Characterization of porcine T lymphocytes and their immune response against viral antigens

Journal of Biotechnology

Volumn 73, Issue 2-3, 1999, Pages 223-233

  Saalmüller, Armin ^a   Pauly, Thomas ^a   Höhlich, Bettina Judith ^a   Pfaff, Eberhard ^a  

^a Institut fur Immunologie   (Germany)

Author keywords

Classical swine fever virus; Cytolytic T lymphocytes; Differentiation antigens; Natural killer cells; Porcine T lymphocytes; Pseudorabies virus; T helper cells

Indexed keywords

ANTIGENS; BLOOD; IMMUNIZATION; MONOCLONAL ANTIBODIES; VIRUSES;

CYTOLYTIC LYMPHOCYTES; IMMUNE RESPONSE; PSEUDORABIES VIRUS; VACCINATION; VIRAL ANTIGENS;

CELLS;

CD4 ANTIGEN; CD6 ANTIGEN; CD8 ANTIGEN; DIFFERENTIATION ANTIGEN; EPITOPE; LEUKOCYTE ANTIGEN; LYMPHOCYTE ANTIBODY; MONOCLONAL ANTIBODY; VIRUS ANTIGEN;

ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; CONFERENCE PAPER; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; HELPER CELL; IMMUNE RESPONSE; LYMPHOCYTE SUBPOPULATION; NONHUMAN; PESTIVIRUS; PRIORITY JOURNAL; PSEUDORABIES HERPETOVIRUS; SWINE; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD4; ANTIGENS, CD8; ANTIGENS, VIRAL; BIOTECHNOLOGY; CYTOTOXICITY, IMMUNOLOGIC; LYMPHOCYTE ACTIVATION; PHENOTYPE; SWINE; T-LYMPHOCYTE SUBSETS;

CLASSICAL SWINE FEVER VIRUS; SUID HERPESVIRUS 1; SUIDAE; SUS SCROFA;

EID: 0344631090     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1656(99)00140-6     Document Type: Conference Paper

References (70)

