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Volumn 19, Issue 4, 2013, Pages 237-249

CCN3 regulates proliferation and migration properties in Jeg3 trophoblast cells via ERK1/2, akt and notch signalling

Author keywords

CCN3 (NOV); Glycosylation; Signalling; Trophoblast migration; Trophoblast proliferation

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1A; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NEPHROBLASTOMA OVEREXPRESSED PROTEIN; NOTCH RECEPTOR; NOTCH1 RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RECOMBINANT PROTEIN; VERY LATE ACTIVATION ANTIGEN 5;

EID: 84875631842     PISSN: 13609947     EISSN: 14602407     Source Type: Journal    
DOI: 10.1093/molehr/gas061     Document Type: Article
Times cited : (31)

References (50)
  • 1
    • 77953719496 scopus 로고    scopus 로고
    • PI3K/ Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells
    • Aksamitiene E, Kholodenko BN, Kolch W, Hoek JB, Kiyatkin A. PI3K/ Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells. Cell Signal 2010;22:1369-1378.
    • (2010) Cell Signal , vol.22 , pp. 1369-1378
    • Aksamitiene, E.1    Kholodenko, B.N.2    Kolch, W.3    Hoek, J.B.4    Kiyatkin, A.5
  • 2
    • 0027243804 scopus 로고
    • Expression of integrin alpha 6 beta 4 in human trophoblast and its loss from extravillous cells
    • Aplin JD. Expression of integrin alpha 6 beta 4 in human trophoblast and its loss from extravillous cells. Placenta 1993;14:203-215.
    • (1993) Placenta , vol.14 , pp. 203-215
    • Aplin, J.D.1
  • 3
    • 0029418480 scopus 로고
    • Intrauterine programming of adult disease
    • Barker DJ. Intrauterine programming of adult disease. Mol Med Today 1995;1:418-423.
    • (1995) Mol Med Today , vol.1 , pp. 418-423
    • Barker, D.J.1
  • 5
    • 33645231002 scopus 로고    scopus 로고
    • CCN proteins and cancer: two to tango
    • Bleau AM, Planque N, Perbal B. CCN proteins and cancer: two to tango. Front Biosci 2005;10:998-1009.
    • (2005) Front Biosci , vol.10 , pp. 998-1009
    • Bleau, A.M.1    Planque, N.2    Perbal, B.3
  • 6
    • 77956309916 scopus 로고    scopus 로고
    • Notch targets and their regulation
    • Bray S, Bernard F. Notch targets and their regulation. Curr Top Dev Biol 2010;92:253-275.
    • (2010) Curr Top Dev Biol , vol.92 , pp. 253-275
    • Bray, S.1    Bernard, F.2
  • 7
    • 0036407347 scopus 로고    scopus 로고
    • Hepatocyte growth factor induced human trophoblast motility involves phosphatidylinositol-3-kinase, mitogen-activated protein kinase, and inducible nitric oxide synthase
    • Cartwright JE, Tse WK, Whitley GS. Hepatocyte growth factor induced human trophoblast motility involves phosphatidylinositol-3-kinase, mitogen-activated protein kinase, and inducible nitric oxide synthase. Exp Cell Res 2002;279:219-226.
    • (2002) Exp Cell Res , vol.279 , pp. 219-226
    • Cartwright, J.E.1    Tse, W.K.2    Whitley, G.S.3
  • 8
    • 59649107705 scopus 로고    scopus 로고
    • Functions and mechanisms of action of CCN matricellular proteins
    • Chen CC, Lau LF. Functions and mechanisms of action of CCN matricellular proteins. Int J Biochem Cell Biol 2009;41:771-783.
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 771-783
    • Chen, C.C.1    Lau, L.F.2
  • 10
    • 33847290472 scopus 로고    scopus 로고
    • Molecular circuits shared by placental and cancer cells, and their implications in the proliferative, invasive and migratory capacities of trophoblasts
    • Ferretti C, Bruni L, Dangles-Marie V, Pecking AP, Bellet D. Molecular circuits shared by placental and cancer cells, and their implications in the proliferative, invasive and migratory capacities of trophoblasts. Hum Reprod Update 2007;13:121-141.
