Comparative pharmacokinetics of perfluorohexanesulfonate (PFHxS) in rats, mice, and monkeys

Reproductive Toxicology

Volumn 33, Issue 4, 2012, Pages 441-451

  Sundström, Maria ^a   Chang, Shu Ching ^b   Noker, Patricia E ^c   Gorman, Gregory S ^c,d   Hart, Jill A ^b   Ehresman, David J ^b   Bergman, åke ^a   Butenhoff, John L ^b  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b 3M COMPANY   (United States)

^c SOUTHERN RESEARCH INSTITUTE   (United States)

^d SAMFORD UNIVERSITY   (United States)

Author keywords

Mice; Monkeys; Perfluorohexanesulfonate; PFHxS; Pharmacokinetics; Rats

Indexed keywords

PERFLUORO COMPOUND; PERFLUOROHEXANESULFONATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EXPERIMENTAL MONKEY; EXPERIMENTAL MOUSE; EXPERIMENTAL RAT; FECES; FEMALE; LIMIT OF QUANTITATION; LIVER LEVEL; MALE; MOUSE; NONHUMAN; PLASMA HALF LIFE; RAT; SEX DIFFERENCE; TOXICITY TESTING; TOXICOKINETICS; URINARY EXCRETION;

ADMINISTRATION, ORAL; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; FECES; FEMALE; HALF-LIFE; INJECTIONS, INTRAVENOUS; LIVER; MACACA FASCICULARIS; MALE; METABOLIC CLEARANCE RATE; MICE; MICE, INBRED STRAINS; RATS; RATS, SPRAGUE-DAWLEY; SEX FACTORS; SPECIES SPECIFICITY; SULFONIC ACIDS; TISSUE DISTRIBUTION;

MUS; RATTUS; RODENTIA;

EID: 84861528584     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2011.07.004     Document Type: Article

References (64)

