Drug transporters on arachnoid barrier cells contribute to the blood-cerebrospinal fluid barrier

Drug Metabolism and Disposition

Volumn 41, Issue 4, 2013, Pages 923-931

  Yasuda, Kazuto ^a   Cline, Cynthia ^a   Vogel, Peter ^a   Onciu, Mihaela ^a,e   Fatima, Soghra ^a   Sorrentino, Brian P ^a   Thirumaran, Ranjit K ^a   Ekins, Sean ^b   Urade, Yoshihiro ^c   Fujimori, Ko ^d   Schuetz, Erin G ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b Collaborations in Chemistry ^*  (United States)

^c OSAKA BIOSCIENCE INSTITUTE   (Japan)

^d OSAKA MEDICAL COLLEGE   (Japan)

^e OncoMetrix   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; DRUG METABOLIZING ENZYME; MULTIDRUG RESISTANCE PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; APICAL MEMBRANE; ARACHNOID; ARTICLE; BASEMENT MEMBRANE; BLOOD CEREBROSPINAL FLUID BARRIER; CELL IMMORTALIZATION; CONTROLLED STUDY; DRUG TRANSPORT; FEMALE; GENE EXPRESSION NERVOUS SYSTEM ATLAS DATABASE; GENETIC DATABASE; HUMAN; MENINX; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; ARACHNOID; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; CELL LINE; GENE EXPRESSION; HAPLORHINI; HUMANS; MICE; MICE, KNOCKOUT; NEOPLASM PROTEINS; P-GLYCOPROTEIN; SPINAL CORD;

EID: 84875868665     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.112.050344     Document Type: Article

References (34)

