Neuroprotective effects of aqueous extracts of Uncaria tomentosa: Insights from 6-OHDA induced cell damage and transgenic Caenorhabditis elegans model

Neurochemistry International

Volumn 62, Issue 7, 2013, Pages 940-947

  Shi, Zhenhua ^a   Lu, Zhongbing ^b   Zhao, Yashuo ^a   Wang, Yueqi ^a   Zhao Wilson, Xi ^c   Guan, Peng ^a   Duan, Xianglin ^a   Chang, Yan Zhong ^a   Zhao, Baolu ^d,e  

^a HEBEI NORMAL UNIVERSITY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c BioMarker Pharmaceuticals Inc   (United States)

^d Pony Testing International Group   (China)

^e INSTITUTE OF BIOPHYSICS   (China)

Author keywords

Synuclein aggregation; AC11; Oxidative stress; Parkinson's disease

Indexed keywords

AC11; ALPHA SYNUCLEIN; ANTIOXIDANT; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FREE RADICAL; HYDROXYL GROUP; I KAPPA B; INDUCIBLE NITRIC OXIDE SYNTHASE; NEUROPROTECTIVE AGENT; NITRIC OXIDE; OXIDOPAMINE; RADICAL; REACTIVE OXYGEN METABOLITE; SCAVENGER; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA; UNCARIA TOMENTOSA EXTRACT; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CAENORHABDITIS ELEGANS; CELL DAMAGE; CELL LOSS; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIPID PEROXIDATION; MITOCHONDRIAL MEMBRANE POTENTIAL; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; UNCARIA TOMENTOSA; UPREGULATION;

ALPHA-SYNUCLEIN; ANIMALS; CAENORHABDITIS ELEGANS; CAT'S CLAW; CELL SURVIVAL; MEMBRANE POTENTIAL, MITOCHONDRIAL; NEURONS; NEUROPROTECTIVE AGENTS; OXIDOPAMINE; PARKINSON DISEASE; PLANT EXTRACTS; REACTIVE OXYGEN SPECIES;

CAENORHABDITIS ELEGANS; UNCARIA TOMENTOSA;

EID: 84875921567     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2013.03.001     Document Type: Article

References (29)

