Inhibition of insulin secretion from rat pancreatic islets by dexmedetomidine and medetomidine, two sedatives frequently used in clinical settings

Endocrine Journal

Volumn 60, Issue 3, 2013, Pages 337-346

  Yamato Kodera, Shiho ^a   Yoshida, Masashi ^a   Dezaki, Katsuya ^a   Yada, Toshihiko ^a   Murayama, Takanori ^a   Kawakami, Masanobu ^b   Kakei, Masafumi ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b Nerima Hikarigaoka Hospital   (Japan)

Author keywords

Dexmedetomidine; Insulin secretion; Medetomidine; Rat pancreatic islets

Indexed keywords

COLLAGENASE; DEXMEDETOMIDINE; GLUCOSE; MEDETOMIDINE; PERTUSSIS TOXIN; TETRYLAMMONIUM; TOLBUTAMIDE; VOLTAGE GATED CALCIUM CHANNEL; YOHIMBINE;

ADULT ANIMAL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG EFFECT; DRUG EXPOSURE; DRUG POTENCY; DRUG STRUCTURE; HORMONE INHIBITION; IC 50; INCUBATION TIME; INSULIN RELEASE; MALE; MEMBRANE POTENTIAL; MICHAELIS MENTEN KINETICS; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; RAT;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; DEXMEDETOMIDINE; GTP-BINDING PROTEINS; HYPNOTICS AND SEDATIVES; INSULIN; INSULIN ANTAGONISTS; ISLETS OF LANGERHANS; MALE; MEDETOMIDINE; OMEGA-CONOTOXINS; PERTUSSIS TOXIN; POTASSIUM CHANNELS, VOLTAGE-GATED; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-2; TETRAETHYLAMMONIUM; YOHIMBINE;

EID: 84875899704     PISSN: 09188959     EISSN: 13484540     Source Type: Journal    
DOI: 10.1507/endocrj.EJ12-0308     Document Type: Article

References (34)

