메뉴 건너뛰기




Volumn 253, Issue 1, 2013, Pages 129-145

The Yin and Yang of microRNAs: Leukemia and immunity

Author keywords

Cancer; Hematopoiesis; Leukemia; MicroRNA 125b; MicroRNA 146a; MicroRNA 155

Indexed keywords

B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; COLONY STIMULATING FACTOR 1; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN HEAVY CHAIN; INTERFERON REGULATORY FACTOR 4; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 6; MICRORNA 125B; MICRORNA 146A; MICRORNA 155; TUMOR NECROSIS FACTOR ALPHA;

EID: 84875786889     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/imr.12043     Document Type: Review
Times cited : (52)

References (93)
  • 1
    • 0027751663 scopus 로고
    • The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993;75:843-854.
    • (1993) Cell , vol.75 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 2
    • 0024963695 scopus 로고
    • A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegans
    • Ambros V. A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegans. Cell 1989;57:49-57.
    • (1989) Cell , vol.57 , pp. 49-57
    • Ambros, V.1
  • 3
    • 0019509303 scopus 로고
    • Mutations that lead to reiterations in the cell lineages of C. elegans
    • Chalfie M, Horvitz HR, Sulston JE. Mutations that lead to reiterations in the cell lineages of C. elegans. Cell 1981;24:59-69.
    • (1981) Cell , vol.24 , pp. 59-69
    • Chalfie, M.1    Horvitz, H.R.2    Sulston, J.E.3
  • 4
    • 33747608638 scopus 로고    scopus 로고
    • NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
    • Taganov KD, Boldin MP, Chang KJ, Baltimore D. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci USA 2006;103:12481-12486.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 12481-12486
    • Taganov, K.D.1    Boldin, M.P.2    Chang, K.J.3    Baltimore, D.4
  • 6
    • 78650722292 scopus 로고    scopus 로고
    • MicroRNA-125b expands hematopoietic stem cells and enriches for the lymphoid-balanced and lymphoid-biased subsets
    • Ooi AG, Sahoo D, Adorno M, Wang Y, Weissman IL, Park CY. MicroRNA-125b expands hematopoietic stem cells and enriches for the lymphoid-balanced and lymphoid-biased subsets. Proc Natl Acad Sci USA 2010;107:21505-21510.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 21505-21510
    • Ooi, A.G.1    Sahoo, D.2    Adorno, M.3    Wang, Y.4    Weissman, I.L.5    Park, C.Y.6
  • 7
    • 84855824354 scopus 로고    scopus 로고
    • Genetic screen identifies microRNA cluster 99b/let-7e/125a as a regulator of primitive hematopoietic cells
    • Gerrits A, et al. Genetic screen identifies microRNA cluster 99b/let-7e/125a as a regulator of primitive hematopoietic cells. Blood 2012;119:377-387.
    • (2012) Blood , vol.119 , pp. 377-387
    • Gerrits, A.1
  • 8
    • 77956270732 scopus 로고    scopus 로고
    • MicroRNA miR-125a controls hematopoietic stem cell number
    • Guo S, et al. MicroRNA miR-125a controls hematopoietic stem cell number. Proc Natl Acad Sci USA 2010;107:14229-14234.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 14229-14234
    • Guo, S.1
  • 9
    • 84858257170 scopus 로고    scopus 로고
    • Oncomir miR-125b regulates hematopoiesis by targeting the gene Lin28A
    • Chaudhuri AA, So AY, Mehta A, et al. Oncomir miR-125b regulates hematopoiesis by targeting the gene Lin28A. Proc Natl Acad Sci USA 2012;109:4233-4238.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 4233-4238
    • Chaudhuri, A.A.1    So, A.Y.2    Mehta, A.3
  • 10
    • 84867397504 scopus 로고    scopus 로고
    • B-cell regulator of immunoglobulin heavy chain transcription (Bright)/ARID3a is a direct target of the oncomir microRNA-125b in progenitor B-cells
    • Puissegur MP, et al. B-cell regulator of immunoglobulin heavy chain transcription (Bright)/ARID3a is a direct target of the oncomir microRNA-125b in progenitor B-cells. Leukemia 2012;26:2224-2232.
    • (2012) Leukemia , vol.26 , pp. 2224-2232
    • Puissegur, M.P.1
  • 11
    • 77954263256 scopus 로고    scopus 로고
    • MicroRNA 125b inhibition of B cell differentiation in germinal centers
    • Gururajan M, et al. MicroRNA 125b inhibition of B cell differentiation in germinal centers. Int Immunol 2010;22:583-592.