    • (2007) Hum Reprod Update , vol.13 , pp. 121-141
    • Ferretti, C.1    Bruni, L.2    Dangles-Marie, V.3    Pecking, A.P.4    Bellet, D.5
  • 12
    • 33745589760 scopus 로고    scopus 로고
    • Decreased expression of the angiogenic regulators CYR61 (CCN1) and NOV (CCN3) in human placenta is associated with pre-eclampsia
    • Gellhaus A, Schmidt M, Dunk C, Lye SJ, Kimmig R, Winterhager E. Decreased expression of the angiogenic regulators CYR61 (CCN1) and NOV (CCN3) in human placenta is associated with pre-eclampsia. Mol Hum Reprod 2006;12:389-399.
    • (2006) Mol Hum Reprod , vol.12 , pp. 389-399
    • Gellhaus, A.1    Schmidt, M.2    Dunk, C.3    Lye, S.J.4    Kimmig, R.5    Winterhager, E.6
  • 13
    • 38749086173 scopus 로고    scopus 로고
    • The circulating proangiogenic factors CYR61 (CCN1) and NOV (CCN3) are significantly decreased in placentae and sera of preeclamptic patients
    • Gellhaus A, Schmidt M, Dunk C, Lye SJ, Winterhager E. The circulating proangiogenic factors CYR61 (CCN1) and NOV (CCN3) are significantly decreased in placentae and sera of preeclamptic patients. Reprod Sci 2007;14:46-52.
    • (2007) Reprod Sci , vol.14 , pp. 46-52
    • Gellhaus, A.1    Schmidt, M.2    Dunk, C.3    Lye, S.J.4    Winterhager, E.5
  • 14
    • 0034971842 scopus 로고    scopus 로고
    • Insulin-like growth factor-binding protein 1 stimulates human trophoblast migration by signalling through alpha 5 beta 1 Integrin via mitogen-activated protein Kinase pathway
    • Gleeson LM, Chakraborty C, McKinnon T, Lala PK. Insulin-like growth factor-binding protein 1 stimulates human trophoblast migration by signalling through alpha 5 beta 1 Integrin via mitogen-activated protein Kinase pathway. J Clin Endocrinol Metab 2001;86:2484-2493.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 2484-2493
    • Gleeson, L.M.1    Chakraborty, C.2    McKinnon, T.3    Lala, P.K.4
  • 15
    • 79960538052 scopus 로고    scopus 로고
    • The long-term effects of prenatal development on growth and metabolism
    • Godfrey KM, Inskip HM, Hanson MA. The long-term effects of prenatal development on growth and metabolism. Semin Reprod Med 2011; 29:257-265.
    • (2011) Semin Reprod Med , vol.29 , pp. 257-265
    • Godfrey, K.M.1    Inskip, H.M.2    Hanson, M.A.3
  • 17
    • 79960578614 scopus 로고    scopus 로고
    • Expression patterns of Notch receptors and their ligands Jagged and Delta in human placenta
    • Herr F, Schreiner I, Baal N, Pfarrer C, Zygmunt M. Expression patterns of Notch receptors and their ligands Jagged and Delta in human placenta. Placenta 2011;32:554-563.
    • (2011) Placenta , vol.32 , pp. 554-563
    • Herr, F.1    Schreiner, I.2    Baal, N.3    Pfarrer, C.4    Zygmunt, M.5
  • 18
    • 79551474865 scopus 로고    scopus 로고
    • Nephroblastoma overexpressed gene (NOV) enhances cell motility and COX-2 upregulation of human osteosarcoma involves alphavbeta5 integrin
    • HuangCY, LeeCY, ChenMY, Tsai HC, Hsu HC, Tang CH. Nephroblastoma overexpressed gene (NOV) enhances cell motility and COX-2 upregulation of human osteosarcoma involves alphavbeta5 integrin, ILK and AP-1-dependent pathways. Biochem Pharmacol 2011;81:577-585.