1. Lehmler H.J. Synthesis of environmentally relevant fluorinated surfactants--a review. Chemosphere 2005, 58(March (11)):1471-1496.
2. Lau C., Anitole K., Hodes C., Lai D., Pfahles-Hutchens A., Seed J., et al. A review of monitoring and toxicological findings. Toxicol Sci 2007, 99(2):366-394.
3. Kissa E. Fluorinated surfactants and repellents 2001, Marcel Dekker, New York.
4. Hansen K.J., Clemen L.A., Ellefson M.E., Johnson H.O. Compound-specific, quantitative characterization of organic fluorochemicals in biological matrices. Environ Sci Technol 2001, 35(February (4)):766-770.
5. Olsen G.W., Burris J.M., Ehresman D.J., Froehlich J.W., Seacat A.M., Butenhoff J.L., et al. Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers. Environ Health Perspect 2007, 115(September (9)):1298-1305.
6. Calafat A.M., Wong L.Y., Kuklenyik Z., Reidy J.A., Needham L.L. Polyfluoroalkyl chemicals in the U.S. population: data from the National Health and Nutrition Examination Survey (NHANES) 2003-2004 and comparisons with NHANES 1999-2000. Environ Health Perspect 2007, 115(November (11)):1596-1602.
7. Olsen G.W., Mair D.C., Church T.R., Ellefson M.E., Reagen W.K., Boyd T.M., et al. Decline in perfluorooctanesulfonate and other polyfluoroalkyl chemicals in American Red Cross adult blood donors, 2000-2006. Environ Sci Technol 2008, 42(13):4989-4995.
8. Holzer J., Midasch O., Rauchfuss K., Kraft M., Reupert R., Angerer J., et al. Biomonitoring of perfluorinated compounds in children and adults exposed to perfluorooctanoate (PFOA) - contaminated drinking water. Environ Health Perspect 2008, 116(February (5)):651-657.
9. Haug L.S., Thomsen C., Becher G. Time trends and the influence of age and gender on serum concentrations of perfluorinated compounds in archived human samples. Environ Sci Technol 2009, 43(6):2131-2136.
10. Spliethoff H.M., Tao L., Shaver S.M., Aldous K.M., Pass K.A., Kannan K., et al. Use of newborn screening program blood spots for exposure assesment: declining levels of perfluorinated compounds in New York state infants. Environ Sci Technol 2008, 42:5361-5367.
11. Kato K, Wong L-Y, Jia LT, Kuklenyik Z, Calafat AM. Trends in exposure to polyfluoroalkyl chemicals in the U.S. population: 1999-2008. Environ Sci Technol; , online April 6, 2011., in press. doi:10.1021/es1043613.
12. Olsen G.W., Church T.R., Hansen K.J., Burris J.M., Butenhoff J.L., Mandel J.H., et al. Quantitative evaluation of perfluorooctanesulfonate (PFOS) and other fluorochemicals in the serum of children. J Child Health 2004, 2:53-76.
13. Monroy R., Morrison K., Teo K., Atkinson S., Kubwabo C., Stewart B., et al. Serum levels of perfluoroalkyl compounds in human maternal and umbilical cord blood samples. Environ Res 2008, 108(1):56-62.
14. Hanssen L., Rollin H., Odland J.O., Moe M.K., Sandanger T.M. Perfluorinated compounds in maternal serum and cord blood from selected areas of South Africa: results of a pilot study. J Environ Monit 2010, 12(6):1355-1361.
15. Wang I.-J., Hsieh W.-S., Chen C.-Y., Fletcher T., Lien G.-W., Chiang H.-L., et al. The effect of prenatal perfluorinated chemicals exposure on pediatric atopy. Environ Res 2011, 111(6):785-791.
16. Brede E., Wilhelm M., Goen T., Muller J., Raunchfuss K., Kraft M., et al. Two-year follow-up biomonitoring pilot study of residents' and controls' PFC plasma levels after PFOA reduction in public drinking water system in Arnsberg, Germany. Int J Hyg Environ Health 2010, 213(3):217-223.
17. Sundström M., Ehresman D.J., Bignert A., Butenhoff J.L., Olsen G.W., Chang S.C., et al. A temporal trend study (1972-2008) of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in pooled human milk samples from Stockholm, Sweden. Environ Int 2011, 37(1):178-183.
18. Karrman A., Ericson I., van Bavel B., Darnerud P.O., Aune M., Glynn A., et al. Exposure of perfluorinated chemicals through lactation: levels of matched human milk and serum and a temporal trend, 1996-2004, in Sweden. Environ Health Perspect 2007, 115(February (2)):226-230.
19. D'Hollander W., Roosens L., Covaci A., Cornelis C., Reynders H., Van Campenhout K., et al. Brominated flame retardants and perfluorinated compounds in indoor dust from homes and offices in Flanders, Belgium. Chemosphere 2010, 81(4):478-487.
20. Kato K., Calafat A.M., Needham L. Polyfluoroalkyl chemicals in house dust. Environ Res 2009, 109(5):518-523.
21. Kubwabo C., Stewart B., Zhu J., Marro L. Occurrence of perfluorosulfonates and other perfluorochemicals in dust from selected homes in the city of Ottawa, Canada. J Environ Monit 2005, 7(November (11)):1074-1078.
22. Strynar M.J., Lindstrom A.B. Perfluorinated compounds in house dust from Ohio and North Carolina, USA. Environ Sci Technol 2008, 42(10):3751-3756.