    • (2010) Int Immunol , vol.22 , pp. 583-592
    • Gururajan, M.1
  • 12
    • 77649143631 scopus 로고    scopus 로고
    • miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia
    • Klusmann JH, et al. miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia. Genes Dev 2010;24:478-490.
    • (2010) Genes Dev , vol.24 , pp. 478-490
    • Klusmann, J.H.1
  • 13
    • 80052035077 scopus 로고    scopus 로고
    • Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b
    • Rossi RL, et al. Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b. Nat Immunol 2011;12:796-803.
    • (2011) Nat Immunol , vol.12 , pp. 796-803
    • Rossi, R.L.1
  • 14
    • 34948817683 scopus 로고    scopus 로고
    • Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes
    • Huang J, et al. Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes. Nat Med 2007;13:1241-1247.
    • (2007) Nat Med , vol.13 , pp. 1241-1247
    • Huang, J.1
  • 15
    • 0037452711 scopus 로고    scopus 로고
    • Gene expression and viral prodution in latently infected, resting CD4+ T cells in viremic versus aviremic HIV-infected individuals
    • Chun TW, et al. Gene expression and viral prodution in latently infected, resting CD4+ T cells in viremic versus aviremic HIV-infected individuals. Proc Natl Acad Sci USA 2003;100:1908-1913.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 1908-1913
    • Chun, T.W.1
  • 16
    • 0033609374 scopus 로고    scopus 로고
    • Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients receiving potent antiretroviral therapy
    • Furtado MR, et al. Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients receiving potent antiretroviral therapy. N Engl J Med 1999;340:1614-1622.
    • (1999) N Engl J Med , vol.340 , pp. 1614-1622
    • Furtado, M.R.1
  • 17
    • 0033609373 scopus 로고    scopus 로고
    • Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy
    • Zhang L, et al. Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy. N Engl J Med 1999;340:1605-1613.
    • (1999) N Engl J Med , vol.340 , pp. 1605-1613
    • Zhang, L.1
  • 18
    • 81455141958 scopus 로고    scopus 로고
    • MicroRNA-125b potentiates macrophage activation
    • Chaudhuri AA, et al. MicroRNA-125b potentiates macrophage activation. J Immunol 2011;187:5062-5068.
    • (2011) J Immunol , vol.187 , pp. 5062-5068
    • Chaudhuri, A.A.1
  • 19
    • 12144290519 scopus 로고    scopus 로고
    • Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
    • Calin GA, et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA 2004;101:2999-3004.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 2999-3004
    • Calin, G.A.1
  • 20
    • 77954658856 scopus 로고    scopus 로고
    • A new recurrent translocation t(11;14)(q24;q32) involving IGH@ and miR-125b-1 in B-cell progenitor acute lymphoblastic leukemia
    • Chapiro E, et al. A new recurrent translocation t(11;14)(q24;q32) involving IGH@ and miR-125b-1 in B-cell progenitor acute lymphoblastic leukemia. Leukemia 2010;24:1362-1364.
    • (2010) Leukemia , vol.24 , pp. 1362-1364
    • Chapiro, E.1
  • 21
    • 83555166166 scopus 로고    scopus 로고
    • Emu/miR-125b transgenic mice develop lethal B-cell malignancies
    • Enomoto Y, et al. Emu/miR-125b transgenic mice develop lethal B-cell malignancies. Leukemia 2011;25:1849-1856.
    • (2011) Leukemia , vol.25 , pp. 1849-1856
    • Enomoto, Y.1
  • 22
    • 27644442420 scopus 로고    scopus 로고
    • Insertion of microRNA-125b-1, a human homologue of lin-4, into a rearranged immunoglobulin heavy chain gene locus in a patient with precursor B-cell acute lymphoblastic leukemia
    • Sonoki T, Iwanaga E, Mitsuya H, Asou N. Insertion of microRNA-125b-1, a human homologue of lin-4, into a rearranged immunoglobulin heavy chain gene locus in a patient with precursor B-cell acute lymphoblastic leukemia. Leukemia 2005;19:2009-2010.
    • (2005) Leukemia , vol.19 , pp. 2009-2010
    • Sonoki, T.1    Iwanaga, E.2    Mitsuya, H.3    Asou, N.4
  • 23
    • 77953493212 scopus 로고    scopus 로고
    • MicroRNA-125b-1 and BLID upregulation resulting from a novel IGH translocation in childhood B-Cell precursor acute lymphoblastic leukemia
    • Tassano E, Acquila M, Tavella E, Micalizzi C, Panarello C, Morerio C. MicroRNA-125b-1 and BLID upregulation resulting from a novel IGH translocation in childhood B-Cell precursor acute lymphoblastic leukemia. Genes Chromosom Cancer 2010;49:682-687.
