Symptom-pattern phenotype and pulmonary function in preschool wheezers

Journal of Allergy and Clinical Immunology

Volumn 126, Issue 3, 2010, Pages

  Sonnappa, Samatha ^a   Bastardo, Cristina M ^a   Wade, Angela ^b   Saglani, Sejal ^c   McKenzie, Sheila A ^d   Bush, Andrew ^c   Aurora, Paul ^a  

^a GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c ROYAL BROMPTON HOSPITAL   (United Kingdom)

^d ROYAL LONDON HOSPITAL   (United Kingdom)

Author keywords

Children; episodic (viral) wheeze; multiple trigger wheeze; phenotype; preschool wheeze; pulmonary function; symptom pattern

Indexed keywords

NITRIC OXIDE;

AIRWAY RESISTANCE; ARTICLE; ATOPY; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EXHALATION; FEMALE; HUMAN; LUNG CLEARANCE; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRESCHOOL CHILD; PRICK TEST; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SYMPTOMATOLOGY; WHEEZING; COMPLICATION; LUNG DISEASE; LUNG FUNCTION TEST; METABOLISM; ONSET AGE; PATHOPHYSIOLOGY; RESPIRATORY SOUNDS; RESPIRATORY TRACT ALLERGY; STANDARD; STATISTICAL MODEL; VIROLOGY;

AGE OF ONSET; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; LINEAR MODELS; LUNG DISEASES; MALE; NITRIC OXIDE; PHENOTYPE; REFERENCE STANDARDS; RESPIRATORY FUNCTION TESTS; RESPIRATORY HYPERSENSITIVITY; RESPIRATORY SOUNDS; SENSITIVITY AND SPECIFICITY;

EID: 77953260904     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2010.04.018     Document Type: Article

References (43)

