Synthesis and relaxometric characterization of a MRI Gd-based probe responsive to glutamic acid decarboxylase enzymatic activity

Journal of Medicinal Chemistry

Volumn 56, Issue 6, 2013, Pages 2466-2477

  Napolitano, Roberta ^a   Pariani, Giorgio ^a   Fedeli, Franco ^a   Baranyai, Zsolt ^b   Aswendt, Markus ^c   Aime, Silvio ^a   Gianolio, Eliana ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY OF DEBRECEN   (Hungary)

^c MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 [5 [[N,N' BIS[3,10,17 TRIAZA 4,11,18 TRIOXO 21 CARBOXYL 21 AMINOEINECOSANE]] N METHYLAMINOCARBONYL]PENTYL] 1,4,7,10 TETRAAZACYCLODODECANE 4,7,10 TRIACETATE GADOLINATE; CHELIDAMIC ACID; CONTRAST MEDIUM; ENZYME INHIBITOR; GADOLINIUM; GLUTAMATE DECARBOXYLASE; GLUTAMATE DECARBOXYLASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BRAIN NERVE CELL; CELL LABELING; CONTROLLED STUDY; DRUG BINDING; DRUG DESIGN; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; HYDRATION; IN VITRO STUDY; MACROMOLECULE; MOLECULAR PROBE; NEUROIMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PROTEIN EXPRESSION; QUANTITATIVE ASSAY;

CHEMISTRY TECHNIQUES, SYNTHETIC; CONTRAST MEDIA; GADOLINIUM; GLUTAMATE DECARBOXYLASE; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR PROBES; NEURONS; STATIC ELECTRICITY;

EID: 84875706236     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301831f     Document Type: Article

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