    • (2010) Genes Chromosom Cancer , vol.49 , pp. 682-687
    • Tassano, E.1    Acquila, M.2    Tavella, E.3    Micalizzi, C.4    Panarello, C.5    Morerio, C.6
  • 24
    • 58149145653 scopus 로고    scopus 로고
    • Myeloid cell differentiation arrest by miR-125b-1 in myelodysplastic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation
    • Bousquet M, et al. Myeloid cell differentiation arrest by miR-125b-1 in myelodysplastic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation. J Exp Med 2008;205:2499-2506.
    • (2008) J Exp Med , vol.205 , pp. 2499-2506
    • Bousquet, M.1
  • 25
    • 77955274827 scopus 로고    scopus 로고
    • Aberrant microRNA expression pattern in myelodysplastic bone marrow cells
    • Hussein K, et al. Aberrant microRNA expression pattern in myelodysplastic bone marrow cells. Leukemia Res 2010;34:1169-1174.
    • (2010) Leukemia Res , vol.34 , pp. 1169-1174
    • Hussein, K.1
  • 26
    • 78650885126 scopus 로고    scopus 로고
    • Differential expression of microRNAs in CD34+ cells of 5q- syndrome
    • Votavova H, et al. Differential expression of microRNAs in CD34+ cells of 5q- syndrome. J Hematol Oncol 2011;4:1.
    • (2011) J Hematol Oncol , vol.4 , pp. 1
    • Votavova, H.1
  • 27
    • 77951540421 scopus 로고    scopus 로고
    • Differential expression of specific microRNA and their targets in acute myeloid leukemia
    • Cammarata G, et al. Differential expression of specific microRNA and their targets in acute myeloid leukemia. A, J Hematol 2010;85:331-339.
    • (2010) A, J Hematol , vol.85 , pp. 331-339
    • Cammarata, G.1
  • 28
    • 70649110008 scopus 로고    scopus 로고
    • MicroRNA patterns associated with clinical prognostic parameters and CNS relapse prediction in pediatric acute leukemia
    • Zhang H, et al. MicroRNA patterns associated with clinical prognostic parameters and CNS relapse prediction in pediatric acute leukemia. PLoS ONE 2009;4:e7826.
    • (2009) PLoS ONE , vol.4
    • Zhang, H.1
  • 29
    • 20444440706 scopus 로고    scopus 로고
    • Depletion of human micro-RNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the down-regulation of putative targets during differentiation
    • Lee YS, Kim HK, Chung S, Kim KS, Dutta A. Depletion of human micro-RNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the down-regulation of putative targets during differentiation. J Biol Chem 2005;280:16635-16641.
    • (2005) J Biol Chem , vol.280 , pp. 16635-16641
    • Lee, Y.S.1    Kim, H.K.2    Chung, S.3    Kim, K.S.4    Dutta, A.5
  • 31
    • 84861148197 scopus 로고    scopus 로고
    • Regulation of monocyte functional heterogeneity by miR-146a and Relb
    • Etzrodt M, et al. Regulation of monocyte functional heterogeneity by miR-146a and Relb. Cell Rep 2012;1:317-324.
    • (2012) Cell Rep , vol.1 , pp. 317-324
    • Etzrodt, M.1
  • 32
    • 77954488963 scopus 로고    scopus 로고
    • miR-146a is differentially expressed by myeloid dendritic cell subsets and desensitizes cells to TLR2-dependent activation
    • Jurkin J, et al. miR-146a is differentially expressed by myeloid dendritic cell subsets and desensitizes cells to TLR2-dependent activation. J Immunol 2010;184:4955-4965.
    • (2010) J Immunol , vol.184 , pp. 4955-4965
    • Jurkin, J.1
  • 33
    • 79958257077 scopus 로고    scopus 로고
    • miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice
    • Boldin MP, et al. miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice. J Exp Med 2011;208:1189-1201.
    • (2011) J Exp Med , vol.208 , pp. 1189-1201
    • Boldin, M.P.1
  • 34
    • 84866354593 scopus 로고    scopus 로고
    • miR-146a controls the resolution of T cell responses in mice
    • Yang L, et al. miR-146a controls the resolution of T cell responses in mice. J Exp Med 2012;209:1655-1670.
    • (2012) J Exp Med , vol.209 , pp. 1655-1670
    • Yang, L.1
  • 35
    • 78751523598 scopus 로고    scopus 로고
    • MicroRNA-146a disrupts hematopoietic differentiation and survival
    • e4.
    • Starczynowski DT, et al. MicroRNA-146a disrupts hematopoietic differentiation and survival. Exp Hematol 2011;39:167-178e4.
