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Volumn 188, Issue 1, 2010, Pages 255-263

Percutaneous exposure to the nerve agent VX: Efficacy of combined atropine, obidoxime and diazepam treatment

Author keywords

EEG; Organophosphate; Percutaneous; Physiology; Treatment; VX

Indexed keywords

ACETYLCHOLINESTERASE; ATROPINE; CHOLINESTERASE; DIAZEPAM; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; OBIDOXIME; ANTIDOTE; CHEMICAL WARFARE AGENT; PHOSPHOROTHIOIC ACID DERIVATIVE;

EID: 77956172546     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.06.010     Document Type: Article
Times cited : (28)

References (21)
  • 1
    • 0042063598 scopus 로고    scopus 로고
    • Toxicokinetics of the nerve agent (+/-)-VX in anesthetized and atropinized hairless guinea pigs and marmosets after intravenous and percutaneous administration
    • van der Schans M.J., Lander B.J., van der W.H., Langenberg J.P., Benschop H.P. Toxicokinetics of the nerve agent (+/-)-VX in anesthetized and atropinized hairless guinea pigs and marmosets after intravenous and percutaneous administration. Toxicol. Appl. Pharmacol. 2003, 191:48-62.
    • (2003) Toxicol. Appl. Pharmacol. , vol.191 , pp. 48-62
    • van der Schans, M.J.1    Lander, B.J.2    van der, W.H.3    Langenberg, J.P.4    Benschop, H.P.5
  • 2
    • 77956172961 scopus 로고    scopus 로고
    • Chemical Warfare Agents, Chemistry, Pharmacology, Toxicology, and Therapeutics Romano, J.A., Jr., Lukey, B.J., Salem, H., (Eds.). Boca Raton, USA: CRC Press.
    • Chemical Warfare Agents, Chemistry, Pharmacology, Toxicology, and Therapeutics Romano, J.A., Jr., Lukey, B.J., Salem, H., (Eds.). Boca Raton, USA: CRC Press.
  • 3
    • 38349156961 scopus 로고    scopus 로고
    • Percutaneous exposure to VX: clinical signs, effects on brain acetylcholine levels and EEG
    • Joosen M.J., van der Schans M.J., van Helden H.P. Percutaneous exposure to VX: clinical signs, effects on brain acetylcholine levels and EEG. Neurochem. Res. 2008, 33:308-317.
    • (2008) Neurochem. Res. , vol.33 , pp. 308-317
    • Joosen, M.J.1    van der Schans, M.J.2    van Helden, H.P.3
  • 4
    • 34047099192 scopus 로고    scopus 로고
    • Development of next generation medical countermeasures to nerve agent poisoning
    • Wetherell J., Price M., Mumford H., Armstrong S., Scott L. Development of next generation medical countermeasures to nerve agent poisoning. Toxicology 2007, 233:120-127.
    • (2007) Toxicology , vol.233 , pp. 120-127
    • Wetherell, J.1    Price, M.2    Mumford, H.3    Armstrong, S.4    Scott, L.5
  • 5
    • 33749861610 scopus 로고    scopus 로고
    • Absorption of the nerve agent VX (O-ethyl-S-[2(di-isopropylamino)ethyl] methyl phosphonothioate) through pig, human and guinea pig skin in vitro
    • Dalton C.H., Hattersley I.J., Rutter S.J., Chilcott R.P. Absorption of the nerve agent VX (O-ethyl-S-[2(di-isopropylamino)ethyl] methyl phosphonothioate) through pig, human and guinea pig skin in vitro. Toxicol. In Vitro 2006, 20:1532-1536.
    • (2006) Toxicol. In Vitro , vol.20 , pp. 1532-1536
    • Dalton, C.H.1    Hattersley, I.J.2    Rutter, S.J.3    Chilcott, R.P.4
  • 6
    • 16644373376 scopus 로고    scopus 로고
    • Clinical aspects of percutaneous poisoning by the chemical warfare agent VX: effects of application site and decontamination
    • Hamilton M.G., Hill I., Conley J., Sawyer T.W., Caneva D.C., Lundy P.M. Clinical aspects of percutaneous poisoning by the chemical warfare agent VX: effects of application site and decontamination. Mil. Med. 2004, 169:856-862.
    • (2004) Mil. Med. , vol.169 , pp. 856-862
    • Hamilton, M.G.1    Hill, I.2    Conley, J.3    Sawyer, T.W.4    Caneva, D.C.5    Lundy, P.M.6
  • 7
    • 70350623102 scopus 로고    scopus 로고
    • A paired comparison between human skin and hairless guinea pig skin in vitro permeability and lag time measurements for 6 industrial chemicals
    • Frasch H.F., Barbero A.M. A paired comparison between human skin and hairless guinea pig skin in vitro permeability and lag time measurements for 6 industrial chemicals. Cutan. Ocul. Toxicol. 2009, 28:107-113.
    • (2009) Cutan. Ocul. Toxicol. , vol.28 , pp. 107-113
    • Frasch, H.F.1    Barbero, A.M.2
  • 9
    • 0036381465 scopus 로고    scopus 로고
    • Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates
