Absorption, distribution, and milk secretion of the perfluoroalkyl acids PFBS, PFHxS, PFOS, and PFOA by dairy cows fed naturally contaminated feed

Journal of Agricultural and Food Chemistry

Volumn 61, Issue 12, 2013, Pages 2903-2912

  Kowalczyk, Janine ^a   Ehlers, Susan ^b   Oberhausen, Anja ^a   Tischer, Marion ^a   Fürst, Peter ^b   Schafft, Helmut ^a   Lahrssen Wiederholt, Monika ^a  

^a FEDERAL INSTITUTE FOR RISK ASSESSMENT   (Germany)

^b CVUA MEL Chemical and Veterinary Analytical Institute Münsterland Emscher Lippe   (Germany)

Author keywords

ADMET; dairy cows; milk; perfluoroalkyl acids; PFAA; PFBS; PFHxS; PFOA; PFOS; toxicokinetics

Indexed keywords

ADMET; DAIRY COW; MILK; PERFLUOROALKYL ACIDS; PFAA; PFBS; PFHXS; PFOA; PFOS; TOXICOKINETICS;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MUSCLE; PHYSIOLOGY; PLASMAS;

DAIRIES;

ALKANESULFONIC ACID; FLUOROCARBON; OCTANOIC ACID DERIVATIVE; PERFLUBUTANE; PERFLUOROHEXANESULFONIC ACID; PERFLUOROOCTANESULFONIC ACID; PERFLUOROOCTANOIC ACID; SULFONIC ACID DERIVATIVE;

ANIMAL; ANIMAL FOOD; ARTICLE; CATTLE; CHEMISTRY; COMPARATIVE STUDY; DAIRYING; FEMALE; FOOD CONTAMINATION; KIDNEY; LIVER; MEAT; METABOLISM; MILK;

ALKANESULFONIC ACIDS; ANIMAL FEED; ANIMALS; CAPRYLATES; CATTLE; DAIRYING; FEMALE; FLUOROCARBONS; FOOD CONTAMINATION; KIDNEY; LIVER; MEAT; MILK; SULFONIC ACIDS;

BOS;

EID: 84875695041     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf304680j     Document Type: Article

References (61)

