Design and synthesis of new bifunctional sigma-1 selective ligands with antioxidant activity

Journal of Medicinal Chemistry

Volumn 56, Issue 6, 2013, Pages 2447-2455

  Prezzavento, O ^a   Arena, E ^a   Parenti, C ^a   Pasquinucci, L ^a   Arico G ^a   Scoto, G M ^a   Grancara, S ^b   Toninello, A ^b   Ronsisvalle, S ^a  

^a UNIVERSITY OF CATANIA   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 BENZYLPIPERAZIN 1 YL) 5 (1,2 DITHIOLAN 3 YL)PENTAN 1 ONE; 1 BENZYLPIPERIDIN 4 YL 5 (1,2 DITHIOLAN 3 YL)PENTANOATE; ANTIOXIDANT; CALCIUM ION; KAPPA OPIATE RECEPTOR; LIGAND; SIGMA 1 OPIATE RECEPTOR; THIOCTIC ACID; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; BINDING AFFINITY; BRAIN MITOCHONDRION; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; IN VIVO STUDY; LIVER MITOCHONDRION; MALE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; RAT; STRUCTURE ANALYSIS;

ANIMALS; ANTIOXIDANTS; BRAIN; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG DESIGN; LIGANDS; LIVER; MALE; MITOCHONDRIA; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SIGMA; SUBSTRATE SPECIFICITY; THIOCTIC ACID;

EID: 84875707034     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm3017893     Document Type: Article

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