PLGA nanoparticles enhance the expression of retinaldehyde dehydrogenase enzymes in dendritic cells and induce FoxP3+ T-cells in vitro

Journal of Controlled Release

Volumn 168, Issue 1, 2013, Pages 35-40

  Keijzer, Chantal ^a   Spiering, Rachel ^a   Silva, Ana Luísa ^b   Van Eden, Willem ^a   Jiskoot, Wim ^b   Vervelde, Lonneke ^a,c   Broere, Femke ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Dendritic cells; FoxP3+CD4+ T cells; PLGA and TMC TPP nanoparticles; Retinaldehyde dehydrogenase enzyme (RALDH); Retinoic acid (RA)

Indexed keywords

DENDRITIC CELLS; DENDRITIC CELLS (DCS); INGUINAL LYMPH NODES; N-TRIMETHYL CHITOSANS; PHYSICOCHEMICAL PROPERTY; POLY LACTIC-CO-GLYCOLIC ACID; RETINALDEHYDE DEHYDROGENASE ENZYME (RALDH); RETINOIC ACIDS;

CELLS; CHEMICAL PROPERTIES; COPOLYMERS; CYTOLOGY; ENZYMES; NANOPARTICLES;

T-CELLS;

APC; CHITOSAN; GAMMA INTERFERON; INTERLEUKIN 10; N TRIMETHYL CHITOSAN TRIPOLYPHOSPHATE; NANOPARTICLE; OVALBUMIN; POLYGLACTIN; RETINAL DEHYDROGENASE; RETINOIC ACID; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD4+ T LYMPHOCYTE; CELL ISOLATION; CELL SELECTION; CERVICAL LYMPH NODE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; DRUG DELIVERY SYSTEM; FEMALE; IMMUNE RESPONSE; IN VITRO STUDY; INGUINAL LYMPH NODE; LYMPHOCYTE DIFFERENTIATION; MOUSE; NANOENCAPSULATION; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH17 CELL;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; DENDRITIC CELLS; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; ISOENZYMES; LACTIC ACID; LYMPH NODES; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; NANOPARTICLES; OVALBUMIN; POLYGLYCOLIC ACID; RECEPTORS, ANTIGEN, T-CELL; RETINAL DEHYDROGENASE;

EID: 84875655988     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.02.027     Document Type: Article

References (23)