1. Fricke, M.; Lahl, U. Risikobewertung von Perfluortensiden als Beitrag zur aktuellen Diskussion zum REACH-Dossier der EU-Kommission UWSF-Z. Umweltchem. Okotox. 2005, 17 (1) 36-49
2. Buck, R. C.; Franklin, J.; Berger, U.; Conder, J. M.; Cousin, I. T.; deVoogt, P.; Jensen, A. A.; Kannan, K.; Mabury, S. A.; van Leeuwen, S. P. J. Perfluoroalkyl and polyfluoroalkyl substances in the environment: terminology, classification, and origins Integr. Environ. Assess. Manage. 2001, 7, 513-541
3. Calafat, A. M.; Wong, L.-Y.; Kulenyik, Z.; Reidy, J. A.; Needham, L. L. Polyflouroalkyl chemicals in the U.S. population: data from the national health and nutrition examination survey (NHANES) 2003-2004 and comparisons with NHANES 1999-2000 Environ. Health Perspect. 2007, 115 (11) 1596-1602
4. von Ehrenstein, O. S.; Fenton, S. E.; Kato, K.; Kuklenyik, Z.; Calafat, A. M.; Hines, E. P. Polyfluoroalkyl chemicals in the serum and milk of breastfeeding women Reprod. Toxicol. 2009, 27, 239-245
5. Sundström, M.; Chang, A.-C.; Noker, P. E.; Gorman, G. S.; Hart, J. A.; Ehresman, D. J.; Bergman, A.; Butenhoff, J. L. Comparative pharmacokinetics of perfluorohexanesulfonate (PFHxS) in rats, mice, and monkeys Reprod. Toxicol. 2012, 33, 441-451
6. Sundström, M.; Ehresman, D. J.; Bignert, A.; Butenhoff, J. L.; Olsen, G. W. A temporal trend study (1972-2008) of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in pooled human milk samples from Stockholm, Sweden Environ. Int. 2011, 37, 178-183
7. Giesy, J. P.; Kannan, K. Global distribution of perfluorooctane sulfonate in wildlife Environ. Sci. Technol. 2001, 35 (7) 1339-1342
8. Dai, J.; Li, M.; Jin, Y.; Saito, N.; Xu, M.; Wei, F. Perfluorooctanesulfonate and perfluorooctanoate in Red Panda and Giant Panda from China Environ. Sci. Technol. 2006, 40 (18) 5647-5652
9. Lau, C.; Anitole, K.; Hodes, C.; Lai, D.; Pfahles-Hutchens, A.; Seed, J. Perfluoroalkyl acids: a review of monitoring and toxicological findings Toxicol. Sci. 2007, 99 (2) 366-394
10. Li, X.; Yeung, L. W. Y.; Taniyasu, S.; Lam, P. K. S.; Yamashita, N.; Xu, M.; Dai, J. Accumulation of perfluorinated compounds in captive Bengal tigers (Panthera tigris tigris) and African lions (Panthera leo Linnaeus) in China Chemosphere 2008, 73, 1649-1653
11. Ostertag, S. K.; Tague, B. A.; Humphries, M. M.; Tittlemier, S. A.; Chan, H. M. Estimated dietary exposure to fluorinated compounds from traditional foods among Inuit in Nunavut, Canada Chemosphere 2009, 75, 1165-1172
12. Organisation for Economic Co-operation and Development (OECD). Hazard assessment of perflurooctane sulfonate (PFOS) and its salts. ENV/JM/RD (2002)17/FINAL; http://www.oecd.org/chemicalsafety/assessmentofchemicals/ 2382880.pdf (accessed Oct 26, 2012).
13. Luebker, D. J.; Case, M. T.; York, G. Y.; Moore, J. A.; Hansen, K. J.; Butenhoff, J. L. Two-generation reproduction and cross-foster studies of perflurooctanesulfonate (PFOS) in rats Toxicology 2005, 215 (2005) 126-148
14. European Food Safety Authority (EFSA) Scientific opinion of the panel on contaminants in the food chain on perfluoroctane sulfonate (PFOS), perfluoroctanoic acid (PFOA) and their salts EFSA J. 2008, 653, 1-131
15. Butenhoff, J. L.; Chang, S.-C.; Ehresman, D. J.; York, R. G. Evaluation of potential reproductive and developmental toxicity of potassium perfluorohexanesulfonate in Sprague Dawley rats Reprod. Toxicol. 2009, 27, 331-341
