NAD+ influx through connexin hemichannels prevents poly(ADP-ribose) polymerase-mediated astrocyte death

Life Sciences

Volumn 92, Issue 13, 2013, Pages 808-814

  Okuda, Hiroto ^a   Nishida, Kentaro ^a   Higashi, Youichirou ^a   Nagasawa, Kazuki ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Astrocyte; Connexin hemichannel; NAD+; P2X7 receptor; Poly(ADP ribose) polymerase

Indexed keywords

ADENOSINE; CARBENOXOLONE; GAP JUNCTION PROTEIN; LACTATE DEHYDROGENASE; METHYLNITRONITROSOGUANIDINE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OCTANOL; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; MOUSE; NONHUMAN;

ADENOSINE; ANIMALS; ASTROCYTES; BIOLOGICAL TRANSPORT; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; CONNEXINS; METHYLNITRONITROSOGUANIDINE; MICE; NAD; NIACINAMIDE; POLY(ADP-RIBOSE) POLYMERASES; PURINERGIC P2X RECEPTOR ANTAGONISTS; RECEPTORS, PURINERGIC P2X7;

EID: 84875702648     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2013.02.010     Document Type: Article

References (29)

1. + depletion and mitochondrial permeability transition J Biol Chem 279 18 2004 18895 18902
2. + depletion is necessary and sufficient for poly(ADP-ribose) polymerase-1-mediated neuronal death J Neurosci 30 8 2010 2967 2978
3. + metabolism in health and disease Trends Biochem Sci 32 1 2007 12 19
4. V.C. Besson, I. Margaill, M. Plotkine, and C. Marchand-Verrecchia Deleterious activation of poly(ADP-ribose)polymerase-1 in brain after in vivo oxidative stress Free Radic Res 37 11 2003 1201 1208
5. + fluxes in intact cells FASEB J 15 1 2001 10 12
6. A.T. Chaytor, W.H. Evans, and T.M. Griffith Peptides homologous to extracellular loop motifs of connexin 43 reversibly abolish rhythmic contractile activity in rabbit arteries J Physiol 503 Pt 1 1997 99 110
7. J.E. Contreras, H.A. Sánchez, E.A. Eugenin, D. Speidel, M. Theis, and K. Willecke Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture Proc Natl Acad Sci U S A 99 1 2002 495 500
8. D. D'Amours, S. Desnoyers, I. D'Silva, and G.G. Poirier Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions Biochem J 342 Pt 2 1999 249 268
9. M. Endres, Z.Q. Wang, S. Namura, C. Waeber, and M.A. Moskowitz Ischemic brain injury is mediated by the activation of poly(ADP-ribose) polymerase J Cereb Blood Flow Metab 17 11 1997 1143 1151
10. R. Iglesias, G. Dahl, F. Qiu, D.C. Spray, and E. Scemes Pannexin 1: the molecular substrate of astrocyte "hemichannels" J Neurosci 29 21 2009 7092 7097
11. H. Lu, D. Burns, P. Garnier, G. Wei, K. Zhu, and W. Ying P2X7 receptors mediate NADH transport across the plasma membranes of astrocytes Biochem Biophys Res Commun 362 4 2007 946 950
12. K. Nagasawa, T. Kakuda, Y. Higashi, and S. Fujimoto Possible involvement of 12-lipoxygenase activation in glucose-deprivation/reload-treated neurons Neurosci Lett 429 2-3 2007 120 125
13. K. Nagasawa, C. Escartin, and R.A. Swanson Astrocyte cultures exhibit P2X7 receptor channel opening in the absence of exogenous ligands Glia 57 6 2009 622 633
14. H. Okuda, Y. Higashi, K. Nishida, S. Fujimoto, and K. Nagasawa Contribution of P2X7 receptors to adenosine uptake by cultured mouse astrocytes Glia 58 14 2010 1757 1765
15. J.A. Orellana, D.E. Hernández, P. Ezan, V. Velarde, M.V. Bennett, and C. Giaume Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels Glia 58 3 2010 329 343
16. P. Pelegrin, and A. Surprenant Pannexin-1 mediates large pore formation and interleukin-1β release by the ATP-gated P2X7 receptor EMBO J 25 21 2006 5071 5082
17. M.A. Retamal, N. Froger, N. Palacios-Prado, P. Ezan, P.J. Sáez, and J.C. Sáez Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia J Neurosci 27 50 2007 13781 13792
18. J.C. Sáez, J.E. Contreras, F.F. Bukauskas, M.A. Retamal, and M.V. Bennett Gap junction hemichannels in astrocytes of the CNS Acta Physiol Scand 179 1 2003 9 22
19. J.C. Sáez, M.A. Retamal, D. Basilio, F.F. Bukauskas, and M.V. Bennett Connexin-based gap junction hemichannels: gating mechanisms Biochim Biophys Acta 1711 2 2005 215 224
20. W. Silverman, S. Locovei, and G. Dahl Probenecid, a gout remedy, inhibits pannexin 1 channels Am J Physiol Cell Physiol 295 3 2008 C761 C767
21. E. Suzuki, H. Okuda, K. Nishida, S. Fujimoto, and K. Nagasawa Protective effect of nicotinamide against astrocyte death induced by extensive activation of poly(ADP-ribose) polymerase-1 depends on its transporter-mediated uptake Life Sci 86 17-18 2010 676 682
22. L. Virág, and C. Szabó The therapeutic potential of poly(ADP-ribose) polymerase inhibitors Pharmacol Rev 54 3 2002 375 429
23. S. Wang, Z. Xing, P.S. Vosler, H. Yin, W. Li, and F. Zhang Cellular NAD replenishment confers marked neuroprotection against ischemic cell death: role of enhanced DNA repair Stroke 39 9 2008 2587 2595
24. S.J. Won, B.Y. Choi, B.H. Yoo, M. Sohn, W. Ying, and R.A. Swanson Prevention of traumatic brain injury-induced neuron death by intranasal delivery of nicotinamide adenine dinucleotide J Neurotrauma 29 7 2012 1401 1409
25. + repletion prevents PARP-1-induced glycolytic blockade and cell death in cultured mouse astrocytes Biochem Biophys Res Commun 308 4 2003 809 813
26. + as a metabolic link between DNA damage and cell death J Neurosci Res 79 1-2 2005 216 223
27. + profoundly decreases brain injury in a rat model of transient focal ischemia Front Biosci 12 2007 2728 2734
28. S.W. Yu, H. Wang, M.F. Poitras, C. Coombs, W.J. Bowers, and H.J. Federoff Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor Science 297 5579 2002 259 263
29. + metabolism and signaling to the control of cellular functions Biochim Biophys Acta 1804 8 2010 1666 1675