1. L. Allen-Hall, J.T. Arnason, P. Cano, and R.M. Lafrenie Uncaria tomentosa acts as a potent TNF-alpha inhibitor through NF-kappaB J. Ethnopharmacol. 127 2010 685 693
2. M.F. Beal Aging, energy, and oxidative stress in neurodegenerative diseases Ann. Neurol. 38 1995 357 366
3. M. Bors, B. Bukowska, R. Pilarski, K. Gulewicz, J. Oszmianski, J. Michalowicz, and M. Koter-Michalak Protective activity of the Uncaria tomentosa extracts on human erythrocytes in oxidative stress induced by 2,4-dichlorophenol (2,4-DCP) and catechol Food Chem. Toxicol. 49 2011 2202 2211
4. L. Broom, L. Marinova-Mutafchieva, M. Sadeghian, J.B. Davis, A.D. Medhurst, and D.T. Dexter Neuroprotection by the selective iNOS inhibitor GW274150 in a model of Parkinson disease Free Radic. Biol. Med. 50 2011 633 640
5. M. Caruana, T. Hogen, J. Levin, A. Hillmer, A. Giese, and N. Vassallo Inhibition and disaggregation of alpha-synuclein oligomers by natural polyphenolic compounds FEBS Lett. 585 2011 1113 1120
6. S. Fahn, and G. Cohen The oxidant stress hypothesis in Parkinson's disease: evidence supporting it Ann. Neurol. 32 1992 804 812
7. P.M. Flood, L. Qian, L.J. Peterson, F. Zhang, J.S. Shi, H.M. Gao, and J.S. Hong Transcriptional Factor NF-kappaB as a Target for Therapy in Parkinson's Disease Parkinsons Dis. 2011 2011 216298
8. A. Ghosh, A. Roy, X. Liu, J.H. Kordower, E.J. Mufson, D.M. Hartley, S. Ghosh, R.L. Mosley, H.E. Gendelman, and K. Pahan Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease Proc. Natl. Acad. Sci. USA 104 2007 18754 18759
9. S. Guo, E. Bezard, and B. Zhao Protective effect of green tea polyphenols on the SH-SY5Y cells against 6-OHDA induced apoptosis through ROS-NO pathway Free Radic. Biol. Med. 39 2005 682 695
10. S. Guo, J. Yan, T. Yang, X. Yang, E. Bezard, and B. Zhao Protective effects of green tea polyphenols in the 6-OHDA rat model of Parkinson's disease through inhibition of ROS-NO pathway Biol. Psychiatry 62 2007 1353 1362
11. M.E. Heitzman, C.C. Neto, E. Winiarz, A.J. Vaisberg, and G.B. Hammond Ethnobotany, phytochemistry and pharmacology of Uncaria (Rubiaceae) Phytochemistry 66 2005 5 29
12. S. Hunot, B. Brugg, D. Ricard, P.P. Michel, M.P. Muriel, M. Ruberg, B.A. Faucheux, Y. Agid, and E.C. Hirsch Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with parkinson disease Proc. Natl. Acad. Sci. USA 94 1997 7531 7536
13. P. Jadiya, A. Khan, S.R. Sammi, S. Kaur, S.S. Mir, and A. Nazir Anti-Parkinsonian effects of Bacopa monnieri: insights from transgenic and pharmacological Caenorhabditis elegans models of Parkinson's disease Biochem. Biophys. Res. Commun. 413 2011 605 610
14. Z. Lu, G. Nie, P.S. Belton, H. Tang, and B. Zhao Structure-activity relationship analysis of antioxidant ability and neuroprotective effect of gallic acid derivatives Neurochem. Int. 48 2006 263 274
15. Z. Lu, Y. Tao, Z. Zhou, J. Zhang, C. Li, L. Ou, and B. Zhao Mitochondrial reactive oxygen species and nitric oxide-mediated cancer cell apoptosis in 2-butylamino-2-demethoxyhypocrellin B photodynamic treatment Free Radic. Biol. Med. 41 2006 1590 1605
16. T. Mammone, C. Akesson, D. Gan, V. Giampapa, and R.W. Pero A water soluble extract from Uncaria tomentosa (Cat's Claw) is a potent enhancer of DNA repair in primary organ cultures of human skin Phytother. Res. 20 2006 178 183
17. Y. Noda, K. Anzai, A. Mori, M. Kohno, M. Shinmei, and L. Packer Hydroxyl and superoxide anion radical scavenging activities of natural source antioxidants using the computerized JES-FR30 ESR spectrometer system Biochem. Mol. Biol. Int. 42 1997 35 44
18. V.K. Parihar, J. Dhawan, S. Kumar, S.N. Manjula, G. Subramanian, M.K. Unnikrishnan, and C.M. Rao Free radical scavenging and radioprotective activity of dehydrozingerone against whole body gamma irradiation in Swiss albino mice Chem. Biol. Interact. 170 2007 49 58
19. K.N. Prasad, W.C. Cole, and B. Kumar Multiple antioxidants in the prevention and treatment of Parkinson's disease J. Am. Coll. Nutr. 18 1999 413 423
20. M. Sandoval, N.N. Okuhama, X.J. Zhang, L.A. Condezo, J. Lao, F.M. Angeles', R.A. Musah, P. Bobrowski, and M.J. Miller Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content Phytomedicine 9 2002 325 337
21. M. Sandoval-Chacon, J.H. Thompson, X.J. Zhang, X. Liu, E.E. Mannick, H. Sadowska-Krowicka, R.M. Charbonnet, D.A. Clark, and M.J. Miller Antiinflammatory actions of cat's claw: the role of NF-kappaB Aliment Pharmacol. Ther. 12 1998 1279 1289
22. A.H. Schapira, M. Gu, J.W. Taanman, S.J. Tabrizi, T. Seaton, M. Cleeter, and J.M. Cooper Mitochondria in the etiology and pathogenesis of Parkinson's disease Ann. Neurol. 44 1998 S89 S98
23. B.S. Shastry Neurodegenerative disorders of protein aggregation Neurochem. Int. 43 2003 1 7
24. Y. Sheng, C. Bryngelsson, and R.W. Pero Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa J. Ethnopharmacol. 69 2000 115 126
25. Y. Sheng, L. Li, K. Holmgren, and R.W. Pero DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study Phytomedicine 8 2001 275 282
26. M.A. Tirmenstein, C.X. Hu, M.S. Scicchitano, P.K. Narayanan, D.C. McFarland, H.C. Thomas, and L.W. Schwartz Effects of 6-hydroxydopamine on mitochondrial function and glutathione status in SH-SY5Y human neuroblastoma cells Toxicol. In Vitro 19 2005 471 479
27. T.J. Van Ham, K.L. Thijssen, R. Breitling, R.M.W. Hofstra, and R.H.A. Plasterk C. elegans model identifies genetic modifiers of α-synuclein inclusion formation during aging PLoS Genet. 4 3 2008 e1000027 10.1371/journal.pgen.1000027
28. H. Yang, T. Wu, M. Zhang, and Z. Zhang A novel photosensitizer, 2-butylamino-2-demethoxy-hypocrellin B (2-BA-2-DMHB) - its photodynamic effects on HeLa cells: efficacy and apoptosis Biochim. Biophys. Acta 1540 2001 22 31
29. B. Zhao Natural antioxidants protect neurons in Alzheimer's disease and Parkinson's disease Neurochem. Res. 34 2009 630 638