23. Noorlander C.W., van Leeuwen S.P.J., Dirk te Biesebeek J., Mengelers M.J.B., Zeilmaker M.J. Levels of perfluorinated compounds in food and dietary intake of PFOS and PFOA in The Netherlands. J Agric Food Chem 2011, 59(13):7496-7505.
24. Kato K., Calafat A.M., Wong L.Y., Wanigatunga A.A., Caudill S.P., Needham L. Polyfluoroalkyl compounds in pooled sera from children participating in the National Health and Nutrition Examination Survey 2001-2002. Environ Sci Technol 2009, 43(7):2641-2647.
25. Bloom M.S., Kannan K., Spliethoff H.M., Tao L., Aldous K.M., Vena J.E. Exploratory assessment of perfluorinated compounds and human thyroid function. Physiol Behav 2010, 99(2):240-245.
26. Chan E., Burstyn I., Cherry N., Bamforth F., Martin J.W. Perfluorinated acids and hypothyroxinemia in pregnant women. Environ Res 2011, 111(4):559-564.
27. Hamm M.P., Cherry N.M., Chan E., Martin J.W., Burstyn I. Maternal exposure to perfluorinated acids and fetal growth. J Exposure Sci Environ Epidemiol 2010, 20:589-597.
28. Stein CR, Savitz DA. Serum perfluorinated compound concentration and attention deficit/hyperactivity disorder in children aged 5 to 18 years. Environ Health Perspect; , online June 10, 2011., in press. doi:10.1289/ehp.1003538.
29. Nelson J.W., Hatch E.E., Webster T.F. Exposure to polyfluoroalkyl chemicals and cholesterol, body weight, and insulin resistance in the general U.S. population. Environ Health Perspect 2010, 118(2):197-202.
30. Butenhoff J.L., Chang S.C., Ehresman D.J., York R.G. Evaluation of potential reproductive and developmental toxicity of potassium perfluorohexanesulfonate in Sprague Dawley rats. Reprod Toxicol 2009, 27(3-4):331-341.
31. Wolf C.J., Takacs M.L., Schmid J.E., Lau C., Abbott B.D. Activation of mouse and human peroxisome proliferator-activated receptor alpha by perfluoroalkyl acids of different functional groups and chain lengths. Toxicol Sci 2008, 106(November (1)):162-171.
32. Bjork J.A., Wallace K.B. Structure-activity relationships and human relevance for perfluoroalkyl acid-induced transcriptional activation of peroxisome proliferation in liver cell cultures. Toxicol Sci 2009, 111(September (1)):89-99.
33. Bijland S, Rensen PCN, Pieterman EJ, Maas ACE, van der Hoorn JW, van Erk MJ, et al. Perfluoroalkyl sulfonates cause chain length-dependent hepatic steatosis and hypolipidemia mainly by impairing lipoprotein production in APOE*3-Leiden.CETP mice. Toxicol Sci; , online june 24, 2011, in press. doi:10.1093/toxsci/kfr%20142.
34. Chang S., Das K., Ehresman D.J., Ellefson M.E., Gorman G.S., Hart J.A., et al. Comparative pharmacokinetics of perfluorobutyrate (PFBA) in rats, mice, monkeys, and humans and relevance to human exposure via drinking water. Toxicol Sci 2008, 104:40-53.
35. Olsen G.W., Chang S.C., Noker P.E., Gorman G.S., Ehresman D.J., Lieder P.H., et al. A comparison of the pharmacokinetics of perfluorobutanesulfonate (PFBS) in rats, monkeys, and humans. Toxicology 2009, 256(1-2):65-74.
36. Butenhoff J.L., Kennedy G.L., Hinderliter P.M., Lieder P.H., Jung R., Hansen K.J., et al. Pharmacokinetics of perfluorooctanoate in cynomolgus monkeys. Toxicol Sci 2004, 82(December (2)):394-406.
37. ILAR Guide for the care and use of laboratory animals 1996, National Research Council, Institute of Laboratory Animal Resources. National Academy Press, Washington, DC.
38. Ehresman D.J., Froehlich J.W., Olsen G.W., Chang S.C., Butenhoff J.L. Comparison of human whole blood, plasma, and serum matrices for the determination of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and other fluorochemicals. Environ Res 2007, 103(February (2)):176-184.
39. Chang S.C., Thibodeaux J.R., Eastvold M.L., Ehresman D.J., Bjork J.A., Froehlich J.W., et al. Negative bias from analog methods used in the analysis of free thyroxine in rat serum containing perfluorooctanesulfonate (PFOS). Toxicology 2007, 234(May (1-2)):21-33.
40. Chang S.C., Ehresman D.J., Bjork J.A., Wallace K., Parker G.A., Stump D.G., et al. Gestational and lactational exposure to potassium perfluorooctanesulfonate (K+PFOS) in rats: toxicokinetics, thyroid hormone status, and related gene expression. Reprod Toxicol 2009, 27(3-4):387-399.
41. Griffith F.D., Long J.E. Animal toxicity studies with ammonium perfluorooctanoate. Am Ind Hyg Assoc J 1980, 41(August (8)):576-583.
42. Kudo N., Kawashima Y. Toxicity and toxicokinetics of perfluorooctanoic acid in humans and animals. J Toxicol Sci 2003, 28(May (2)):49-57.
43. Chang S-C, Noker PE, Gorman GS, Gibson SJ, Hart JA, Ehresman DJ, et al. Comparative pharmacokinetics of perfluorooctanesulfonate (PFOS) in rats, mice, and monkeys. Reprod Toxicol; in press.
44. Benskin J.P., De Silva A.O., Martin L.J., Arsenault G., McCrindle R., Riddell N., et al. Disposition of perfluorinated acid isomers in Sprague-Dawley rats; part 1: single dose. Environ Toxicol Chem 2009, 28(March (3)):542-554.
