Protective effect of nicotinamide against poly(ADP-ribose) polymerase-1-mediated astrocyte death depends on its transporter-mediated uptake

Life Sciences

Volumn 86, Issue 17-18, 2010, Pages 676-682

  Suzuki, Eri ^a   Okuda, Hiroto ^a   Nishida, Kentaro ^a   Fujimoto, Sadaki ^a   Nagasawa, Kazuki ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Astrocyte; Nicotinamide; Oxidative stress; Poly(ADP ribose) polymerase; Transporter

Indexed keywords

3,4 DIHYDRO 5 [4 (1 PIPERIDINYL)BUTOXY] 1(2H) ISOQUINOLINONE; ALKYLATING AGENT; CARBON 14; LACTATE DEHYDROGENASE; METHYLNITRONITROSOGUANIDINE; N METHYLNICOTINAMIDE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; ORGANIC CATION TRANSPORTER; POLY(ADENOSINE DIPHOSPHATE RIBOSE); POLYDEOXYRIBONUCLEOTIDE SYNTHASE; UNCLASSIFIED DRUG; DRUG DERIVATIVE; N-METHYLNICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; POLY(ADP RIBOSE)POLYMERASE 1, MOUSE; POLY(ADP-RIBOSE)POLYMERASE-1, MOUSE; VITAMIN B COMPLEX;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN CELL; CELL DEATH; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME SUBSTRATE; IMMUNOCYTOCHEMISTRY; INJURY; ISCHEMIA; MOUSE; NERVE CELL CULTURE; NEWBORN; NONHUMAN; PH; TEMPERATURE DEPENDENCE; TIME; ANIMAL; CELL SURVIVAL; DRUG EFFECT; METABOLISM; TEMPERATURE; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; ASTROCYTES; BIOLOGICAL TRANSPORT; CELL DEATH; CELL SURVIVAL; HYDROGEN-ION CONCENTRATION; MICE; NIACINAMIDE; POLY(ADP-RIBOSE) POLYMERASES; TEMPERATURE; TIME FACTORS; VITAMIN B COMPLEX;

EID: 77951222649     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2010.02.019     Document Type: Article

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