Increasing the oral bioavailability of poorly water-soluble carbamazepine using immediate-release pellets supported on SBA-15 mesoporous silica

International Journal of Nanomedicine

Volumn 7, Issue , 2012, Pages 5807-5818

  Wang, Zhouhua ^a   Chen, Bao ^a   Quan, Guilan ^a   Li, Feng ^a   Wu, Qiaoli ^a   Dian, Linghui ^a   Dong, Yixuan ^a   Li, Ge ^a   Wu, Chuanbin ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Bioavailability; Carbamazepine; Extrusion; Ordered mesoporous silica; Pellets; Poorly water soluble drug; Spheronization

Indexed keywords

AMORPHOUS 15; CARBAMAZEPINE; SILICON DIOXIDE; UNCLASSIFIED DRUG; ANTICONVULSIVE AGENT; NANOCAPSULE; SBA 15; SBA-15; WATER;

ANGLE OF REPOSE; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BULK DENSITY; CONTACT ANGLE; CONTROLLED STUDY; DOG; DRUG ADSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG HALF LIFE; DRUG RELEASE; DRUG SOLUBILITY; FEMALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PHYSICAL CHEMISTRY; POWDER FLOW; SCANNING ELECTRON MICROSCOPY; TIME TO MAXIMUM PLASMA CONCENTRATION; TRANSMISSION ELECTRON MICROSCOPY; WETTABILITY; ADSORPTION; ANIMAL; BIOAVAILABILITY; CHEMISTRY; DELAYED RELEASE FORMULATION; DOSE RESPONSE; ORAL DRUG ADMINISTRATION; POROSITY; SOLUBILITY;

CANIS FAMILIARIS;

ADMINISTRATION, ORAL; ADSORPTION; ANIMALS; ANTICONVULSANTS; BIOLOGICAL AVAILABILITY; CARBAMAZEPINE; DELAYED-ACTION PREPARATIONS; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; NANOCAPSULES; POROSITY; SILICON DIOXIDE; SOLUBILITY; WATER; WETTABILITY;

EID: 84875845728     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S37650     Document Type: Article

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