16. Lieder, P. H.; Chang, S.-C.; York, R. G.; Butenhoff, J. L. Toxicological evaluation of potassium perfluorobutanesulfonate in a 90-day oral gavage study with Sprague-Dawley rats Toxicology 2009, 255, 45-52
17. Lieder, P. H.; York, R. G.; Hakes, D. C.; Chang, S.-C.; Butenhoff, J. L. A two-generation oral gavage reproduction study with potassium perfluorobutanesulfonate (K+PFBS) in Sprague Dawley rats Toxicology 2009, 259, 33-45
18. Olsen, G. W.; Chang, S.-C.; Noker, P. E.; Gorman, G. S.; Ehresman, D. J.; Lieder, P. H.; Butenhoff, J. L. A comparison of the pharmacokinetics of perfluorobutanesulfonate (PFBS) in rats, monkeys, and humans Toxicology 2009, 256, 65-74
19. Han, X.; Snow, T. A.; Kemper, R. A.; Jepson, G. W. Binding of perfluorooctanoic acid to rat and human plasma proteins Chem. Res. Toxicol. 2003, 16, 775-781
20. Jones, P. L.; Hu, W.; de Coen, W.; Newstedt, J. L.; Giesy, J. P. Binding of perfluorinated fatty acids to serum proteins Environ. Toxicol. Chem. 2003, 22 (11) 2639-2649
21. Olsen, G. W.; Burris, J. M.; Ehresman, D. J.; Froehlich, J. W.; Seacat, A. M.; Butenhoff, J. L.; Zobel, L. R. Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers Environ. Health Perspect. 2007, 115 (9) 1298-1305
22. 14C]-PFHx) in rats and mice Toxicology 2011, 283, 55-62
23. Kudo, N.; Katakura, M.; Sato, Y.; Kawashima, Y. Sex hormone-regulated renal transport of perfluorooctanoic acid Chem.-Biol. Interact. 2002, 139, 301-3165
24. Yang, C.-H.; Glover, K. P.; Han, X. Organic anion transporting polypeptide (Oatp) 1a1-mediated perfluorooctanoate transport and evidence for renal reabsorption mechanism of Oatp1a1 in renal elimination of perfluorocarboxylates in rats Toxicol. Lett. 2009, 190, 163-171
25. Weaver, Y. M.; Ehresman, D. J.; Butenhoff, J. L.; Hagenbuch, B. Roles of rat renal organic anion transporter in transporting perfluorinated carboxylates with different chain lengths Toxicol. Sci. 2010, 113 (2) 305-314
26. 14C] perfluorooctanesulfonate Fundam. Appl. Toxicol. 1984, 4, 972-976
27. Hundley, S. G.; Sarrif, A. M.; Kennedy, G. L., Jr. Absorption, distribution, and excretion of ammonium perfluorooctanoate (APFO) after oral administration to various species Drug Chem. Toxicol. 2006, 29, 137-145
28. 14C-perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) in beef cattle Organohalogen Compd. 2011, 73, 1150-1153
29. Kärrman, A.; Ericson, I.; van Bavel, B.; Darnerud, P. O.; Aune, M.; Glynn, A.; Lignell, S.; Lindström, G. Exposure of perfluorinated chemicals through lactation: levels of matched human milk and serum and a temporal trend, 1996-2004, in Sweden Environ. Health Perspect. 2007, 115 (2) 226-230
30. Kuklenyik, Z.; Reich, J. A.; Tully, J. S.; Needham, L. L.; Calafat, A. M. Automated solid-phase extraction and measurement of perfluorinated organic acids and amides in human serum and milk Environ. Sci. Technol. 2004, 38, 3698-3704
31. Hinderliter, P. M.; Mylchreest, E.; Gannon, S. A.; Butenhoff, J. L.; Kennedy, G. L., Jr. Perfluorooctanoate: placental and lactational transport pharmacokinetics in rats Toxicology 2005, 211, 139-148
32. Kowalczyk, J.; Ehlers, S.; Fürst, P.; Schafft, H.; Lahrssen-Wiederholt, M. Transfer of perfluoroctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) from contaminated feed into milk and meat of sheep: pilot study Arch. Environ. Contam. Toxicol. 2012, 63, 288-298
