메뉴 건너뛰기




Volumn 65, Issue 1, 2013, Pages 122-133

Influence of ezetimibe on ADMA-DDAH-NO pathway in rat liver subjected to partial ischemia followed by global reperfusion

Author keywords

ADMA; ENOS; Ezetimibe; Ischemia reperfusion; Liver; Rat

Indexed keywords

6 N,N' DIMETHYLARGININE; ALANINE AMINOTRANSFERASE; AMINOTRANSFERASE; ARGININE; ASPARTATE AMINOTRANSFERASE; DIMETHYLARGININASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; EZETIMIBE; HEPARIN; KETAMINE; MEDETOMIDINE; PLACEBO; PROTEIN ARGININE METHYLTRANSFERASE;

EID: 84875769868     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/S1734-1140(13)70970-8     Document Type: Article
Times cited : (10)

References (50)
  • 2
    • 26044473080 scopus 로고    scopus 로고
    • Endothelial function in the forearm circulation of patients with the metabolic syndrome - Effect of different lipid-lowering regimens
    • Bulut D, Hanefeld C, Bulut-Streich N, Graf C, Mugge A, Spiecker M: Endothelial function in the forearm circulation of patients with the metabolic syndrome - effect of different lipid-lowering regimens. Cardiology, 2005, 104, 176-180.
    • (2005) Cardiology , vol.104 , pp. 176-180
    • Bulut, D.1    Hanefeld, C.2    Bulut-Streich, N.3    Graf, C.4    Mugge, A.5    Spiecker, M.6
  • 3
    • 33847757915 scopus 로고    scopus 로고
    • Evidence for the pathophysiological role of endogenous methylarginines in regulation of endothelial NO production and vascular function
    • Cardounel AJ, Cui H, Samouilov A, Johnson W, Kearns P, Tsai AL, Berka V, Zweier JL: Evidence for the pathophysiological role of endogenous methylarginines in regulation of endothelial NO production and vascular function. J Biol Chem, 2007, 282, 879-887.
    • (2007) J Biol Chem , vol.282 , pp. 879-887
    • Cardounel, A.J.1    Cui, H.2    Samouilov, A.3    Johnson, W.4    Kearns, P.5    Tsai, A.L.6    Berka, V.7    Zweier, J.L.8
  • 4
    • 34848821201 scopus 로고    scopus 로고
    • GC-MS assay for hepatic DDAH activity in diabetic and non-diabetic rats by measuring dimethylamine (DMA) formed from asymmetric dimethylarginine (ADMA): Evaluation of the importance of S-nitrosothiols as inhibitors of DDAH activity in vitro and in vivo in humans
    • Chobanyan K, Thum T, Suchy MT, Zhu B, Mitschke A, Gutzki FM, Beckmann B et al.: GC-MS assay for hepatic DDAH activity in diabetic and non-diabetic rats by measuring dimethylamine (DMA) formed from asymmetric dimethylarginine (ADMA): evaluation of the importance of S-nitrosothiols as inhibitors of DDAH activity in vitro and in vivo in humans. J Chromatogr B Analyt Technol Biomed Life Sci, 2007, 858, 32-41.
    • (2007) J Chromatogr B Analyt Technol Biomed Life Sci , vol.858 , pp. 32-41
    • Chobanyan, K.1    Thum, T.2    Suchy, M.T.3    Zhu, B.4    Mitschke, A.5    Gutzki, F.M.6    Beckmann, B.7
  • 5
    • 0018685730 scopus 로고
    • Protein degradation in metabolic and nutritional disorders
    • Dice JF, Walker CD: Protein degradation in metabolic and nutritional disorders. Ciba Found Symp, 1979, 75, 331-350.
    • (1979) Ciba Found Symp , vol.75 , pp. 331-350
    • Dice, J.F.1    Walker, C.D.2
  • 6
    • 42549154343 scopus 로고    scopus 로고
    • Plasma biomarkers of endothelial dysfunction in patients with hypertrophic cardiomyopathy
    • Dimitrow PP, Undas A, Bober M, Tracz W, Dubiel JS: Plasma biomarkers of endothelial dysfunction in patients with hypertrophic cardiomyopathy. Pharmacol Rep, 2007, 59, 715-720.
