Thrombopoietic activity of recombinant human interleukin 11 (rHuIL-11) in normal and myelosuppressed nonhuman primates

Stem Cells

Volumn 14, Issue 5, 1996, Pages 517-532

  Schlerman, Franklin J ^a   Bree, Andrea G ^a   Kaviani, Michelle D ^a   Nagle, Sandra L ^a   Donnelly, Lori H ^a   Mason, Lawrence E ^a   Schaub, Robert G ^a   Grupp, Stephan A ^b   Goldman, Samuel J ^a  

^a PFIZER INC   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Chemotherapy; Megakaryocytopoiesis; Nonhuman primate; rHuIL 11; Thrombopoiesis

Indexed keywords

CARBOPLATIN; RECOMBINANT INTERLEUKIN 11;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW SUPPRESSION; CHEMOTHERAPY; CONTROLLED STUDY; MALE; MEGAKARYOCYTE; MEGAKARYOPOIESIS; MONKEY; NONHUMAN; SUBCUTANEOUS DRUG ADMINISTRATION; THROMBOCYTE COUNT; THROMBOCYTOPENIA; THROMBOCYTOPOIESIS;

ANIMALIA; MACACA FASCICULARIS; PRIMATES;

EID: 0029778822     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.140517     Document Type: Article

References (43)

