterology 118, 1025-1030 (2000). (Pubitemid 30346978)
-
(2000)
Gastroenterology
, vol.118
, Issue.6
, pp. 1025-1030
-
-
Colombel, J.1
Ferrari, N.2
Debuysere, H.3
Marteau, P.4
Gendre, J.5
Bonaz, B.6
Soule, J.-C.7
Modigliani, R.8
Touze, Y.9
Catala, P.10
Libersa, C.11
Broly, F.12
-
8
-
-
33845411925
-
Monitorización de la tiopurina metiltransferasa y de los metabolitos tiopurínicos para optimizar el tratamiento con azatioprina en la enfermedad inflamatoria intestinal
-
DOI 10.1157/13094355
-
Gisbert JP, Gonzalez-Lama Y, Mate J. Monitoring of thiopurine methyltransferase and thiopurine metabolites to optimize azathioprine therapy in inflammatory bowel disease. Gastroenterol. Hepatol. 29, 568-583 (2006). (Pubitemid 44902306)
-
(2006)
Gastroenterologia y Hepatologia
, vol.29
, Issue.9
, pp. 568-583
-
-
Gisbert, J.P.1
Gonzalez-Lama, Y.2
Mate, J.3
-
10
-
-
33846136090
-
Glutathione-S-transferase genotypes and the adverse effects of azathioprine in young patients with inflammatory bowel disease
-
DOI 10.1002/ibd.20004
-
Stocco G, Martelossi S, Barabino A et al. Glutathione-S-transferase genotypes and the adverse effects of azathioprine in young patients with inflammatory bowel disease. Inflamm. Bowel Dis. 13, 57-64 (2007). (Pubitemid 46080010)
-
(2007)
Inflammatory Bowel Diseases
, vol.13
, Issue.1
, pp. 57-64
-
-
Stocco, G.1
Martelossi, S.2
Barabino, A.3
Decorti, G.4
Bartoli, F.5
Montico, M.6
Gotti, A.7
Ventura, A.8
-
12
-
-
79955711085
-
Genome-wide association study on obesity and obesity-related traits
-
Wang K, Li W-D, Zhang CK. Genome-wide association study on obesity and obesity-related traits. PLoS ONE 6, e18939 (2011).
-
(2011)
PLoS ONE
, vol.6
-
-
Wang, K.1
Li, W.-D.2
Zhang, C.K.3
-
13
-
-
0036790212
-
Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease
-
Ansari A, Hassan C, Duley J et al. Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease. Aliment. Pharmacol. Ther. 16, 1743-1750 (2002).
-
(2002)
Aliment. Pharmacol. Ther
, vol.16
, pp. 1743-1750
-
-
Ansari, A.1
Hassan, C.2
Duley, J.3
-
14
-
-
78651100696
-
Data quality control in genetic case-control association studies Nat
-
Anderson CA, Petterssohn FH, Clarke GM et al. Data quality control in genetic case-control association studies, Nat. Protoc. 5, 1564-1573 (2010).
