Conophylline Promotes the Proliferation of Immortalized Mesenchymal Stem Cells Derived from Fetal Porcine Pancreas (iPMSCs)

Journal of Integrative Agriculture

Volumn 12, Issue 4, 2013, Pages 678-686

  Zhang, Hui ru ^a,b   Li, Dan ^a,b   Cao, Hui ^b   Lü, Xiao ^b   Chu, Yuan kui ^b   Bai, Yao fu ^b   Jin, Ya ping ^b   Peng, Sha ^b   Dou, Zhong ying ^b   Hua, Jin lian ^b  

^a HENAN UNIVERSITY OF TECHNOLOGY   (China)

^b NORTHWEST A F UNIVERSITY   (China)

Author keywords

Conophylline; Immortalized pancreatic mesenchymal stem cells (iPMSCs); Insulin producing cells; PI3K

Indexed keywords

ASPIDOSPERMA; RATTUS; SUS; TABERNAEMONTANA; TABERNAEMONTANA DIVARICATA;

EID: 84875955531     PISSN: 20953119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S2095-3119(13)60286-5     Document Type: Article

References (28)

1. Anton S, Melville L, Rena G Epigallocatechin gallate (EGCG) mimics insulin action on the transcription factor FOXO1a and elicits cellular responses in the presence and absence of insulin. Cellular Signaling 2007, 19:378-383.
2. Boucher MJ, Selander L, Carlsson L, Edlund H Phosphorylation marks IPF1/PDX1 protein for degradation by glycogen synthase kinase 3-dependent mechanisms. The Journal of Biological Chemistry 2006, 281:6395-6403.
3. Cao H, Chu Y, Zhu H, Sun J, Pu Y, Gao Z, Yang C, Peng S, Dou Z, Hua J Characterization of immortalized mesenchymal stem cells derived from fetal porcine pancreas. Cell Proliferation 2011, 44:19-32.
4. Costoya JA, Hobbs RM, Barna M, Cattoretti G, Manova K, Sukhwani M, Orwig KE, Wolgemuth DJ, Pandolfi PP Essential role of Plzf in maintenance of spermatogonial stem cells. Nature Genetics 2004, 36:653-659.
5. Denis N, Kitzis A, Kruh J, Dautry F, Corcos D Stimulation of methotrexate resistance and dihydrofolate reductase gene amplification by c-myc. Oncogene 1991, 6:1453-1457.
6. Dravid G, Ye Z, Ham H, Chen H, Pyle A, Donovan P, Yu X, Cheng L Defining the role of Wnt/b-catenin signaling in the survival, proliferation, and self-renewal of human embryonic stem cells. Stem Cells 2005, 23:1489-1501.
7. Elliott RB, Basta G, Luca G, Calafiore R. 2008. Methods for preparing xenotransplantable porcine islets. United States Patent Application. 20080070301.
8. Feng R, Zhang H, Wang Y, Qiao H, Zhao T, Shen W, Dou Z Isolation, culture and induced differentiation of fetal porcine islet derived pancreatic stem cell. Agricultural Sciences in China 2007, 6:742-748.
9. Fujii M, Takei I, Umezawa K Antidiabetic effect of orally administered conophylline-containing plant extract on streptozotocin-treated and Goto-Kakizaki rats. Biomedidine Pharmacotheraphy 2009, 63:710-716.
10. Gregory MA, Qi Y, Hann SR Phosphorylation by glycogen synthase kinase-3 controls c-myc proteolysis and subnuclear localization. The Journal of Biological Chemistry 2003, 278:51606-51612.
11. Guo T, Hebrok M Stem cells to pancreatic b-cells: new sources for diabetes cell therapy. Endocrine Reviews 2009, 30:214-227.
12. Han-ya Y, Tokuyama H, Fukuyama T Total synthesis of (-)-conophylline and (-)-conophyllidine. Angewandte Chemie International Edition 2011, 50:4884-4887.
13. Heo JS, Han HJ ATP stimulates mouse embryonic stem cell proliferation via protein kinase C, phosphatidylinositol 3-kinase/AKT, and mitogen-activated protein kinase signaling pathways. Stem Cells 2006, 24:2637-2648.