    • (2011) ILK and AP-1-dependent pathways. Biochem Pharmacol , vol.81 , pp. 577-585
    • Huang, C.Y.1    Lee, C.Y.2    Chen, M.Y.3    Tsai, H.C.4    Hsu, H.C.5    Tang, C.H.6
  • 21
    • 82455198983 scopus 로고    scopus 로고
    • Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets
    • Jun JI, Lau LF. Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets. Nat Rev Drug Discov 2011;10:945-963.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 945-963
    • Jun, J.I.1    Lau, L.F.2
  • 23
    • 77950350575 scopus 로고    scopus 로고
    • Critical growth factors and signalling pathways controlling human trophoblast invasion
    • Knofler M. Critical growth factors and signalling pathways controlling human trophoblast invasion. Int J Dev Biol 2010;54:269-280.
    • (2010) Int J Dev Biol , vol.54 , pp. 269-280
    • Knofler, M.1
  • 24
    • 84855996001 scopus 로고    scopus 로고
    • IFPA award in placentology lecture: molecular regulation of human trophoblast invasion
    • Knöfler M, Pollheimer J. IFPA award in placentology lecture: molecular regulation of human trophoblast invasion. Placenta 2012; 33(Suppl):S55-S62.
    • (2012) Placenta , vol.33 , Issue.SUPPL.
    • Knöfler, M.1    Pollheimer, J.2
  • 28
    • 14844311198 scopus 로고    scopus 로고
    • Integrin-dependent functions of the angiogenic inducer NOV (CCN3): implication in wound healing
    • Lin CG, Chen CC, Leu SJ, Grzeszkiewicz TM, Lau LF. Integrin-dependent functions of the angiogenic inducer NOV (CCN3): implication in wound healing. J Biol Chem 2005;280:8229-8237.
    • (2005) J Biol Chem , vol.280 , pp. 8229-8237
    • Lin, C.G.1    Chen, C.C.2    Leu, S.J.3    Grzeszkiewicz, T.M.4    Lau, L.F.5
  • 31
    • 0034885755 scopus 로고    scopus 로고
    • Stimulation of human extravillous trophoblast migration by IGF-II is mediated by IGF type 2 receptor involving inhibitory G protein(s) and phosphorylation of MAPK
    • McKinnon T, Chakraborty C, Gleeson LM, Chidiac P, Lala PK. Stimulation of human extravillous trophoblast migration by IGF-II is mediated by IGF type 2 receptor involving inhibitory G protein(s) and phosphorylation of MAPK. J Clin Endocrinol Metab 2001;86:3665-3674.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 3665-3674
    • McKinnon, T.1    Chakraborty, C.2    Gleeson, L.M.3    Chidiac, P.4    Lala, P.K.5
  • 32
    • 8644241070 scopus 로고    scopus 로고
    • Abnormal placentation and the syndrome of preeclampsia
    • McMaster MT, Zhou Y, Fisher SJ. Abnormal placentation and the syndrome of preeclampsia. Semin Nephrol 2004;24:540-547.
    • (2004) Semin Nephrol , vol.24 , pp. 540-547
    • McMaster, M.T.1    Zhou, Y.2    Fisher, S.J.3
  • 33
    • 0035060101 scopus 로고    scopus 로고
    • NOV (nephroblastoma overexpressed) and the CCN family of genes: structural and functional issues
    • Perbal B. NOV (nephroblastoma overexpressed) and the CCN family of genes: structural and functional issues. Mol Pathol 2001;54:57-79.
    • (2001) Mol Pathol , vol.54 , pp. 57-79
    • Perbal, B.1
  • 34
    • 17044399745 scopus 로고    scopus 로고
    • Signalling pathways regulating the invasive differentiation of human trophoblasts: a review
    • Pollheimer J, Knofler M. Signalling pathways regulating the invasive differentiation of human trophoblasts: a review. Placenta 2005; 26(Suppl A):S21-S30.
