The specific interaction of the photosensitizer methylene blue with acetylcholinesterase provides a model system for studying the molecular consequences of photodynamic therapy

Chemico-Biological Interactions

Volumn 203, Issue 1, 2013, Pages 63-66

  Silman, Israel ^a   Roth, Esther ^a   Paz, Aviv ^a,d   Triquigneaux, Mathilde M ^b   Ehrenshaft, Marilyn ^b   Xu, Yechun ^a,e   Shnyrov, Valery L ^c   Sussman, Joel L ^a   Deterding, Leesa J ^b   Ashani, Yacov ^a   Mason, Ronald P ^b   Weiner, Lev ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c UNIVERSITY OF SALAMANCA   (Spain)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Acetylcholinesterase; Mass spectroscopy; Methylene blue; Photodynamic therapy; Photosensitizer; Singlet oxygen

Indexed keywords

ACETYLCHOLINESTERASE; METHYLENE BLUE; OXYGEN; TRYPTOPHAN;

COMPLEX FORMATION; CONFERENCE PAPER; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; ENZYME DENATURATION; PHOTODYNAMIC THERAPY; PHOTOOXIDATION; TORPEDO CALIFORNICA;

ACETYLCHOLINESTERASE; AMINO ACID SEQUENCE; ANIMALS; BIOPHYSICAL PHENOMENA; CATALYTIC DOMAIN; CHOLINESTERASE INHIBITORS; KINETICS; METHYLENE BLUE; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; PROTEIN CONFORMATION; TORPEDO;

TORPEDO CALIFORNICA;

EID: 84875805537     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2012.10.021     Document Type: Conference Paper

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