    • (2011) Exp Hematol , vol.39 , pp. 167-178
    • Starczynowski, D.T.1
  • 36
    • 68149165370 scopus 로고    scopus 로고
    • MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2
    • Hou J, et al. MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2. J Immunol 2009;183:2150-2158.
    • (2009) J Immunol , vol.183 , pp. 2150-2158
    • Hou, J.1
  • 37
    • 78149457930 scopus 로고    scopus 로고
    • Regulation of miRNA transcription in macrophages in response to Candida albicans
    • Monk CE, Hutvagner G, Arthur JS. Regulation of miRNA transcription in macrophages in response to Candida albicans. PLoS ONE 2010;5:e13669.
    • (2010) PLoS ONE , vol.5
    • Monk, C.E.1    Hutvagner, G.2    Arthur, J.S.3
  • 38
    • 38849160013 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways
    • Cameron JE, et al. Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways. J Virol 2008;82:1946-1958.
    • (2008) J Virol , vol.82 , pp. 1946-1958
    • Cameron, J.E.1
  • 39
    • 80052149793 scopus 로고    scopus 로고
    • Macrophage development from HSCs requires PU.1-coordinated microRNA expression
    • Ghani S, et al. Macrophage development from HSCs requires PU.1-coordinated microRNA expression. Blood 2011;118:2275-2284.
    • (2011) Blood , vol.118 , pp. 2275-2284
    • Ghani, S.1
  • 40
    • 75649108622 scopus 로고    scopus 로고
    • An emerging player in the adaptive immune response: microRNA-146a is a modulator of IL-2 expression and activation-induced cell death in T lymphocytes
    • Curtale G, et al. An emerging player in the adaptive immune response: microRNA-146a is a modulator of IL-2 expression and activation-induced cell death in T lymphocytes. Blood 2010;115:265-273.
    • (2010) Blood , vol.115 , pp. 265-273
    • Curtale, G.1
  • 41
    • 46449092527 scopus 로고    scopus 로고
    • A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis
    • Labbaye C, et al. A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis. Nat Cell Biol 2008;10:788-801.
    • (2008) Nat Cell Biol , vol.10 , pp. 788-801
    • Labbaye, C.1
  • 42
    • 37549008310 scopus 로고    scopus 로고
    • Widespread microRNA repression by Myc contributes to tumorigenesis
    • Chang TC, et al. Widespread microRNA repression by Myc contributes to tumorigenesis. Nat Genet 2008;40:43-50.
    • (2008) Nat Genet , vol.40 , pp. 43-50
    • Chang, T.C.1
  • 43
    • 58049186787 scopus 로고    scopus 로고
    • Suppression of LPS-induced Interferon-gamma and nitric oxide in splenic lymphocytes by select estrogen-regulated microRNAs: a novel mechanism of immune modulation
    • Dai R, Phillips RA, Zhang Y, Khan D, Crasta O, Ahmed SA. Suppression of LPS-induced Interferon-gamma and nitric oxide in splenic lymphocytes by select estrogen-regulated microRNAs: a novel mechanism of immune modulation. Blood 2008;112:4591-4597.
    • (2008) Blood , vol.112 , pp. 4591-4597
    • Dai, R.1    Phillips, R.A.2    Zhang, Y.3    Khan, D.4    Crasta, O.5    Ahmed, S.A.6
  • 44
    • 67349107523 scopus 로고    scopus 로고
    • microRNA-146b inhibits glioma cell migration and invasion by targeting MMPs
    • Xia H, et al. microRNA-146b inhibits glioma cell migration and invasion by targeting MMPs. Brain Res 2009;1269:158-165.
    • (2009) Brain Res , vol.1269 , pp. 158-165
    • Xia, H.1
  • 45
    • 77952386365 scopus 로고    scopus 로고
    • miR-146b is highly expressed in adult papillary thyroid carcinomas with high risk features including extrathyroidal invasion and the BRAF(V600E) mutation
    • Chou CK, et al. miR-146b is highly expressed in adult papillary thyroid carcinomas with high risk features including extrathyroidal invasion and the BRAF(V600E) mutation. Thyroid 2010;20:489-494.
    • (2010) Thyroid , vol.20 , pp. 489-494
    • Chou, C.K.1
  • 46
    • 84859746790 scopus 로고    scopus 로고
    • MicroRNA miR-146b-5p regulates signal transduction of TGF-beta by repressing SMAD4 in thyroid cancer
    • Geraldo MV, Yamashita AS, Kimura ET. MicroRNA miR-146b-5p regulates signal transduction of TGF-beta by repressing SMAD4 in thyroid cancer. Oncogene 2012;31:1910-1922.