33. Chengelis, C. P.; Kirkpatrick, J. B.; Myers, N. R.; Shinohara, M.; Stetson, P. L.; Sved, D. W. Comparison of the toxicokinetic behaviour of perfluorohexanoic acid (PFHxA) and nonafluorobutane-1-sulfonic acid (PFBS) in cynomolgus monkeys and rats Reprod. Toxicol. 2009, 27, 400-406
34. Vanden Heuvel, J. P.; Kuslikis, B. I.; van Rafelghem, M. J.; Peterson, R. E. Tissue distribution, metabolism, and elimination of perfluorooctanoic acid in male and female rats J. Biochem. Toxicol. 1991, 6 (2) 83-92
35. Yeung, L. W. Y.; Loi, E. I. H.; Wong, V. Y. Y.; Guruge, K. S.; Yamanaka, N.; Tanimura, N.; Hasegawa, J.; Yamashita, N.; Miyazaki, S.; Lam, P. K. S. Biochemical responses and accumulation properties of long-chain perfluorinated compounds (PFOS/PFDA/PFOA) in juvenile chickens (Gallus gallus) Arch. Environ. Contam. Toxicol. 2009, 57, 377
36. Yoo, H.; Gururge, K. S.; Yamanaka, N.; Sato, C.; Mikami, O.; Miyazaki, S.; Yamashita, N.; Giesy, J. P. Depuration kinetics and tissue disposition of PFOA and PFOS in white leghorn chickens (Gallus gallus) administered by subcutaneous implantation Ecotoxicol. Environ. Saf. 2009, 72, 26-36
37. 14C-perfluorooctanoic acid (PFOA) in Angus cattle (Bos taurus) J. Agric. Food Chem. 2012, 60, 1128-1134
38. Guruge, K. S.; Manage, P. M.; Yamanaka, N.; Miyazaki, S.; Taniyasu, S.; Yamashita, N. Species-specific concentrations of perfluoroalkyl contaminants in farm and pet animals in Japan Chemosphere 2008, 73, 210-215
39. Haug, L. S.; Salihovic, S.; Ericson Jogsten, I.; Thomsen, C.; van Bavel, B.; Lindström, G.; Becher, G. Levels in food and breverages and daily intake of perfluorinated compounds in Norway Chemosphere 2010, 80, 1137-1143
40. Landesamt für Natur, Umwelt und Verbraucherschutz Nordrhein-Westfalen (LANUV). Verbreitung von PFT in der Umwelt. Ursachen-Untersuchungsstrategie-Ergebnisse-Maßnahmen. LANUV-Fachbericht 34; http://www.lanuv.nrw.de/veroeffentlichungen/fachberichte/fabe34/fabe34.pdf (accessed Oct 26, 2012).
41. European Food Safety Authority (EFSA). Scientific report of EFSA on perfluoroalkylated substances in food: occurrence and dietary exposure. EFSA Journal 2012, 10 (6):2743, 1-55
42. Gesellschaft für Ernährungsphysiologie (GfE). Empfehlungen zur Energie- und Nährstoffversorgung der Milchkühe und Aufzuchtsrinder; DLG-Verlag: Frankfurt, Germany, 2001.
43. Kärrman, A.; van Bavel, B.; Järnberg, U.; Hardell, L.; Lindström, G. Development of a solid-phase extraction-HPLC/single quadropole MS method for quantification of perfluorochemicals in whole blood Anal. Chem. 2005, 77, 864-870
44. Bernsmann, T.; Fuerst, P. Determination of perfluorinated compounds in human milk Organohalogen Compd. 2008, 70, 718-721
45. Ehlers, S. Analytik von Perfluoralkylsäuren in verschiedenen Matrices zur Klärung der Toxikokinetik in Tierarten, die der Lebensmittelgewinnung dienen. Dissertation an der Westfälischen, Wilhelms-Universität Münster, 2012.
46. Taniyasu, S.; Kannan, K.; So, M. K.; Gulkowska, A.; Sinclair, E.; Okazawa, T.; Yamashita, N. Analysis of fluorotelomer alcohols, fluorotelomer acids, and short- and long-chain perfluorinated acids in water and biota J. Chromatogr., A 2005, 1093, 89-97