1. F.D. Martinez, A.L. Wright, L.M. Taussig, C.J. Holberg, M. Halonen, and W.J. Morgan Asthma and wheezing in the first six years of life. The Group Health Medical Associates N Engl J Med 332 1995 133 138
2. B.D. Spycher, M. Silverman, A.M. Brooke, C.E. Minder, and C.E. Kuehni Distinguishing phenotypes of childhood wheeze and cough using latent class analysis Eur Respir J 31 2008 974 981
3. R.J. Kurukulaaratchy, M.H. Fenn, L.M. Waterhouse, S.M. Matthews, S.T. Holgate, and S.H. Arshad Characterization of wheezing phenotypes in the first 10 years of life Clin Exp Allergy 33 2003 573 578
4. S. Lau, S. Illi, C. Sommerfeld, B. Niggemann, K. Volkel, and C. Madloch Transient early wheeze is not associated with impaired lung function in 7-yr-old children Eur Respir J 21 2003 834 841
5. W.J. Morgan, D.A. Stern, D.L. Sherrill, S. Guerra, C.J. Holberg, and T.W. Guilbert Outcome of asthma and wheezing in the first 6 years of life: follow-up through adolescence Am J Respir Crit Care Med 172 2005 1253 1258
6. R.J. Kurukulaaratchy, M. Fenn, S. Matthews, and S.H. Arshad Characterisation of atopic and non-atopic wheeze in 10 year old children Thorax 59 2004 563 568
7. J. Henderson, R. Granell, J. Heron, A. Sherriff, A. Simpson, and A. Woodcock Associations of wheezing phenotypes in the first 6 years of life with atopy, lung function and airway responsiveness in mid-childhood Thorax 63 2008 974 980
8. S. Illi, E. von Mutius, S. Lau, B. Niggemann, C. Gruber, and U. Wahn Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study Lancet 368 2006 763 770
9. G. Turato, A. Barbato, S. Baraldo, M.E. Zanin, E. Bazzan, and K. Lokar-Oliani Nonatopic children with multitrigger wheezing have airway pathology comparable to atopic asthma Am J Respir Crit Care Med 178 2008 476 482
10. J.E. Brussee, H.A. Smit, M. Kerkhof, L.P. Koopman, A.H. Wijga, and D.S. Postma Exhaled nitric oxide in 4-year-old children: relationship with asthma and atopy Eur Respir J 25 2005 455 461
11. P.L. Brand, E. Baraldi, H. Bisgaard, A.L. Boner, J.A. Castro-Rodriguez, and A. Custovic Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach Eur Respir J 32 2008 1096 1110
12. U. Frey, and M.E. von The challenge of managing wheezing in infants N Engl J Med 360 2009 2130 2133
13. N. Beydon, S.D. Davis, E. Lombardi, J.L. Allen, H.G. Arets, and P. Aurora An official American thoracic society/European respiratory society statement: pulmonary function testing in preschool children Am J Respir Crit Care Med 175 2007 1304 1345
14. L.A. Lowe, A. Simpson, A. Woodcock, J. Morris, C.S. Murray, and A. Custovic Wheeze phenotypes and lung function in preschool children Am J Respir Crit Care Med 171 2005 231 237
15. P. Aurora, A. Bush, P. Gustafsson, C. Oliver, C. Wallis, and J. Price Multiple-breath washout as a marker of lung disease in preschool children with cystic fibrosis Am J Respir Crit Care Med 171 2005 249 256
16. J.G. Venegas, T. Winkler, G. Musch, M.F. Vidal Melo, D. Layfield, and N. Tgavalekos Self-organized patchiness in asthma as a prelude to catastrophic shifts Nature 434 2005 777 782
17. N.T. Tgavalekos, G. Musch, R.S. Harris, M.F. Vidal Melo, T. Winkler, and T. Schroeder Relationship between airway narrowing, patchy ventilation and lung mechanics in asthmatics Eur Respir J 29 2007 1174 1181
18. S. Saglani, D.N. Payne, J. Zhu, Z. Wang, A.G. Nicholson, and A. Bush Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers Am J Respir Crit Care Med 176 2007 858 864
19. S. Lum, A.F. Hoo, C. Dezateux, I. Goetz, A. Wade, and L. DeRooy The association between birthweight, sex, and airway function in infants of nonsmoking mothers Am J Respir Crit Care Med 164 2001 2078 2084
20. A.F. Hoo, J. Stocks, S. Lum, A.M. Wade, R.A. Castle, and K.L. Costeloe Development of lung function in early life: influence of birth weight in infants of nonsmokers Am J Respir Crit Care Med 170 2004 527 533
21. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005 Am J Respir Crit Care Med 171 2005 912 930
22. P. Aurora, W. Kozlowska, and J. Stocks Gas mixing efficiency from birth to adulthood measured by multiple-breath washout Respir Physiol Neurobiol 148 2005 125 139
23. Aurora P. Multiple-breath inert gas washout to detect inhomogeneity of ventilation distribution in preschool children with cystic fibrosis [PhD Thesis]. London: Institute of Child Health, University College London; 2005.
24. I.D. Johnston, J.M. Bland, and H.R. Anderson Ethnic variation in respiratory morbidity and lung function in childhood Thorax 42 1987 542 548
25. A.L. Whittaker, A.J. Sutton, and C.S. Beardsmore Are ethnic differences in lung function explained by chest size? Arch Dis Child Fetal Neonatal Ed 90 2005 F423 F428
26. J. Cohen Statistical Power Analysis for the Behavioral Sciences 2nd ed. 1988 Lawrence Erlbaum Associates Hillsdale (NJ)
27. J.A. Castro-Rodriguez, and G.J. Rodrigo Efficacy of inhaled corticosteroids in infants and preschoolers with recurrent wheezing and asthma: a systematic review with meta-analysis Pediatrics 123 2009 e519 e525
28. P.M. Gustafsson Peripheral airway involvement in CF and asthma compared by inert gas washout Pediatr Pulmonol 42 2007 168 176
29. S. Verbanck, D. Schuermans, M. Noppen, A. Van Muylem, M. Paiva, and W. Vincken Evidence of acinar airway involvement in asthma Am J Respir Crit Care Med 159 1999 1545 1550
30. S. Verbanck, D. Schuermans, M. Paiva, and W. Vincken Nonreversible conductive airway ventilation heterogeneity in mild asthma J Appl Physiol 94 2003 1380 1386
31. S.R. Downie, C.M. Salome, S. Verbanck, B. Thompson, N. Berend, and G.G. King Ventilation heterogeneity is a major determinant of airway hyperresponsiveness in asthma, independent of airway inflammation Thorax 62 2007 684 689
32. K.A. Macleod, A.R. Horsley, N.J. Bell, A.P. Greening, J.A. Innes, and S. Cunningham Ventilation heterogeneity in children with well controlled asthma with normal spirometry indicates residual airways disease Thorax 64 2009 33 37
33. W.W. Busse, S. Banks-Schlegel, and S.E. Wenzel Pathophysiology of severe asthma J Allergy Clin Immunol 106 2000 1033 1042
34. J.E. Fish, and S.P. Peters Airway remodeling and persistent airway obstruction in asthma J Allergy Clin Immunol 104 1999 509 516
35. E. Goleva, P.J. Hauk, J. Boguniewicz, R.J. Martin, and D.Y. Leung Airway remodeling and lack of bronchodilator response in steroid-resistant asthma J Allergy Clin Immunol 120 2007 1065 1072
36. R.S. Cane, S.C. Ranganathan, and S.A. McKenzie What do parents of wheezy children understand by "wheeze"? Arch Dis Child 82 2000 327 332
37. G. Michel, M. Silverman, M.P. Strippoli, M. Zwahlen, A.M. Brooke, and J. Grigg Parental understanding of wheeze and its impact on asthma prevalence estimates Eur Respir J 28 2006 1124 1130
38. K. Kasahara, K. Shiba, T. Ozawa, K. Okuda, and M. Adachi Correlation between the bronchial subepithelial layer and whole airway wall thickness in patients with asthma Thorax 57 2002 242 246
39. D.N. Payne, Y. Qiu, J. Zhu, L. Peachey, M. Scallan, and A. Bush Airway inflammation in children with difficult asthma: relationships with airflow limitation and persistent symptoms Thorax 59 2004 862 869
40. H. Razzouk, S.L. dos, J. Giudicelli, M. Queiros, C.M. de Lurdes, and A. Castro A comparison of the bronchodilatory effect of 50 and 100 microg salbutamol via Turbuhaler and 100 microg salbutamol via pressurized metered dose inhaler in children with stable asthma Int J Pharm 180 1999 169 175
41. C.G. Lofdahl, L. Andersson, E. Bondesson, L.G. Carlsson, K. Friberg, and J. Hedner Differences in bronchodilating potency of salbutamol in Turbuhaler as compared with a pressurized metered-dose inhaler formulation in patients with reversible airway obstruction Eur Respir J 10 1997 2474 2478
42. J.P. Kemp, C.T. Furukawa, E.A. Bronsky, J. Grossman, R.F. Lemanske, and L.E. Mansfield Albuterol treatment for children with asthma: a comparison of inhaled powder and aerosol J Allergy Clin Immunol 83 1989 697 702
43. D.A. Stern, W.J. Morgan, M. Halonen, A.L. Wright, and F.D. Martinez Wheezing and bronchial hyper-responsiveness in early childhood as predictors of newly diagnosed asthma in early adulthood: a longitudinal birth-cohort study Lancet 372 2008 1058 1064