    • (2012) Oncogene , vol.31 , pp. 1910-1922
    • Geraldo, M.V.1    Yamashita, A.S.2    Kimura, E.T.3
  • 47
    • 78649258023 scopus 로고    scopus 로고
    • MiR-146b-5p suppresses EGFR expression and reduces in vitro migration and invasion of glioma
    • Katakowski M, Zheng X, Jiang F, Rogers T, Szalad A, Chopp M. MiR-146b-5p suppresses EGFR expression and reduces in vitro migration and invasion of glioma. Cancer Invest 2010;28:1024-1030.
    • (2010) Cancer Invest , vol.28 , pp. 1024-1030
    • Katakowski, M.1    Zheng, X.2    Jiang, F.3    Rogers, T.4    Szalad, A.5    Chopp, M.6
  • 48
    • 80054680434 scopus 로고    scopus 로고
    • Aberrant expression of chromogranin A, miR-146a, and miR-146b-5p in prostate structures with focally disrupted basal cell layers: an early sign of invasion and hormone-refractory cancer?
    • Man YG, et al. Aberrant expression of chromogranin A, miR-146a, and miR-146b-5p in prostate structures with focally disrupted basal cell layers: an early sign of invasion and hormone-refractory cancer? Cancer Genomics Proteomics 2011;8:235-244.
    • (2011) Cancer Genomics Proteomics , vol.8 , pp. 235-244
    • Man, Y.G.1
  • 49
    • 70349884016 scopus 로고    scopus 로고
    • Divergent intracellular pathways regulate interleukin-1beta-induced miR-146a and miR-146b expression and chemokine release in human alveolar epithelial cells
    • Perry MM, Williams AE, Tsitsiou E, Larner-Svensson HM, Lindsay MA. Divergent intracellular pathways regulate interleukin-1beta-induced miR-146a and miR-146b expression and chemokine release in human alveolar epithelial cells. FEBS Lett 2009;583:3349-3355.
    • (2009) FEBS Lett , vol.583 , pp. 3349-3355
    • Perry, M.M.1    Williams, A.E.2    Tsitsiou, E.3    Larner-Svensson, H.M.4    Lindsay, M.A.5
  • 50
    • 84858722006 scopus 로고    scopus 로고
    • MicroRNAs, new effectors and regulators of NF-kappaB
    • Boldin MP, Baltimore D. MicroRNAs, new effectors and regulators of NF-kappaB. Immunol Rev 2012;246:205-220.
    • (2012) Immunol Rev , vol.246 , pp. 205-220
    • Boldin, M.P.1    Baltimore, D.2
  • 51
    • 73849121794 scopus 로고    scopus 로고
    • Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype
    • Starczynowski DT, et al. Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype. Nat Med 2010;16:49-58.
    • (2010) Nat Med , vol.16 , pp. 49-58
    • Starczynowski, D.T.1
  • 52
    • 33847311819 scopus 로고    scopus 로고
    • MicroRNAs and immunity: tiny players in a big field
    • Taganov KD, Boldin MP, Baltimore D. MicroRNAs and immunity: tiny players in a big field. Immunity 2007;26:133-137.
    • (2007) Immunity , vol.26 , pp. 133-137
    • Taganov, K.D.1    Boldin, M.P.2    Baltimore, D.3
  • 53
    • 71749096218 scopus 로고    scopus 로고
    • miR-146a is critical for endotoxin-induced tolerance: implication in innate immunity
    • Nahid MA, Pauley KM, Satoh M, Chan EK. miR-146a is critical for endotoxin-induced tolerance: implication in innate immunity. J Biol Chem 2009;284:34590-34599.
    • (2009) J Biol Chem , vol.284 , pp. 34590-34599
    • Nahid, M.A.1    Pauley, K.M.2    Satoh, M.3    Chan, E.K.4
  • 54
    • 79251592866 scopus 로고    scopus 로고
    • Mechanistic role of microRNA-146a in endotoxin-induced differential cross-regulation of TLR signaling
    • Nahid MA, Satoh M, Chan EK. Mechanistic role of microRNA-146a in endotoxin-induced differential cross-regulation of TLR signaling. J Immunol 2011;186:1723-1734.
    • (2011) J Immunol , vol.186 , pp. 1723-1734
    • Nahid, M.A.1    Satoh, M.2    Chan, E.K.3
  • 55
    • 80052364758 scopus 로고    scopus 로고
    • MicroRNA-146a regulates both transcription silencing and translation disruption of TNF-alpha during TLR4-induced gene reprogramming
    • El Gazzar M, Church A, Liu T, McCall CE. MicroRNA-146a regulates both transcription silencing and translation disruption of TNF-alpha during TLR4-induced gene reprogramming. J Leukoc Biol 2011;90:509-519.
