Both mitogen-activated protein kinase and phosphatidylinositol 3-kinase signalling are required in epidermal growth factor-induced human trophoblast migration

Molecular Human Reproduction

Volumn 10, Issue 9, 2004, Pages 677-684

  Qiu, Qing ^a   Yang, Mingyan ^a   Tsang, Benjamin K ^a,b   Gruslin, Andrée ^a,b  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

Author keywords

MAPK; Migration; p70S6K; PI3K; Trophoblast

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAPAMYCIN; S6 KINASE; SERINE; TARGET OF RAPAMYCIN KINASE; THREONINE; WORTMANNIN;

ARTICLE; CELL MIGRATION; CONCENTRATION RESPONSE; DATA ANALYSIS; ENZYME PHOSPHORYLATION; PLACENTA; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TROPHOBLAST;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BUTADIENES; CELL LINE; CELL MOVEMENT; EPIDERMAL GROWTH FACTOR; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; NITRILES; PHOSPHORYLATION; PLACENTA; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SIROLIMUS; TROPHOBLASTS;

MAMMALIA;

EID: 5044246271     PISSN: 13609947     EISSN: None     Source Type: Journal    
DOI: 10.1093/molehr/gah088     Document Type: Article

References (41)

1. Andresen JL, Ledet T and Ehlers N (1997) Keratocyte migration and peptide growth factors: the effect of PDGF, bFGF, EGF, IGF-I, aFGF and TGF-beta on human keratocyte migration in a collagen gel. Curr Eye Res 16,605-613.
2. Avruch J, Belham C, Weng Q, Hara K and Yonezawa K (2001) The p70 S6 kinase integrates nutrient and growth signals to control translational capacity. Prog Mol Subcell Biol 26,115-154.
3. Bass KE, Morrish D, Roth I, Bhardwaj D, Taylor R, Zhou Y and Fisher SJ (1994) Human cytotrophoblast invasion is up-regulated by epidermal growth factor: evidence that paracrine factors modify this process. Dev Biol 164,550-561.
4. Berven LA and Crouch MF (2000) Cellular function of p70S6K: a role in regulating cell motility. Immunol Cell Biol 78,447-451.
5. Blagosklonny MV (2002) Are p27 and p21 cytoplasmic oncoproteins? Cell Cycle 1,391-393.
6. Brunet A, Bonni A, Zigmond MJ et al. (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96, 857-868.
7. Cartwright JE, Tse WK and Whitley GS (2002) Hepatocyte growth factor induced human trophoblast motility involves phosphatidylinositol-3-kinase, mitogen-activated protein kinase, and inducible nitric oxide synthase. Exp Cell Res 279,219-226.
8. Chakraborty C, Barbin YP, Chakrabarti S, Chidiac P, Dixon SJ and Lala PK (2003) Endothelin-1 promotes migration and induces elevation of [Ca(2+)](i) and phosphorylation of MAP kinase of a human extravillous trophoblast cell line. Mol Cell Endocrinol 201,63-73.
9. Chan TO, Rittenhouse SE and Tsichlis PN (1999) AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation. Annu Rev Biochem 68,965-1014.
10. Chou MM and Blenis J (1995) The 70kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling. Curr Opin Cell Biol 7, 806-814.
11. Chou MM and Blenis J (1996) The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1. Cell 85,573-583.
12. Choudhury GG, Karamitsos C, Hernandez J, Gentilini A, Bardgette J and Abboud HE (1997) PI-3-kinase MAPK regulate mesangial cell proliferation and migration in response to PDGF. Am J Physiol 273,F931-F938.
13. Chung J, Grammer TC, Lemon KP, Kazlauskas A and Blenis J (1994) PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase. Nature 370,71-75.
14. Duan C, Bauchat JR and Hsieh T (2000) Phosphatidylinositol 3-kinase is required for insulin-like growth factor-I-induced vascular smooth muscle cell proliferation and migration. Circ Res 86,15-23.
15. Eguchi S, Iwasaki H, Ueno H, Frank GD, Motley ED, Eguchi K, Marumo F, Hirata Y and Inagami T (1999) Intracellular signaling of angiotensin II-induced p70 S6 kinase phosphorylation at Ser(411) in vascular smooth muscle cells. Possible requirement of epidermal growth factor receptor, Ras, extracellular signal-regulated kinase, and Akt. J Biol Chem 274, 36843-36851.
16. Filippa N, Sable CL, Filloux C, Hemmings B and Van Obberghen E (1999) Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase. Mol Cell Biol 19,4989-5000.
17. Genbacev O, Bass KE, Joslin RJ and Fisher SJ (1995) Maternal smoking inhibits early human cytotrophoblast differentiation. Reprod Toxicol 9, 245-255.
18. Gleeson LM, Chakraborty C, McKinnon T and Lala PK (2001) Insulin-like growth factor-binding protein 1 stimulates human trophoblast migration by signaling through alpha 5 beta 1 integrin via mitogen-activated protein Kinase pathway. J Clin Endocrinol Metab 86,2484-2493.
