Enhanced uptake and cytotoxity of folate-conjugated mitoxantrone-loaded micelles via receptor up-regulation by dexamethasone

International Journal of Pharmaceutics

Volumn 448, Issue 1, 2013, Pages 142-149

  Chen, Han ^a   Zhang, Tong ^a   Zhou, Zhimin ^a   Guan, Man ^a   Wang, Jingjie ^a   Liu, Lingrong ^a   Zhang, Qiqing ^a,b  

^a INSTITUTE OF BIOMEDICAL ENGINEERING   (China)

^b FUZHOU UNIVERSITY   (China)

Author keywords

Endocytosis; Folate targeting; Lipid core micelles; Receptor up regulation

Indexed keywords

DEXAMETHASONE; FOLATE RECEPTOR 1; FOLIC ACID; MESSENGER RNA; MITOXANTRONE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL SURFACE; CONFOCAL MICROSCOPY; CYTOTOXICITY TEST; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG SYNTHESIS; ENDOCYTOSIS; FLOW CYTOMETRY; HELA CELL; IN VITRO STUDY; MICELLE; MODULATION; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; THERAPY EFFECT;

ANTINEOPLASTIC AGENTS; CELL SURVIVAL; COUMARINS; DEXAMETHASONE; ENDOCYTOSIS; FOLATE RECEPTOR 1; FOLIC ACID; HELA CELLS; HUMANS; MICELLES; MITOXANTRONE; PHOSPHATIDYLETHANOLAMINES; POLYETHYLENE GLYCOLS; RNA, MESSENGER; THIAZOLES; UP-REGULATION;

EID: 84875957462     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.03.032     Document Type: Article

References (37)

