Timing of decontamination and treatment in case of percutaneous VX poisoning: A mini review

Chemico-Biological Interactions

Volumn 203, Issue 1, 2013, Pages 149-153

  Joosen, Marloes J A ^a   Van Der Schans, Marcel J ^a   Kuijpers, Willem C ^a   Van Helden, Herman P M ^a   Noort, Daan ^a  

^a TNO   (Netherlands)

Author keywords

Decontamination; Nerve agent; Percutaneous; Repeated treatment; VX

Indexed keywords

ACETYLCHOLINESTERASE; ATROPINE; CHOLINESTERASE; DIAZEPAM; OBIDOXIME; ORGANOPHOSPHORUS COMPOUND; PROCYCLIDINE; PYRIDOSTIGMINE; SCOPOLAMINE; VOLATILE AGENT;

ACUTE DRUG ADMINISTRATION; CHOLINERGIC SYSTEM; CHRONIC DRUG ADMINISTRATION; CLINICAL FEATURE; CONFERENCE PAPER; DETOXIFICATION; DIAGNOSTIC TEST; ENZYME INHIBITION; GUINEA PIG; INTOXICATION; NEUROLOGIC DISEASE; NONHUMAN; PERCUTANEOUS VX POISONING; SEIZURE; SKIN ABSORPTION; SKIN DECONTAMINATION; SURVIVAL TIME; TOXICOKINETICS;

ACETYLCHOLINESTERASE; ANIMALS; BUTYRYLCHOLINESTERASE; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; DECONTAMINATION; DISEASE MODELS, ANIMAL; GUINEA PIGS; ORGANOPHOSPHATE POISONING; ORGANOTHIOPHOSPHORUS COMPOUNDS; PROCYCLIDINE; PYRIDOSTIGMINE BROMIDE; SCOPOLAMINE HYDROBROMIDE; SKIN; TIME FACTORS;

ANIMALIA; CAVIA;

EID: 84875812785     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2012.10.002     Document Type: Conference Paper

References (20)

1. M.J. van der Schans, B.J. Lander, H. van der Wiel, J.P. Langenberg, and H.P. Benschop Toxicokinetics of the nerve agent (+/-)-VX in anesthetized and atropinized hairless guinea pigs and marmosets after intravenous and percutaneous administration Toxicol. Appl. Pharmacol. 191 2003 48 62
2. M.J. van der Schans, H.P. Benschop, and C.M. Whalley Toxicokinetics of nerve agents J.A. Romano Jr. B.J. Lukey, H. Salem, Chemical Warfare Agents, Chemistry, Pharmacology, Toxicology, and Therapeutics 2008 CRC Press Boca Raton, USA 97 122
3. M.J. Joosen, M.J. van der Schans, and H.P. van Helden Percutaneous exposure to VX: clinical signs, effects on brain acetylcholine levels and EEG Neurochem. Res. 33 2008 308 317
4. M.J. Joosen, M.J. van der Schans, and H.P. van Helden Percutaneous exposure to the nerve agent VX: efficacy of combined atropine, obidoxime and diazepam treatment Chem. Biol. Interact. 188 2010 255 263
5. J. Wetherell, M. Price, H. Mumford, S. Armstrong, and L. Scott Development of next generation medical countermeasures to nerve agent poisoning Toxicology 233 2007 120 127
6. H. Thiermann, L. Szinicz, P. Eyer, N. Felgenhauer, T. Zilker, and F. Worek Lessons to be learnt from organophosphorus pesticide poisoning for the treatment of nerve agent poisoning Toxicology 233 2007 145 154
7. H.F. Frasch, and A.M. Barbero A paired comparison between human skin and hairless guinea pig skin in vitro permeability and lag time measurements for 6 industrial chemicals Cutan. Ocul. Toxicol. 28 2009 107 113
8. H.P. van Helden, M.J. Joosen, and I.H. Philippens Non-enzymatic pretreatment of nerve agent (soman) poisoning: a brief state-of-the-art review Toxicol. Lett. 206 2011 35 40
9. J. Wetherell, T. Hall, and S. Passingham Physostigmine and hyoscine improves protection against the lethal and incapacitating effects of nerve agent poisoning in the guinea-pig Neurotoxicology 23 2002 341 349
10. J. Wetherell, M. Price, and H. Mumford A novel approach for medical countermeasures to nerve agent poisoning in the guinea-pig Neurotoxicology 27 2006 485 491
11. P. Rolland, M.A. Bolzinger, C. Cruz, S. Briancon, and D. Josse Human scalp permeability to the chemical warfare agent VX Toxicol. In Vitro 25 2011 1974 1980
12. J. Lademann, H. Richter, U.F. Schaefer, U. Blume-Peytavi, A. Teichmann, N. Otberg, and W. Sterry Hair follicles-a long-term reservoir for drug delivery Skin Pharmacol. Physiol. 19 2006 232 236
13. C.H. Dalton, I.J. Hattersley, S.J. Rutter, and R.P. Chilcott Absorption of the nerve agent VX (O-ethyl-S-[2(di-isopropylamino)ethyl] methyl phosphonothioate) through pig, human and guinea pig skin in vitro Toxicol. In Vitro 20 2006 1532 1536
14. M.G. Hamilton, I. Hill, J. Conley, T.W. Sawyer, D.C. Caneva, and P.M. Lundy Clinical aspects of percutaneous poisoning by the chemical warfare agent VX: effects of application site and decontamination Mil. Med. 169 2004 856 862
15. J.R. Wetherell, S.J. Armstrong, R.W. Read, and G.F. Clough VX Penetration following percutaneous poisoning: a dermal microdialysis study in the guinea pig Toxicol. Mech. Methods 18 2008 313 321
16. M.J. Joosen, A.B. Smit, and H.P. van Helden Treatment efficacy in a soman-poisoned guinea pig model: added value of physostigmine? Arch. Toxicol. 85 2011 227 237
17. H. Mumford, and J.K. Troyer Post-exposure therapy with recombinant human BuChE following percutaneous VX challenge in guinea-pigs Toxicol. Lett. 206 2011 29 34
18. S. Bjarnason, J. Mikler, I. Hill, C. Tenn, M. Garrett, N. Caddy, and T.W. Sawyer Comparison of selected skin decontaminant products and regimens against VX in domestic swine Hum. Exp. Toxicol. 27 2008 253 261
19. E.H. Braue Jr., K.H. Smith, B.F. Doxzon, H.L. Lumpkin, and E.D. Clarkson Efficacy studies of reactive skin decontamination lotion, M291 skin decontamination Kit, 0.5% bleach, 1% soapy water, and skin exposure reduction paste against chemical warfare agents, part 1: guinea pigs challenged with VX Cutan. Ocul. Toxicol. 30 2011 15 28
20. D.R. Verstappen, A.G. Hulst, A. Fidder, N.P. Vermeulen, and D. Noort Interactions of organophosphates with keratins in the cornified epithelium of human skin Chem. Biol. Interact. 197 2012 93 102