-
(2010)
Protoc
, vol.5
, pp. 1564-1573
-
-
Anderson, C.A.1
Petterssohn, F.H.2
Clarke, G.M.3
-
15
-
-
34548292504
-
PLINK: A tool set for whole-genome association and population-based linkage analyses
-
DOI 10.1086/519795
-
Purcell S, Neale B, Todd-Brown K et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559-575 (2007). (Pubitemid 47330214)
-
(2007)
American Journal of Human Genetics
, vol.81
, Issue.3
, pp. 559-575
-
-
Purcell, S.1
Neale, B.2
Todd-Brown, K.3
Thomas, L.4
Ferreira, M.A.R.5
Bender, D.6
Maller, J.7
Sklar, P.8
De Bakker, P.I.W.9
Daly, M.J.10
Sham, P.C.11
-
16
-
-
34047179603
-
SNPassoc: An R package to perform whole genome association studies
-
DOI 10.1093/bioinformatics/btm025
-
Gonzalez JR, Armengol L, Sole X et al. SNPassoc: an R package to perform whole genome association studies. Bioinformatics 23, 644-645 (2007). (Pubitemid 46522604)
-
(2007)
Bioinformatics
, vol.23
, Issue.5
, pp. 644-645
-
-
Gonzalez, J.R.1
Armengol, L.2
Sole, X.3
Guino, E.4
Mercader, J.M.5
Estivill, X.6
Moreno, V.7
-
17
-
-
0034118493
-
Inference of population structure using multilocus genotype data
-
Pritchard JK, Stephens M, Donnelly P. Inference of population structure using multilocus genotype data. Genetics 155, 945-959 (2000). (Pubitemid 30397141)
-
(2000)
Genetics
, vol.155
, Issue.2
, pp. 945-959
-
-
Pritchard, J.K.1
Stephens, M.2
Donnelly, P.3
-
18
-
-
9844227496
-
Chi-square tests with 1 degree of freedom-extensions of the Mantel-Haenszel procedure
-
Mantel N. Chi-square tests with 1 degree of freedom-extensions of the Mantel-Haenszel procedure. J. Am. Stat. Assoc. 58, 690-700 (1963).
-
(1963)
J. Am. Stat. Assoc
, vol.58
, pp. 690-700
-
-
Mantel, N.1
-
19
-
-
27744461917
-
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease
-
DOI 10.1111/j.1440-1746.2005.03832.x
-
Gearry RB, Barclay ML. Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease. J. Gastroenterol. Hepatol. 20, 1149-1157 (2005). (Pubitemid 41602556)
-
(2005)
Journal of Gastroenterology and Hepatology
, vol.20
, Issue.8
, pp. 1149-1157
-
-
Gearry, R.B.1
Barclay, M.L.2
-
20
-
-
0036801121
-
Terapia individualizada con azatioprina o 6-mercaptopurina mediante monitorización de la actividad de la tiopurina metiltransferasa (TPMT)
-
Gisbert JP, Gomollon F, Mate J et al. Individualized therapy with azathioprine or 6-mercaptopurine by monitoring thiopurine methyl-transferase (TPMT) activity. Rev. Clin. Esp. 202, 555-562 (2002). (Pubitemid 35277186)
-
(2002)
Revista Clinica Espanola
, vol.202
, Issue.10
, pp. 555-562
-
-
Gisbert, J.P.1
Gomollon, F.2
Mate, J.3
Pajares, J.M.4
-
21
-
-
0036076821
-
TPMT in the treatment of Crohn's disease with azathioprine
-
DOI 10.1136/gut.51.2.143
-
Lennard L. TPMT in the treatment of Crohn's disease with azathioprine. Gut 51, 143-146 (2002). (Pubitemid 34791433)
-
(2002)
Gut
, vol.51
, Issue.2
, pp. 143-146
-
-
Lennard, L.1
-
22
-
-
27444437058
-
ITPA genotyping is not predictive for the development of side effects in AZA treated inflammatory bowel disease patients
-
Van Dieren J, Van Vuuren A, Kusters J et al. ITPA genotyping is not predictive for the development of side effects in AZA treated inflammatory bowel disease patients. Gut 54, 1664-1664 (2005).
-
(2005)
Gut
, vol.54
, pp. 1664-1664
-
-
Van Dieren, J.1
Van Vuuren, A.2
Kusters, J.3
-
23
-
-
22444442637
-
Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor
-
DOI 10.1038/nsmb941, PII NSMB941
-
Skiniotis G, Boulanger MJ, Garcia KC et al. Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor. Nat. Struct. Mol. Biol. 12, 545-551 (2005). (Pubitemid 43085886)
-
(2005)
Nature Structural and Molecular Biology
, vol.12
, Issue.6
, pp. 545-551
-
-
Skiniotis, G.1
Boulanger, M.J.2
Garcia, K.C.3
Walz, T.4
-
24
-
-
0028117163
-
Cytokine signal transduction
-
DOI 10.1016/0092-8674(94)90333-6
-
Kishimoto T, Taga T, Akira S. Cytokine signal transduction. Cell 76, 253-262 (1994). (Pubitemid 24046688)
-
(1994)
Cell
, vol.76
, Issue.2
, pp. 253-262
-
-
Kishimoto, T.1
Taga, T.2
Akirat, S.3
-
25
-
-
78649741783
-
Gp130 at the nexus of inflammation, autoimmunity, and cancer
-
Silver JS, Hunter CA. Gp130 at the nexus of inflammation, autoimmunity, and cancer. J. Leukoc. Biol. 88, 1145-1156 (2010).