    • (2011) J Leukoc Biol , vol.90 , pp. 509-519
    • El Gazzar, M.1    Church, A.2    Liu, T.3    McCall, C.E.4
  • 56
    • 65249138193 scopus 로고    scopus 로고
    • MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins
    • Tang Y, et al. MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins. Arthritis Rheum 2009;60:1065-1075.
    • (2009) Arthritis Rheum , vol.60 , pp. 1065-1075
    • Tang, Y.1
  • 57
    • 77956632634 scopus 로고    scopus 로고
    • Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses
    • Lu LF, et al. Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell 2010;142:914-929.
    • (2010) Cell , vol.142 , pp. 914-929
    • Lu, L.F.1
  • 58
    • 79959362128 scopus 로고    scopus 로고
    • NF-kappaB dysregulation in microRNA-146a-deficient mice drives the development of myeloid malignancies
    • Zhao JL, Rao DS, Boldin MP, Taganov KD, O'Connell RM, Baltimore D. NF-kappaB dysregulation in microRNA-146a-deficient mice drives the development of myeloid malignancies. Proc Natl Acad Sci U S A 2011;108(22):9184-9189.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.22 , pp. 9184-9189
    • Zhao, J.L.1    Rao, D.S.2    Boldin, M.P.3    Taganov, K.D.4    O'Connell, R.M.5    Baltimore, D.6
  • 59
    • 78649729095 scopus 로고    scopus 로고
    • MicroRNA expression in maturing murine megakaryocytes
    • Opalinska JB, et al. MicroRNA expression in maturing murine megakaryocytes. Blood 2010;116:e128-e138.
    • (2010) Blood , vol.116
    • Opalinska, J.B.1
  • 60
    • 77958105934 scopus 로고    scopus 로고
    • miR-146a mediates protective innate immune tolerance in the neonate intestine
    • Chassin C, et al. miR-146a mediates protective innate immune tolerance in the neonate intestine. Cell Host Microbe 2010;8:358-368.
    • (2010) Cell Host Microbe , vol.8 , pp. 358-368
    • Chassin, C.1
  • 61
    • 45549101837 scopus 로고    scopus 로고
    • Rapid changes in microRNA-146a expression negatively regulate the IL-1beta-induced inflammatory response in human lung alveolar epithelial cells
    • Perry MM, Moschos SA, Williams AE, Shepherd NJ, Larner-Svensson HM, Lindsay MA. Rapid changes in microRNA-146a expression negatively regulate the IL-1beta-induced inflammatory response in human lung alveolar epithelial cells. J Immunol 2008;180:5689-5698.
    • (2008) J Immunol , vol.180 , pp. 5689-5698
    • Perry, M.M.1    Moschos, S.A.2    Williams, A.E.3    Shepherd, N.J.4    Larner-Svensson, H.M.5    Lindsay, M.A.6
  • 62
    • 84859910035 scopus 로고    scopus 로고
    • Genetic association of miRNA-146a with systemic lupus erythematosus in Europeans through decreased expression of the gene
    • Lofgren SE, et al. Genetic association of miRNA-146a with systemic lupus erythematosus in Europeans through decreased expression of the gene. Genes Immun 2012;13:268-274.
    • (2012) Genes Immun , vol.13 , pp. 268-274
    • Lofgren, S.E.1
  • 63
    • 79959836816 scopus 로고    scopus 로고
    • A functional variant in microRNA-146a promoter modulates its expression and confers disease risk for systemic lupus erythematosus
    • Luo X, et al. A functional variant in microRNA-146a promoter modulates its expression and confers disease risk for systemic lupus erythematosus. PLoS Genet 2011;7:e1002128.
    • (2011) PLoS Genet , vol.7
    • Luo, X.1
  • 64
    • 65249161685 scopus 로고    scopus 로고
    • Contrast in aberrant microRNA expression in systemic lupus erythematosus and rheumatoid arthritis: is microRNA-146 all we need?
    • Chan EK, Satoh M, Pauley KM. Contrast in aberrant microRNA expression in systemic lupus erythematosus and rheumatoid arthritis: is microRNA-146 all we need? Arthritis Rheum 2009;60:912-915.
    • (2009) Arthritis Rheum , vol.60 , pp. 912-915
    • Chan, E.K.1    Satoh, M.2    Pauley, K.M.3
  • 65
    • 81755162841 scopus 로고    scopus 로고
    • MicroRNA 146a expression in rheumatoid arthritis: association with tumor necrosis factor-alpha and disease activity
    • Abou-Zeid A, Saad M, Soliman E. MicroRNA 146a expression in rheumatoid arthritis: association with tumor necrosis factor-alpha and disease activity. Genet Test Mol Biomarkers 2011;15:807-812.
