β-Gal gene expression MRI reporter in melanoma tumor cells. Design, synthesis, and in vitro and in vivo testing of a Gd(III) containing probe forming a high relaxivity, Melanin-like structure upon β-Gal enzymatic activation

Bioconjugate Chemistry

Volumn 22, Issue 12, 2011, Pages 2625-2635

  Arena, Francesca ^a   Singh, Jebasingh Bhagavath ^a   Gianolio, Eliana ^a   Stefanìa, Rachele ^a   Aime, Silvio ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CYTOLOGY; DERMATOLOGY; DIRECT INJECTION; GADOLINIUM COMPOUNDS; GENE EXPRESSION; MELANIN; OLIGOMERS; ONCOLOGY; PROBES;

GD-DOTA; GENES EXPRESSION; IN-VITRO; IN-VIVO; MELANOMA CELLS; MELANOMA TUMOURS; PYRANOSE; RELAXATION RATES; Β- GALACTOSIDASE; Β-GALACTOSIDASE GENE;

TUMORS;

BETA GALACTOSIDASE; GADOLINIUM 1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID TYROSINE; GADOLINIUM 1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID TYROSINE GALACTOSE; MELANIN; MONOPHENOL MONOOXYGENASE; NUCLEAR MAGNETIC RESONANCE IMAGING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; MELANOMA CELL; MOLECULAR IMAGING; MOUSE; NONHUMAN;

MURINAE; MUS;

EID: 84555186662     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc200486j     Document Type: Article

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