Intracellular accumulation of advanced glycation end products induces apoptosis via endoplasmic reticulum stress in chondrocytes

FEBS Journal

Volumn 280, Issue 7, 2013, Pages 1617-1629

  Yamabe, Soichiro ^a   Hirose, Jun ^b   Uehara, Yusuke ^a   Okada, Tatsuya ^a   Okamoto, Nobukazu ^a   Oka, Kiyoshi ^a   Taniwaki, Takuya ^a   Mizuta, Hiroshi ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b KUMAMOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

advanced glycation end product; apoptosis; chondrocyte; endoplasmic reticulum stress; osteoarthritis

Indexed keywords

ADVANCED GLYCATION END PRODUCT; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CARTILAGE DEGENERATION; CONTROLLED STUDY; DISEASE COURSE; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; ENZYME INHIBITION; IN VITRO STUDY; IN VIVO STUDY; MALE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; OSTEOARTHRITIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION;

ACETALDEHYDE; ANIMALS; APOPTOSIS; CARTILAGE, ARTICULAR; CELLS, CULTURED; CHONDROCYTES; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM STRESS; GLYCOSYLATION END PRODUCTS, ADVANCED; GUANIDINES; HEAT-SHOCK PROTEINS; MALE; MICE; MICE, INBRED C57BL; TRANSCRIPTION FACTOR CHOP; TRANSCRIPTION FACTORS;

MAMMALIA;

EID: 84875818047     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12170     Document Type: Article

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