14. Jiang J, Au M, Kuanghui L, Eshpeter A, Gregory K, Greg F, Majumdar AS Generation of insulin-producing islet-like clusters from human embryonic stem cells. Stem Cells 2007, 25:1940-1953.
15. Kam TS, Loh KY, Lim LH, Loong WL, Chuah CH, Wei C New alkaloids from the leaves of Tabernaemontana divaricata. Tetrahedron Letters 1992, 33:969.
16. Kawakami M, Hirayama A, Tsuchiya K, Ohgawara H, Nakamura M, Umezawa K Promotion of beta-cell differentiation by the alkaloid conophylline in porcine pancreatic endocrine cells. Biomedidine Pharmacotheraphy 2010, 64:226-231.
17. Mairet-Coello G, Tury A, DiCicco-Bloom E Insulinlike growth factor-1 promotes G1/S cell cycle progression through bidirectional regulation of cyclins and cyclin-dependent kinase inhibitors via the phosphatidylinositol 3-kinase/AKT pathway in developing rat cerebral cortex. The Journal of Neuroscience 2009, 29:775-788.
18. Mussmann R, Geese M, Harder F, Kegel S, Andag U, Lomow A, Burk Ue, Onichtchouk D, Dohrmann C, Austen M Inhibition of GSK3 promotes replication and survival of pancreatic beta cells. The Journal of Biological Chemistry 2007, 282:12030-12037.
19. Ogata T, Li L, Yamada S, Yamamoto Y, Tanaka Y, Takei I, Umezawa K, Kojima I Promotion of b-cell differentiation by conophylline in fetal and neonatal rat pancreas. Diabetes 2004, 5:2506-2602.
20. Rogers SA, Chen F, Talcott MR, Faulkner C, Thomas JM, Thevis M, Hammerman MR Long-term engraftment following transplantation of pig pancreatic primordia into non-immunosuppressed diabetic rhesus macaques. Xenotransplantation 2007, 14:591. 560.
21. Rulifson IC, Karnik SK, Heiser PW, Berge D, Chen H, Gu X, Taketo MM, Nusse R, Hebrok M, Kim SK Wnt signaling regulates pancreatic b cell proliferation. The Proceedings of the National Academy of Sciences of the United States of America 2007, 104:6247-6252.
22. Sears R, Nuckolls F, Haura E, Taya Y, Tamai K, Nevins JR Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes & Development 2000, 14:2501-2514.
23. Suzuki A, Nakauchi H, Taniguchi H Prospective isolation of multipotent pancreatic progenitors using flow-cytometric cell sorting. Diabetes 2004, 53:2143-2152.
24. Umezawa K, Hiroki A, Kawakami M, Naka H, Takei I, Ogata T, Kojima I, Koyano T, Kowithayakorn T, Pang HS, et al. Induction of insulin production in rat pancreatic acinar carcinoma cells by conophylline. Biomedidine Pharmacotheraphy 2003, 57:341-350.
25. Umezawa K, Ohse T, Yamamoto T, Koyano T, Takahashi Y Isolation of a new vinca alkaloid from the leaves of Ervatamia microphylla as an inhibitor of ras functions. Anticancer Research 1994, 14:2413-2417.
26. Wang W, Walkerb JR, Wang X, Tremblay MS, Lee JW, Wu X, Schultz PG Identification of small molecule inducers of pancreatic b-cell expansion. The Proceedings of the National Academy of Sciences of the United States of America 2009, 106:1427-1432.
27. Wrobel KH, Bickel D, Kujat R Immunohistochemical study of seminiferous epithelium in adult bovine testis using monoclonal antibodies against Ki-67 protein and proliferating cell nuclear antigen (PCNA). Cell and Tissue Research 1996, 283:191-201.
28. Xu Y, Shi Y, Ding S A chemical approach to stem cell biology. Nature 2008, 453:338-344.