    • (2007) Pharmacol Rep , vol.59 , pp. 715-720
    • Dimitrow, P.P.1    Undas, A.2    Bober, M.3    Tracz, W.4    Dubiel, J.S.5
  • 7
    • 0032881237 scopus 로고    scopus 로고
    • Therapeutic approaches for ischemia/reperfusion injury in the liver
    • Fan C, Zwacka RM, Engelhardt JF: Therapeutic approaches for ischemia/reperfusion injury in the liver. J Mol Med, 1999, 77, 577-596.
    • (1999) J Mol Med , vol.77 , pp. 577-596
    • Fan, C.1    Zwacka, R.M.2    Engelhardt, J.F.3
  • 8
    • 77957242914 scopus 로고    scopus 로고
    • Ezetimibe ameliorates cardiovascular complications and hepatic steatosis in obese and type 2 diabetic db/db mice
    • Fukuda M, Nakamura T, Kataoka K, Nako H, Tokutomi Y, Dong YF, Yasuda O et al.: Ezetimibe ameliorates cardiovascular complications and hepatic steatosis in obese and type 2 diabetic db/db mice. J Pharmacol Exp Ther, 2010, 335, 70-75.
    • (2010) J Pharmacol Exp Ther , vol.335 , pp. 70-75
    • Fukuda, M.1    Nakamura, T.2    Kataoka, K.3    Nako, H.4    Tokutomi, Y.5    Dong, Y.F.6    Yasuda, O.7
  • 9
    • 0030577061 scopus 로고    scopus 로고
    • The 1996 Albert Lasker Medical Research Awards. The discovery of endothelium-derived relaxing factor and its importance in the identification of nitric oxide
    • Furchgott RF. The 1996 Albert Lasker Medical Research Awards. The discovery of endothelium-derived relaxing factor and its importance in the identification of nitric oxide. JAMA, 1996, 276, 1186-1188.
    • (1996) JAMA , vol.276 , pp. 1186-1188
    • Furchgott, R.F.1
  • 11
    • 18044372229 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase protects the post-ischemic liver: Potential interactions with superoxide
    • Hines IN, Harada H, Flores S, Gao B, McCord JM, Grisham MB: Endothelial nitric oxide synthase protects the post-ischemic liver: potential interactions with superoxide. Biomed Pharmacother, 2005, 59, 183-189.
    • (2005) Biomed Pharmacother , vol.59 , pp. 183-189
    • Hines, I.N.1    Harada, H.2    Flores, S.3    Gao, B.4    McCord, J.M.5    Grisham, M.B.6
  • 12
    • 4243352021 scopus 로고    scopus 로고
    • Plasma levels of ADMA are increased and inversely related to endothelium-mediated vasodilation in patients with chronic heart failure: A new predictor of endothelial dysfunction?
    • Hornig B, Arakawa N, Böger RH, Bode-Böger SM, Frölich JC, Drexler H: Plasma levels of ADMA are increased and inversely related to endothelium-mediated vasodilation in patients with chronic heart failure: a new predictor of endothelial dysfunction? Circulation, 1998, 98, Suppl I, 318.
    • (1998) Circulation , vol.98 , Issue.SUPPL I , pp. 318
    • Hornig, B.1    Arakawa, N.2    Böger, R.H.3    Bode-Böger, S.M.4    Frölich, J.C.5    Drexler, H.6
  • 13
    • 66349132215 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine and the effect of folate substitution in children with familial hypercholesterolemia and diabetes mellitus type 1
    • Jehlicka P, Stozický F, Mayer O Jr, Varvarovská J, Racek J, Trefil L, Siala K: Asymmetric dimethylarginine and the effect of folate substitution in children with familial hypercholesterolemia and diabetes mellitus type 1. Physiol Res, 2009, 58, 179-184.
    • (2009) Physiol Res , vol.58 , pp. 179-184
    • Jehlicka, P.1    Stozický, F.2    Mayer Jr., O.3    Varvarovská, J.4    Racek, J.5    Trefil, L.6    Siala, K.7
  • 14
    • 32944479991 scopus 로고    scopus 로고
    • A role for asymmetric dimethylarginine in the pathophysiology of portal hypertension in rats with biliary cirrhosis
    • Laleman W, Omasta A, Van de Casteele M, Zeegers M, Vander Elst I, Van Landeghem L, Severi T et al.: A role for asymmetric dimethylarginine in the pathophysiology of portal hypertension in rats with biliary cirrhosis. Hepatology, 2005, 42, 1382-1390.