1. C. Allen, D. Maysinger, and A. Eisenberg Nano-engineering block copolymer aggregates for drug delivery Colloids Surf. B: Biointerfaces 16 1999 3 27
2. S. Bhattacharya, A. Franz, X. Li, and B. Jasti Synthesis of folate-conjugated amphiphiles for tumor-targeted drug delivery J. Drug Target. 16 2008 780 789
3. S.D. Conner, and S.L. Schmid Regulated portals of entry into the cell Nature 422 2003 37 44 (Pubitemid 36323287)
4. J.G. Eley, V.D. Pujari, and J. McLane Poly (lactide-co-glycolide) nanoparticles containing coumarin-6 for suppository delivery: in vitro release profile and in vivo tissue distribution Drug Deliv. 11 2004 255 261 (Pubitemid 39096044)
5. J. Fang, H. Nakamura, and H. Maeda The EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect Adv. Drug Deliv. Rev. 63 2011 136 151
6. Z. Gao, A.N. Lukyanov, A.R. Chakilam, and V.P. Torchilin PEG-PE/phosphatidylcholine mixed immunomicelles specifically deliver encapsulated taxol to tumor cells of different origin and promote their efficient killing J. Drug Target. 11 2003 87 92 (Pubitemid 36869181)
7. J. Gong, M. Chen, Y. Zheng, S. Wang, and Y. Wang Polymeric micelles drug delivery system in oncology J. Control. Release 159 2012 312 323
8. X. Han, J. Liu, M. Liu, C. Xie, C. Zhan, B. Gu, F.L. Liu Yu, and W. Lu 9-NC-loaded folate-conjugated polymer micelles as tumor targeted drug delivery system: preparation and evaluation in vitro Int. J Pharm. 372 2009 125 131
9. S.K. Hobbs, W.L. Monsky, F.R. Yuan, W.L. GregoryGriffith, V.P. Torchilin, and K. Rakesh Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment Proc. Natl. Acad. Sci. U.S.A. 95 1998 4607 4612 (Pubitemid 28207960)
10. M.D. Howard, M. Jay, T.D. Dziubla, and X. Lu PEGylation of nanocarrier drug delivery systems: state of the art J. Biomed. Nanotechnol. 4 2008 133 148
11. J.V. Jokerst, T. Lobovkina, R.N. Zare, and S.S. Gambhir Nanoparticle PEGylation for imaging and therapy Nanomedicine 6 2011 715 728
12. B.A. Kamen, and A.K. Smith A review of folate receptor alpha cycling and 5-methyltetrahydrofolate accumulation with an emphasis on cell models in vitro Adv. Drug Deliv. Rev. 56 2004 1085 1097 (Pubitemid 38496509)
13. K. Kim, H. Cho, J.Y. Hahn, T.Y. Kim, K.W. Park, B.K. Koo, S.C. Soo, C.H. Kim, B.H. Oh, M.M. Lee, Y.B. Park, and H.S. Kim Beta-catenin overexpression augments angiogenesis and skeletal muscle regeneration through dual mechanism of vascular endothelial growth factor-mediated endothelial cell proliferation and progenitor cell mobilization Arterioscler. Thromb. Vasc. Biol. 26 2006 91 98 (Pubitemid 43732233)
14. C.P. Leamon, and J.A. Reddy Folate-targeted chemotherapy Adv. Drug Deliv. Rev. 56 2004 1127 1141 (Pubitemid 38496512)
15. R.J. Lee, and P.S. Low Delivery of liposomes into cultured KB cells via folate receptor-mediated endocytosis J. Biol. Chem. 269 1994 3198 3204 (Pubitemid 24237629)
16. P.S. Low, and S.A. Kularatne Folate-targeted therapeutic and imaging agents for cancer Curr. Opin. Chem. Biol. 13 2009 256 262
17. F. Marcucci, and F. Lefoulon Active targeting with particulate drug carriers in tumor therapy: fundamentals and recent progress Drug Discov. Today 9 2004 219 228 (Pubitemid 38230021)
18. D. Maysinger, J. Lovrić, A. Eisenberg, and R. Savić Fate of micelles and quantum dots in cells Eur. J. Pharm. Biopharm. 65 2007 270 281
19. T. Musacchio, and V.P. Torchilin Recent developments in lipid-based pharmaceutical nanocarriers Front. Biosci. 16 2011 1388 1422
20. C. Oerlemans, W. Bult, M. Bos, G. Storm, J. Nijsen, and W. Hennink Polymeric micelles in anticancer therapy: targeting, imaging and triggered release Pharm. Res. 27 2010 2569 2589
21. E.K. Park, S.Y. Kim, B. Lee Sang, and Y.M. Lee Folate-conjugated methoxy poly (ethylene glycol)/poly (ε-caprolactone) amphiphilic block copolymeric micelles for tumor-targeted drug delivery J. Control. Release 109 2005 158 168 (Pubitemid 41737262)
22. L. Qiu, X. Wu, and Y. Jin Doxorubicin-loaded polymeric micelles based on amphiphilic polyphosphazenes with poly (N-isopropylacrylamide-co-N,N- dimethylacrylamide) and ethyl glycinate as side groups: synthesis, preparation and in vitro evaluation Pharm. Res. 26 2009 946 957
23. K.M. Rentsch, R.A. Schwendener, and E. Hänseler Determination of mitoxantrone in mouse whole blood and different tissues by high-performance liquid chromatography J. Chromatogr. B: Biomed. Sci. Appl. 679 1996 185 192 (Pubitemid 26159970)
24. R.R. Sawant, R.M. Sawant, and V.P. Torchilin Mixed PEG-PE/vitamin E tumor-targeted immunomicelles as carriers for poorly soluble anti-cancer drugs: improved drug solubilization and enhanced in vitro cytotoxicity Eur. J. Pharm. Biopharm. 70 2008 51 57
25. V.P. Torchilin Recent advances with liposomes as pharmaceutical carriers Nat. Rev. Drug Discov. 4 2005 145 160 (Pubitemid 40282557)
26. V.P. Torchilin Micellar nanocarriers: pharmaceutical perspectives Pharm. Res. 24 2007 1 16 (Pubitemid 44902565)
27. G. Toffoli, C. Cernigoi, A. Russo, A. Gallo, M. Bagnoli, and M. Boiocchi Overexpression of folate binding protein in ovarian cancers Int. J. Cancer 74 1997 193 198 (Pubitemid 27234510)
28. T. Tran, A. Shatnawi, X. Zheng, K.M. Kelley, and M. Ratnam Enhancement of folate receptor α expression in tumor cells through the glucocorticoid receptor: a promising means to improved tumor detection and targeting Cancer Res. 65 2005 4431 4441 (Pubitemid 40775683)
29. M.E. Werner, S. Karve, R. Sukumar, N.D. Cummings, J.A. Copp, R.C. Chen, T. Zhang, and A.Z. Wang Folate-targeted nanoparticle delivery of chemo- and radiotherapeutics for the treatment of ovarian cancer peritoneal metastasis Biomaterials 32 2011 8548 8554
30. M. Wu, W. Gunning, and M. Ratnam Expression of folate receptor type α in relation to cell type, malignancy, and differentiation in ovary, uterus, and cervix Cancer Epidemiol. Biomarkers Prev. 8 1999 775 782 (Pubitemid 29445014)
31. J. Wu, Q. Liu, and R.J. Lee A folate receptor-targeted liposomal formulation for paclitaxel Int. J. Pharm. 316 2006 148 153 (Pubitemid 43786219)
32. G. Xiang, J. Wu, Y. Lu, Z. Liu, and R.J. Lee Synthesis and evaluation of a novel ligand for folate-mediated targeting liposomes Int. J. Pharm. 356 2008 29 36
33. H.S. Yoo, and T.G. Park Folate receptor targeted biodegradable polymeric doxorubicin micelles J. Control. Release 96 2004 273 283 (Pubitemid 38481509)
34. F. Yuan, M. Dellian, D. Fukumura, M. Leunig, D.A. Berk, V.P. Torchilin, and R.K. Jain Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size Cancer Res. 55 1995 3752 3756
35. Y. Zhang, X. Wang, J. Wang, X. Zhang, and Q. Zhang Octreotide-modified polymeric micelles as potential carriers for targeted docetaxel delivery to somatostatin receptor overexpressing tumor cells Pharm. Res. 28 2011 1167 1178
36. X. Zhao, H. Li, and R.J. Lee Targeted drug delivery via folate receptors Expert Opin. Drug Deliv. 5 2008 309 319 (Pubitemid 351454380)
37. Q. Zhou, X. Guo, T. Chen, Z. Zhang, S. Shao, C. Luo, J. Li, and S. Zhou Target-specific cellular uptake of folate-decorated biodegradable polymer micelles J. Phys. Chem. B 115 2011 12662 12670