New lycorine-type alkaloid from Lycoris traubii and evaluation of antitrypanosomal and antimalarial activities of lycorine derivatives

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 24, 2008, Pages 10182-10189

  Toriizuka, Yosuke ^a   Kinoshita, Eri ^a   Kogure, Noriyuki ^a   Kitajima, Mariko ^a   Ishiyama, Aki ^b   Otoguro, Kazuhiko ^b   Yamada, Haruki ^b   Omura, Satoshi ^b   Takayama, Hiromitsu ^a  

^a CHIBA UNIVERSITY   (Japan)

^b KITASATO UNIVERSITY   (Japan)

Author keywords

Alkaloid; Antimalarial activity; Antitrypanosomal activity; Lycorine; Lycoris; Structure elucidation; Structure activity relationship

Indexed keywords

1 O HYDROXYBUTANOYLLYCORINE; 1 O PROPANOYLLYCORINE; 1,2 DI O BUTANOYLLYCORINE; 2 O ACETYLLYCORINE; AMARYLLIDACEAE ALKALOID; ANTIMALARIAL AGENT; ANTITRYPANOSOMAL AGENT; ARTEMISIN; EFLORNITHINE; LT1; LYCORINE; LYCORIS TRAUBII EXTRACT; PENTAMIDINE; PLANT EXTRACT; SURAMIN; UNCLASSIFIED DRUG;

AFRICAN TRYPANOSOMIASIS; ANTIMALARIAL ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG POTENCY; DRUG SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; LYCORICE TRAUBII; MALARIA; MEDICINAL PLANT; NONHUMAN; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA BRUCEI;

ALKALOIDS; AMARYLLIDACEAE ALKALOIDS; ANIMALS; ANTIMALARIALS; INHIBITORY CONCENTRATION 50; LILIACEAE; PARASITIC SENSITIVITY TESTS; PHENANTHRIDINES; PLASMODIUM FALCIPARUM; TRYPANOCIDAL AGENTS;

AMARYLLIDACEAE; LYCORIS; LYCORIS TRAUBII; PLASMODIUM FALCIPARUM; TRYPANOSOMA BRUCEI BRUCEI;

EID: 56349143450     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.10.061     Document Type: Article

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