    • (2005) Hepatology , vol.42 , pp. 1382-1390
    • Laleman, W.1    Omasta, A.2    Van De Casteele, M.3    Zeegers, M.4    Vander Elst, I.5    Van Landeghem, L.6    Severi, T.7
  • 15
    • 20844463066 scopus 로고    scopus 로고
    • Simvastatin versus ezetimibe: Pleiotropic and lipid-lowering effects on endothelial function in humans
    • Landmesser U, Bahlmann F, Mueller M, Spiekermann S, Kirchhoff N, Schulz S, Manes C et al.: Simvastatin versus ezetimibe: pleiotropic and lipid-lowering effects on endothelial function in humans. Circulation, 2005, 111, 2356-2363.
    • (2005) Circulation , vol.111 , pp. 2356-2363
    • Landmesser, U.1    Bahlmann, F.2    Mueller, M.3    Spiekermann, S.4    Kirchhoff, N.5    Schulz, S.6    Manes, C.7
  • 16
    • 0037108966 scopus 로고    scopus 로고
    • S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: Further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase
    • Leiper J, Murray-Rust J, McDonald N, Vallance P: S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase. Proc Natl Acad Sci USA, 2002, 99, 13527-13532.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13527-13532
    • Leiper, J.1    Murray-Rust, J.2    McDonald, N.3    Vallance, P.4
  • 17
    • 0033214074 scopus 로고    scopus 로고
    • Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases
    • Leiper J, Santa Maria J, Chubb A, MacAllister RJ, Charles IG, Whitley GS, Vallance P: Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases. Biochem J, 1999, 343, 209-214.
    • (1999) Biochem J , vol.343 , pp. 209-214
    • Leiper, J.1    Santa Maria, J.2    Chubb, A.3    Macallister, R.J.4    Charles, I.G.5    Whitley, G.S.6    Vallance, P.7
  • 18
    • 0033566683 scopus 로고    scopus 로고
    • Biological significance of endogenous methylarginines that inhibit nitric oxide synthases
    • Leiper J, Vallance P: Biological significance of endogenous methylarginines that inhibit nitric oxide synthases. Cardiovasc Res, 1999, 43, 542-548.
    • (1999) Cardiovasc Res , vol.43 , pp. 542-548
    • Leiper, J.1    Vallance, P.2
  • 20
    • 0037143637 scopus 로고    scopus 로고
    • Impaired nitric oxide sythase pathway in diabetes mellitus: Role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase
    • Lin KY, Ito A, Asagami T, Tsao PS, Adimoolam S, Kimoto M, Tsuji H et al.: Impaired nitric oxide sythase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase. Circulation, 2002, 106, 987-992.
    • (2002) Circulation , vol.106 , pp. 987-992
    • Lin, K.Y.1    Ito, A.2    Asagami, T.3    Tsao, P.S.4    Adimoolam, S.5    Kimoto, M.6    Tsuji, H.7
  • 22
    • 31344440297 scopus 로고    scopus 로고
    • Pharmacotherapies and their influence on asymmetric dimethylargine (ADMA)
    • Maas R: Pharmacotherapies and their influence on asymmetric dimethylargine (ADMA). Vasc Med, 2005, 10, Suppl 1, S49-S57.
    • (2005) Vasc Med , vol.10 , Issue.SUPPL. 1
    • Maas, R.1
  • 23
    • 12244253769 scopus 로고    scopus 로고
    • Presence of methylated arginine derivatives in orthotopic human liver transplantation: Relevance for liver function
    • Martin-Sanz P, Olmedilla L, Dulin E, Casado M, Callejas NA, Pérez-Peña J, Garutti I et al.: Presence of methylated arginine derivatives in orthotopic human liver transplantation: relevance for liver function. Liver Transpl, 2003, 9, 40-48.
