Temporal and spatial distribution of gentamicin in the peripheral vestibular system after transtympanic administration in guinea pigs

Hearing Research

Volumn 298, Issue , 2013, Pages 49-59

  Zhang, Ru ^a   Zhang, Yi Bo ^a   Dai, Chun Fu ^a   Steyger, Peter S ^b  

^a FUDAN UNIVERSITY   (China)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENTAMICIN;

AMPULLARY CREST; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; DOSE RESPONSE; DRUG ADMINISTRATION; DRUG DISTRIBUTION; DRUG DOSE INCREASE; FEMALE; FLUORESCENCE; GUINEA PIG; HAIR CELL; MALE; NONHUMAN; PRIORITY JOURNAL; SACCULUS; SEMICIRCULAR CANAL; TRANSTYMPANIC DRUG ADMINISTRATION; UTRICLE; VESTIBULAR MACULA; VESTIBULAR SYSTEM;

ACOUSTIC MACULAE; ANIMALS; BIOLOGICAL TRANSPORT; EPITHELIAL CELLS; FEMALE; FLUORESCENT DYES; GENTAMICINS; GUINEA PIGS; INJECTIONS; MALE; MICROSCOPY, CONFOCAL; SEMICIRCULAR DUCTS; TIME FACTORS; TISSUE DISTRIBUTION; TYMPANIC MEMBRANE; VESTIBULE, LABYRINTH; XANTHENES;

EID: 84875812305     PISSN: 03785955     EISSN: 18785891     Source Type: Journal    
DOI: 10.1016/j.heares.2013.01.010     Document Type: Article

References (51)

