-
1
-
-
0036632368
-
The phosphatidylinositol 3-kinase- AKT pathway in human cancer
-
Vivanco I and Sawyers CL: The phosphatidylinositol 3-kinase- AKT pathway in human cancer. Nat Rev Cancer 2: 489-501, 2002.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
2
-
-
27844445642
-
Perturbations of the AKT signaling pathway in human cancer
-
Altomare DA and Testa JR: Perturbations of the AKT signaling pathway in human cancer. Oncogene 24: 7455-7464, 2005.
-
(2005)
Oncogene
, vol.24
, pp. 7455-7464
-
-
Altomare, D.A.1
Testa, J.R.2
-
3
-
-
32044466838
-
Exploiting the PI3K/AKT pathway for cancer drug discovery
-
Hennessy BT, Smith DL, Ram PT, Lu Y and Mills GB: Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov 4: 988-1004, 2005.
-
(2005)
Nat Rev Drug Discov
, vol.4
, pp. 988-1004
-
-
Hennessy, B.T.1
Smith, D.L.2
Ram, P.T.3
Lu, Y.4
Mills, G.B.5
-
4
-
-
24944480788
-
The Akt-mTOR tango and its relevance to cancer
-
Hay N: The Akt-mTOR tango and its relevance to cancer. Cancer Cell 8: 179-183, 2005.
-
(2005)
Cancer Cell
, vol.8
, pp. 179-183
-
-
Hay, N.1
-
5
-
-
33745307617
-
Ras PI(3)K and MTOR signaling controls tumour cell growth
-
Shaw RJ and Cantley LC: Ras, PI(3)K and mTOR signaling controls tumour cell growth. Nature 441: 424-430, 2006.
-
(2006)
Nature
, vol.441
, pp. 424-430
-
-
Shaw, R.J.1
Cantley, L.C.2
-
6
-
-
34548079500
-
Targeting the Akt protein kinase for cancer chemoprevention
-
Crowell JA, Steele VE and Fay JR: Targeting the Akt protein kinase for cancer chemoprevention. Mol Cancer Ther 6: 2139-2148, 2007.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 2139-2148
-
-
Crowell, J.A.1
Steele, V.E.2
Fay, J.R.3
-
7
-
-
0017647580
-
Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma
-
Staal SP, Hartley JW and Rowe WP: Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma. Proc Natl Acad Sci USA 74: 3065-3067, 2007.
-
(2007)
Proc Natl Acad Sci USA
, vol.74
, pp. 3065-3067
-
-
Staal, S.P.1
Hartley, J.W.2
Rowe, W.P.3
-
8
-
-
0036195196
-
AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis
-
Roy HK, Olusola BF, Clemens DL, Karolski WJ, Ratashak A, Lynch HT and Smyrk TC: AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis. Carcinogenesis 23: 201-205, 2002.
-
(2002)
Carcinogenesis
, vol.23
, pp. 201-205
-
-
Roy, H.K.1
Olusola, B.F.2
Clemens, D.L.3
Karolski, W.J.4
Ratashak, A.5
Lynch, H.T.6
Smyrk, T.C.7
-
9
-
-
47649105292
-
Cardiac hormones and urodilatin eliminate up to 86% of human small-cell lung carcinomas in mice
-
Eichelbaum EJ, Sun Y, Alli AA, Gower WR Jr. and Vesely DL: Cardiac hormones and urodilatin eliminate up to 86% of human small-cell lung carcinomas in mice. Eur J Clin Invest 38: 562-570, 2008.
-
(2008)
Eur J Clin Invest
, vol.38
, pp. 562-570
-
-
Eichelbaum, E.J.1
Sun, Y.2
Alli, A.A.3
Gower Jr., W.R.4
Vesely, D.L.5
-
10
-
-
34250172696
-
Elimination of up to 80% of human pancreatic adenocarcinomas in athymic mice by cardiac hormones
-
Vesely DL, Eichelbaum EJ, Sun Y, Alli AA, Vesely BA, Luther SL and Gower WR Jr.: Elimination of up to 80% of human pancreatic adenocarcinomas in athymic mice by cardiac hormones. In Vivo 21: 445-452, 2007.