    • Worek F., Reiter G., Eyer P., Szinicz L. Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates. Arch. Toxicol. 2002, 76:523-529.
    • (2002) Arch. Toxicol. , vol.76 , pp. 523-529
    • Worek, F.1    Reiter, G.2    Eyer, P.3    Szinicz, L.4
  • 10
    • 33845885861 scopus 로고    scopus 로고
    • Anticonvulsants for nerve agent-induced seizures: the influence of the therapeutic dose of atropine
    • Shih T.M., Rowland T.C., McDonough J.H. Anticonvulsants for nerve agent-induced seizures: the influence of the therapeutic dose of atropine. J. Pharmacol. Exp. Ther. 2007, 320:154-161.
    • (2007) J. Pharmacol. Exp. Ther. , vol.320 , pp. 154-161
    • Shih, T.M.1    Rowland, T.C.2    McDonough, J.H.3
  • 11
    • 61849124739 scopus 로고    scopus 로고
    • Toxicodynamic analysis of the combined cholinesterase inhibition by paraoxon and methamidophos in human whole blood
    • Bosgra S., van Eijkeren J.C., van der Schans M.J., Langenberg J.P., Slob W. Toxicodynamic analysis of the combined cholinesterase inhibition by paraoxon and methamidophos in human whole blood. Toxicol. Appl. Pharmacol. 2009, 236:9-15.
    • (2009) Toxicol. Appl. Pharmacol. , vol.236 , pp. 9-15
    • Bosgra, S.1    van Eijkeren, J.C.2    van der Schans, M.J.3    Langenberg, J.P.4    Slob, W.5
  • 13
    • 77956181247 scopus 로고    scopus 로고
    • Textbook of Military Medicine: Medical Aspects of Chemical and Biological Warfare. Washington DC: Office of the Surgeon General.
    • F.R. Sidel, E.T. Takafuji, D.R. Franz. Textbook of Military Medicine: Medical Aspects of Chemical and Biological Warfare. Washington DC: Office of the Surgeon General.
    • Sidel, F.R.1    Takafuji, E.T.2    Franz, D.R.3
  • 14
    • 0001396424 scopus 로고
    • Kinetics and mechanisms of hydrolysis of phosphonothiolates in dilute solution
    • Epstein J., Callahan J.J., Bauer V.E. Kinetics and mechanisms of hydrolysis of phosphonothiolates in dilute solution. Phosphorus 1974, 4:157-163.
    • (1974) Phosphorus , vol.4 , pp. 157-163
    • Epstein, J.1    Callahan, J.J.2    Bauer, V.E.3
  • 15
    • 0030453341 scopus 로고    scopus 로고
    • Characterization and treatment of the toxicity of O-isobutyl S-(2-(diethylamino)ethyl)methylphosphothionate, a structural isomer of VX, in guinea pigs
    • Maxwell D.M., Brecht K.M., Koplovitz I. Characterization and treatment of the toxicity of O-isobutyl S-(2-(diethylamino)ethyl)methylphosphothionate, a structural isomer of VX, in guinea pigs. J. Am. Coll. Toxicol. 1997, S78-S88.
    • (1997) J. Am. Coll. Toxicol.
    • Maxwell, D.M.1    Brecht, K.M.2    Koplovitz, I.3
  • 16
    • 0033566755 scopus 로고    scopus 로고
    • Low concentrations of the organophosphate VX affect spontaneous and evoked transmitter release from hippocampal neurons: toxicological relevance of cholinesterase-independent actions
    • Rocha E.S., Santos M.D., Chebabo S.R., Aracava Y., Albuquerque E.X. Low concentrations of the organophosphate VX affect spontaneous and evoked transmitter release from hippocampal neurons: toxicological relevance of cholinesterase-independent actions. Toxicol. Appl. Pharmacol. 1999, 159:31-40.
    • (1999) Toxicol. Appl. Pharmacol. , vol.159 , pp. 31-40
    • Rocha, E.S.1    Santos, M.D.2    Chebabo, S.R.3    Aracava, Y.4    Albuquerque, E.X.5
  • 17
    • 0031684256 scopus 로고    scopus 로고
    • Cardiorespiratory effects of O-isobutyl S-[2-(diethylamino)-ethyl] methylphosphonothioate - a structural isomer of VX
    • Chang F.C., Gouty S.C., Eder L.C., Hoffman B.E., Maxwell D.M., Brecht K.M. Cardiorespiratory effects of O-isobutyl S-[2-(diethylamino)-ethyl] methylphosphonothioate - a structural isomer of VX. J. Appl. Toxicol. 1998, 18:337-347.
    • (1998) J. Appl. Toxicol. , vol.18 , pp. 337-347
    • Chang, F.C.1    Gouty, S.C.2    Eder, L.C.3    Hoffman, B.E.4    Maxwell, D.M.5    Brecht, K.M.6
  • 18
    • 0028558573 scopus 로고
    • Effects of a novel NMDA receptor antagonist on experimental stroke quantitatively assessed by spectral EEG and infarct volume
    • Cohen R.A., Hasegawa Y., Fisher M. Effects of a novel NMDA receptor antagonist on experimental stroke quantitatively assessed by spectral EEG and infarct volume. Neurol. Res. 1994, 16:443-448.
    • (1994) Neurol. Res. , vol.16 , pp. 443-448
    • Cohen, R.A.1    Hasegawa, Y.2    Fisher, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.