    • (2011) Genet Test Mol Biomarkers , vol.15 , pp. 807-812
    • Abou-Zeid, A.1    Saad, M.2    Soliman, E.3
  • 66
    • 43949136123 scopus 로고    scopus 로고
    • Expression of microRNA-146 in rheumatoid arthritis synovial tissue
    • Nakasa T, et al. Expression of microRNA-146 in rheumatoid arthritis synovial tissue. Arthritis Rheum 2008;58:1284-1292.
    • (2008) Arthritis Rheum , vol.58 , pp. 1284-1292
    • Nakasa, T.1
  • 67
    • 65249191384 scopus 로고    scopus 로고
    • Expression of MicroRNA-146a in osteoarthritis cartilage
    • Yamasaki K, et al. Expression of MicroRNA-146a in osteoarthritis cartilage. Arthritis Rheum 2009;60:1035-1041.
    • (2009) Arthritis Rheum , vol.60 , pp. 1035-1041
    • Yamasaki, K.1
  • 69
    • 79551475486 scopus 로고    scopus 로고
    • MicroRNA-146a regulates the maturation process and pro-inflammatory cytokine secretion by targeting CD40L in oxLDL-stimulated dendritic cells
    • Chen T, et al. MicroRNA-146a regulates the maturation process and pro-inflammatory cytokine secretion by targeting CD40L in oxLDL-stimulated dendritic cells. FEBS Lett 2011;585:567-573.
    • (2011) FEBS Lett , vol.585 , pp. 567-573
    • Chen, T.1
  • 70
    • 79952575527 scopus 로고    scopus 로고
    • MiR-146a inhibits oxidized low-density lipoprotein-induced lipid accumulation and inflammatory response via targeting toll-like receptor 4
    • Yang K, et al. MiR-146a inhibits oxidized low-density lipoprotein-induced lipid accumulation and inflammatory response via targeting toll-like receptor 4. FEBS Lett 2011;585:854-860.
    • (2011) FEBS Lett , vol.585 , pp. 854-860
    • Yang, K.1
  • 71
    • 79952164235 scopus 로고    scopus 로고
    • Unraveling the molecular pathophysiology of myelodysplastic syndromes
    • Bejar R, Levine R, Ebert BL. Unraveling the molecular pathophysiology of myelodysplastic syndromes. J Clin Oncol 2011;29:504-515.
    • (2011) J Clin Oncol , vol.29 , pp. 504-515
    • Bejar, R.1    Levine, R.2    Ebert, B.L.3
  • 72
    • 84875910316 scopus 로고    scopus 로고
    • Molecular pathophysiology of myelodysplastic syndromes
    • Lindsley RC, Ebert BL. Molecular pathophysiology of myelodysplastic syndromes. Annu Rev Pathol 2013;8:21-47.
    • (2013) Annu Rev Pathol , vol.8 , pp. 21-47
    • Lindsley, R.C.1    Ebert, B.L.2
  • 73
    • 84856709581 scopus 로고    scopus 로고
    • Deregulation of microRNAs in myelodysplastic syndrome
    • Rhyasen GW, Starczynowski DT. Deregulation of microRNAs in myelodysplastic syndrome. Leukemia 2012;26:13-22.
    • (2012) Leukemia , vol.26 , pp. 13-22
    • Rhyasen, G.W.1    Starczynowski, D.T.2
  • 75
    • 42449141513 scopus 로고    scopus 로고
    • MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia
    • Garzon R, et al. MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia. Blood 2008;111:3183-3189.
    • (2008) Blood , vol.111 , pp. 3183-3189
    • Garzon, R.1
  • 76
    • 76849084080 scopus 로고    scopus 로고
    • MicroRNAs expression signatures are associated with lineage and survival in acute leukemias
    • Wang Y, et al. MicroRNAs expression signatures are associated with lineage and survival in acute leukemias. Blood Cells Mol Dis 2010;44:191-197.
    • (2010) Blood Cells Mol Dis , vol.44 , pp. 191-197
    • Wang, Y.1
  • 77
    • 79960434259 scopus 로고    scopus 로고
    • MicroRNA-146a downregulates NFkappaB activity via targeting TRAF6 and functions as a tumor suppressor having strong prognostic implications in NK/T cell lymphoma
    • Paik JH, et al. MicroRNA-146a downregulates NFkappaB activity via targeting TRAF6 and functions as a tumor suppressor having strong prognostic implications in NK/T cell lymphoma. Clin Cancer Res 2011;17:4761-4771.
    • (2011) Clin Cancer Res , vol.17 , pp. 4761-4771
    • Paik, J.H.1
  • 78
    • 84857420754 scopus 로고    scopus 로고
    • MicroRNAs and hematopoietic cell development
    • O'Connell RM, Baltimore D. MicroRNAs and hematopoietic cell development. Curr Top Dev Biol 2012;99:145-174.