1. Allison J.P., Lanier L.L. Structure, function, and serology of the T-cell antigen receptor complex. Annu. Rev. Immunol. 5:1987;503-540.
2. Anton I.M., Sune C., Meloen R.H., Borras-Cuesta F., Enjuanes L. A transmissible gastroenteritis coronavirus nucleoprotein epitope elicits T helper cells that collaborate in the in vitro antibody synthesis to the three major structural viral proteins. Virology. 212:1995;746-751.
3. Anton I.M., Gonzalez S., Bullido M.J., Corsin M., Risco C., Langeveld J.P., Enjuanes L. Cooperation between transmissible gastroenteritis coronavirus (TGEV) structural proteins in the in vitro induction of virus-specific antibodies. Virus Res. 46:1996;111-124.
4. Binns R.M. The Null/γ δ TCR+T cell family in the pig. Vet. Immunol. Immunopathol. 43:1994;69-77.
5. Binns R.M., Pabst R., Licence S.T. Subpopulations of T lymphocytes emigrating in venous blood draining pig thymus labelled in vivo with fluorochrome. Immunology. 63:1988;261-267.
6. Binns R.M., Duncan I.A., Powis S.J., Hutchings A., Butcher G.W. Subsets of null and γ δ T-cell receptor+ T lymphocytes in the blood of young pigs identified by specific monoclonal antibodies. Immunology. 77:1992;219-227.
7. Binns R.M., Bischof R., Carr M.M., Davis W.C., Licence S.T., Misfeldt M., Pospisil R. Report on the behaviour of monoclonal antibodies in the First International Pig CD Workshop identifying the Null cell families. Vet. Immunol. Immunopathol. 43:1994;279-287.
8. Brown M.H., Sewell W.A., Mason D.Y., Rothbard J.B., Crumpton M.J. Species conservation of the T cell lymphocyte CD2 cell surface antigen. Eur. J. Immunol. 18:1988;1223-1227.
9. Canals A., Alonso F., Tomillo J., Dominguez J. Analysis of T lymphocyte subsets proliferating in response to infective and UV-inactivated African swine fever viruses. Vet. Microbiol. 33:1992;117-127.
10. Carr M.M., Howard C.J., Sopp P., Manser J.M., Parsons K.R. Expression on porcine γ δ lymphocytes of a phylogenetically conserved surface antigen previously restricted in expression to ruminant gamma delta T lymphocytes. Immunology. 81:1994;36-40.
11. Chinsakchai S., Molitor T.W. Immunobiology of pseudorabies virus infection in swine. Vet. Immunol. Immunopathol. 43:1994;107-116.
12. Clevers H., Alarcon B., Wileman T., Terhorst C. The T cell receptor/CD3 complex: a dynamic protein ensemble. Annu. Rev. Immunol. 6:1988;629-662.
13. Davis W.C., Zuckermann F.A., Hamilton M.J., Barbosa J.I., Saalmüller A., Binns R.M., Licence S.T. Analysis of monoclonal antibodies that recognize γ/δ T/Null cells. Vet. Immunol. Immunopathol. 60:1998;305-316.
14. Hammerberg C., Schurig G.G. Characterization of monoclonal antibodies directed against swine leukocytes. Vet. Immunol. Immunopathol. 11:1986;107-121.
15. Hirt W., Saalmüller A., Reddehase M.J. Distinct γ/δ T cell receptors define two subsets of circulating porcine CD2-CD4-CD8- T lymphocytes. Eur. J. Immunol. 20:1990;265-269.
16. Hirt W., Saalmüller A., Reddehase M.J. Expression of γ/δ T cell receptors in porcine thymus. Immunobiology. 188:1993;70-81.
17. Hood L., Kronenberg M., Hunkapiller T. T cell antigen receptors and the immunoglobulin supergene family. Cell. 40:1985;225-229.
18. Jonjic S., Koszinowski U.H. Monoclonal antibodies reactive with swine lymphocytes. I. Antibodies to membrane structures that define the cytolytic T lymphocyte subset in the swine. J. Immunol. 133:1984;647-652.
19. Kimman T.G., Bianchi A.T., Wensvoort G., de Bruin T.G., Meliefste C. Cellular immune response to hog cholera virus (HCV): T cells of immune pigs proliferate in vitro upon stimulation with live HCV, but the E1 envelope glycoprotein is not a major T-cell antigen. J. Virol. 67:1993;2922-2927.
20. Kimman T.G., De Bruin T.M., Voermans J.J., Peeters B.P., Bianchi A.T. Development and antigen specificity of the lymphoproliferation responses of pigs to pseudorabies virus: dichotomy between secondary B- and T-cell responses. Immunology. 86:1995;372-378.
21. Kimman T.G., DeBruin T.G., Voermans J.J., Bianchi A.T. Cell-mediated immunity to pseudorabies virus: cytolytic effector cells with characteristics of lymphokine-activated killer cells lyse virus-infected and glycoprotein gB- and gC-transfected L14 cells. J. Gen. Virol. 77:1996;987-990.
22. Kirkham P.A., Takamatsu H., Yang H., Parkhouse R.M. Porcine CD3 epsilon: its characterization, expression and involvement in activation of porcine T lymphocytes. Immunology. 87:1996;616-623.
