Effects of intratympanic gentamicin on vestibular afferents and hair cells in the chinchilla

Journal of Neurophysiology

Volumn 93, Issue 2, 2005, Pages 643-655

  Hirvonen, Timo P ^a,b   Minor, Lloyd B ^a   Hullar, Timothy E ^a,c   Carey, Joan P ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENTAMICIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHINCHILLA; CONTROLLED STUDY; DRUG EFFECT; GALVANIC VESTIBULAR TEST; HAIR CELL; HEAD TILTING; MENIERE DISEASE; NERVE POTENTIAL; NONHUMAN; OTOLITH; OTOTOXICITY; PRIORITY JOURNAL; ROTATION; SENSORY NERVE; SIGNAL TRANSDUCTION; VESTIBULAR NERVE; VESTIBULE;

NON-PROGRAMMATIC;

AFFERENT PATHWAYS; ANIMALS; CHINCHILLA; EAR, MIDDLE; GENTAMICINS; HAIR CELLS, VESTIBULAR; TYMPANIC MEMBRANE;

EID: 12544260531     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.00160.2004     Document Type: Article

References (46)

1. Adrian ED. Discharges from vestibular receptors in the cat. J Physiol 101: 389-407, 1943.
2. Annoni JM, Cochran SL, and Precht W. Pharmacology of the vestibular hair cell-afferent fiber synapse in the frog. J Neurosci 4: 2106-2116, 1984.
3. Baird RA, Desmadryl G, Fernandez C, and Goldberg JM. The vestibular nerve of the chinchilla. II. Relation between afferent response properties and peripheral innervation patterns in the semicircular canals. J Neurophysiol 60: 182-203, 1988.
4. Blakley BW. Update on intratympanic gentamicin for Meniere's disease. Laryngoscope 110: 236-240, 2000.
5. Boyle R, Highstein SM, Carey JP, and Xu J. Functional recovery of anterior semicircular canal afferents following hair cell regeneration in birds. J Assoc Res Otolaryngol 3: 149-166, 2002.
6. Carey JP, Hirvonen T, Peng GC, Della Santina CC, Cremer PD, Haslwanter T, and Minor LB. Changes in the angular vestibulo-ocular reflex after a single dose of intratympanic gentamicin for Meniere's disease. Ann NY Acad Sci 956: 581-584, 2002a.
7. Carey JP, Minor LB, Peng GC, Della Santina CC, Cremer PD, and Haslwanter T. Changes in the three-dimensional angular vestibulo-ocular reflex following intratympanic gentamicin for Meniere's disease. J Assoc Res Otolaryngol 3: 430-443, 2002b.
8. Chen JM, Kakigi A, Hirakawa H, Mount RJ, and Harrison RV. Middle ear instillation of gentamicin and streptomycin in chinchillas: morphologic appraisal of selective ototoxicity. J Otolaryngol 28: 121-128, 1999.
9. Cochran SL and Correia MJ. Functional support of glutamate as a vestibular hair cell transmitter in an amniote. Brain Res 670: 321-325, 1995.
10. Curthoys IS, Curthoys EJ, Blanks RH, and Markham CH. The orientation of the semicircular canals in the guinea pig. Acta Otolaryngol 80: 197-205, 1975.
11. Curthoys IS and Halmagyi GM. Vestibular compensation: a review of the oculomotor, neural, and clinical consequences of unilateral vestibular loss. J Vestib Res 5: 67-107, 1995.
12. Duckert LG and Rubel EW. Morphological correlates of functional recovery in the chicken inner ear after gentamycin treatment. J Comp Neurol 331: 75-96, 1993.
13. Dupont J, Guilhaume A, and Aran JM. Neuronal degeneration of primary cochlear and vestibular innervations after local injection of sisomicin in the guinea pig. Hear Res 68: 217-228, 1993.
14. Duvall AJ and Wersall J. Site of action of streptomycin upon inner ear sensory cells. Acta Otolaryngol (Stockh) 57: 581-598, 1964.
15. Fernandez C, Baird RA, and Goldberg JM. The vestibular nerve of the chinchilla. I. Peripheral innervation patterns in the horizontal and superior semicircular canals. J Neurophysiol 60: 167-181, 1988.
16. Fernandez C, Lysakowski A, and Goldberg JM. Hair-cell counts and afferent innervation patterns in the cristae ampullares of the squirrel monkey with a comparison to the chinchilla. J Neurophysiol 73: 1253-1269, 1995.
17. Gillespie MB and Minor LB. Prognosis in bilateral vestibular hypofunction. Laryngoscope 109: 35-41, 1999.
18. Goldberg JM. Afferent diversity and the organization of central vestibular pathways. Exp Brain Res 130: 277-297, 2000.
19. Goldberg JM, Desmadryl G, Baird RA, and Fernandez C. The vestibular nerve of the chinchilla IV. Discharge properties of utricular afferents. J Neurophysiol 63: 781-790, 1990.
20. Goldberg JM and Fernandez C. Physiology of peripheral neurons innervating semicircular canals of the squirrel monkey I. Resting discharge and response to constant angular accelerations. J Neurophysiol 34: 635-660, 1971.