-
(2007)
In Vivo
, vol.21
, pp. 445-452
-
-
Vesely, D.L.1
Eichelbaum, E.J.2
Sun, Y.3
Alli, A.A.4
Vesely, B.A.5
Luther, S.L.6
Gower Jr., W.R.7
-
11
-
-
37349091248
-
Four cardiac hormones eliminate up to twothirds of human breast cancers in athymic mice
-
Vesely DL, Vesely BA, Eichelbaum EJ, Sun Y, Alli AA and Gower WR Jr.: Four cardiac hormones eliminate up to twothirds of human breast cancers in athymic mice. In Vivo 21: 973-978, 2007.
-
(2007)
In Vivo
, vol.21
, pp. 973-978
-
-
Vesely, D.L.1
Vesely, B.A.2
Eichelbaum, E.J.3
Sun, Y.4
Alli, A.A.5
Gower Jr., W.R.6
-
12
-
-
33745697992
-
Four peptides decrease human colon adenocarcinoma cell number and DNA synthesis via guanosine 3',5'-cyclic monophosphate
-
Gower WR Jr., Vesely BA, Alli AA and Vesely DL: Four peptides decrease human colon adenocarcinoma cell number and DNA synthesis via guanosine 3',5'-cyclic monophosphate. Int J Gastrointestinal Cancer 36: 77-87, 2005.
-
(2005)
Int J Gastrointestinal Cancer
, vol.36
, pp. 77-87
-
-
Gower Jr., W.R.1
Vesely, B.A.2
Alli, A.A.3
Vesely, D.L.4
-
13
-
-
64949135331
-
Vessel dilator and kaliuretic peptide inhibit Ras in human prostate cancer cells
-
Sun Y, Eichelbaum EJ, Skelton WP IV, Lenz A, Regales N, Wang H and Vesely DL: Vessel dilator and kaliuretic peptide inhibit Ras in human prostate cancer cells. Anticancer Res 29: 971-975, 2009.
-
(2009)
Anticancer Res
, vol.29
, pp. 971-975
-
-
Sun, Y.1
Eichelbaum, E.J.2
Skelton, W.P.I.V.3
Lenz, A.4
Regales, N.5
Wang, H.6
Vesely, D.L.7
-
14
-
-
67650925065
-
Atrial natriuretic peptide and long-acting natriuretic peptide inhibit Ras in human prostate cancer cells
-
Sun Y, Eichelbaum EJ, Lenz A, Skelton WP IV, Wang H and Vesely DL: Atrial natriuretic peptide and long-acting natriuretic peptide inhibit Ras in human prostate cancer cells. Anticancer Res 29: 1889-1893, 2009.
-
(2009)
Anticancer Res
, vol.29
, pp. 1889-1893
-
-
Sun, Y.1
Eichelbaum, E.J.2
Lenz, A.3
Skelton, W.P.I.V.4
Wang, H.5
Vesely, D.L.6
-
15
-
-
77951218958
-
Epidermal growth factor's activation of Ras is inhibited by four cardiac hormones
-
SunY, Eichelbaum EJ, Lenz A, Wang H and Vesely DL: Epidermal growth factor's activation of Ras is inhibited by four cardiac hormones. Eur J Clin Invest 40: 408-413, 2010.
-
(2010)
Eur J Clin Invest
, vol.40
, pp. 408-413
-
-
Sun, Y.1
Eichelbaum, E.J.2
Lenz, A.3
Wang, H.4
Vesely, D.L.5
-
16
-
-
0035882030
-
Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia
-
Zhang X, Gaspard JP and Chung DC: Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia. Cancer Res 61: 6050-6054, 2001.
-
(2001)
Cancer Res
, vol.61
, pp. 6050-6054
-
-
Zhang, X.1
Gaspard, J.P.2
Chung, D.C.3
-
17
-
-
85013312416
-
Tumor angiogenesis: Therapeutic implications
-
Folkman J: Tumor angiogenesis: therapeutic implications. N Engl J Med 295: 1182-1186, 1971.
-
(1971)
N Engl J Med
, vol.295
, pp. 1182-1186
-
-
Folkman, J.1
-
18
-
-
4143136640
-
Vascular endothelial growth factor: Basic science and clinical progress
-
Ferrara N: Vascular endothelial growth factor: Basic science and clinical progress. Endocrine Reviews 25: 581-611, 2004.
