Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction

Nature

Volumn 496, Issue 7443, 2013, Pages 114-118

  Chang, Wei Chen ^a,c   Dey, Mishtu ^b,d   Liu, Pinghua ^a,e   Mansoorabadi, Steven O ^a,f   Moon, Sung Ju ^a,g   Zhao, Zongbao K ^a,h   Drennan, Catherine L ^b   Liu, Hung Wen ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

^d E11 SSH   (United States)

^e Boston University   (United States)

^f AUBURN UNIVERSITY   (United States)

^g Agensys   (United States)

^h DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYPROPYLPHOSPHONATE EPOXIDASE; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBIOTICS; CRYSTALLOGRAPHY; ENZYME ACTIVITY; PROTEIN; RADICAL; SUBSTRATE; X-RAY SPECTROSCOPY;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CRYSTAL STRUCTURE; DEHYDROGENATION; DIASTEREOISOMER; ELECTRON TRANSPORT; ENANTIOMER; HYDROLYSIS; IN VIVO STUDY; OXYGENATION; PRIORITY JOURNAL; STEREOCHEMISTRY; X RAY CRYSTALLOGRAPHY;

BIOCATALYSIS; BIOLOGICAL AGENTS; CRYSTALLOGRAPHY, X-RAY; FOSFOMYCIN; HYDROGENATION; IRON; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; NONHEME IRON PROTEINS; ORGANOPHOSPHONATES; OXIDOREDUCTASES; SUBSTRATE SPECIFICITY; TIME FACTORS;

EID: 84875894498     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature11998     Document Type: Article

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