    • (2003) Liver Transpl , vol.9 , pp. 40-48
    • Martin-Sanz, P.1    Olmedilla, L.2    Dulin, E.3    Casado, M.4    Callejas, N.A.5    Pérez-Peña, J.6    Garutti, I.7
  • 24
    • 33746559772 scopus 로고    scopus 로고
    • Molecular mechanism for elevation of asymmetric dimethylarginine and its role for hypertension in chronic kidney disease
    • Matsuguma K, Ueda S, Yamagishi S, Matsumoto Y, Kaneyuki U, Shibata R, Fujimura T et al.: Molecular mechanism for elevation of asymmetric dimethylarginine and its role for hypertension in chronic kidney disease. J Am Soc Nephrol, 2006, 17, 2176-2183.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 2176-2183
    • Matsuguma, K.1    Ueda, S.2    Yamagishi, S.3    Matsumoto, Y.4    Kaneyuki, U.5    Shibata, R.6    Fujimura, T.7
  • 25
    • 77953779764 scopus 로고    scopus 로고
    • Effects of partial liver ischemia followed by global liver reperfusion on the remote tissue expression of nitric oxide synthase: Lungs and kidneys
    • Miranda LE, Capellini VK, Reis GS, Celotto AC, Carlotti CG Jr, Evora PR: Effects of partial liver ischemia followed by global liver reperfusion on the remote tissue expression of nitric oxide synthase: lungs and kidneys. Transplant Proc, 2010, 42, 1557-1562.
    • (2010) Transplant Proc , vol.42 , pp. 1557-1562
    • Miranda, L.E.1    Capellini, V.K.2    Reis, G.S.3    Celotto, A.C.4    Carlotti Jr., C.G.5    Evora, P.R.6
  • 27
    • 32944470443 scopus 로고    scopus 로고
    • Decreased hepatic extraction of asymmetric and symmetric dimethylarginine (ADMA/SDMA-NOS inhibitors) in acute alcoholic hepatitis may contribute to impaired end-organ function
    • Mookerjee RP, Davies NA, Sen S, Hodges SJ, Turner C, Dalton RN, Williams R, Jalan R: Decreased hepatic extraction of asymmetric and symmetric dimethylarginine (ADMA/SDMA-NOS inhibitors) in acute alcoholic hepatitis may contribute to impaired end-organ function. Hepatology, 2005, 42, 419A.
    • (2005) Hepatology , vol.42
    • Mookerjee, R.P.1    Davies, N.A.2    Sen, S.3    Hodges, S.J.4    Turner, C.5    Dalton, R.N.6    Williams, R.7    Jalan, R.8
  • 30
    • 70349331942 scopus 로고    scopus 로고
    • Ezetimibe decreases serum levels of asymmetric dimethylarginine (ADMA) and ameliorates renal injury in non-diabetic chronic kidney disease patients in a cholesterol-independent manner
    • Nakamura T, Sato E, Fujiwara N, Kawagoe Y, Ueda Y, Suzuki T, Ueda S et al.: Ezetimibe decreases serum levels of asymmetric dimethylarginine (ADMA) and ameliorates renal injury in non-diabetic chronic kidney disease patients in a cholesterol-independent manner. Pharmacol Res, 2009, 60, 525-528.
    • (2009) Pharmacol Res , vol.60 , pp. 525-528
    • Nakamura, T.1    Sato, E.2    Fujiwara, N.3    Kawagoe, Y.4    Ueda, Y.5    Suzuki, T.6    Ueda, S.7
  • 32
    • 0037630713 scopus 로고    scopus 로고
    • Influence of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors on endothelial nitric oxide synthase and the formation of oxidants in the vasculature
    • Parker RA, Huang Q, Tesfamariam B: Influence of 3-hydroxy-3- methylglutaryl-CoA (HMG-CoA) reductase inhibitors on endothelial nitric oxide synthase and the formation of oxidants in the vasculature. Atherosclerosis, 2003, 169, 19-29.
    • (2003) Atherosclerosis , vol.169 , pp. 19-29
    • Parker, R.A.1    Huang, Q.2    Tesfamariam, B.3
  • 33
    • 0035956919 scopus 로고    scopus 로고
    • Endogenous nitric oxide and exogenous nitric oxide supplementation in hepatic ischemia-reperfusion injury in the rat
    • Peralta C, Rull R, Rimola A, Deulofeu R, Roselló- Catafau J, Gelpí E, Rodés J: Endogenous nitric oxide and exogenous nitric oxide supplementation in hepatic ischemia-reperfusion injury in the rat. Transplantation, 2001, 71, 529-536.
