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Volumn 42, Issue 10, 2012, Pages 1061-1067

Novel dual inhibitors of vascular endothelial growth factor and VEGFR2 receptor

Author keywords

Atrial natriuretic peptide; Kaliuretic peptide; Long acting natriuretic peptide; Vascular endothelial growth factor (VEGF); VEGFR2 KDR Flk 1 receptor; Vessel dilator

Indexed keywords

ATRIAL NATRIURETIC FACTOR; KALIURETIC PEPTIDE; LONG ACTING NATRIURETIC PEPTIDE; NATRIURETIC FACTOR; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR 2;

EID: 84866275052     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2012.02695.x     Document Type: Article
Times cited : (22)

References (33)
  • 1
    • 33947732977 scopus 로고    scopus 로고
    • Angiogenesis: an organizing principle for drug discovery?
    • Folkman J. Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov 2007;6:273-86.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 273-286
    • Folkman, J.1
  • 2
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: basic science and clinical progress
    • Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev 2004;25:581-611.
    • (2004) Endocr Rev , vol.25 , pp. 581-611
    • Ferrara, N.1
  • 4
    • 85013312416 scopus 로고
    • Tumor angiogenesis: therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971;295:1182-6.
    • (1971) N Engl J Med , vol.295 , pp. 1182-1186
    • Folkman, J.1
  • 5
    • 0016218630 scopus 로고
    • Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation
    • Liotta LA, Kleinerman J, Saidel GM. Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation. Cancer Res 1974;34:997-1004.
    • (1974) Cancer Res , vol.34 , pp. 997-1004
    • Liotta, L.A.1    Kleinerman, J.2    Saidel, G.M.3
  • 7
    • 0035966004 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induction of the angiogenic phenotype requires Ras activation
    • Meadows KN, Bryant P, Pumiglia K. Vascular endothelial growth factor induction of the angiogenic phenotype requires Ras activation. J Biol Chem 2001;276:49289-98.
    • (2001) J Biol Chem , vol.276 , pp. 49289-49298
    • Meadows, K.N.1    Bryant, P.2    Pumiglia, K.3
  • 8
    • 30944440262 scopus 로고    scopus 로고
    • Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF)
    • Byrne AM, Bouchier-Hayes DJ, Harmey JH. Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF). J Cell Mol Med 2005;9:777-94.
    • (2005) J Cell Mol Med , vol.9 , pp. 777-794
    • Byrne, A.M.1    Bouchier-Hayes, D.J.2    Harmey, J.H.3
  • 9
    • 70449646016 scopus 로고    scopus 로고
    • Hypoxia enhances FGF-2 and VEGF stimulated human placental artery endothelial cell proliferation: roles of MEK-1/2/ERK-1/2 and PI3K/AKT1 Pathways
    • Wang K, Jiang YZ, Chen DB, Zheng J. Hypoxia enhances FGF-2 and VEGF stimulated human placental artery endothelial cell proliferation: roles of MEK-1/2/ERK-1/2 and PI3K/AKT1 Pathways. Placenta 2009;30:1045-51.
    • (2009) Placenta , vol.30 , pp. 1045-1051
    • Wang, K.1    Jiang, Y.Z.2    Chen, D.B.3    Zheng, J.4
  • 10
    • 0033558798 scopus 로고    scopus 로고
    • VEGF prevents apoptosis of human microvascular endothelial cells via opposing effects on MAPK/ERK and SAPK/JNK signaling
    • Gupta I, Kshirsagar S, Li W, Gui L, Ramakrishnan S, Gupta P et al. VEGF prevents apoptosis of human microvascular endothelial cells via opposing effects on MAPK/ERK and SAPK/JNK signaling. Exp Cell Res 1999;247:495-504.
    • (1999) Exp Cell Res , vol.247 , pp. 495-504
    • Gupta, I.1    Kshirsagar, S.2    Li, W.3    Gui, L.4    Ramakrishnan, S.5    Gupta, P.6
  • 11
    • 0037235049 scopus 로고    scopus 로고
    • VEGF increases endothelial permeability by separate signaling pathways involving ERK-1/2 and nitric oxide
    • Breslin JW, Pappas PJ, Cerveira JJ, Hobson RW II, Duran WN. VEGF increases endothelial permeability by separate signaling pathways involving ERK-1/2 and nitric oxide. Am J Physiol 2003;284:H92-100.
    • (2003) Am J Physiol , vol.284
    • Breslin, J.W.1    Pappas, P.J.2    Cerveira, J.J.3    Hobson II, R.W.4    Duran, W.N.5
  • 13
    • 0034000699 scopus 로고    scopus 로고
    • VEGF receptor signaling in tumor angiogenesis
    • McMahon G. VEGF receptor signaling in tumor angiogenesis. Oncologist 2000;5(Suppl 1):S3-10.