-
(2010)
J. Leukoc. Biol
, vol.88
, pp. 1145-1156
-
-
Silver, J.S.1
Hunter, C.A.2
-
26
-
-
52949126357
-
Conditional gp130 deficient mouse mutants
-
Fasnacht N, Muller W. Conditional gp130 deficient mouse mutants. Semin. Cell Dev. Biol. 19, 379-384 (2008).
-
(2008)
Semin. Cell Dev. Biol
, vol.19
, pp. 379-384
-
-
Fasnacht, N.1
Muller, W.2
-
27
-
-
0033574574
-
Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress
-
Hirota H, Chen J, Betz UA et al. Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress. Cell 97, 189-198 (1999). (Pubitemid 29194270)
-
(1999)
Cell
, vol.97
, Issue.2
, pp. 189-198
-
-
Hirota, H.1
Chen, J.2
Betz, U.A.K.3
Rajewsky, K.4
Gu, Y.5
Ross Jr., J.6
Muller, W.7
Chien, K.R.8
-
28
-
-
0036796060
-
Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice
-
DOI 10.1038/nm763
-
Tebbutt NC, Giraud AS, Inglese M et al. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat. Med. 8, 1089-1097 (2002). (Pubitemid 35175963)
-
(2002)
Nature Medicine
, vol.8
, Issue.10
, pp. 1089-1097
-
-
Tebbutt, N.C.1
Giraud, A.S.2
Inglese, M.3
Jenkins, B.4
Waring, P.5
Clay, F.J.6
Malki, S.7
Alderman, B.M.8
Grail, D.9
Hollande, F.10
Heath, J.K.11
Ernst, M.12
-
29
-
-
0037037586
-
A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis
-
Atsumi T, Ishihara K, Kamimura D et al. A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis. J. Exp. Med. 196, 979-990 (2002).
-
(2002)
J. Exp. Med
, vol.196
, pp. 979-990
-
-
Atsumi, T.1
Ishihara, K.2
Kamimura, D.3
-
30
-
-
77949903848
-
IL-6 positively regulates Foxp3+CD8+ T cells in vivo
-
Nakagawa T, Tsuruoka M, Ogura H et al. IL-6 positively regulates Foxp3+CD8+ T cells in vivo. Int. Immunol. 22, 129-139 (2010).
-
(2010)
Int. Immunol
, vol.22
, pp. 129-139
-
-
Nakagawa, T.1
Tsuruoka, M.2
Ogura, H.3
-
31
-
-
77953693531
-
Molecular classification of hepatocellular carcinoma
-
Zucman-Rossi J. Molecular classification of hepatocellular carcinoma. Dig. Liver Dis. 42(Suppl. 3), S235-S241 (2010).