1. Musashi M, Yang Y, Paul SR et al. Direct and synergistic effects of interleukin-11 on murine hematopoiesis in culture. Proc Natl Acad Sci USA 1991;88:765-769.
2. Musashi M, Clark SC, Sudo T et al. Synergistic interactions between interleukin-11 and interleukin-4 in support of proliferation of primitive hematopoietic progenitors of mice. Blood 1991;78:1448-1451.
3. Hirayama F, Shih J, Awgulewitsch A et al. Clonal proliferation of murine lymphohematopoietic progenitors in culture. Proc Natl Acad Sci USA 1992;89:5907-5911.
4. Quesniaux VFJ, Clark SC, Turner K et al. Interleukin-11 stimulates multiple phases of erythropoiesis in vitro. Blood 1992;80:1218-1223.
5. Teramura M, Kobayashi S, Hoshino S et al. Interleukin-11 enhances human megakaryocytopoiesis in vitro. Blood 1992;79:327-331.
6. Burstein SA, Mei R, Henthorn J et al. Leukemia inhibitory factor and interleukin-11 promote the maturation of murine and human megakaryocyte in vitro. J Cell Physiol 1992;153:305-312.
7. Bruno E, Briddell RA, Cooper RJ et al. Effects of recombinant interleukin-11 on human megakaryocyte progenitor cells. Exp Hematol 1991;19:378-381.
8. Broudy VC, Lin NL, Kaushansky K. Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro. Blood 1995;85:1719-1786.
9. Quesniaux VFJ, Mayer P, Liehl E et al. Review of a novel hematopoietic cytokine, interleukin-11. Int Rev Exp Pathol 1992;34:205-214.
10. Neben TY, Loebelenz J, Hayes L et al. Recombinant human interleukin-11 stimulates megakaryocytopoiesis and increases peripheral platelets in normal and splenectomized mice. Blood 1993;81:901-908.
11. Yonemura Y, Kawakita M, Masuda T et al. Effect of recombinant human interleukin-11 on rat megakaryopoiesis and thrombopoiesis in vivo: comparative study with interleukin-6. Br J Haematol 1992;84:16-23.
12. Leonard JP, Neben TY, Kozitza MK et al. Constant subcutaneous infusion of rh1L-11 in mice: efficient delivery enhance biological activity. Exp Hematol 1996;24:270-276.
13. Du XX, Keller D, Maze R et al. Comparative effects of in vivo treatment using interleukin-11 and stem cell factor on reconstitution in mice after bone marrow transplantation. Blood 1993;82:1016-1022.
14. Leonard JP, Quinto CM, Kozitza MK et al. Recombinant human interleukin-11 stimulates multilineage hematopoietic recovery in mice after a myelosuppressive regimen of sublethal irradiation and carboplatin. Blood 1994;83:1499-1506.
15. Hangoc G, Yin T, Cooper S et al. In vivo effects of recombinant interleukin-11 on myelopoiesis in mice. Blood 1993;81:965-972.
16. Paul SR, Hayes LL, Palmer R et al. Interleukin-11 expression in donor bone marrow cells improves hematological reconstitution in lethally irradiated mice. Exp Hematol 1994;22:295-301.
17. Hawley RG, Fong AZC, Ngan Y et al. Progenitor cell hyperplasia with rare development of myeloid leukemia in interleukin-11 bone marrow chimeras. J Exp Med 1993;178:1175-1188.
18. Maze R, Moritz T, Williams DA. Increased survival and multilineage hematopoietic production from delayed and severe myelosuppressive effects of a nitrosourea with recombinant interleukin-11 (IL-11). Cancer Res 1994;54:4947-4951.
19. Nash R, Seidel K, Storb R et al. Effects of rhIL-11 on normal dogs and after sublethal radiation. Exp Hematol 1995;23:389-396.
20. Gordon MS, Battiato L, Hoffman R et al. Subcutaneously (SC) administered recombinant human interleukin-11 (Neumega™ rhIL-11 growth factor; rhIL-11) prevents thrombocytopenia following chemotherapy (CT) with cyclophosphamide (c) and doxorubicin (A) in women with breast cancer (BC). Blood 1993;82(suppl 1):318a.
21. Gordon MS, Sledge GW, Battiato L et al. The in vivo effects of subcutaneously (SC) administered recombinant human interleukin-11 (Neumega™ rhIL-11 growth factor; rhIL-11) in women with breast cancer (BC). Blood 1993;82(suppl 1):498a.
22. Lee LG, Chen CH, Chiu LA. Thiazole orange: a new dye for reticulocyte analysis. Cytometry 1986;7:508-517.
23. AuLt KA, Rinder H, Mitchell J et al. The significance of platelets with increased RNA content (reticulated platelets): a measure of the rate of thrombopoiesis. J Clin Lab Invest 1992;98:637-646.
24. Ault KA, Mitchell J, Knowles C et al. Recombinant human interleukin eleven (Neumega™ rhIL-11 growth factor) increases plasma volume and decreases urine sodium excretion in normal human subjects. Blood 1994;84(suppl 1):276a.
25. Ault K, Knowles C. In vivo biotinylation demonstrates that reticulated platelets are the youngest platelets in circulation. Exp Hematol 1995;23:996-1001.
26. Dale GL, Friese P, Hynes LA et al. Demonstration that thiazole-orange-positive platelets in the dog are less than 24 hours old. Blood 1995;85:1822-1825.
27. Goldman S. Preclinical biology of interleukin-11: a multifunctional hematopoietic cytokine with potent thrombopoietic activity. STEM CELLS 1995;13:462-471.
28. Stahl CP, Zucker-Franklin D, Evatt BL et al. Effects of human interleukin-6 on megakaryocyte development and thrombocytopoiesis in primates. Blood 1991;78:1467-1475.
29. Yonemura Y, Kawakita M, Masuda T et al. Synergistic effects of interleukin 3 and interleukin 11 on murine megakaryopoiesis in serum-free culture. Exp Hematol 1992;20:1011-1016.
30. Turner KJ, Clark SC. Interleukin-11: biological and clinical perspectives. In: Mertelsmann R, Herrmann F, eds. Hematopoietic Growth Factors in Clinical Applications. New York: Marcel Dekker, Inc., 1995:315-336.
31. Monroy RL, Davis TA, Donahue RE et al. In vivo stimulation of platelet production in a primate model using IL-1 and IL-3. Exp Hematol 1991;19:629-635.
32. Guinan EC, Lee YS, Lopez KD et al. Effects of interleukin-3 and granulocyte-macrophage colony-stimulating factor on thrombopoiesis in congenital amegakaryocytic thrombocytopenia. Blood 1993;81:1691-1698.
33. D'Hondt V, Humblet Y, Guillaume T et al. Thrombopoietic effects and toxicity of interleukin-6 in patients with ovarian cancer before and after chemotherapy: a multicenter placebo controlled, randomized phase Ib study. Blood 1995;85:2347-2353.
34. MacVittie TJ, Farese AM, Patchen ML et al. Therapeutic efficacy of recombinant interleukin-6 (IL-6) alone and combined with recombinant human IL-3 in a nonhuman primate model of high-dose, sublethal radiation-induced marrow aplasia. Blood 1994;84:2515-2522.
35. Winton EF, Srinivasiah J, Kim BK et al. Effects of recombinant human interleukin-6 (rhIL-6) and rhIL-3 on hematopoietic regeneration as demonstrated in a nonhuman primate chemotherapy model. Blood 1994;84:65-73.
36. Harker LA, Hunt P, Marzec UM et al. Regulation of platelet production and function by megakaryocyte growth and development factor in nonhuman primates. Blood 1996;87:1833-1844.
37. Farese AM, Hunt P, Boone T et al. Recombinant human megakaryocyte growth and development factor stimulates thrombocytopoiesis in normal nonhuman primates. Blood 1995;86:54-59.
38. Yan XQ, Lacey D, Fletcher F et al. Chronic exposure to retroviral vector encoded MGDF (mpl-ligand) induces lineage-specific growth and differentiation of megakaryocytes in mice. Blood 1995;86:4025-4033.
39. Ulich TR, del Castillo J, Yin S et al. Megakaryocyte growth and development factor ameliorates carboplatin-induced thrombocytopenia in mice. Blood 1995;86:971-976.
40. Fibbe WE, Heemskerk DP, Laterveer L et al. Accelerated reconstitution of platelets and erythrocytes after syngeneic transplantation of bone marrow cells derived from thrombopoietin pretreated donor mice. Blood 1995;86:3308-3313.
41. Kaushansky K, Broudy VC, Grossmann A et al. Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy. J Clin Invest 1995;96:1683-1687.
42. Bree A, Schlerman F, Timony G et al. Pharmacokinetics and thrombopoietic effects of recombinant human interleukin-11 (rhIL-11) in nonhuman primates and rodents. Blood 1991;78(suppl 1):132a.
43. Schlerman F, Bree A, Stoudemire J et al. Effects of subcutaneous administration of recombinant human interleukin 11 (rhIL-11) or recombinant human granulocyte macrophage colony stimulating factor (rhGM-CSF) alone, or rhIL-11 in combination with recombinant human interleukin-3 (rhIL-3) or rhGM-CSF in nonhuman primates. Blood 1992;80(suppl 1):64a.