-
(2004)
Endocrine Reviews
, vol.25
, pp. 581-611
-
-
Ferrara, N.1
-
19
-
-
10644279947
-
Vascular endothelial growth factor
-
Hoeben A, Landuyt B, Highley MS, Wilders H, Van Oosterom AT and DeBruijin EA: Vascular endothelial growth factor. Pharmacol Rev 56: 549-580, 2004.
-
(2004)
Pharmacol Rev
, vol.56
, pp. 549-580
-
-
Hoeben, A.1
Landuyt, B.2
Highley, M.S.3
Wilders, H.4
Van Oosterom, A.T.5
Debruijin, E.A.6
-
20
-
-
0034000699
-
VEGF receptor signaling in tumor angiogenesis
-
McMahon G: VEGF receptor signaling in tumor angiogenesis. Oncologist 5(Suppl 1): S3-S10, 2000.
-
(2000)
Oncologist
, vol.5
, Issue.SUPPL. 1
-
-
McMahon, G.1
-
21
-
-
0032515047
-
Vascular endothelial growth factor regulates endothelial cell survival through the phospatidylinositol 3'- kinase/Akt signal transduction pathway: Requirement for Flk- 1/KDR activation
-
Gerber HP, McMurtrey A, Kowalski J, Yan M, Keyt BA, Dixit V and Ferrara N: Vascular endothelial growth factor regulates endothelial cell survival through the phospatidylinositol 3'- kinase/Akt signal transduction pathway: requirement for Flk- 1/KDR activation. J Biol Chem 273: 30336-30343, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 30336-30343
-
-
Gerber, H.P.1
McMurtrey, A.2
Kowalski, J.3
Yan, M.4
Keyt, B.A.5
Dixit, V.6
Ferrara, N.7
-
22
-
-
0033522927
-
Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchoragedependent manner
-
Fujio Y and Walsh K: Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchoragedependent manner. J Biol Chem 274: 16349-16354, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 16349-16354
-
-
Fujio, Y.1
Walsh, K.2
-
23
-
-
0033573895
-
VEGF stimulates MAPK through a pathway that is unique for receptor tyrosine kinases
-
Doanes AM, Hegland DD, Sethi R, Kovesdi I, Bruder JT and Finkel T: VEGF stimulates MAPK through a pathway that is unique for receptor tyrosine kinases. Biochem Biophys Res Commun 255: 545-548, 1999.
-
(1999)
Biochem Biophys Res Commun
, vol.255
, pp. 545-548
-
-
Doanes, A.M.1
Hegland, D.D.2
Sethi, R.3
Kovesdi, I.4
Bruder, J.T.5
Finkel, T.6
-
24
-
-
0035966004
-
Vascular endothelial growth factor induction of the angiogenic phenotype requires Ras activation
-
Meadows KN, Bryant P and Pumiglia K: Vascular endothelial growth factor induction of the angiogenic phenotype requires Ras activation. J Biol Chem 276: 49289-49298, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 49289-49298
-
-
Meadows, K.N.1
Bryant, P.2
Pumiglia, K.3
-
25
-
-
0032584108
-
Impact of oncogenes in tumor angiogenesis: Mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells
-
Okada F, Rak JW, St Croix B, Lieubeau B, Kaya M, Roncari L, Shirasawa S, Sasazuki T and Kerbel RS: Impact of oncogenes in tumor angiogenesis: mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells. Proc Natl Acad Sci USA 95: 3609-3614, 1998.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 3609-3614
-
-
Okada, F.1
Rak, J.W.2
St Croix, B.3
Lieubeau, B.4
Kaya, M.5
Roncari, L.6
Shirasawa, S.7
Sasazuki, T.8
Kerbel, R.S.9
-
26
-
-
84866275052
-
Novel dual inhibitors of vascular endothelial growth factor and the VEGFR2 receptor
-
Nguyen JP, Frost CD, Lane ML, Skelton WP IV, Skelton M and Vesely DL: Novel dual inhibitors of vascular endothelial growth factor and the VEGFR2 receptor. Eur J Clin Invest 42: 1061-1067, 2012.