1. Tan JA, Ho KM (2010) Use of dexmedetomidine as a sedative and analgesic agent in critically ill adult patients: a meta-analysis. Intensive Care Med 36: 926-939.
2. Walker J, Maccallum M, Fischer C, Kopcha R, Saylors R, et al. (2006) Sedation using dexmedetomidine in pediatric burn patients. J Burn Care Res 27: 206-210.
3. Ambrisko TD, Hikasa Y (2003) The antagonistic effects of atipamezole and yohimbine on stress-related neurohormonal and metabolic responses induced by medetomidine in dogs. Can J Vet Res 67: 64-67.
4. Nishimura R, Kim HY, Matsunaga S, Hayashi K, Tamura H, et al. (1994) Effects of medetomidine-midazolam on plasma glucose and insulin concentrations in laboratory pigs. J Vet Med Sci 56: 559-561.
5. Rorsman P, Bokvist K, Ammala C, Arkhammar P, Berggren PO, et al. (1991) Activation by adrenaline of a low-conductance G protein-dependent K+ channel in mouse pancreatic B cells. Nature 349: 77-79.
6. Sieg A, Su J, Munoz A, Buchenau M, Nakazaki M, et al. (2004) Epinephrine-induced hyperpolarization of islet cells without KATP channels. Am J Physiol Endocrinol Metab 286: E463-471.
7. Mason KP, Lerman J (2011) Review article: Dexmedetomidine in children: current knowledge and future applications. Anesth Analg 113: 1129-1142.
8. Benson GJ, Grubb TL, Neff-Davis C, Olson WA, Thurmon JC, et al. (2000) Perioperative stress response in the dog: effect of pre-emptive administration of medetomidine. Vet Surg 29: 85-91.
9. Murrell JC, Hellebrekers LJ (2005) Medetomidine and dexmedetomidine: a review of cardiovascular effects and antinociceptive properties in the dog. Vet Anaesth Analg 32: 117-127.
10. Nakazaki M, Kakei M, Koriyama N, Tanaka H (1995) Involvement of ATP-sensitive K+ channels in free radical-mediated inhibition of insulin secretion in rat pancreatic beta-cells. Diabetes 44: 878-883.
11. Dezaki K, Damdindorj B, Sone H, Dyachok O, Tengholm A, et al. (2011) Ghrelin Attenuates cAMP-.PKA Signaling to Evoke Insulinostatic Cascade in Islet {beta}-Cells. Diabetes 60: 2315-2324.
12. Yang SN, Berggren PO (2005) Beta-cell CaV channel regulation in physiology and pathophysiology. Am J Physiol Endocrinol Metab 288: E16-28.
13. Vignali S, Leiss V, Karl R, Hofmann F, Welling A (2006) Characterization of voltage-dependent sodium and calcium channels in mouse pancreatic A- and B-cells. J Physiol 572: 691-706.
14. Ebert TJ, Hall JE, Barney JA, Uhrich TD, Colinco MD (2000) The effects of increasing plasma concentrations of dexmedetomidine in humans. Anesthesiology 93: 382-394.
15. Yamazaki S, Katada T, Ui M (1982) Alpha 2-adrenergic inhibition of insulin secretion via interference with cyclic AMP generation in rat pancreatic islets. Mol Pharmacol 21: 648-653.
16. Schermerhorn T, Sharp GW (2000) Norepinephrine acts on the KATP channel and produces different effects on [Ca2+]i in oscillating and non-oscillating HIT-T15 cells. Cell Calcium 27: 163-173.
17. Holz GG, Heart E, Leech CA (2008) Synchronizing Ca2+ and cAMP oscillations in pancreatic beta-cells: a role for glucose metabolism and GLP-1 receptors? Focus on «regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic beta-cell: a computational approach». Am J Physiol Cell Physiol 294: C4-6.
18. Gromada J, Brock B, Schmitz O, Rorsman P (2004) Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential. Basic Clin Pharmacol Toxicol 95: 252-262.
19. Ammala C, Ashcroft FM, Rorsman P (1993) Calciumindependent potentiation of insulin release by cyclic AMP in single beta-cells. Nature 363: 356-358.
20. Leech CA, Dzhura I, Chepurny OG, Schwede F, Genieser HG, et al. (2010) Facilitation of ss-cell K(ATP) channel sulfonylurea sensitivity by a cAMP analog selective for the cAMP-regulated guanine nucleotide exchange factor Epac. Islets 2: 72-81.
21. Seino S, Shibasaki T (2005) PKA-dependent and PKAindependent pathways for cAMP-regulated exocytosis. Physiol Rev 85: 1303-1342.
22. Peterhoff M, Sieg A, Brede M, Chao CM, Hein L, et al. (2003) Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice. Eur J Endocrinol 149: 343-350.
23. Zhao Y, Fang Q, Straub SG, Sharp GW (2008) Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel. J Biol Chem 283: 5306-5316.
24. Gentili F, Pigini M, Piergentili A, Giannella M (2007) Agonists and antagonists targeting the different alpha2--adrenoceptor subtypes. Curr Top Med Chem 7: 163-186.
25. Yoshida M, Nakata M, Yamato S, Dezaki K, Sugawara H, et al. (2010) Voltage-dependent metabolic regulation of Kv2.1 channels in pancreatic beta-cells. Biochem Biophys Res Commun 396: 304-309.
26. Jacobson DA, Philipson LH (2007) Action potentials and insulin secretion: new insights into the role of Kv channels. Diabetes Obes Metab 9 Suppl 2: 89-98.
27. Yoshida M, Dezaki K, Yamato S, Aoki A, Sugawara H, et al. (2009) Regulation of voltage-gated K+ channels by glucose metabolism in pancreatic beta-cells. FEBS Lett 583: 2225-2230.
28. Yan L, Figueroa DJ, Austin CP, Liu Y, Bugianesi RM, et al. (2004) Expression of voltage-gated potassium channels in human and rhesus pancreatic islets. Diabetes 53: 597-607.
29. MacDonald PE, Wheeler MB (2003) Voltage-dependent K+ channels in pancreatic beta cells: role, regulation and potential as therapeutic targets. Diabetologia 46: 1046-1062.
30. Misonou H, Thompson SM, Cai X (2008) Dynamic regulation of the Kv2.1 voltage-gated potassium channel during brain ischemia through neuroglial interaction. J Neurosci 28: 8529-8538.
31. Park KS, Mohapatra DP, Misonou H, Trimmer JS (2006) Graded regulation of the Kv2.1 potassium channel by variable phosphorylation. Science 313: 976-979.
32. Ullrich S, Wollheim CB (1988) GTP-dependent inhibition of insulin secretion by epinephrine in permeabilized RINm5F cells. Lack of correlation between insulin secretion and cyclic AMP levels. J Biol Chem 263: 8615-8620.
33. Renstrom E, Ding WG, Bokvist K, Rorsman P (1996) Neurotransmitter-induced inhibition of exocytosis in insulin-secreting beta cells by activation of calcineurin. Neuron 17: 513-522.
34. Sharp GW, Le Marchand-Brustel Y, Yada T, Russo LL, Bliss CR, et al. (1989) Galanin can inhibit insulin release by a mechanism other than membrane hyperpolarization or inhibition of adenylate cyclase. J Biol Chem 264: 7302-7309.