GC-MS assay for hepatic DDAH activity in diabetic and non-diabetic rats by measuring dimethylamine (DMA) formed from asymmetric dimethylarginine (ADMA): Evaluation of the importance of S-nitrosothiols as inhibitors of DDAH activity in vitro and in vivo in humans

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 858, Issue 1-2, 2007, Pages 32-41

  Chobanyan, Kristine ^a   Thum, Thomas ^b   Suchy, Maria Theresia ^a   Zhu, Bijun ^a   Mitschke, Anja ^a   Gutzki, Frank Mathias ^a   Beckmann, Bibiana ^a   Stichtenoth, Dirk O ^a   Tsikas, Dimitrios ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Diabetes; Enzyme inhibition; Michaelis Menten; Nitric oxide; S Nitrosothiols; SNACET

Indexed keywords

ASYMMETRIC DIMETHYLARGININE (ADMA); DIMETHYLAMINE (DMA); DIMETHYLARGININE DIMETHYLAMINOHYDROLASE (DDAH); PENTAFLUOROBENZAMIDE DERIVATIVES;

CATALYST ACTIVITY; ENZYME INHIBITION; MOLECULAR STRUCTURE; NITRATES; NITRIC OXIDE; SYNTHESIS (CHEMICAL);

MEDICAL PROBLEMS;

BENZAMIDE DERIVATIVE; CREATININE; DIMETHYLAMINE; DIMETHYLARGININASE; N(G),N(G) DIMETHYLARGININE; PENTAFLUOROBENZAMIDE; S NITROSOCYSTEINE; S NITROSOCYSTEINE ETHYL ESTER; S NITROSOGLUTATHIONE; S NITROSOHOMOCYSTEINE; S NITROSOTHIOL; STREPTOZOCIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVITY; ENZYME KINETICS; FEMALE; GAS CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; LIPOPHILICITY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; RAT;

AMIDOHYDROLASES; ANIMALS; ARGININE; CATALYSIS; DIABETES MELLITUS, EXPERIMENTAL; DIMETHYLAMINES; ENZYME INHIBITORS; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; KINETICS; LIVER; MALE; MOLECULAR STRUCTURE; NITRATES; NITRITES; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; S-NITROSOTHIOLS;

RATTUS;

EID: 34848821201     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.08.002     Document Type: Article

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