1. Bartolami S., Gaboyard S., Quentin J., Travo C., Cavalier M., Barhanin J., Chabbert C. Critical roles of transitional cells and Na/K-ATPase in the formation of vestibular endolymph. J. Neurosci. 2011, 31:16541-16549.
2. Becvarovski Z., Bojrab D.I., Michaelides E.M., Kartush J.M., Zappia J.J., LaRouere M.J. Round window gentamicin absorption: an in vivo human model. Laryngoscope 2002, 112:1610-1613.
3. Brismar H., Trepte O., Ulfhake B. Spectra and fluorescence lifetimes of lissamine rhodamine, tetramethylrhodamine isothiocyanate, texas red, and cyanine 3.18 fluorophores: influences of some environmental factors recorded with a confocal laser scanning microscope. J. Histochem. Cytochem. 1995, 43:699-707.
4. Chen J.W., Eatock R.A. Major potassium conductance in type I hair cells from rat semicircular canals: characterization and modulation by nitric oxide. J. Neurophysiol. 2000, 84:139-151.
5. Cohen-Kerem R., Kisilevsky V., Einarson T.R., Kozer E., Koren G., Rutka J.A. Intratympanic gentamicin for Meniere's disease: a meta-analysis. Laryngoscope 2004, 114:2085-2091.
6. Cureoglu S., Schachern P.A., Paparella M.M. Effect of parenteral aminoglycoside administration on dark cells in the crista ampullaris. Arch. Otolaryngol. Head Neck Surg. 2003, 129:626-628.
7. Curthoys I.S., Manzari L., Smulders Y.E., Burgess A.M. A review of the scientific basis and practical application of a new test of utricular function - ocular vestibular-evoked myogenic potentials to bone-conducted vibration. Acta Otorhinolaryngol. Ital. 2009, 29:179-186.
8. Dai C.F., Mangiardi D., Cotanche D.A., Steyger P.S. Uptake of fluorescent gentamicin by vertebrate sensory cells in vivo. Hear. Res. 2006, 213:64-78.
9. Day A.S., Lue J.H., Yang T.H., Young Y.H. Effect of intratympanic application of aminoglycosides on click-evoked myogenic potentials in Guinea pigs. Ear Hear. 2007, 28:18-25.
10. De Waele C., Meguenni R., Freyss G., Zamith F., Bellalimat N., Vidal P.P., Tran B.H.P. Intratympanic gentamicin injections for Meniere disease: vestibular hair cell impairment and regeneration. Neurology 2002, 59:1442-1444.
11. Dravis C., Wu T., Chumley M.J., Yokoyama N., Wei S., Wu D.K., Marcus D.C., Henkemeyer M. EphB2 and ephrin-B2 regulate the ionic homeostasis of vestibular endolymph. Hear. Res. 2007, 223:93-104.
12. Fiorino F., Pizzini F.B., Barbieri F., Beltramello A. Magnetic resonance imaging fails to show evidence of reduced endolymphatic hydrops in gentamicin treatment of Meniere's disease. Otol. Neurotol. 2012, 33:629-633.
13. Ge X., Shea J.J. Intramuscular streptomycin effect on dark cells of utricle in guinea pigs. Am. J. Otol. 1993, 14:74-78.
14. Ge X., Shea J.J. Scanning electron microscopic observation of dark cells after streptomycin perfusion of the vestibule in guinea pigs. Scanning Microsc. 1995, 9:283-288.
15. Hashino E., Shero M. Endocytosis of aminoglycoside antibiotics in sensory hair cells. Brain Res. 1995, 704:135-140.
16. Hashino E., Shero M., Salvi R.J. Lysosomal targeting and accumulation of aminoglycoside antibiotics in sensory hair cells. Brain Res. 1997, 777:75-85.
17. Hayashida T., Nomura Y., Iwamori M., Nagai Y., Kurata T. Distribution of gentamicin by immunofluorescence in the guinea pig inner ear. Arch. Otorhinolaryngol. 1985, 242:257-264.
18. Helling K., Schonfeld U., Clarke A.H. Treatment of Meniere's disease by low-dosage intratympanic gentamicin application: effect on otolith function. Laryngoscope 2007, 117:2244-2250.
19. Hirvonen T.P., Minor L.B., Hullar T.E., Carey J.P. Effects of intratympanic gentamicin on vestibular afferents and hair cells in the chinchilla. J. Neurophysiol. 2005, 93:643-655.
20. Ikeda M., Morgenstern C. Immunohistochemical findings of IgG recognized in the planum semilunatum of the guinea pig. J. Laryngol. Otol. 1992, 106:93-97.
21. Imamura S., Adams J.C. Distribution of gentamicin in the guinea pig inner ear after local or systemic application. J. Assoc. Res. Otolaryngol. 2003, 4:176-195.
22. Karasawa T., Wang Q., David L.L., Steyger P.S. CLIMP-63 is a gentamicin-binding protein that is involved in drug-induced cytotoxicity. Cell Death Dis. 2010, 1:e102.
23. Karasawa T., Wang Q., David L.L., Steyger P.S. Calreticulin binds to gentamicin and reduces drug-induced ototoxicity. Toxicol. Sci. 2011, 124:378-387.
24. King E.B., Salt A.N., Eastwood H.T., O'Leary S.J. Direct entry of gadolinium into the vestibule following intratympanic applications in Guinea pigs and the influence of cochlear implantation. J. Assoc. Res. Otolaryngol. 2011, 12:741-751.
25. Kuo S.W., Yang T.H., Young Y.H. Changes in vestibular evoked myogenic potentials after Meniere attacks. Ann. Otol. Rhinol. Laryngol. 2005, 114:717-721.