-
(2012)
Eur J Clin Invest
, vol.42
, pp. 1061-1067
-
-
Nguyen, J.P.1
Frost, C.D.2
Lane, M.L.3
Skelton, W.P.I.V.4
Skelton, M.5
Vesely, D.L.6
-
27
-
-
84859027559
-
Antiproliferative effect of atrial natriuretic peptide on colorectal cancer cells: Evidence for an Akt-mediated cross-talk between acidic tumor microenvironment and Wnt/beta-catenin signaling
-
Serafino A, Moroni N, Psaila R, Zonfrillo M, Andreola F, Wannenes F, Mercuri L, Rasi G and Pierimarchi P: Antiproliferative effect of atrial natriuretic peptide on colorectal cancer cells: evidence for an Akt-mediated cross-talk between acidic tumor microenvironment and Wnt/beta-catenin signaling. Biochim Biophys Acta 1822: 1004-1018, 2012.
-
(2012)
Biochim Biophys Acta
, vol.1822
, pp. 1004-1018
-
-
Serafino, A.1
Moroni, N.2
Psaila, R.3
Zonfrillo, M.4
Andreola, F.5
Wannenes, F.6
Mercuri, L.7
Rasi, G.8
Pierimarchi, P.9
-
28
-
-
0035907390
-
Akt participation in the Wnt signaling pathway through dishevelled
-
Fukumoto S, Hsieh C-M, Maemura K, Layne MD, Yet S-F, Lee K-H, Matsui T, Rosenzweig A, Taylor WG, Rubin JS, Perrella MA and Lee ME: Akt participation in the Wnt signaling pathway through dishevelled. J Biol Chem 276: 17479-17483, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 17479-17483
-
-
Fukumoto, S.1
Hsieh, C.-M.2
Maemura, K.3
Layne, M.D.4
Yet, S.-F.5
Lee, K.-H.6
Matsui, T.7
Rosenzweig, A.8
Taylor, W.G.9
Rubin, J.S.10
Perrella, M.A.11
Lee, M.E.12
-
29
-
-
20444449617
-
Oncogenic K-ras stimulates Wnt signaling in colon cancer through inhibition of GSK-3beta
-
Li J, Mizukiami Y, Zhang X, Jo W-S and Chung DC: Oncogenic K-ras stimulates Wnt signaling in colon cancer through inhibition of GSK-3beta. Gastroenterology 128: 1907-1918, 2005.
-
(2005)
Gastroenterology
, vol.128
, pp. 1907-1918
-
-
Li, J.1
Mizukiami, Y.2
Zhang, X.3
Jo, W.-S.4
Chung, D.C.5
-
30
-
-
11144354317
-
Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma
-
Yamamoto S, Tomita Y, Hoshida Y, Morooka T, Nagano H, Dono K, Umeshita K, Sakon M, Ishikawa O, Ohigashi H, Nakamori S, Monden M and Aozasa K: Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma. Clin Cancer Res 10: 2846-2850, 2004.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 2846-2850
-
-
Yamamoto, S.1
Tomita, Y.2
Hoshida, Y.3
Morooka, T.4
Nagano, H.5
Dono, K.6
Umeshita, K.7
Sakon, M.8
Ishikawa, O.9
Ohigashi, H.10
Nakamori, S.11
Monden, M.12
Aozasa, K.13
-
31
-
-
79952851688
-
Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers
-
Baba Y, Nosho K, Shima K, Hayashi M, Meyerhardt JA, Chan AT, Giovannucci E, Fuchs CS and Ogino S: Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers. Cancer 117: 1398-1408, 2011.
-
(2011)
Cancer
, vol.117
, pp. 1398-1408
-
-
Baba, Y.1
Nosho, K.2
Shima, K.3
Hayashi, M.4
Meyerhardt, J.A.5
Chan, A.T.6
Giovannucci, E.7
Fuchs, C.S.8
Ogino, S.9
-
32
-
-
33744902875
-
The phosphoinositide 3-kinase/Akt pathway: A new target in human renal cell carcinoma therapy
-
Sourbier C, Lindner V, Lang H, Agouni A, Schordan E, Danilin S, Rothhut S, Jacqmin D, Helwig JJ and Massfelder T: The phosphoinositide 3-kinase/Akt pathway: a new target in human renal cell carcinoma therapy. Cancer Res 66: 5130-5142, 2006.
-
(2006)
Cancer Res
, vol.66
, pp. 5130-5142
-
-
Sourbier, C.1
Lindner, V.2
Lang, H.3
Agouni, A.4
Schordan, E.5
Danilin, S.6
Rothhut, S.7
Jacqmin, D.8
Helwig, J.J.9
Massfelder, T.10
|