-
(2010)
Dig. Liver Dis
, vol.42
, Issue.SUPPL. 3
-
-
Zucman-Rossi, J.1
-
32
-
-
0029778822
-
Thrombopoietic activity of recombinant human interleukin 11 (rHuIL-11) in normal and myelosuppressed nonhuman primates
-
Schlerman FJ, Bree AG, Kaviani MD et al. Thrombopoietic activity of recombinant human interleukin 11 (rHuIL-11) in normal and myelosuppressed nonhuman primates. Stem Cells 14, 517-532 (1996). (Pubitemid 26322113)
-
(1996)
Stem Cells
, vol.14
, Issue.5
, pp. 517-532
-
-
Schlerman, F.J.1
Bree, A.G.2
Kaviani, M.D.3
Nagle, S.L.4
Donnelly, L.H.5
Mason, L.E.6
Schaub, R.G.7
Grupp, S.A.8
Goldman, S.J.9
-
33
-
-
4143118839
-
Effects of recombinant human interleukin 11 on thrombocytopenia and neutropenia in irradiated rhesus monkeys
-
DOI 10.1667/RR3202
-
Hao J, Sun L, Huang H et al. Effects of recombinant human interleukin 11 on thrombocytopenia and neutropenia in irradiated rhesus monkeys. Radiat. Res. 162, 157-163 (2004). (Pubitemid 39100015)
-
(2004)
Radiation Research
, vol.162
, Issue.2
, pp. 157-163
-
-
Hao, J.1
Sun, L.2
Huang, H.3
Xiong, G.4
Liu, X.5
Qiu, L.6
Chen, G.7
Dong, B.8
Li, Y.9
Chen, W.10
Buechler, Y.11
Sun, J.12
Shen, C.13
Luo, Q.14
-
34
-
-
0036442199
-
Effects of interleukin-11 on the hematopoietic action of granulocyte colony-stimulating factor
-
Momose K, Taguchi K, Saitoh M et al. Effects of interleukin-11 on the hematopoietic action of granulocyte colony-stimulating factor. Arzneimittelforschung 52, 857-861 (2002). (Pubitemid 35398737)
-
(2002)
Arzneimittel-Forschung/Drug Research
, vol.52
, Issue.11
, pp. 857-861
-
-
Momose, K.1
Taguchi, K.2
Saitoh, M.3
Yasuda, S.4
Miyata, K.5
-
35
-
-
0033551248
-
Assigning protein functions by comparative genome analysis: Protein phylogenetic profiles
-
DOI 10.1073/pnas.96.8.4285
-
Pellegrini M, Marcotte EM, Thompson MJ et al. Assigning protein functions by comparative genome analysis: protein phylogenetic profiles. Proc. Natl Acad. Sci. USA 96, 4285-4288 (1999). (Pubitemid 29190328)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.8
, pp. 4285-4288
-
-
Pellegrini, M.1
Marcotte, E.M.2
Thompson, M.J.3
Eisenberg, D.4
Yeates, T.O.5
-
36
-
-
77955467884
-
Genetic polymorphisms and plasma levels of matrix metalloproteinases and their relationships with developing acute myocardial infarction
-
Ghaderian SM, Akbarzadeh Najar R, Tabatabaei Panah AS. Genetic polymorphisms and plasma levels of matrix metalloproteinases and their relationships with developing acute myocardial infarction. Coron. Artery Dis. 21, 330-335 (2010).
-
(2010)
Coron. Artery Dis
, vol.21
, pp. 330-335
-
-
Ghaderian, S.M.1
Akbarzadeh Najar, R.2
Tabatabaei Panah, A.S.3
-
37
-
-
78650420447
-
Promoter polymorphisms in matrix metallopeptidase 1 and risk of cutaneous melanoma
-
Wang LE, Huang YJ, Yin M et al. Promoter polymorphisms in matrix metallopeptidase 1 and risk of cutaneous melanoma. Eur. J. Cancer 47, 107-115 (2011).
-
(2011)
Eur. J. Cancer
, vol.47
, pp. 107-115
-
-
Wang, L.E.1
Huang, Y.J.2
Yin, M.3
-
38
-
-
77958596170
-
Association of matrix metalloproteinases 1 7, and 9 gene polymorphisms with genetic susceptibility to colorectal carcinoma in a Han Chinese population
-
Fang WL, Liang WB, He H et al. Association of matrix metalloproteinases 1, 7, and 9 gene polymorphisms with genetic susceptibility to colorectal carcinoma in a Han Chinese population. DNA Cell Biol. 29, 657-661 (2010).
-
(2010)
DNA Cell Biol.
, vol.29
, pp. 657-661
-
-
Fang, W.L.1
Liang, W.B.2
He, H.3
-
39
-
-
78649278104
-
Functional polymorphism of the MMP-1 promoter (-1607 1G/2G) in potentially malignant and malignant head and neck lesions in an Indian population
-
Chaudhary AK, Pandya S, Mehrotra R et al. Functional polymorphism of the MMP-1 promoter (-1607 1G/2G) in potentially malignant and malignant head and neck lesions in an Indian population. Biomarkers 15, 684-692 (2010).
