Radiation mitigating properties of the lignan component in flaxseed

BMC Cancer

Volumn 13, Issue , 2013, Pages

  Pietrofesa, Ralph ^a   Turowski, Jason ^a   Tyagi, Sonia ^a   Dukes, Floyd ^a   Arguiri, Evguenia ^a   Busch, Theresa M ^b   Gallagher Colombo, Shannon M ^b   Solomides, Charalambos C ^c   Cengel, Keith A ^b   Christofidou Solomidou, Melpo ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^c THOMAS JEFFERSON UNIVERSITY HOSPITAL   (United States)

Author keywords

Antioxidant; Flaxseed lignan complex; Lung fibrosis; Mitigation; Nitrotyrosine; Radiation dispersion device; Radiation pneumonopathy; ROS; SARRP; SDG; TBARS; TGF beta 1

Indexed keywords

3 NITROTYROSINE; CYTOKINE; LIGNAN; MALONALDEHYDE; PLANT MEDICINAL PRODUCT; SECOISOLARICIRESINOL DIGLUCOSIDE; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD OXYGENATION; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFICACY; DRUG MECHANISM; FEMALE; IMMUNOHISTOCHEMISTRY; LINSEED; LIPID OXIDATION; LUNG FIBROSIS; LUNG INJURY; LUNG LAVAGE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PNEUMONIA; RADIATION DOSE FRACTIONATION; RADIATION EXPOSURE; RADIATION HAZARD; RADIATION PROTECTION; SURVIVAL RATE; SURVIVAL TIME; THORAX RADIOGRAPHY; X RAY;

ANIMAL FEED; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; BUTYLENE GLYCOLS; CYTOKINES; FEMALE; FIBROSIS; FLAX; GLUCOSIDES; KAPLAN-MEIER ESTIMATE; LIGNANS; LUNG; LUNG INJURY; MALONDIALDEHYDE; MICE; MICE, INBRED C57BL; NEUTROPHILS; OXYGEN; PHYTOTHERAPY; RADIATION INJURIES, EXPERIMENTAL; RADIATION PNEUMONITIS; RADIATION-PROTECTIVE AGENTS; SEEDS; SURVIVAL RATE; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA1; TYROSINE;

EID: 84875688783     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-13-179     Document Type: Article

References (43)