    • (2001) Transplantation , vol.71 , pp. 529-536
    • Peralta, C.1    Rull, R.2    Rimola, A.3    Deulofeu, R.4    Roselló-Catafau, J.5    Gelpí, E.6    Rodés, J.7
  • 34
    • 21844466507 scopus 로고    scopus 로고
    • Oxidative stress and apoptosis in fetal rat liver induced by maternal cholestasis. Protective effect of ursodeoxycholic acid
    • Perez MJ, Macias RI, Duran C, Monte MJ, Gonzalez-Buitrago JM, Marin JJ: Oxidative stress and apoptosis in fetal rat liver induced by maternal cholestasis. Protective effect of ursodeoxycholic acid. J Hepatol, 2005, 43, 324-332.
    • (2005) J Hepatol , vol.43 , pp. 324-332
    • Perez, M.J.1    Macias, R.I.2    Duran, C.3    Monte, M.J.4    Gonzalez-Buitrago, J.M.5    Marin, J.J.6
  • 37
    • 0031442394 scopus 로고    scopus 로고
    • Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids
    • Shah V, Haddad FG, Garcia-Cardena G, Frangos JA, Mennone A, Groszmann RJ, Sessa WC: Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids. J Clin Invest, 1997, 100, 2923-2930.
    • (1997) J Clin Invest , vol.100 , pp. 2923-2930
    • Shah, V.1    Haddad, F.G.2    Garcia-Cardena, G.3    Frangos, J.A.4    Mennone, A.5    Groszmann, R.J.6    Sessa, W.C.7
  • 38
    • 0032738990 scopus 로고    scopus 로고
    • Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat
    • Shah V, Toruner M, Haddad F, Cadelina G, Papapetropoulos A, Choo K, Sessa WC, Groszmann RJ: Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat. Gastroenterology, 1999, 117, 1222-1228.
    • (1999) Gastroenterology , vol.117 , pp. 1222-1228
    • Shah, V.1    Toruner, M.2    Haddad, F.3    Cadelina, G.4    Papapetropoulos, A.5    Choo, K.6    Sessa, W.C.7    Groszmann, R.J.8
  • 39
    • 0035923560 scopus 로고    scopus 로고
    • Homocysteine impairs the nitric oxide synthase pathway: Role of asymmetric dimethylarginine
    • Stuhlinger MC, Tsao PS, Her JH, Kimoto M, Balint RF, Cooke JP: Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine. Circulation, 2001, 104, 2569-2575.
    • (2001) Circulation , vol.104 , pp. 2569-2575
    • Stuhlinger, M.C.1    Tsao, P.S.2    Her, J.H.3    Kimoto, M.4    Balint, R.F.5    Cooke, J.P.6
  • 40
    • 0036424159 scopus 로고    scopus 로고
    • Cholesterol absorption inhibitors for the treatment of hypercholesterolemia
    • Sudhop T, von Bergmann K: Cholesterol absorption inhibitors for the treatment of hypercholesterolemia. Drugs, 2002, 62, 2333-2347.
    • (2002) Drugs , vol.62 , pp. 2333-2347
    • Sudhop, T.1    Von Bergmann, K.2
  • 41
    • 84857490179 scopus 로고    scopus 로고
    • Ezetimibe - A new approach in hypercholesterolemia management
    • Suchy D, Łabuzek K, Stadnicki A, Okopień B: Ezetimibe - a new approach in hypercholesterolemia management. Pharmacol Rep, 2011, 63, 1335-1348.
    • (2011) Pharmacol Rep , vol.63 , pp. 1335-1348
    • Suchy, D.1    Łabuzek, K.2    Stadnicki, A.3    Okopień, B.4
  • 44
    • 77953302292 scopus 로고    scopus 로고
    • Effect of simvastatin on nitric oxide synthases (eNOS, iNOS) and arginine and its derivatives (ADMA, SDMA) in ischemia/reperfusion injury in rat liver
    • Trocha M, Merwid-La̧d A, Szuba A, Chlebda E, Pieoeniewska M, Sozański T, Szela̧g A: Effect of simvastatin on nitric oxide synthases (eNOS, iNOS) and arginine and its derivatives (ADMA, SDMA) in ischemia/reperfusion injury in rat liver. Pharmacol Rep, 2010, 62, 343-351.
