Prospective isolation of murine hematopoietic stem cells by expression of an Abcg2/GFP allele

Stem Cells

Volumn 24, Issue 6, 2006, Pages 1556-1563

  Tadjali, Mehrdad ^a   Zhou, Sheng ^a   Rehg, Jerold ^a   Sorrentino, Brian P ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Abcg2; ATP binding cassette transporters; Hematopoietic stem cells; Transplantation

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; GREEN FLUORESCENT PROTEIN; ABC TRANSPORTER; ABCG2 PROTEIN, MOUSE; MESSENGER RNA; RECOMBINANT PROTEIN;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL ACTIVITY; CELL POPULATION; ERYTHROID CELL; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENE LOCUS; HEMATOPOIETIC STEM CELL; MALE; NONHUMAN; PHENOTYPE; ANIMAL; C57BL MOUSE; CELL SEPARATION; CYTOLOGY; GENETICS; METABOLISM; METHODOLOGY; MOUSE; REPORTER GENE; TRANSGENIC MOUSE;

MURINAE;

ALLELES; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CELL SEPARATION; FLOW CYTOMETRY; GENE EXPRESSION; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HEMATOPOIETIC STEM CELLS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RECOMBINANT PROTEINS; RNA, MESSENGER;

EID: 33746804860     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2005-0562     Document Type: Article

References (29)

1. Goodell MA, Brose K, Paradis G et al. Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J Exp Med 1996;183:1797-1806.
2. Zhou S, Morris JJ, Barnes Y et al. Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo. Proc Natl Acad Sci U S A 2002;99:12339-12344.
3. Zhou S, Schuetz JD, Bunting KD et al. The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nat Med 2001;7:1028-1034.
4. Scharenberg CW, Harkey MA, Torok-Storb B. The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors. Blood 2002;99:507-512.
5. Doyle LA, Yang W, Abruzzo LV et al. A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc Natl Acad Sci U S A 1998;95:15665-15670. Erratum in: Proc Natl Acad Sci U S A 1999;96:2569.
6. Miyake K, Mickley L, Litman T et al. Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: Demonstration of homology to ABC transport genes. Cancer Res 1999;59:8-13.
7. Maliepaard M, Scheffer GL, Faneyte IF et al. Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues. Cancer Res 2001;61:3458-3464.
8. Jonker JW, Buitelaar M, Wagenaar E et al. The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria. Proc Natl Acad Sci U S A 2002;99:15649-15654.
9. van Herwaarden AE, Jonker JW, Wagenaar E et al. The breast cancer resistance protein (Bcrp1/Abcg2) restricts exposure to the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Cancer Res 2003;63:6447-6452.
10. Uchida N, Fujisaki T, Eaves AC et al. Transplantable hematopoietic stem cells in human fetal liver have a CD34(+) side population (SP) phenotype. J Clin Invest 2001;108:1071-1077.
11. Mohrs M, Shinkai K, Mohrs K et al. Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter. Immunity 2001;15:303-311.
12. O'Gorman S, Dagenais NA, Qian M et al. Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells. Proc Natl Acad Sci U S A 1997;94:14602-14607.
13. Zhou S, Zong Y, Ney PA et al. Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin IX levels. Blood 2005;105:2571-2576.
14. Matsuzaki Y, Kinjo K, Mulligan RC et al. Unexpectedly efficient homing capacity of purified murine hematopoietic stem cells. Immunity 2004;20:87-93.
15. Goodell MA, Rosenzweig M, Kim H et al. Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species. Nat Med 1997;3:1337-1345.
16. Gussoni E, Soneoka Y, Strickland CD et al. Dystrophin expression in the mdx mouse restored by stem cell transplantation. Nature 1999;401:390-394.
17. Martin CM, Meeson AP, Robertson SM et al. Persistent expression of the ATP-binding cassette transporter, Abcg2, identifies cardiac SP cells in the developing and adult heart. Dev Biol 2004;265:262-275.
18. Kim M, Morshead CM. Distinct populations of forebrain neural stem and progenitor cells can be isolated using side-population analysis. J Neurosci 2003;23:10703-10709.
19. Bhattacharya S, Jackson JD, Das AV et al. Direct identification and enrichment of retinal stem cells/progenitors by Hoechst dye efflux assay. Invest Ophthalmol Vis Sci 2003;44:2764-2773.
20. Budak MT, Alpdogan OS, Zhou M et al. Ocular surface epithelia contain ABCG2-dependent side population cells exhibiting features associated with stem cells. J Cell Sci 2005;118:1715-1724.
21. Abbott BL, Colapietro AM, Barnes Y et al. Low levels of ABCG2 expression in adult AML blast samples. Blood 2002;100:4594-4601.
22. Hirschmann-Jax C, Foster AE, Wulf GG et al. A distinct "side population" of cells with high drug efflux capacity in human tumor cells. Proc Natl Acad Sci U S A 2004;101:14228-14233.
23. Wulf GG, Wang RY, Kuehnle I et al. A leukemic stem cell with intrinsic drug efflux capacity in acute myeloid leukemia. Blood 2001;98:1166-1173.
24. Montanaro F, Liadaki K, Schienda J et al. Demystifying SP cell purification: Viability, yield, and phenotype are defined by isolation parameters. Exp Cell Res 2004;298:144-154.
25. Bachrach E, Li S, Perez AL et al. Systemic delivery of human microdystrophin to regenerating mouse dystrophic muscle by muscle progenitor cells. Proc Natl Acad Sci U S A 2004;101:3581-3586.
26. Chen CZ, Li L, Li M et al. The endoglin(positive) sca-1(positive) rhodamine(low) phenotype defines a near-homogeneous population of long-term repopulating hematopoietic stem cells. Immunity 2003;19:525-533.
27. Robey RW, Steadman K, Polgar O et al. Pheophorbide a is a specific probe for ABCG2 function and inhibition. Cancer Res 2004;64:1242-1246.
28. Ozvegy-Laczka C, Varady G, Koblos G et al. Function-dependent conformational changes of the ABCG2 multidrug transporter modify its interaction with a monoclonal antibody on the cell surface. J Biol Chem 2005;280:4219-4227.
29. Naylor CS, Jaworska E, Branson K et al. Side population/ABCG2-positive cells represent a heterogeneous group of haemopoietic cells: Implications for the use of adult stem cells in transplantation and plasticity protocols. Bone Marrow Transplant 2005;35:353-360.