21. Gong W and Merfeld DM. Prototype neural semicircular canal prosthesis using patterned electrical stimulation. Ann Biomed Eng 28: 572-581, 2000.
22. Gundersen HJ. Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. J Microsc 143: 3-45, 1986.
23. Harner SG, Driscoll CL, Facer GW, Beatty CW, and McDonald TJ. Long-term follow-up of transtympanic gentamicin for Meniere's syndrome. Otol Neurotol 22: 210-214, 2001.
24. Hashino E, Shero M, and Salvi RJ. Lysosomal targeting and accumulation of aminoglycoside antibiotics in sensory hair cells. Brain Res 777: 75-85, 1997.
25. Hibi T, Suzuki T, and Nakashima T. Perilymphatic concentration of gentamicin administered intratympanically in guinea pigs. Acta Otolaryngol 121: 336-341, 2001.
26. Hilton M, Chen J, Kakigi A, Hirakawa H, Mount RJ, and Harrison RV. Middle ear instillation of gentamicin and streptomycin in chinchillas: electrophysiological appraisal of selective ototoxicity. Clin Otolaryngol 27: 529-535, 2002.
27. Hoffer ME, Allen K, Kopke RD, Weisskopf P, Gottshall K, and Wester D. Transtympanic versus sustained-release administration of gentamicin: kinetics, morphology, and function. Laryngoscope 111: 1343-1357, 2001.
28. Hullar TE and Minor LB. High-frequency dynamics of regularly discharging canal afferents provide a linear signal for angular vestibuloocular reflexes. J Neurophysiol 82: 2000-2005, 1999.
29. Jensen DW. Survival of function in the deafferentated vestibular nerve. Brain Res 273: 175-178, 1983.
30. Li L, Nevill G, and Forge A. Two modes of hair cell loss from the vestibular sensory epithelia of the guinea pig inner ear. J Comp Neurol 355: 405-417, 1995.
31. Lindeman HH. Regional differences in sensitivity of the vestibular sensory epithelia to ototoxic antibiotics. Acta Otolaryngol (Stockh) 67: 177-189, 1969.
32. Lopez I, Honrubia V, Lee SC, Schoeman G, and Beykirch K. Quantification of the process of hair cell loss and recovery in the chinchilla crista ampullaris after gentamicin treatment. Int J Dev Neurosci 15: 447-461, 1997.
33. Lowenstein O and Sand A. The mechanism of the semicircular canal. A study of the responses of single-fibre preparations to angular accelerations and to rotation at constant speed. Proc Roy Soc Lond Ser B Biol Sci 129: 256-275, 1940.
34. Lysakowski A and Goldberg JM. A regional ultrastructural analysis of the cellular synaptic architecture in the chinchilla cristae ampullares. J Comp Neurol 389: 419-443, 1997.
35. Minor LB. Gentamicin-induced bilateral vestibular hypofunction. J Am Med Assoc 279: 541-544, 1998.
36. Nakagawa T and Yamane H. Cytochrome c redistribution in apoptosis of guinea pig vestibular hair cells. Brain Res 847: 357-359, 1999.
37. Nakagawa T, Yamane H, Shibata S, and Nakai Y. Gentamicin ototoxicity induced apoptosis of the vestibular hair cells of guinea pigs. Eur Arch Otorhinolaryngol 254: 9-14, 1997.
38. Plotnik M, Marlinski V, and Goldberg JM. Reflections of efferent activity in rotational responses of chinchilla vestibular afferents. J Neurophysiol 88: 1234-1244, 2002.
39. Schacht J. Biochemical basis of aminoglycoside ototoxicity. Otolaryngol Clin North Am 26: 845-856, 1993.
40. Sirkin DW, Precht W, and Courjon J-H. Initial, rapid phase of recovery from unilateral vestibular lesion in rat not dependent on survival of central portion of vestibular nerve. Brain Res 302: 245-256, 1984.
41. Smith BM and Myers MG. The penetration of gentamicin and neomycin into perilymph across the round window membrane. Otolaryngol Head Neck Surg 87: 888-891, 1979.
42. Smith CE and Goldberg JM. A stochastic after hyperpolarization model of repetitive activity in vestibular afferents. Biol Cybern 54: 41-51, 1986.
43. Song BB, Sha SH, and Schacht J. Iron chelators protect from aminoglycoside-induced cochleo- and vestibulo-toxicity. Free Radic Biol Med 25: 189-195, 1998.
44. Tanyeri H, Lopez I, and Honrubia V. Histological evidence for hair cell regeneration after ototoxic cell destruction with local application of gentamicin in the chinchilla crista ampullaris. Hear Res 89: 194-202, 1995.
45. Weisleder P and Rubel EW. Hair cell regeneration after streptomycin toxicity in the avian vestibular epithelium. J Comp Neurol 331: 97-110, 1993.
46. Zheng JL, Keller G, and Gao WQ. Immunocytochemical and morphological evidence for intracellular self- repair as an important contributor to mammalian hair cell recovery. J Neurosci 19: 2161-2170, 1999.