23. Kronenberg M., Kraig E., Hood L. Finding the T-cell antigen receptor: past attempts and future promise. Cell. 34:1983;327-329.
24. Kronenberg M., Siu G., Hood L.E., Shastri N. The molecular genetics of the T-cell antigen receptor and T-cell antigen recognition. Annu. Rev. Immunol. 4:1986;529-591.
25. Kronenberg M., Brines R., Kaufman J. MHC evolution: a long term investment in defense. Immunol. Today. 15:1994;4-6.
26. Lanier L.L., Allison J.P., Phillips J.H. Correlation of cell surface antigen expression on human thymocytes by multi-color flow cytometric analysis: implications for differentiation. J. Immunol. 137:1986;2501-2507.
27. Lunney J.K. Characterization of swine leukocyte differentiation antigens. Immunol. Today. 14:1993;147-148.
28. Mackay C.R., Hein W.R. Analysis of γ δ T cells in ruminants reveals further heterogeneity in γ δ T-cell features and function among species. Res. Immunol. 141:1990;611-614.
29. Mackay C.R., Maddox J.F., Brandon M.R. Three distinct subpopulations of sheep T lymphocytes. Eur. J. Immunol. 16:1986;19-25.
30. Martins C.L., Leitao A.C. Porcine immune responses to African swine fever virus (ASFV) infection. Vet. Immunol. Immunopathol. 43:1994;99-106.
31. Martins C.L., Lawman M.J., Scholl T., Mebus C.A., Lunney J.K. African swine fever virus specific porcine cytotoxic T cell activity. Arch. Virol. 129:1993;211-225.
32. + memory T-helper cells in swine. J. Virol. 72:1998;4866-4873.
33. Pauly T., Elbers K., König M., Lengsfeld T., Saalmüller A., Thiel H.J. Classical swine fever virus-specific cytotoxic T lymphocytes and identification of a T cell epitope. J. Gen. Virol. 76:1995;3039-3049.
34. Pauly T., Weiland E., Hirt W., Dreyer-Bux C., Maurer S., Summerfield A., Saalmüller A. Differentiation between MHC-restricted and non-MHC-restricted porcine cytolytic T lymphocytes. Immunology. 88:1996;238-246.
35. Pescovitz M.D., Lunney J.K., Sachs D.H. Preparation and characterization of monoclonal antibodies reactive with porcine PBL. J. Immunol. 133:1984;368-375.
36. Pescovitz M.D., Lunney J.K., Sachs D.H. Murine anti-swine T4 and T8 monoclonal antibodies: distribution and effects on proliferative and cytotoxic T cells. J. Immunol. 134:1985;37-44.
37. Pescovitz M.D., Lowman M.A., Sachs D.H. Expression of T-cell associated antigens by porcine natural killer cells. Immunology. 65:1988;267-271.
38. Pescovitz M.D., Hsu S.M., Katz S.I., Lunney J.K., Shimada S., Sachs D.H. Characterization of a porcine CD1-specific mAb that distinguishes CD4/CD8 double-positive thymic from peripheral T lymphocytes. Tissue Antigens. 35:1990;151-156.
39. Pescovitz M.D., Aasted B., Canals A., Dominguez J., Vizcaino J.S., Pospisil R., Trebichavsky I., Salmon H., Valpotic I., Davis W.C., Sinkora J. Analysis of monoclonal antibodies reactive with the porcine CD4 antigen. Vet. Immunol. Immunopathol. 43:1994;233-236.
40. Pescovitz M.D., Sakopoulos A.G., Gaddy J.A., Husmann R.J., Zuckermann F.A. Porcine peripheral blood CD4+/CD8+ dual expressing T-cells. Vet. Immunol. Immunopathol. 43:1994;53-62.
41. Pescovitz M.D., Book B.K., Aasted B., Dominguez J., Esquerra A., Trebichavsky I., Novikov B., Valpotic I., Nielsen J., Arn J.S., Sachs D.H., Lunney J.K., Boyd P.C., Walker I.D., Lee R., Lackovic G., Kirkham P.A., Parkhouse R.M., Saalmüller A. Analyses of monoclonal antibodies reacting with porcine CD3: result from the Second International Swine CD workshop. Vet. Immunol. Immunopathol. 60:1998;261-268.
42. Reddehase M.J., Saalmüller A., Hirt W. Gamma/delta T-lymphocyte subsets in swine. Curr. Top. Microbiol. Immunol. 173:1991;113-117.
43. Revilla Y., Pena L., Vinuela E. Interferon-γ production by African swine fever virus-specific lymphocytes. Scand. J. Immunol. 35:1992;225-230.
44. Rodriguez A., Saiz J.C., Novella I.S., Andreu D., Sobrino F. Antigenic specificity of porcine T cell response against foot-and-mouth disease virus structural proteins: identification of T helper epitopes in VP1. Virology. 205:1994;24-33.
45. Rodriguez A., Saiz J.C., Sobrino F. In vitro synthesis of foot-and-mouth disease virus specific antibodies by porcine leukocytes. Arch. Virol. 140:1995;1645-1652.
46. Saalmüller A. Characterization of swine leukocyte differentiation antigens. Immunol. Today. 17:1996;352-354.
47. Saalmüller A., Bryant J. Characteristics of porcine T lymphocytes and T-cell lines. Vet. Immunol. Immunopathol. 43:1994;45-52.