1. J. Holmgren, and C. Czerkinsky Mucosal immunity and vaccines Nat. Med. 11 2005 S45 S53
2. H.Y. Wu, and M.W. Russell Induction of mucosal and systemic immune responses by intranasal immunization using recombinant cholera toxin B subunit as an adjuvant Vaccine 16 1998 286 292
3. A. Iwasaki, and B.L. Kelsall Mucosal immunity and inflammation. I. Mucosal dendritic cells: their specialized role in initiating T cell responses Am. J. Physiol. 276 1999 G1074 G1078
4. W.W. Unger, F. Hauet-Broere, W. Jansen, L.A. van Berkel, G. Kraal, and J.N. Samsom Early events in peripheral regulatory T cell induction via the nasal mucosa J. Immunol. 171 2003 4592 4603
5. A.A. Itano, and M.K. Jenkins Antigen presentation to naive CD4 T cells in the lymph node Nat. Immunol. 4 2003 733 739
6. J. Zhu, and W.E. Paul Peripheral CD4 + T-cell differentiation regulated by networks of cytokines and transcription factors Immunol. Rev. 238 2010 247 262
7. J.L. Coombes, K.R. Siddiqui, C.V. Arancibia-Carcamo, J. Hall, C.M. Sun, Y. Belkaid, and F. Powrie A functionally specialized population of mucosal CD103 + DCs induces Foxp3 + regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism J. Exp. Med. 204 2007 1757 1764
8. D. Mucida, Y. Park, G. Kim, O. Turovskaya, I. Scott, M. Kronenberg, and H. Cheroutre Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid Science 317 2007 256 260
9. B. Slutter, S. Bal, C. Keijzer, R. Mallants, N. Hagenaars, I. Que, E. Kaijzel, W. van Eden, P. Augustijns, C. Lowik, J. Bouwstra, F. Broere, and W. Jiskoot Nasal vaccination with N-trimethyl chitosan and PLGA based NP: NP characteristics determine quality and strength of the antibody response in mice against the encapsulated antigen Vaccine 28 2010 6282 6291
10. C. Keijzer, B. Slütter, R. van der Zee, W. Jiskoot, W. van Eden, and F. Broere PLGA, PLGA-TMC and TMC-TPP NP differentially modulate the outcome of nasal vaccination by inducing tolerance or enhancing humoral immunity PLoS One 6 2011 e26684
11. M. Amidi, S.G. Romeijn, J.C. Verhoef, H.E. Junginger, L. Bungener, A. Huckriede, D.J. Crommelin, and W. Jiskoot N-trimethyl chitosan (TMC) NP loaded with influenza subunit antigen for intranasal vaccination: biological properties and immunogenicity in a mouse model Vaccine 25 2007 144 153
12. W.U. Kim, W.K. Lee, J.W. Ryoo, S.H. Kim, J. Kim, J. Youn, S.Y. Min, E.Y. Bae, S.Y. Hwang, S.H. Park, C.S. Cho, J.S. Park, and H.Y. Kim Suppression of collagen-induced arthritis by single administration of poly(lactic-co-glycolic acid) NP entrapping type II collagen: a novel treatment strategy for induction of oral tolerance Arthritis Rheum. 46 2002 1109 1120
13. J.A. Hall, J.R. Grainger, S.P. Spencer, and Y. Belkaid The role of retinoic acid in tolerance and immunity Immunity 35 2011 13 22
14. A.B. Sieval, M. Thanou, A.F. Kotze, J.C. Verhoef, J. Brussee, and H.E. Junginger Preparation and NMR characterization of highly substituted N-trimethyl chitosan chloride Carbohydr. Polym. 36 1998 157 165
15. B. Slütter, L. Plapied, V. Fievez, M.A. Sande, A. des Rieux, Y.J. Schneider, E. Van Riet, W. Jiskoot, and V. Preat Mechanistic study of the adjuvant effect of biodegradable NP in mucosal vaccination J. Control. Release 138 2009 113 121
16. H. Sah A new strategy to determine the actual protein content of poly(lactide-co-glycolide) microspheres J. Pharm. Sci. 86 1997 1315 1318
17. D.A. Wolvers, C.J. Coenen-de Roo, R.E. Mebius, M.J. van der Cammen, F. Tirion, A.M. Miltenburg, and G. Kraal Intranasally induced immunological tolerance is determined by characteristics of the draining lymph nodes: studies with OVA and human cartilage gp-39 J. Immunol. 162 1999 1994 1998
18. H.R. Jiang, N. Taylor, L. Duncan, A.D. Dick, and J.V. Forrester Total dose and frequency of administration critically affect success of nasal mucosal tolerance induction Br. J. Ophthalmol. 85 2001 739 744
19. Y. Waeckerle-Men, E.U. Allmen, B. Gander, E. Scandella, E. Schlosser, G. Schmidtke, H.P. Merkle, and M. Groettrup Encapsulation of proteins and peptides into biodegradable poly(d, l-lactide-co-glycolide) microspheres prolongs and enhances antigen presentation by human dendritic cells Vaccine 24 2006 1847 1857
20. V. Kanchan, and A.K. Panda Interactions of antigen-loaded polylactide particles with macrophages and their correlation with the immune response Biomaterials 28 2007 5344 5357
21. I. Gutierro, R.M. Hernandez, M. Igartua, A.R. Gascon, and J.L. Pedraz Size dependent immune response after subcutaneous, oral and intranasal administration of BSA loaded nanospheres Vaccine 21 2002 67 77
22. C. Foged, B. Brodin, S. Frokjaer, and A. Sundblad Particle size and surface charge affect particle uptake by human dendritic cells in an in vitro model Int. J. Pharm. 298 2005 315 322
23. J.K. Vasir, and V. Labhasetwar Quantification of the force of NP-cell membrane interactions and its influence on intracellular trafficking of NP Biomaterials 29 2008 4244 4252