Gene expression profiling of rotenone-mediated cortical neuronal death: Evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling

Neurochemistry International

Volumn 62, Issue 5, 2013, Pages 653-663

  Yap, Yann Wan ^a   Chen, Minghui Jessica ^b   Peng, Zhao Feng ^c,d   Manikandan, Jayapal ^e,f   Ng, Jian Ming Jeremy ^b   Llanos, Roxana M ^a   La Fontaine, Sharon ^a   Beart, Philip M ^g   Cheung, Nam Sang ^a,b  

^a DEAKIN UNIVERSITY   (Australia)

^b UNIVERSITY OF TASMANIA   (Australia)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d CHINA UNIVERSITY OF GEOSCIENCES   (China)

^e KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^f UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^g UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Mitochondria complex I inhibition; Neurodegeneration; Oxidative stress; Programmed cell death; Protein handling; Rotenone

Indexed keywords

CHAPERONE; PROTEASOME; ROTENONE; UBIQUITIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOPHAGY; BRAIN CELL; BRAIN CORTEX; CALCIUM SIGNALING; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG MECHANISM; DRUG TARGETING; FETUS; GENE EXPRESSION; GENE EXPRESSION PROFILING; LYSOSOME; MICROARRAY ANALYSIS; MOLECULAR PROBE; MOUSE; NEOCORTEX; NERVE CELL CULTURE; NERVE CELL NECROSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PARKINSON DISEASE; PRIORITY JOURNAL; TRANSCRIPTOMICS;

ANIMALS; AUTOPHAGY; CALCIUM SIGNALING; CELL DEATH; CEREBRAL CORTEX; GENE EXPRESSION PROFILING; LYSOSOMES; MICE; MITOCHONDRIA; NEURONS; PROTEASOME ENDOPEPTIDASE COMPLEX; REAL-TIME POLYMERASE CHAIN REACTION; ROTENONE; UBIQUITIN;

EID: 84875757800     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2012.11.011     Document Type: Article

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