48. Saalmüller A., Jonjic S., Bühring H.J., Reddehase M.J., Koszinowski U.H. Monoclonal antibodies reactive with swine lymphocytes. II. Detection of an antigen on resting T cells down-regulated after activation. J. Immunol. 138:1987;1852-1857.
49. Saalmüller A., Reddehase M.J., Bühring H.J., Jonjic S., Koszinowski U.H. Simultaneous expression of CD4 and CD8 antigens by a substantial proportion of resting porcine T lymphocytes. Eur. J. Immunol. 17:1987;1297-1301.
50. Saalmüller A., Hirt W., Reddehase M.J. Phenotypic discrimination between thymic and extrathymic CD4-CD8- and CD4+CD8+ porcine T lymphocytes. Eur. J. Immunol. 19:1989;2011-2016.
51. Saalmüller A., Hirt W., Reddehase M.J. Porcine γ/δ T lymphocyte subsets differing in their propensity to home to lymphoid tissue. Eur. J. Immunol. 20:1990;2343-2346.
52. Saalmüller A., Weiland F., Reddehase M.J. Resting porcine T lymphocytes expressing class II major histocompatibility antigen. Immunobiology. 183:1991;102-114.
53. Saalmüller A., Aasted B., Canals A., Dominguez J., Goldman T., Lunney J.K., Maurer S., Pauly T., Pescovitz M.D., Pospisil R., Salmon H. Analyses of monoclonal antibodies reactive with porcine CD6. Vet. Immunol. Immunopathol. 43:1994;243-247.
54. Saalmüller A., Aasted B., Canals A., Dominguez J., Goldman T., Lunney J.K., Maurer S., Pescovitz M.D., Pospisil R., Salmon H. et al. Analyses of mAb reactive with porcine CD8. Vet. Immunol. Immunopathol. 43:1994;249-254.
55. Saalmüller A., Aasted B., Canals A., Dominguez J., Goldman T., Lunney J.K., Maurer S., Pescovitz M.D., Pospisil R., Salmon H. et al. Analyses of monoclonal antibodies reactive with porcine CD5. Vet. Immunol. Immunopathol. 43:1994;237-242.
56. Saalmüller A., Hirt W., Maurer S., Weiland E. Discrimination between two subsets of porcine CD8+ cytolytic T lymphocytes by the expression of CD5 antigen. Immunology. 81:1994;578-583.
57. Saif L.J., van Cott J.L., Brim T.A. Immunity to transmissible gastroenteritis virus and porcine respiratory coronavirus infections in swine. Vet. Immunol. Immunopathol. 43:1994;89-97.
58. Scollay R., Bartlett P., Shortman K. T cell development in the adult murine thymus: changes in the expression of the surface antigens Ly2, L3T4 and B2A2 during development from early precursor cells to emigrants. Immunol. Rev. 82:1984;79-103.
59. Shimizu M., Shimizu Y. Demonstration of cytotoxic lymphocytes to virus-infected target cells in pigs inoculated with transmissible gastroenteritis virus. Am. J. Vet. Res. 40:1979;208-213.
60. Shimizu M., Pan I.C., Hess W.R. Cellular immunity demonstrated in pigs infected with African swine fever virus. Am. J. Vet. Res. 38:1977;27-31.
61. Summerfield A., Rziha H.J., Saalmüller A. Functional characterization of porcine CD4+CD8+ extrathymic T lymphocytes. Cell. Immunol. 168:1996;291-296.
62. Susa M., König M., Saalmüller A., Reddehase M.J., Thiel H.J. Pathogenesis of classical swine fever: B-lymphocyte deficiency caused by hog cholera virus. J. Virol. 66:1992;1171-1175.
63. Thome A., Saalmüller A., Pfaff E. Molecular cloning of porcine T cell receptor α, β, γ and δ chains using polymerase chain reaction fragments of the constant regions. Eur. J. Immunol. 23:1993;1005-1010.
64. Thome M., Hirt W., Pfaff E., Reddehase M.J., Saalmüller A. Porcine T-cell receptors: molecular and biochemical characterization. Vet. Immunol. Immunopathol. 43:1994;13-18.
65. Wardley R.C. Effect of African swine fever on lymphocyte mitogenesis. Immunology. 46:1982;215-220.
66. Woods R.D. Humoral and cellular responses in swine exposed to transmissible gastroenteritis virus. Am. J. Vet. Res. 40:1979;108-110.
67. Yang H., Parkhouse R.M. Phenotypic classification of porcine lymphocyte subpopulations in blood and lymphoid tissues. Immunology. 89:1996;76-83.
68. Yang H., Oura C.A., Kirkham P.A., Parkhouse R.M. Preparation of monoclonal anti-porcine CD3 antibodies and preliminary characterization of porcine T lymphocytes. Immunology. 88:1996;577-585.
69. Zuckermann F.A., Gaskins H.R. Distribution of porcine CD4/CD8 double-positive T lymphocytes in mucosa-associated lymphoid tissues. Immunology. 87:1996;493-499.
70. Zuckermann F.A., Zsak L., Mettenleiter T.C., Ben-Porat T. Pseudorabies virus glycoprotein gIII is a major target antigen for murine and swine virus-specific cytotoxic T lymphocytes. J. Virol. 64:1990;802-812.