    • (2012) Curr Top Dev Biol , vol.99 , pp. 145-174
    • O'Connell, R.M.1    Baltimore, D.2
  • 79
    • 75649139134 scopus 로고    scopus 로고
    • Physiological and pathological roles for microRNAs in the immune system
    • O'Connell RM, Rao DS, Chaudhuri AA, Baltimore D. Physiological and pathological roles for microRNAs in the immune system. Nat Rev Immunol 2010;10:111-122.
    • (2010) Nat Rev Immunol , vol.10 , pp. 111-122
    • O'Connell, R.M.1    Rao, D.S.2    Chaudhuri, A.A.3    Baltimore, D.4
  • 80
    • 80052936529 scopus 로고    scopus 로고
    • MicroRNA function in myeloid biology
    • O'Connell RM, Zhao JL, Rao DS. MicroRNA function in myeloid biology. Blood 2011;118:2960-2969.
    • (2011) Blood , vol.118 , pp. 2960-2969
    • O'Connell, R.M.1    Zhao, J.L.2    Rao, D.S.3
  • 81
    • 80051959463 scopus 로고    scopus 로고
    • NF-kappaB is 25
    • Baltimore D. NF-kappaB is 25. Nat Immunol 2011;12:683-685.
    • (2011) Nat Immunol , vol.12 , pp. 683-685
    • Baltimore, D.1
  • 82
    • 20644450804 scopus 로고    scopus 로고
    • Negative regulation of toll-like receptor-mediated immune responses
    • Liew FY, Xu D, Brint EK, O'Neill LA. Negative regulation of toll-like receptor-mediated immune responses. Nat Rev Immunol 2005;5:446-458.
    • (2005) Nat Rev Immunol , vol.5 , pp. 446-458
    • Liew, F.Y.1    Xu, D.2    Brint, E.K.3    O'Neill, L.A.4
  • 83
    • 80052014052 scopus 로고    scopus 로고
    • Inflammation meets cancer, with NF-kappaB as the matchmaker
    • Ben-Neriah Y, Karin M. Inflammation meets cancer, with NF-kappaB as the matchmaker. Nat Immunol 2011;12:715-723.
    • (2011) Nat Immunol , vol.12 , pp. 715-723
    • Ben-Neriah, Y.1    Karin, M.2
  • 84
    • 41149130219 scopus 로고    scopus 로고
    • Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder
    • O'Connell RM, et al. Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder. J Exp Med 2008;205:585-594.
    • (2008) J Exp Med , vol.205 , pp. 585-594
    • O'Connell, R.M.1
  • 87
    • 68649091506 scopus 로고    scopus 로고
    • The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs
    • Androulidaki A, et al. The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs. Immunity 2009;31:220-231.
    • (2009) Immunity , vol.31 , pp. 220-231
    • Androulidaki, A.1
  • 88
    • 38049030287 scopus 로고    scopus 로고
    • Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock
    • Tili E, et al. Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock. J Immunol 2007;179:5082-5089.
    • (2007) J Immunol , vol.179 , pp. 5082-5089
    • Tili, E.1
  • 89
    • 34247584465 scopus 로고    scopus 로고
    • Requirement of bic/microRNA-155 for normal immune function
    • Rodriguez A, et al. Requirement of bic/microRNA-155 for normal immune function. Science 2007;316:608-611.
    • (2007) Science , vol.316 , pp. 608-611
    • Rodriguez, A.1
  • 90
    • 34247594818 scopus 로고    scopus 로고
    • Regulation of the germinal center response by microRNA-155
    • Thai TH, et al. Regulation of the germinal center response by microRNA-155. Science 2007;316:604-608.
    • (2007) Science , vol.316 , pp. 604-608
    • Thai, T.H.1
  • 91
    • 77958495102 scopus 로고    scopus 로고
    • MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development
    • O'Connell RM, et al. MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development. Immunity 2010;33:607-619.
    • (2010) Immunity , vol.33 , pp. 607-619
    • O'Connell, R.M.1
  • 92
    • 84875767072 scopus 로고    scopus 로고
    • Opposing roles for microRNAs 155 and 146a during antitumor immunity Cell Rep
    • Huffaker T, et al. Opposing roles for microRNAs 155 and 146a during antitumor immunity Cell Rep 2012;1:317-324.
    • (2012) , vol.1 , pp. 317-324
    • Huffaker, T.1
  • 93
    • 33646471662 scopus 로고    scopus 로고
    • Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice
    • Costinean S, et al. Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice. Proc Natl Acad Sci USA 2006;103:7024-7029.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 7024-7029
    • Costinean, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.