Preparation and antimalarial activity of semisynthetic lycorenine derivatives

European Journal of Medicinal Chemistry

Volumn 63, Issue , 2013, Pages 722-730

  Cedrón, Juan C ^a,b,c   Gutiérrez, David ^d   Flores, Ninoska ^d   Ravelo, Ángel G ^a,b   Estévez Braun, Ana ^a,b  

^a Instituto Universitario de Bio Organica Antonio Gonzalez   (Spain)

^b Madrid Spain   (Spain)

^c Research Center for Heritage Conservation   (Peru)

^d UNIVERSIDAD MAYOR DE SAN ANDRÉS   (Bolivia)

Author keywords

Amaryllidaceae alkaloids; Antiplasmodial activity; Hippeastrine; Lycorenine

Indexed keywords

2 ( 4 BROMOBENZOYL)HIPPEASTRINE; 2 ( 4 PENTENOYL)HIPPEASTRINE; 2 ( 4 VINYLBENZOYL)HIPPEASTRINE; 2 [ 3,5 BIS(METHOXYCARBONYL)BENZOYL]HIPPEASTRINE; 2 ACETYLHIPPEASTRINE; 2 ISOBUTYRYLHIPPEASTRINE; 2 NICOTYLHIPPEASTRINE; 2 OXOHIPPEASTRINE; 3 DIHYDROHIPPEASTRINE; 3,4 DIHYDRO 2 DEOXY 2,3,4,11 TETRADEHYDROHIPPEASTRINE; 6 [ 2 (DIMETHYLAMINO) 3 VINYLPHENYL] 1,3 BENZODIOXOLE 5 CARBOXYLIC ACID; 8,9 NOR 8,9 DIMETHOXYHIPPEASTRINE; 8,9 NORHIPPEASTRINE; ALKALOID DERIVATIVE; ANTIMALARIAL AGENT; BROMOHYDROXYHIPPEASTRINE; CHLORO 2,3 DEHYDRO 3,4 DIHYDRO 2 DEOXYHIPPEASTRINE; CHLOROQUINE; DIBROMOHIPPEASTRINE; DIHYDROXYHIPPEASTRINE; DIMER; ETHYLHIPPEASTRINYLCARBONIC ACID; FUNCTIONAL GROUP; HIPPEASTRINE; HIPPEASTRINE LACTAM; HIPPEASTRINE N OXIDE; LYCORENINE DERIVATIVE; METHYL 6 [ 5 (ACETYLOXY) 1 METHYL 2,3 DIHYDRO 1H INDOL 7 YL] 1,3 BENZODIOXOLE 5 CARBOXYLIC ACID; PANCRATININE A; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANTIMALARIAL ACTIVITY; ARTICLE; BIOTRANSFORMATION; CHEMICAL MODIFICATION; CONTROLLED STUDY; CYTOTOXICITY; DIMERIZATION; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; NONHUMAN; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

AMARYLLIDACEAE ALKALOIDS; ANTIMALARIALS; DIMERIZATION; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PARASITEMIA; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84875932940     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.03.018     Document Type: Article

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