1. Anderson CM and Thwaites DT (2010) Hijacking solute carriers for proton-coupled drug transport. Physiology (Bethesda) 25:364-377.
2. Baehr C, Reichel V, and Fricker G (2006) Choroid plexus epithelial monolayers-a cell culture model from porcine brain. Cerebrospinal Fluid Res 3:13.
3. Beuckmann CT, Lazarus M, Gerashchenko D, Mizoguchi A, Nomura S, Mohri I, Uesugi A, Kaneko T, Mizuno N, and Hayaishi O, et al. (2000) Cellular localization of lipocalin-type prostaglandin D synthase (beta-trace) in the central nervous system of the adult rat. J Comp Neurol 428:62-78.
4. Decleves X, Jacob A, Yousif S, Shawahna R, Potin S, and Scherrmann JM (2011) Interplay of drug metabolizing CYP450 enzymes and ABC transporters in the blood-brain barrier. Curr Drug Metab 12:732-741.
5. Fu D, Bebawy M, Kable EP, and Roufogalis BD (2004) Dynamic and intracellular trafficking of P-glycoprotein-EGFP fusion protein: implications in multidrug resistance in cancer. Int J Cancer 109:174-181.
6. Fujimori K, Watanabe M, Urade Y, and Ishikawa K (2007) Increased production of lipocalin-type prostaglandin D synthase in leptomeningeal cells through contact with astrocytes. Neurosci Lett 423:133-137.
7. Gazzin S, Strazielle N, Schmitt C, Fevre-Montange M, Ostrow JD, Tiribelli C, and Ghersi-Egea JF (2008) Differential expression of the multidrug resistance-related proteins ABCb1 and ABCc1 between blood-brain interfaces. J Comp Neurol 510:497-507.
8. Gong S, Zheng C, Doughty ML, Losos K, Didkovsky N, Schambra UB, Nowak NJ, Joyner A, Leblanc G, and Hatten ME, et al. (2003) A gene expression atlas of the central nervous system based on bacterial artificial chromosomes. Nature 425:917-925.
9. Janson C, Romanova L, Hansen E, Hubel A, and Lam C (2011) Immortalization and functional characterization of rat arachnoid cell lines. Neuroscience 177:23-34.
10. Johanson C, Stopa E, McMillan P, Roth D, Funk J, and Krinke G (2011) The distributional nexus of choroid plexus to cerebrospinal fluid, ependyma and brain: toxicologic/pathologic phenomena, periventricular destabilization, and lesion spread. Toxicol Pathol 39:186-212.
11. King M, Su W, Chang A, Zuckerman A, and Pasternak GW (2001) Transport of opioids from the brain to the periphery by P-glycoprotein: peripheral actions of central drugs. Nat Neurosci 4: 268-274.
12. Kodaira H, Kusuhara H, Fujita T, Ushiki J, Fuse E, and Sugiyama Y (2011) Quantitative evaluation of the impact of active efflux by p-glycoprotein and breast cancer resistance protein at the blood-brain barrier on the predictability of the unbound concentrations of drugs in the brain using cerebrospinal fluid concentration as a surrogate. J Pharmacol Exp Ther 339:935-944.
13. Lau C, Ng L, Thompson C, Pathak S, Kuan L, Jones A, and Hawrylycz M (2008) Exploration and visualization of gene expression with neuroanatomy in the adult mouse brain. BMC Bioinformatics 9:153.
14. Miller DS (2004) Confocal imaging of xenobiotic transport across the choroid plexus. Adv Drug Deliv Rev 56:1811-1824.
15. Murphy M, Chen JN, and George DL (1991) Establishment and characterization of a human leptomeningeal cell line. J Neurosci Res 30:475-483.
16. On NH, Chen F, Hinton M, and Miller DW (2011) Assessment of P-glycoprotein activity in the blood-brain barrier (BBB) using near infrared fluorescence (NIRF) imaging techniques. Pharm Res 28:2505-2515.
17. Pippert TR and Umbenhauer DR (2001) The subpopulation of CF-1 mice deficient in Pglycoprotein contains a murine retroviral insertion in the mdr1a gene. J Biochem Mol Toxicol 15:83-89.
18. Pui CH, Campana D, Pei D, Bowman WP, Sandlund JT, Kaste SC, Ribeiro RC, Rubnitz JE, Raimondi SC, and Onciu M, et al. (2009) Treating childhood acute lymphoblastic leukemia without cranial irradiation. N Engl J Med 360:2730-2741.
19. Rao VV, Dahlheimer JL, Bardgett ME, Snyder AZ, Finch RA, Sartorelli AC, and Piwnica-Worms D (1999) Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier. Proc Natl Acad Sci USA 96:3900-3905.
20. Redzic Z (2011) Molecular biology of the blood-brain and the blood-cerebrospinal fluid barriers: similarities and differences. Fluids Barriers CNS 8:3.
21. Roberts LM, Black DS, Raman C, Woodford K, Zhou M, Haggerty JE, Yan AT, Cwirla SE, and Grindstaff KK (2008) Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation. Neuroscience 155: 423-438.
22. Salmon P, Oberholzer J, Occhiodoro T, Morel P, Lou J, and Trono D (2000) Reversible immortalization of human primary cells by lentivector-mediated transfer of specific genes. Mol Ther 2:404-414.
23. Saunders NR, Ek CJ, Habgood MD, and Dziegielewska KM (2008) Barriers in the brain: a renaissance? Trends Neurosci 31:279-286.
24. Schachenmayr W and Friede RL (1978) The origin of subdural neomembranes. I. Fine structure of the dura-arachnoid interface in man. Am J Pathol 92:53-68.
25. Schinkel AH, Smit JJ, van Tellingen O, Beijnen JH, Wagenaar E, van Deemter L, Mol CA, van der Valk MA, Robanus-Maandag EC, and te Riele HP, et al. (1994) Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77:491-502.
26. Stapleton S and Blaney S (2006) New agents for intrathecal administration. Cancer Invest 24: 528-534.
27. Tadjali M, Zhou S, Rehg J, and Sorrentino BP (2006) Prospective isolation of murine hematopoietic stem cells by expression of an Abcg2/GFP allele. Stem Cells 24:1556-1563.
28. Vandenabeele F, Creemers J, and Lambrichts I (1996) Ultrastructure of the human spinal arachnoid mater and dura mater. J Anat 189:417-430.
29. VanWert AL and Sweet DH (2008) Impaired clearance of methotrexate in organic anion transporter 3 (Slc22a8) knockout mice: a gender specific impact of reduced folates. Pharm Res 25:453-462.
30. Vlaming ML, Lagas JS, and Schinkel AH (2009) Physiological and pharmacological roles of ABCG2 (BCRP): recent findings in Abcg2 knockout mice. Adv Drug Deliv Rev 61:14-25.
31. Xiao G, Black C, Hetu G, Sands E, Wang J, Caputo R, Rohde E, and Gan LS (2012) Cerebrospinal fluid can be used as a surrogate to assess brain exposures of breast cancer resistance protein and P-glycoprotein substrates. Drug Metab Dispos 40:779-787.
32. Zappaterra MW and Lehtinen MK (2012) The cerebrospinal fluid: regulator of neurogenesis, behavior, and beyond. Cell Mol Life Sci 69:2863-2878.
33. Zhao R, Diop-Bove N, Visentin M, and Goldman ID (2011) Mechanisms of membrane transport of folates into cells and across epithelia. Annu Rev Nutr 31:177-201.
34. Zhuang Y, Fraga CH, Hubbard KE, Hagedorn N, Panetta JC, Waters CM, and Stewart CF (2006) Topotecan central nervous system penetration is altered by a tyrosine kinase inhibitor. Cancer Res 66:11305-11313.