1. Brenner DJ, Hall EJ. Computed tomography-an increasing source of radiation exposure. N Engl J Med 2007, 357(22):2277-2284. 10.1056/NEJMra072149, 18046031.
2. Vogel H. Rays as weapons. Eur J Radiol 2007, 63(2):167-177. 10.1016/j.ejrad.2007.04.028, 17630244.
3. Chin FK. Scenario of a dirty bomb in an urban environment and acute management of radiation poisoning and injuries. Singapore Med J 2007, 48(10):950-957.
4. Dombroski MJ, Fischbeck PS. An integrated physical dispersion and behavioral response model for risk assessment of radiological dispersion device (RDD) events. Risk Anal 2006, 26(2):501-514. 10.1111/j.1539-6924.2006.00742.x, 16573636.
5. Moulder JE. Post-irradiation approaches to treatment of radiation injuries in the context of radiological terrorism and radiation accidents: a review. Int J Radiat Biol 2004, 80(1):3-10. 10.1080/09553000310001642920, 14761845.
6. Machtay M. From Abeloff's Clinical Oncology. Pulmonary complications of anticancer treatment 2003, 969-981. Philadelphia, PA, 4, chapter 62.
7. Marks LB, Yu X, Vujaskovic Z, Small W, Folz R, Anscher MS. Radiation-induced lung injury. Semin Radiat Oncol 2003, 13(3):333-345. 10.1016/S1053-4296(03)00034-1, 12903021.
8. Keane T, Van Dyk J, Rider W. Idiopathic interstitial pneumonia following bone marrow transplantation. Int J Radiat Oncol Biol Phys 1981, 7:1365-1370. 10.1016/0360-3016(81)90032-8, 7033190.
9. Williams JP, Jackson IL, Shah JR, Czarniecki CW, Maidment BW, DiCarlo AL. Animal models and medical countermeasures development for radiation-induced lung damage: report from an NIAID Workshop. Radiat Res 2012, 177(5):e0025-e0039. 10.1667/RROL04.1, 22468702.
10. Williams JP, Johnston CJ, Finkelstein JN. Treatment for radiation-induced pulmonary late effects: spoiled for choice or looking in the wrong direction?. Curr Drug Targets 2010, 11(11):1386-1394. 10.2174/1389450111009011386, 2948640, 20583979.
11. Franko AJ, Sharplin J. Development of fibrosis after lung irradiation in relation to inflammation and lung function in a mouse strain prone to fibrosis. Radiat Res 1994, 140:347-355. 10.2307/3579112, 7972687.
12. Machtay M, Scherpereel A, Santiago J, Lee J, McDonough J, Kinniry P, Arguiri E, Shuvaev VV, Sun J, Cengel K, et al. Systemic polyethylene glycol-modified (PEGylated) superoxide dismutase and catalase mixture attenuates radiation pulmonary fibrosis in the C57/bl6 mouse. Radiother Oncol 2006, 81:196-205. 10.1016/j.radonc.2006.09.013, 1764603, 17069914.
13. Lee JC, Bhora F, Sun J, Cheng G, Arguiri E, Solomides CC, Chatterjee S, Christofidou-Solomidou M. Dietary flaxseed enhances antioxidant defenses and is protective in a mouse model of lung ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol 2008, 294(2):L255-L265.
14. Travis EL, Parkins CS, Holmes SJ, Down JD, Fowler JF. WR-2721 protection of pneumonitis and fibrosis in mouse lung after single doses of x- rays. Int J Radiat Oncol Biol Phys 1984, 13:1355-1359.
15. Travis EL, Newman RA, Helbing SJ. WR 2721 modification of type II cell and endothelial cell function in mouse lung after single doses of radiation. Int J Radiat Oncol Biol Phys 1987, 13:1355-1359. 10.1016/0360-3016(87)90229-X, 3040647.
16. Epperly M, Bray J, Kraeger S, Zwacka R, Engelhardt J, Travis E, Greenberger J. Prevention of late effects of irradiation lung damage by manganese superoxide dismutase gene therapy. Gene Ther 1998, 5(2):196-208. 10.1038/sj.gt.3300580, 9578839.
17. Chen Y, Okunieff P. Radiation and third-generation chemotherapy. Hematol Oncol Clin North Am 2004, 18(1):55-80. 10.1016/S0889-8588(03)00145-X, 15005281.
18. Reboul FL. Radiotherapy and chemotherapy in locally advanced non-small cell lung cancer: preclinical and early clinical data. Hematol Oncol Clin North Am 2004, 18(1):41-53. 10.1016/S0889-8588(03)00138-2, 15005280.
19. Citrin D, Cotrim AP, Hyodo F, Baum BJ, Krishna MC, Mitchell JB. Radioprotectors and mitigators of radiation-induced normal tissue injury. Oncologist 2010, 15(4):360-371. 10.1634/theoncologist.2009-S104, 3076305,3076305, 20413641.
20. Christofidou-Solomidou M, Tyagi S, Pietrofesa R, Dukes F, Arguiri E, Turowski J, Grieshaber PA, Solomides CC, Cengel KA. Radioprotective role in lung of the flaxseed lignan complex enriched in the phenolic secoisolariciresinol diglucoside (SDG). Radiat Res 2012, 178(6):568-580. 10.1667/RR2980.1, 23106213.
21. Lee JC, Krochak R, Blouin A, Kanterakis S, Chatterjee S, Arguiri E, Vachani A, Solomides CC, Cengel KA, Christofidou-Solomidou M. Dietary flaxseed prevents radiation-induced oxidative lung damage, inflammation and fibrosis in a mouse model of thoracic radiation injury. Cancer Biol Ther 2009, 8(1):47-53. 10.4161/cbt.8.1.7092, 2745149, 18981722.
22. Christofidou-Solomidou M, Tyagi S, Tan KS, Hagan S, Pietrofesa R, Dukes F, Arguiri E, Heitjan DF, Solomides CC, Cengel KA. Dietary flaxseed administered post thoracic radiation treatment improves survival and mitigates radiation-induced pneumonopathy in mice. BMC Cancer 2011, 11(1):269. 10.1186/1471-2407-11-269, 3146937, 21702963.
23. Dileto CL, Travis EL. Fibroblast radiosensitivity in vitro and lung fibrosis in vivo: comparison between a fibrosis-prone and fibrosis-resistant mouse strain. Radiat Res 1996, 146(1):61-67. 10.2307/3579396, 8677299.
