Reengineered carbonyl reductase for reducing methyl-substituted cyclohexanones

Protein Engineering, Design and Selection

Volumn 26, Issue 4, 2013, Pages 291-298

  Jakoblinnert, Andre ^a   Wachtmeister, Jochen ^a   Schukur, Lina ^a   Shivange, Amol V ^a   Bocola, Marco ^a   Ansorge Schumacher, Marion B ^b,c   Schwaneberg, Ulrich ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b TECHNISCHE UNIVERSITÄT BERLIN   (Germany)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

2 methyl cyclohexanone; carbonyl reductase; CPCR; protein engineering

Indexed keywords

CANDIDA PARAPSILOSIS; CARBONYL REDUCTASE; CPCR; CYCLOHEXANONES; IMPROVED ACTIVITIES; PROCHIRAL KETONES; PROTEIN ENGINEERING; SUBSTRATE-BINDING;

GENETIC ENGINEERING; KETONES;

SUBSTRATES;

2 BUTANONE; ACETOPHENONE; CARBONYL REDUCTASE; CYCLOHEXANONE DERIVATIVE;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYST; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME SPECIFICITY; MOLECULAR DOCKING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ENGINEERING; STRUCTURE ACTIVITY RELATION;

ALCOHOL OXIDOREDUCTASES; AMINO ACID SUBSTITUTION; BINDING SITES; CANDIDA; CYCLOHEXANONES; HUMANS; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN ENGINEERING; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

CANDIDA PARAPSILOSIS;

EID: 84875654693     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzt001     Document Type: Article

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