The antagonistic effects of atipamezole and yohimbine on stress-related neurohormonal and metabolic responses induced by medetomidine in dogs

Canadian Journal of Veterinary Research

Volumn 67, Issue 1, 2003, Pages 64-67

  Ambrisko, T D ^a   Hikasa, Y ^a  

^a TOTTORI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; ATIPAMEZOLE; FATTY ACID; GLUCAGON; GLUCOSE; HYDROCORTISONE; INSULIN; LACTIC ACID; MEDETOMIDINE; NEUROHORMONE; NORADRENALIN; SODIUM CHLORIDE; YOHIMBINE;

ADRENALIN BLOOD LEVEL; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DOG; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG ELIMINATION; DRUG HALF LIFE; FATTY ACID BLOOD LEVEL; FEMALE; GLUCAGON BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HORMONAL REGULATION; HYDROCORTISONE BLOOD LEVEL; INSULIN BLOOD LEVEL; LACTATE BLOOD LEVEL; METABOLIC REGULATION; NONHUMAN; NORADRENALIN BLOOD LEVEL; RANDOMIZATION; SEDATION; STRESS;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANALYSIS OF VARIANCE; ANIMALS; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EPINEPHRINE; FATTY ACIDS, NONESTERIFIED; FEMALE; HYDROCORTISONE; HYPNOTICS AND SEDATIVES; IMIDAZOLES; INSULIN; MEDETOMIDINE; NOREPINEPHRINE; RANDOM ALLOCATION; STRESS; YOHIMBINE;

CANIS FAMILIARIS;

EID: 0037255316     PISSN: 08309000     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Maze M, Tranquilli W. Alpha-2 adrenoceptor agonists: Defining the role in clinical anesthesia. Anesthesiol 1991;74:581-605.
2. Benson GJ, Grubb TL, Neff-Davis C, et al. Perioperative stress response in the dog: Effect of pre-emptive administration of medetomidine. Vet Surg 2000;29:85-91.
3. Rosin E. The systemic response to injury. In: Borjab MJ. Pathophysiology in small animal surgery. Philadelphia: Lea & Febiger, 1981:3-11.
4. Vaha-Vahe AT. The clinical effectiveness of atipamezole as a medetomidine antagonist in the dog. J Vet Pharmacol Therap 1990;13:198-205.
5. Carroll GL, Matthews NS, Hartsfield SM, Slater MR, Champney TH, Erickson SW. The effect of detomidine and its antagonism with tolazoline on stress-related hormones, metabolites, physiologic responses, and behavior in awake ponies. Vet Surg 1997;26:69-77.
6. Ranheim B, Horsberg TE, Soli NE, Ryeng KA, Arnemo JM. The effects of medetomidine and its reversal with atipamezole on plasma glucose, cortisol and noradrenaline in cattle and sheep. J Vet Pharmacol Ther 2000;23:379-387.
7. Greene SA. Pros and cons of using α-2 agonists in small animal anesthesia practice. Clin Tech Small Anim Pract 1999;14:10-14.
8. Ambrisko TD, Hikasa Y. Neurohormonal and metabolic effects of medetomidine compared with xylazine in beagle dogs. Can J Vet Res 2002;66:42-49.
9. Bagheri H, Chale JJ, Guyen LN, Tran MA, Berlan M, Montastruc JL. Evidence for activation of both adrenergic and cholinergic nervous pathways by yohimbine, an alpha 2-adrenoceptor antagonist. Fundam Clin Pharmacol 1995;9: 248-254.
10. Karhuvaara S, Kallio A, Scheinin M, Anttila M, Salonen JS, Scheinin H. Pharmacological effects and pharmacokinetics of atipamezole, a novel alpha 2-adrenoceptor antagonist - a randomized, double-blind cross-over study in healthy male volunteers. Br J Clin Pharmacol 1990;30:97-106.
11. Salonen S, Vuorilehto L, Vainio O, Anttila M. Atipamezole increases medetomidine clearance in the dog: an agonist-antagonist interaction. J Vet Pharmacol Therap 1995;18:328-332.
12. Hubbard JW, Pfister SL, Biediger AM, Herzig TC, Keeton TK. The pharmacokinetic properties of yohimbine in the conscious rat. Naunyn Schmiedebergs Arch Pharmacol 1988;337:583-587.
13. Hender T, Edgar B, Edvinsson L, Hender J, Persson B, Pettersson A. Yohimbine pharmacokinetics and interaction with the sympathetic nervous system in normal volunteers. Eur J Clin Pharmacol 1992;43:651-656.