47. Delling, U. Intraoperative Ultraschalluntersuchung der Leber und der Gallenblase des Rindes. Dissertation der Veterinärmedizinische, Fakultät der Universität Leipzig, 2000; http://d-nb.info/963607464/34 (accessed Sept 4, 2012).
48. Mischke, A. Makroskopisch- und mikroskopisch-anatomische Untersuchungen an Herz, Nieren und Nebennieren von normalgeschlachteten Bullen und Färsen der Rasse Holstein-Friesian. Dissertation an der Freien, Universität Berlin, 1997; http://www.diss.fu-berlin.de/diss/servlets/MCRFileNodeServlet/ FUDISS-derivate-000000000054/0-misch.pdf?hosts= (accessed Sept 4, 2012).
49. Branscheid, W.; Honikel, K. O.; von Lengerken, G.; Troeger, K. In Qualität von Fleisch und Fleischwaren Band 1, 2nd ed.; Deutscher Fachverlag: Frankfurt am Main, Germany, 2007.
50. Cui, L.; Zhou, Q.; Liao, C.; Fu, J.; Jiang, G. Studies on the toxicological effects of PFOA and PFOS an rats using histological observation and chemical analysis Arch. Environ. Contam. Toxicol. 2009, 56, 338-349
51. Gavert, H. O.; Kübler, W.; Ordloff, D.; Rabold, K.; Rohr, K.; Schams, D.; Thomasow, J.; Tolle, A. In Die Milch: Erzeugung, Gewinnung, Qualität. Hrsg. Von Hans Otto Gravert; Verlag Eugen Ulmer: Stuttgart, Germany, 1983.
52. Loeffler, K. In Anatomie und Physiologie der Haustiere, 2nd ed.; Verlag Eugen Ulmer: Stuttgart, Germany, 1970.
53. Han, X.; Snow, T. A.; Kemper, R. A.; Jepson, G. W. Binding of perfluorooctanoic acid to rat and human plasma proteins Chem. Res. Toxicol. 2003, 16, 775-781
54. Chen, Y.-M.; Guo, L.-H. Fluorenscence study on site-specific binding of perfluoroalkyl acids to human serum albumin Arch. Toxicol. 2009, 83, 255-261
55. Liu, J.; Li, J.; Liu, Y.; Chan, H. M.; Zhao, Y.; Cai, Z.; Wu, Y. Comparison on gestation and lactation exposure of perfluorinated compounds for newborns Environ. Int. 2011, 37, 1206-1212
56. Bischel, H. N.; Macmanus-Spencer, L. A.; Luthy, R. G. Noncovalent interactions of long-chain perfluoroalkyl acids with serum albumin Environ. Sci. Technol. 2010, 44, 5263-5269
57. De Vos, M. G.; Huijbregts, A. J.; van den Heuvel-Greve, M. J.; Vethaak, A. D.; van de Vijer, K. I.; Leonards, P. E. G.; van Leeuwen, S. P. J.; de Voogt, P.; Hendriks, A. J. Accumulation of perfluorooctane sulfonate (PFOS) in the food chain of the Western Scheldt estuary: comparing field measurements with kinetic modeling Chemosphere 2008, 70, 1766-1773
58. Wang, Y.; Yeung, L. W. Y.; Yamashita, N.; Taniyasu, S.; So, M. K.; Murphy, M. B.; Lam, P. K. S. Perfluorooctane sulfonate (PFOS) and related fluorochemicals in chicken egg in China Chin. Sci. Bull. 2008, 53 (4) 501-507
59. Ericson, I.; Martin-Cid, R.; Nadal, M.; van Bavel, B.; Lindström, G.; Domingo, J. L. Human exposure to perfluorinated chemicals through the diet: intake of perfluorinated compounds in foods from the Catalan (Spain) market J. Agric. Food Chem. 2008, 56, 1787-1794
60. Noorlander, C. W.; van Leeuwen, S. P. J.; te Biesebeek, J. D.; Mengelers, M. J. B.; Zeilmaker, M. J. Levels of perfluorinated compounds in food and dietary intake of PFOS and PFOA in the Netherlands J. Agric. Food Chem. 2010, 59, 7496-7505
61. Kennedy, G. L.; Butenhoff, J. L.; Olsen, G. W.; O'Connor, J. C.; Seacat, A. M.; Perkins, R. G.; Biegel, L. B.; Murphy, S. R.; Farrar, S. G. The toxicology of perfluorooctanoate. critical reviews Toxicology 2004, 34 (4) 351-384