19. Gomez-Cambronero J (2003) Rapamycin inhibits GM-CSF-induced neutrophil migration. FEBS Lett 550,94-100.
20. Graham CH, Hawley TS, Hawley RG, MacDougall JR, Kerbel RS, Khoo N and Lala PK (1993) Establishment and characterization of first trimester human trophoblast cells with extended lifespan. Exp Cell Res 206, 204-211.
21. Haase I, Evans R, Pofahl R and Watt FM (2003) Regulation of keratinocyte shape, migration and wound epithelialization by IGF-1- and EGF-dependent signalling pathways. J Cell Sci 116,3227-3238.
22. Iijima Y, Laser M, Shiraishi H, Willey CD, Sundaravadivel B, Xu L, McDermott PJ and Kuppuswamy D (2002) c-Raf/MEK/ERK pathway controls protein kinase C-mediated p70S6K activation in adult cardiac muscle cells. J Biol Chem 277,23065-23075.
23. Irving JA and Lala PK (1995) Functional role of cell surface integrins on human trophoblast cell migration: regulation by TGF-beta, IGF-II and IGFBP-1. Exp Cell Res 217,419-427.
24. Kaufmann P, Black S and Huppertz B (2003) Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia. Biol Reprod 69,1-7.
25. Kawahara E, Tokuda R and Nakanishi I (1999) Migratory phenotypes of HSC-3 squamous carcinoma cell line induced by EGF and PMA: relevance to migration of loosening of adhesion and vinculin-associated focal contacts with prominent filopodia. Cell Biol Int 23,163-174.
26. Klemke RL, Cai S, Giannini AL, Gallagher PJ, de Lanerolle P and Cheresh DA (1997) Regulation of cell motility by mitogen-activated protein kinase. J. Cell Biol 137,481-492.
27. Lenormand P, McMahon M and Pouyssegur J (1996) Oncogenic Raf-1 activates p70 S6 kinase via a mitogen-activated protein kinase-independent pathway. J Biol Chem 271,15762-15768.
28. Li RH and Zhuang LZ (1997) The effects of growth factors on human normal placental cytotrophoblast cell proliferation. Hum Reprod 12, 830-834.
29. Liu AX, Testa JR, Hamilton TC, Jove R, Nicosia SV and Cheng JQ (1998) AKT2, a member of the protein kinase B family, is activated by growth factors, v-Ha-ras, and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells. Cancer Res 58,2973-2977.
30. Liu J, Chakraborty C, Graham CH, Barbin YP, Dixon SJ and Lala PK (2003) Noncatalytic domain of uPA stimulates human extravillous trophoblast migration by using phospholipase C, phosphatidylinositol 3-kinase and mitogen-activated protein kinase. Exp Cell Res 286,138-151.
31. Maruo T, Matsuo H, Otani T and Mochizuki M (1995) Role of epidermal growth factor (EGF) and its receptor in the development of the human placenta. Reprod Fertil Dev 7,1465-1470.
32. McKinnon T, Chakraborty C, Gleeson LM, Chidiac P and Lala PK (2001) Stimulation of human extravillous trophoblast migration by IGF-II is mediated by IGF type 2 receptor involving inhibitory G protein(s) and phosphorylation of MAPK. J Clin Endocrinol Metab 86, 3665-3674.
33. Ming XF, Burgering BM, Wennstrom S, Claesson-Welsh L, Heldin CH, Bos JL, Kozma SC and Thomas G (1994) Activation of p70/p85 S6 kinase by a pathway independent of p21ras. Nature 371,426-429.
34. Pedersen PH, Ness GO, Engebraaten O, Bjerkvig R, Lillehaug JR and Laerum OD (1994) Heterogeneous response to the growth factors [EGF, PDGF (bb), TGF-alpha, bFGF, IL-2] on glioma spheroid growth, migration and invasion. Int J Cancer 56,255-261.
35. Pullen N and Thomas G (1997) The modular phosphorylation and activation of p70s6k. FEBS Lett 410,78-82.
36. Qian Y, Corum L, Meng Q, Blenis J, Zheng JZ, Shi X, Flynn DC and Jiang BH (2004) PI3K induced actin filament remodeling through Akt and p70S6K1: implication of essential role in cell migration. Am J Physiol Cell 286 (1): C153-63.
37. Shah DM (2001) Perinatal implications of maternal hypertension. Semin Pediatr Neurol 8,108-119.
38. Shiverick KT and Salafia C (1999) Cigarette smoking and pregnancy I: ovarian, uterine and placental effects. Placenta 20,265-272.
39. Squires MS, Hudson EA, Howells L et al. (2003) Relevance of mitogen activated protein kinase (MAPK) and phosphotidylinositol-3-kinase/protein kinase B (PI3K/PKB) pathways to induction of apoptosis by curcumin in breast cells. Biochem Pharmacol 65,361-376.
40. Thomas CY, Chouinard M, Cox M, Parsons S, Stallings-Mann M, Garcia R, Jove R and Wharen R (2003) Spontaneous activation and signaling by overexpressed epidermal growth factor receptors in glioblastoma cells. Int J Cancer 104,19-27.
41. Zotti ME, Replogle WH and Sappenfield WM (2003) Prenatal smoking and birth outcomes among Mississippi residents. J Miss State Med Assoc 44,3-9.