45. Chengelis C.P., Kirkpatrick J.B., Myers N.R., Shinohara M., Stetson P.L., Sved D.W. Comparison of the toxicokinetic behavior of perfluorohexanoic acid (PFHxA) and nonafluorobutane-1-sulfonic acid (PFBS) in cynomolgus monkeys and rats. Reprod Toxicol 2009, 27(3-4):400-406.
46. Hundley S.G., Sarrif A.M., Kennedy G.L. Absorption, distribution, and excretion of ammonium perfluorooctanoate (APFO) after oral administration to various species. Drug Chem Toxicol 2006, 29(2):137-145.
47. Loveless S.E., Finlay C., Everds N.E., Frame S.R., Gillies P.J., O'Connor J.C., et al. Comparative responses of rats and mice exposed to linear/branched, linear, or branched ammonium perfluorooctanoate (APFO). Toxicology 2006, 220(March (2-3)):203-217.
48. Hinderliter P.M., Delorme M.P., Kennedy G.L. Perfluorooctanoic acid: relationship between repeated inhalation exposures and plasma PFOA concentration in the rat. Toxicology 2006, 211(February):139-148.
49. Hinderliter P.M., Han X., Kennedy G.L., Butenhoff J.L. Age effect on perfluorooctanoate (PFOA) plasma concentration in post-weaning rats following oral gavage with ammonium perfluorooctanoate (APFO). Toxicology 2006, 225(August (2-3)):195-203.
50. Hinderliter P.M., Jepson G.W. Development of a biologically based model to describe perfluorooctanoic acid (PFOA) kinetics. Toxicologist 2001, 60s. [Abstract #700 of 40th annual meeting].
51. Hinderliter P.M., Mylchreest E., Gannon S.A., Butenhoff J.L., Kennedy G.L. Perfluorooctanoate: placental and lactational transport pharmacokinetics in rats. Toxicology 2005, 211(July (1-2)):139-148.
52. De Silva A.O., Benskin J.P., Martin L.J., Arsenault G., McCrindle R., Riddell N., et al. Disposition of perfluorinated acid isomers in Sprague-Dawley rats; part 2: subchronic dose. Environ Toxicol Chem 2009, 28(March (3)):555-567.
53. Kudo N., Suzuki E., Katakura M., Ohmori K., Noshiro R., Kawashima Y. Comparison of the elimination between perfluorinated fatty acids with different carbon chain length in rats. Chem Biol Interact 2001, 134(April (2)):203-216.
54. Vanden Heuvel J.P., Davis J.W., Sommers R., Peterson R.E. Renal excretion of perfluorooctanoic acid in male rats: inhibitory effect of testosterone. J Biochem Toxicol 1992, 7(Spring (1)):31-36.
55. Kudo N., Katakura M., Sato Y., Kawashima Y. Sex hormone-regulated renal transport of perfluorooctanoic acid. Chem Biol Interact 2002, 139(March (3)):301-316.
56. Katakura M., Kudo N., Tsuda T., Hibino Y., Mitsumoto A., Kawashima Y. Rat organic anion transporter 3 and organic anion transporting polypeptide 1 mediate perfluorooctanoic acid transport. J Health Sci 2007, 53(1):77-83.
57. Weaver Y.M., Ehresman D.J., Butenhoff J.L., Hagenbuch B. Roles of rat renal organic anion transporters in transporting perfluorinated carboxylates with different chain lengths. Toxicol Sci 2010, 113(2):305-314.
58. Yang C.H., Glover K.P., Han X. Organic anion transporting polypeptide (Oatp) 1a1-mediated perfluorooctanoate transport and evidence for a renal reabsorption mechanism of Oatp1a1 in renal elimination of perfluorocarboxylates in rats. Toxicol Lett 2009, 190(October (2)):163-171.
59. Yang C.H., Glover K.P., Han X. Characterization of cellular uptake of perfluorooctanoate via organic anion transporting polypeptide 1A2, organic anion transporter 4, and urate transporter 1 for their potential roles in mediating human renal reabsorption of perfluorocarboxylates. Toxicol Sci 2010, 117(2):294-302.
60. Nakagawa H., Terada T., Harada K.H., Hitomi T., Inoue K., Inui K., et al. Human organic anion transporter hOAT4 is a transporter of perfluorooctanoic acid. Basic Clin Pharmacol Toxicol 2009, 105:136-138.
61. Andersen M.E., Clewell H.J., Tan Y.M., Butenhoff J.L., Olsen G.W. Pharmacokinetic modeling of saturable, renal resorption of perfluoroalkylacids in monkeys-probing the determinants of long plasma half-lives. Toxicology 2006, 227(October (1-2)):156-164.
62. Benskin J.P., Bataineh M., Martin J.W. Simultaneous characterization of perfluoroalkyl carboxylate, sulfonate, and sulfonamide isomers by liquid chromatography-tandem mass spectrometry. Anal Chem 2007, 79(17):6455-6464. Aug 1.
63. Chan E., Sandhu M., Benskin J.P., Ralitsch M., Thibault N., Birkholz D., et al. Endogenous high-performance liquid chromatography/tandem mass spectrometry interferences and the case of perfluorohexane sulfonate (PFHxS) in human serum; are we overestimating exposure?. Rapid Commun Mass Spectrom 2009, 23(April (10)):1405-1410.
64. Kato K., Basden B.J., Needham L.L., Calafat A.M. Improved selectivity for the analysis of maternal serum and cord serum for polyfluoroalkyl chemicals. J Chromatogr A 2011, 1218(16):2133-2137.