24. Sharplin J, Franko AJ. A quantitative histological study of strain-dependent differences in the effects of irradiation on mouse lung during the intermediate and late phases. Radiat Res 1989, 119(1):15-31. 10.2307/3577364, 2756106.
25. Sharplin J, Franko AJ. A quantitative histological study of strain-dependent differences in the effects of irradiation on mouse lung during the early phase. Radiat Res 1989, 119(1):1-14. 10.2307/3577363, 2756101.
26. Kinniry P, Amrani Y, Vachani A, Solomides CC, Arguiri E, Workman A, Carter J, Christofidou-Solomidou M. Dietary flaxseed supplementation ameliorates inflammation and oxidative tissue damage in experimental models of acute lung injury in mice. J Nutr 2006, 136(6):1545-1551.
27. Lee JC, Kinniry PA, Arguiri E, Serota M, Kanterakis S, Chatterjee S, Solomides CC, Javvadi P, Koumenis C, Cengel KA, Christofidou-Solomidou M, et al. Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice. Radiat Res 2010, 173(5):590-601. 10.1667/RR1522.1, 2873679, 20426658.
28. Baumann BC, Benci JL, Santoiemma PP, Chandrasekaran S, Hollander AB, Kao GD, Dorsey JF. An integrated method for reproducible and accurate image-guided stereotactic cranial irradiation of brain tumors using the small animal radiation research platform. Transl Oncol 2012, 5(4):230-237. 3431032, 22937174.
29. Machtay M, Scherpereel A, Santiago J, Lee J, McDonough J, Kinniry P, Arguiri E, Shuvaev VV, Sun J, Cengel KA, Solomides CC, Christofidou-Solomidou M. Systemic polyethylene glycol-modified (PEGylated) superoxide dismutase and catalase mixture attenuates radiation pulmonary fibrosis in the C57/bl6 mouse. Radiother Oncol 2006, 81:196-205. 10.1016/j.radonc.2006.09.013, 1764603, 17069914.
30. Woessner JF. The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Arch Biochem Biophys 1961, 93:440-447. 10.1016/0003-9861(61)90291-0, 13786180.
31. Heijnen HF, van Donselaar E, Slot JW, Fries DM, Blachard-Fillion B, Hodara R, Lightfoot R, Polydoro M, Spielberg D, Thomson L, et al. Subcellular localization of tyrosine-nitrated proteins is dictated by reactive oxygen species generating enzymes and by proximity to nitric oxide synthase. Free Radic Biol Med 2006, 40(11):1903-1913. 10.1016/j.freeradbiomed.2005.09.006, 16716892.
32. Anscher MS, Thrasher B, Rabbani Z, Teicher B, Vujaskovic Z. Antitransforming growth factor-beta antibody 1D11 ameliorates normal tissue damage caused by high-dose radiation. Int J Radiat Oncol Biol Phys 2006, 65(3):876-881. 10.1016/j.ijrobp.2006.02.051, 16751069.
33. Tsuji C, Shioya S, Hirota Y, Fukuyama N, Kurita D, Tanigaki T, Ohta Y, Nakazawa H. Increased production of nitrotyrosine in lung tissue of rats with radiation-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol 2000, 278(4):L719-L725.
34. Gauter-Fleckenstein B, Fleckenstein K, Owzar K, Jiang C, Reboucas JS, Batinic-Haberle I, Vujaskovic Z. Early and late administration of MnTE-2-PyP5+ in mitigation and treatment of radiation-induced lung damage. Free Radic Biol Med 2010, 48(8):1034-1043. 10.1016/j.freeradbiomed.2010.01.020, 20096348.
35. Park KJ, Oh YT, Kil WJ, Park W, Kang SH, Chun M. Bronchoalveolar lavage findings of radiation induced lung damage in rats. J Radiat Res (Tokyo) 2009, 50(3):177-182.
36. Rubin P, Johnston CJ, Williams JP, McDonald S, Finkelstein JN. A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis. Int J Radiat Oncol Biol Phys 1995, 33(1):99-109. 10.1016/0360-3016(95)00095-G, 7642437.
37. Rabbani ZN, Salahuddin FK, Yarmolenko P, Batinic-Haberle I, Thrasher BA, Gauter-Fleckenstein B, Dewhirst MW, Anscher MS, Vujaskovic Z. Low molecular weight catalytic metalloporphyrin antioxidant AEOL 10150 protects lungs from fractionated radiation. Free Radic Res 2007, 41(11):1273-1282. 10.1080/10715760701689550, 17957541.
38. Travis EL, Harley RA, Fenn JO, Klobukowski CJ, Hargrove HB. Pathologic changes in the lung following single and multi-fraction irradiation. Int J Radiat Oncol Biol Phys 1977, 2(5-6):475-490.
39. Morgan GW, Pharm B, Breit SN. Radiation and the lung: A reevaluation of the mechanisms mediating pulmonary injury. Int J Radiat Oncol Biol Phys 1995, 31:361-369. 10.1016/0360-3016(94)00477-3, 7836090.
40. Muggenburg BA, Boecker BB, Hahn FF, McClellan RO. Lung lavage therapy to lessen the biological effects of inhaled 144Ce in dogs. Radiat Res 1990, 124(2):147-155. 10.2307/3577859, 2247595.
41. Medhora M, Gao F, Jacobs ER, Moulder JE. Radiation damage to the lung: mitigation by angiotensin-converting enzyme (ACE) inhibitors. Respirology 2012, 17(1):66-71. 10.1111/j.1440-1843.2011.02092.x, 3245332, 22023053.
42. Jia D, Koonce NA, Griffin RJ, Jackson C, Corry PM. Prevention and mitigation of acute death of mice after abdominal irradiation by the antioxidant N-acetyl-cysteine (NAC). Radiat Res 2010, 173(5):579-589. 10.1667/RR2030.1, 2982793, 20426657.
43. Rwigema JC, Beck B, Wang W, Doemling A, Epperly MW, Shields D, Goff JP, Franicola D, Dixon T, Frantz MC, et al. Two Strategies for the Development of Mitochondrion-targeted Small Molecule Radiation Damage Mitigators. Int J Radiat Oncol Biol Phys 2011, 80:860-868. 10.1016/j.ijrobp.2011.01.059, 3104115, 21493014.