    • (2010) Pharmacol Rep , vol.62 , pp. 343-351
    • Trocha, M.1    Merwid-La̧d, A.2    Szuba, A.3    Chlebda, E.4    Pieoeniewska, M.5    Sozański, T.6    Szela̧g, A.7
  • 45
    • 77952970094 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine synthesis and degradation under physiological and pathological conditions
    • Trocha M, Merwid-La̧d A, Szuba A, Sozański T, Magdalan J, Szela̧g A: Asymmetric dimethylarginine synthesis and degradation under physiological and pathological conditions. Adv Clin Exp Med, 2010, 19, 223-243.
    • (2010) Adv Clin Exp Med , vol.19 , pp. 223-243
    • Trocha, M.1    Merwid-La̧d, A.2    Szuba, A.3    Sozański, T.4    Magdalan, J.5    Szela̧g, A.6
  • 46
    • 0037423618 scopus 로고    scopus 로고
    • Regulation of cytokine-induced nitric oxide synthesis by asymmetric dimethylarginine: Role of dimethylarginine dimethylaminohydrolase
    • Ueda S, Kato S, Matsuoka H, Kimoto M, Okuda S, Morimatsu M, Imaizumi T: Regulation of cytokine-induced nitric oxide synthesis by asymmetric dimethylarginine: role of dimethylarginine dimethylaminohydrolase. Circ Res, 2003, 92, 226-233.
    • (2003) Circ Res , vol.92 , pp. 226-233
    • Ueda, S.1    Kato, S.2    Matsuoka, H.3    Kimoto, M.4    Okuda, S.5    Morimatsu, M.6    Imaizumi, T.7
  • 47
    • 2942577486 scopus 로고    scopus 로고
    • Cardiovascular biology of the asymmetric dimethylarginine: Dimethylarginine dimethylaminohydrolase pathway
    • Vallance P, Leiper J: Cardiovascular biology of the asymmetric dimethylarginine: dimethylarginine dimethylaminohydrolase pathway. Arterioscler Thromb Vasc Biol, 2004, 24, 1023-1030.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1023-1030
    • Vallance, P.1    Leiper, J.2
  • 48
    • 0036719232 scopus 로고    scopus 로고
    • In vivo gene transfer of endothelial nitric oxide synthase decreases portal pressure in anaesthetised carbon tetrachloride cirrhotic rats
    • Van de Casteele M, Omasta A, Janssens S, Roskams T, Desmet V, Nevens F, Fevery J: In vivo gene transfer of endothelial nitric oxide synthase decreases portal pressure in anaesthetised carbon tetrachloride cirrhotic rats. Gut, 2002, 51, 440-445.
    • (2002) Gut , vol.51 , pp. 440-445
    • Van De Casteele, M.1    Omasta, A.2    Janssens, S.3    Roskams, T.4    Desmet, V.5    Nevens, F.6    Fevery, J.7
  • 49
    • 0042303812 scopus 로고    scopus 로고
    • Elevated levels of the serum endogenous inhibitor of nitric oxide synthase and metabolic control in rats with streptozotocin-induced diabetes
    • Xiong Y, Fu YF, Fu SH, Zhou HH: Elevated levels of the serum endogenous inhibitor of nitric oxide synthase and metabolic control in rats with streptozotocin-induced diabetes. J Cardiovasc Pharmacol, 2003, 42, 191-196.
    • (2003) J Cardiovasc Pharmacol , vol.42 , pp. 191-196
    • Xiong, Y.1    Fu, Y.F.2    Fu, S.H.3    Zhou, H.H.4
  • 50
    • 77957240287 scopus 로고    scopus 로고
    • Protective effects of HGF-MSP chimer (metron factor-1) on liver ischemia-reperfusion injury in rat model
    • Xue F, Zhang JJ, Xu LM, Zhang C, Xia Q: Protective effects of HGF-MSP chimer (metron factor-1) on liver ischemia-reperfusion injury in rat model. J Dig Dis, 2010, 11, 299-305.
    • (2010) J Dig Dis , vol.11 , pp. 299-305
    • Xue, F.1    Zhang, J.J.2    Xu, L.M.3    Zhang, C.4    Xia, Q.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.