    • (2000) Oncologist , vol.5 , Issue.SUPPL. 1
    • McMahon, G.1
  • 14
    • 47649105292 scopus 로고    scopus 로고
    • Cardiac hormones and urodilatin eliminate up to 86% of human small-cell lung carcinomas in mice
    • Eichelbaum EJ, Sun Y, Alli AA, Gower WR Jr, Vesely DL. Cardiac hormones and urodilatin eliminate up to 86% of human small-cell lung carcinomas in mice. Eur J Clin Invest 2008;38:562-70.
    • (2008) Eur J Clin Invest , vol.38 , pp. 562-570
    • Eichelbaum, E.J.1    Sun, Y.2    Alli, A.A.3    Gower Jr, W.R.4    Vesely, D.L.5
  • 15
    • 34250172696 scopus 로고    scopus 로고
    • Elimination of up to 80% of human pancreatic adenocarcinomas in athymic mice by cardiac hormones
    • Vesely DL, Eichelbaum EJ, Sun Y, Alli AA, Vesely BA, Luther SL et al. Elimination of up to 80% of human pancreatic adenocarcinomas in athymic mice by cardiac hormones. In Vivo 2007;21:445-52.
    • (2007) In Vivo , vol.21 , pp. 445-452
    • Vesely, D.L.1    Eichelbaum, E.J.2    Sun, Y.3    Alli, A.A.4    Vesely, B.A.5    Luther, S.L.6
  • 16
    • 37349091248 scopus 로고    scopus 로고
    • Four cardiac hormones eliminate up to two-thirds of human breast cancers in athymic mice
    • Vesely DL, Vesely BA, Eichelbaum EJ, Sun Y, Alli AA, Gower WR Jr. Four cardiac hormones eliminate up to two-thirds of human breast cancers in athymic mice. In Vivo 2007;21:973-8.
    • (2007) In Vivo , vol.21 , pp. 973-978
    • Vesely, D.L.1    Vesely, B.A.2    Eichelbaum, E.J.3    Sun, Y.4    Alli, A.A.5    Gower Jr, W.R.6
  • 18
    • 67650925065 scopus 로고    scopus 로고
    • Atrial natriuretic peptide and long-acting natriuretic peptide inhibit Ras in human prostate cancer cells
    • Sun Y, Eichelbaum EJ, Lenz A, Skelton WP IV, Wang H, Vesely DL. Atrial natriuretic peptide and long-acting natriuretic peptide inhibit Ras in human prostate cancer cells. Anticancer Res 2009;29:1889-93.
    • (2009) Anticancer Res , vol.29 , pp. 1889-1893
    • Sun, Y.1    Eichelbaum, E.J.2    Lenz, A.3    Skelton, W.I.4    Wang, H.5    Vesely, D.L.6
  • 19
    • 34249288341 scopus 로고    scopus 로고
    • Vessel dilator and kaliuretic peptide inhibit MEK 1/2 activation in human prostate cancer cells
    • Sun Y, Eichelbaum EJ, Wang H, Vesely DL. Vessel dilator and kaliuretic peptide inhibit MEK 1/2 activation in human prostate cancer cells. Anticancer Res 2007;27:1387-92.
    • (2007) Anticancer Res , vol.27 , pp. 1387-1392
    • Sun, Y.1    Eichelbaum, E.J.2    Wang, H.3    Vesely, D.L.4
  • 20
    • 37349025338 scopus 로고    scopus 로고
    • Atrial natriuretic peptide and long acting natriuretic peptide inhibit MEK 1/2 activation in human prostate cancer cells
    • Sun Y, Eichelbaum EJ, Wang H, Vesely DL. Atrial natriuretic peptide and long acting natriuretic peptide inhibit MEK 1/2 activation in human prostate cancer cells. Anticancer Res 2007;27:3813-8.
    • (2007) Anticancer Res , vol.27 , pp. 3813-3818
    • Sun, Y.1    Eichelbaum, E.J.2    Wang, H.3    Vesely, D.L.4
  • 21
    • 33750741904 scopus 로고    scopus 로고
    • Vessel dilator and kaliuretic peptide inhibit activation of ERK 1/2 in human prostate cancer cells
    • Sun Y, Eichelbaum EJ, Wang H, Vesely DL. Vessel dilator and kaliuretic peptide inhibit activation of ERK 1/2 in human prostate cancer cells. Anticancer Res 2006;26:3217-22.
    • (2006) Anticancer Res , vol.26 , pp. 3217-3222
    • Sun, Y.1    Eichelbaum, E.J.2    Wang, H.3    Vesely, D.L.4
  • 22
    • 33845930794 scopus 로고    scopus 로고
    • Atrial natriuretic peptide and long acting natriuretic peptide inhibit ERK 1/2 in prostate cancer cells
    • Sun Y, Eichelbaum EJ, Wang H, Vesely DL. Atrial natriuretic peptide and long acting natriuretic peptide inhibit ERK 1/2 in prostate cancer cells. Anticancer Res 2006;26:4143-8.
    • (2006) Anticancer Res , vol.26 , pp. 4143-4148
    • Sun, Y.1    Eichelbaum, E.J.2    Wang, H.3    Vesely, D.L.4
  • 23
    • 33344472286 scopus 로고    scopus 로고
    • Antiangiogenesis in cancer therapy - endostatin and its mechanism of action
    • Folkman J. Antiangiogenesis in cancer therapy - endostatin and its mechanism of action. Exp Cell Res 2006;312:594-607.
    • (2006) Exp Cell Res , vol.312 , pp. 594-607
    • Folkman, J.1
  • 24