26. Lee J.H., Chiba T., Marcus D.C. P2X2 receptor mediates stimulation of parasensory cation absorption by cochlear outer sulcus cells and vestibular transitional cells. J. Neurosci. 2001, 21:9168-9174.
27. Leonard R.B., Kevetter G.A. Molecular probes of the vestibular nerve. I. Peripheral termination patterns of calretinin, calbindin and peripherin containing fibers. Brain Res. 2002, 928:8-17.
28. Lindeman H.H. Regional differences in sensitivity of the vestibular sensory epithelia to ototoxic antibiotics. Acta Otolaryngol. 1969, 67:177-189.
29. Liu W.T., Wu J.H., Li E.S., Selamat E.S. Emission characteristics of fluorescent labels with respect to temperature changes and subsequent effects on DNA microchip studies. Appl. Environ. Microbiol. 2005, 71:6453-6457.
30. Lopez I., Honrubia V., Lee S.C., Schoeman G., Beykirch K. Quantification of the process of hair cell loss and recovery in the chinchilla crista ampullaris after gentamicin treatment. Int. J. Dev. Neurosci. 1997, 15:447-461.
31. Lyford-Pike S., Vogelheim C., Chu E., Della S.C., Carey J.P. Gentamicin is primarily localized in vestibular type I hair cells after intratympanic administration. J. Assoc. Res. Otolaryngol. 2007, 8:497-508.
32. Lysakowski A., Goldberg J. Morphophysiology of the vestibular periphery. The Vestibular System 2004, 57-152. Springer, New York. S.M. Highstein, R.R. Fay, A.N. Popper (Eds.).
33. Manzari L., Burgess A.M., Curthoys I.S. Dissociation between cVEMP and oVEMP responses: different vestibular origins of each VEMP?. Eur. Arch. Otorhinolaryngol. 2010, 267:1487-1489.
34. Marcotti W., van Netten S.M., Kros C.J. The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano-electrical transducer channels. J. Physiol. 2005, 567:505-521.
35. Myrdal S.E., Johnson K.C., Steyger P.S. Cytoplasmic and intra-nuclear binding of gentamicin does not require endocytosis. Hear. Res. 2005, 204:156-169.
36. Nicolas M.T., Lesage F., Reyes R., Barhanin J., Dememes D. Localization of TREK-1, a two-pore-domain K+ channel in the peripheral vestibular system of mouse and rat. Brain Res. 2004, 1017:46-52.
37. Oudar O., Ferrary E., Feldmann G. Ultrastructural study of the semicircular canal cells of the frog Rana esculenta. Anat. Rec. 1988, 220:328-334.
38. Park J.C., Cohen G.M. Vestibular ototoxicity in the chick: effects of streptomycin on equilibrium and on ampullary dark cells. Am. J. Otolaryngol. 1982, 3:117-127.
39. Pender D.J. Gentamicin tympanoclysis: effects on the vestibular secretory cells. Am. J. Otolaryngol. 1985, 6:358-367.
40. Plontke S.K., Mynatt R., Gill R.M., Borgmann S., Salt A.N. Concentration gradient along the scala tympani after local application of gentamicin to the round window membrane. Laryngoscope 2007, 117:1191-1198.
41. Roehm P., Hoffer M., Balaban C.D. Gentamicin uptake in the chinchilla inner ear. Hear. Res. 2007, 230:43-52.
42. Salt A.N., King E.B., Hartsock J.J., Gill R.M., O'Leary S.J. Marker entry into vestibular perilymph via the stapes following applications to the round window niche of guinea pigs. Hear. Res. 2012, 283:14-23.
43. Sandoval R., Leiser J., Molitoris B.A. Aminoglycoside antibiotics traffic to the Golgi complex in LLC-PK1 cells. J. Am. Soc. Nephrol. 1998, 9:167-174.
44. Sandoval R.M., Dunn K.W., Molitoris B.A. Gentamicin traffics rapidly and directly to the Golgi complex in LLC-PK(1) cells. Am. J. Physiol. Renal Physiol. 2000, 279:F884-F890.
45. Schuknecht H.F. Ablation therapy for the relief of Meniere's disease. Laryngoscope 1956, 66:859-870.
46. Steyger P.S., Peters S.L., Rehling J., Hordichok A., Dai C.F. Uptake of gentamicin by bullfrog saccular hair cells in vitro. J. Assoc. Res. Otolaryngol. 2003, 4:565-578.
47. Wang Q., Steyger P.S. Trafficking of systemic fluorescent gentamicin into the cochlea and hair cells. J. Assoc. Res. Otolaryngol. 2009, 10:205-219.
48. Wersall J., Bjorkroth B., Flock A., Lundquist P.G. Sensory hair fusion in vestibular sensory cells after gentamycin exposure. A transmission and scanning electron microscope study. Arch. Klin Exp. Ohren Nasen Kehlkopfheilkd 1971, 200:1-14.
49. Xue J., Peterson E.H. Hair bundle heights in the utricle: differences between macular locations and hair cell types. J. Neurophysiol. 2006, 95:171-186.
50. Yoshihara T., Kaname H., Ishii T., Igarashi M. Effect of gentamycin on vestibular dark cells and melanocytes: an ultrastructural and cytochemical study. ORL J. Otorhinolaryngol. Relat. Spec. 1994, 56:24-30.
51. Zhai F., Liu J.P., Dai C.F., Wang Q., Steyger P.S. Evidence-based modification of intratympanic gentamicin injections in patients with intractable vertigo. Otol. Neurotol. 2010, 31:642-648.