-
(2010)
Biomarkers
, vol.15
, pp. 684-692
-
-
Chaudhary, A.K.1
Pandya, S.2
Mehrotra, R.3
-
40
-
-
78651065963
-
A polymorphism at-1607 2G in the matrix metalloproteinase-1 (MMP-1) increased risk of sudden deafness in Korean population but not at-519A/G in MMP-1
-
Nam SI, Yu GI, Kim HJ et al. A polymorphism at-1607 2G in the matrix metalloproteinase-1 (MMP-1) increased risk of sudden deafness in Korean population but not at-519A/G in MMP-1. Laryngoscope 121, 171-175 (2011).
-
(2011)
Laryngoscope
, vol.121
, pp. 171-175
-
-
Nam, S.I.1
Yu, G.I.2
Kim, H.J.3
-
41
-
-
78650831923
-
MMP-2 mediates angiotensin II-induced hypertension under the transcriptional control of MMP-7 and TACE
-
Odenbach J, Wang X, Cooper S et al. MMP-2 mediates angiotensin II-induced hypertension under the transcriptional control of MMP-7 and TACE. Hypertension 57, 123-130 (2011).
-
(2011)
Hypertension
, vol.57
, pp. 123-130
-
-
Odenbach, J.1
Wang, X.2
Cooper, S.3
-
42
-
-
78650026900
-
Matrix metalloproteinase-2 and matrix metalloproteinase-9 codistribute with transcription factors RUNX1/AML1 and ETV5/ERM at the invasive front of endometrial and ovarian carcinoma
-
Planaguma J, Liljestrom M, Alameda F et al. Matrix metalloproteinase-2 and matrix metalloproteinase-9 codistribute with transcription factors RUNX1/AML1 and ETV5/ERM at the invasive front of endometrial and ovarian carcinoma. Hum. Pathol. 42, 57-67 (2011).
-
(2011)
Hum. Pathol
, vol.42
, pp. 57-67
-
-
Planaguma, J.1
Liljestrom, M.2
Alameda, F.3
-
43
-
-
77957350003
-
Association between metalloproteinases 2 and 9 activity and ERK1/2 phosphorylation status in head and neck cancers: An ex vivo study
-
Garavello W, Maggioni D, Nicolini G et al. Association between metalloproteinases 2 and 9 activity and ERK1/2 phosphorylation status in head and neck cancers: an ex vivo study. Oncol. Rep. 24, 1073-1078 (2010).
-
(2010)
Oncol. Rep
, vol.24
, pp. 1073-1078
-
-
Garavello, W.1
Maggioni, D.2
Nicolini, G.3
-
44
-
-
77957706779
-
TIMP-1 interaction with alphavbeta3 integrin confers resistance to human osteosarcoma cell line MG-63 against TNF-alpha-induced apoptosis
-
Tsagaraki I, Tsilibary EC, Tzinia AK. TIMP-1 interaction with alphavbeta3 integrin confers resistance to human osteosarcoma cell line MG-63 against TNF-alpha-induced apoptosis. Cell Tissue Res. 342, 87-96 (2010).
-
(2010)
Cell Tissue Res
, vol.342
, pp. 87-96
-
-
Tsagaraki, I.1
Tsilibary, E.C.2
Tzinia, A.K.3
-
45
-
-
79955946805
-
Matrix metalloproteinase 12 overexpression in myeloid lineage cells plays a key role in modulating myelopoiesis, immune suppression, and lung tumorigenesis
-
Qu P, Yan C, Du H. Matrix metalloproteinase 12 overexpression in myeloid lineage cells plays a key role in modulating myelopoiesis, immune suppression, and lung tumorigenesis. Blood 117, 4476-4489 (2011).
-
(2011)
Blood
, vol.117
, pp. 4476-4489
-
-
Qu, P.1
Yan, C.2
Du, H.3
|