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers G, Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 2008;8:592-603.
    • (2008) Nat Rev Cancer , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 25
    • 79960108792 scopus 로고    scopus 로고
    • Once on 'fast track' Avastin now derailed
    • Couzin-Frankel J, Ogale Y. Once on 'fast track' Avastin now derailed. Science 2011;333:143-4.
    • (2011) Science , vol.333 , pp. 143-144
    • Couzin-Frankel, J.1    Ogale, Y.2
  • 26
    • 79959426381 scopus 로고    scopus 로고
    • Vascular endothelial growth factor inhibitor-induced hypertension: basics for the primary care physician
    • doi: 10.4061/2011/816897, Published online May 10.
    • Escalante CP, Zalpour A. Vascular endothelial growth factor inhibitor-induced hypertension: basics for the primary care physician. Cardiol Res Pract 2011; 2011:816897, doi: 10.4061/2011/816897, Published online May 10.
    • (2011) Cardiol Res Pract , vol.2011 , pp. 816897
    • Escalante, C.P.1    Zalpour, A.2
  • 27
    • 0028070631 scopus 로고
    • Three peptides from the atrial natriuretic factor prohormone amino terminus lower blood pressure and produce diuresis, natriuresis, and/or kaliuresis in humans
    • Vesely DL, Douglass MA, Dietz JR, Gower WR Jr, McCormick MT, Rodriguez-Paz G et al. Three peptides from the atrial natriuretic factor prohormone amino terminus lower blood pressure and produce diuresis, natriuresis, and/or kaliuresis in humans. Circulation 1994;90:1129-40.
    • (1994) Circulation , vol.90 , pp. 1129-1140
    • Vesely, D.L.1    Douglass, M.A.2    Dietz, J.R.3    Gower Jr, W.R.4    McCormick, M.T.5    Rodriguez-Paz, G.6
  • 28
    • 0032575292 scopus 로고    scopus 로고
    • Vessel dilator enhances sodium and water excretion and has beneficial hemodynamic effects in persons with congestive heart failure
    • Vesely DL, Dietz JR, Parks JR, Baig M, McCormick MT, Cintron G et al. Vessel dilator enhances sodium and water excretion and has beneficial hemodynamic effects in persons with congestive heart failure. Circulation 1998;98:323-9.
    • (1998) Circulation , vol.98 , pp. 323-329
    • Vesely, D.L.1    Dietz, J.R.2    Parks, J.R.3    Baig, M.4    McCormick, M.T.5    Cintron, G.6
  • 29
    • 0034082202 scopus 로고    scopus 로고
    • Amelioration with vessel dilator of acute tubular necrosis and renal failure established for two days
    • Clark LC, Farghaly H, Saba SR, Vesely DL. Amelioration with vessel dilator of acute tubular necrosis and renal failure established for two days. Am J Physiol 2000;278:H1555-64.
    • (2000) Am J Physiol , vol.278
    • Clark, L.C.1    Farghaly, H.2    Saba, S.R.3    Vesely, D.L.4
  • 30
    • 0038824872 scopus 로고    scopus 로고
    • Natriuretic peptides and acute renal failure
    • Vesely DL. Natriuretic peptides and acute renal failure. Am J Physiol 2003;285:F167-77.
    • (2003) Am J Physiol , vol.285
    • Vesely, D.L.1
  • 31
    • 0028822834 scopus 로고
    • Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis
    • Rak J, Mitsuhashi Y, Bayko L, Filmus J, Shirasawa S, Saszuki T et al. Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis. Cancer Res 1995;55:4575-80.
    • (1995) Cancer Res , vol.55 , pp. 4575-4580
    • Rak, J.1    Mitsuhashi, Y.2    Bayko, L.3    Filmus, J.4    Shirasawa, S.5    Saszuki, T.6
  • 32
    • 0028834638 scopus 로고
    • Both v-Ha-Ras and v-Raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells
    • Grugel S, Finkenzeller G, Weindel K, Barleon B, Marmé D. Both v-Ha-Ras and v-Raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells. J Biol Chem 1995;270:25915-9.
    • (1995) J Biol Chem , vol.270 , pp. 25915-25919
    • Grugel, S.1    Finkenzeller, G.2    Weindel, K.3    Barleon, B.4    Marmé, D.5
  • 33
    • 34548443831 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-2: structure, function, intracellular signaling and therapeutic inhibition
    • Holmes K, Roberts OL, Thomas AM, Cross MJ. Vascular endothelial growth factor receptor-2: structure, function, intracellular signaling and therapeutic inhibition. Cellular Signaling 2007;19:2003-12.
    • (2007) Cellular Signaling , vol.19 , pp. 2003-2012
    • Holmes, K.1    Roberts, O.L.2    Thomas, A.M.3    Cross, M.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.