    • (2005) Placenta , vol.26 , Issue.SUPPL A
    • Pollheimer, J.1    Knofler, M.2
  • 35
    • 40849106618 scopus 로고    scopus 로고
    • Human chorionic gonadotropin stimulates trophoblast invasion through extracellularly regulated kinase and AKT signaling
    • Prast J, Saleh L, Husslein H, Sonderegger S, Helmer H, Knöfler M. Human chorionic gonadotropin stimulates trophoblast invasion through extracellularly regulated kinase and AKT signaling. Endocrinology 2008; 149:979-987.
    • (2008) Endocrinology , vol.149 , pp. 979-987
    • Prast, J.1    Saleh, L.2    Husslein, H.3    Sonderegger, S.4    Helmer, H.5    Knöfler, M.6
  • 36
    • 5044246271 scopus 로고    scopus 로고
    • Both mitogen-activated protein kinase and phosphatidylinositol 3-kinase signalling are required in epidermal growth factor-induced human trophoblast migration
    • Qiu Q, Yang M, Tsang BK, Gruslin A. Both mitogen-activated protein kinase and phosphatidylinositol 3-kinase signalling are required in epidermal growth factor-induced human trophoblast migration. Mol Hum Reprod 2004a;10:677-684.
    • (2004) Mol Hum Reprod , vol.10 , pp. 677-684
    • Qiu, Q.1    Yang, M.2    Tsang, B.K.3    Gruslin, A.4
  • 37
    • 4544271532 scopus 로고    scopus 로고
    • EGF-induced trophoblast secretion of MMP-9 and TIMP-1 involves activation of both PI3K and MAPK signalling pathways
    • Qiu Q, Yang M, Tsang BK, Gruslin A. EGF-induced trophoblast secretion of MMP-9 and TIMP-1 involves activation of both PI3K and MAPK signalling pathways. Reproduction 2004b;128:355-363.
    • (2004) Reproduction , vol.128 , pp. 355-363
    • Qiu, Q.1    Yang, M.2    Tsang, B.K.3    Gruslin, A.4
  • 38
    • 0037119414 scopus 로고    scopus 로고
    • The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signalling pathway
    • Sakamoto K, Yamaguchi S, Ando R, Miyawaki A, Kabasawa Y, Takagi M, Li CL, Perbal B, Katsube K. The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signalling pathway. J Biol Chem 2002;277:29399-29405.
    • (2002) J Biol Chem , vol.277 , pp. 29399-29405
    • Sakamoto, K.1    Yamaguchi, S.2    Ando, R.3    Miyawaki, A.4    Kabasawa, Y.5    Takagi, M.6    Li, C.L.7    Perbal, B.8    Katsube, K.9
  • 41
    • 80053135249 scopus 로고    scopus 로고
    • CCN3 increases cell motility and MMP-13 expression in human chondrosarcoma through integrin dependent pathway
    • Tzeng HE, Chen JC, Tsai CH, Kuo CC, Hsu HC, Hwang WL, Fong YC, Tang CH. CCN3 increases cell motility and MMP-13 expression in human chondrosarcoma through integrin dependent pathway. J Cell Physiol 2011;226:3181-3189.
    • (2011) J Cell Physiol , vol.226 , pp. 3181-3189
    • Tzeng, H.E.1    Chen, J.C.2    Tsai, C.H.3    Kuo, C.C.4    Hsu, H.C.5    Hwang, W.L.6    Fong, Y.C.7    Tang, C.H.8
  • 43
    • 0028859275 scopus 로고
    • Trophoblast differentiation during formation of anchoring villi in a model of the early human placenta in vitro
    • Vicovac L, Jones CJ, Aplin JD. Trophoblast differentiation during formation of anchoring villi in a model of the early human placenta in vitro. Placenta 1995;16:41-56.
    • (1995) Placenta , vol.16 , pp. 41-56
    • Vicovac, L.1    Jones, C.J.2    Aplin, J.D.3
  • 44
    • 67649227647 scopus 로고    scopus 로고
    • Preeclampsia: the role of angiogenic factors in its pathogenesis
    • Wang A, Rana S, Karumanchi SA. Preeclampsia: the role of angiogenic factors in its pathogenesis. Physiology (Bethesda) 2009; 24:147-158.
    • (2009) Physiology (Bethesda) , vol.24 , pp. 147-158
    • Wang, A.1    Rana, S.2    Karumanchi, S.A.3
  • 45
    • 77954516498 scopus 로고    scopus 로고
    • Regulation of the matricellular proteins CYR61 (CCN1) and NOV (CCN3) by hypoxia-inducible factor-1{alpha} and transforming-growth factor-{beta}3 in the human trophoblast
    • Wolf N, Yang W, Dunk CE, Gashaw I, Lye SJ, Ring T, Schmidt M, Winterhager E, Gellhaus A. Regulation of the matricellular proteins CYR61 (CCN1) and NOV (CCN3) by hypoxia-inducible factor-1{alpha} and transforming-growth factor-{beta}3 in the human trophoblast. Endocrinology 2010;151:2835-2845.
    • (2010) Endocrinology , vol.151 , pp. 2835-2845
    • Wolf, N.1    Yang, W.2    Dunk, C.E.3    Gashaw, I.4    Lye, S.J.5    Ring, T.6    Schmidt, M.7    Winterhager, E.8    Gellhaus, A.9
  • 46
    • 80052908924 scopus 로고    scopus 로고
    • Impact of CCN3 (NOV) glycosylation on migration/ invasion properties and cell growth of the choriocarcinoma cell line Jeg3
    • Yang W, Wagener J, Wolf N, Schmidt M, Kimmig R, Winterhager E, Gellhaus A. Impact of CCN3 (NOV) glycosylation on migration/ invasion properties and cell growth of the choriocarcinoma cell line Jeg3. Hum Reprod 2011;26:2850-2860.
    • (2011) Hum Reprod , vol.26 , pp. 2850-2860
    • Yang, W.1    Wagener, J.2    Wolf, N.3    Schmidt, M.4    Kimmig, R.5    Winterhager, E.6    Gellhaus, A.7
  • 47
    • 59249094289 scopus 로고    scopus 로고
    • Posttranscriptional regulation of p53 and its targets by RNA-binding proteins
    • Zhang J, Chen X. Posttranscriptional regulation of p53 and its targets by RNA-binding proteins. Curr Mol Med 2008;8:845-849.
    • (2008) Curr Mol Med , vol.8 , pp. 845-849
    • Zhang, J.1    Chen, X.2
  • 48
    • 0027447257 scopus 로고
    • Preeclampsia is associated with abnormal expression of adhesion molecules by invasive cytotrophoblasts
    • Zhou Y, Damsky CH, Chiu K, Roberts JM, Fisher SJ. Preeclampsia is associated with abnormal expression of adhesion molecules by invasive cytotrophoblasts. J Clin Invest 1993;91:950-960.
    • (1993) J Clin Invest , vol.91 , pp. 950-960
    • Zhou, Y.1    Damsky, C.H.2    Chiu, K.3    Roberts, J.M.4    Fisher, S.J.5
  • 50
    • 0031792141 scopus 로고    scopus 로고
    • Invasion of cytotrophoblastic JEG-3 cells is stimulated by hCG in vitro
    • Zygmunt M, Hahn D, Munstedt K, Bischof P, Lang U. Invasion of cytotrophoblastic JEG-3 cells is stimulated by hCG in vitro. Placenta 1998;19:587-593.
    • (1998) Placenta , vol.19 , pp. 587-593
    • Zygmunt, M.1    Hahn, D.2    Munstedt, K.3    Bischof, P.4    Lang, U.5


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