Over-expression of ATR causes autophagic cell death

Genes to Cells

Volumn 18, Issue 4, 2013, Pages 278-287

  Mori, Chihiro ^a   Yamaguchi, Yoshihiro ^b   Teranishi, Mika ^a   Takanami, Takako ^a   Nagase, Takahiro ^b   Kanno, Shinichiro ^a   Yasui, Akira ^a   Higashitani, Atsushi ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b KAZUSA DNA RESEARCH INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ATR PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3; PROTEIN P53; RAS PROTEIN; THIOSALICYLIC ACID; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL DEATH; CELL STRAIN MCF 7; CELL VACUOLE; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENETIC ASSOCIATION; GENETIC REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ATAXIA TELANGIECTASIA; EUKARYOTA;

EID: 84875616549     PISSN: 13569597     EISSN: 13652443     Source Type: Journal    
DOI: 10.1111/gtc.12034     Document Type: Article

References (35)

1. Abou-Zahr, F., Bejjani, B., Kruyt, F.A., Kurg, R., Bacino, C., Shapira, S.K. & Youssoufian, H. (1999) Normal expression of the Fanconi anemia proteins FAA and FAC and sensitivity to mitomycin C in two patients with Seckel syndrome. Am. J. Med. Genet. 83, 388-391.
2. Bhattacharya, S., Ray, R.M. & Johnson, L.R. (2009) Role of polyamines in p53-dependent apoptosis of intestinal epithelial cells. Cell. Signal. 21, 509-522.
3. Brewerton, S.C., Dore, A.S., Drake, A.C., Leuther, K.K. & Blundell, T.L. (2004) Structural analysis of DNA-PKcs: modelling of the repeat units and insights into the detailed molecular architecture. J. Struct. Biol. 145, 295-306.
4. Byun, J.-Y., Yoon, C.-H., An, S., Park, I.-C., Kang, C.-M., Kim, M.-J. & Lee, S.-J. (2009) The Rac1/MKK7/JNK pathway signals upregulation of Atg5 and subsequent autophagic cell death in response to oncogenic Ras. Carcinogenesis 30, 1880-1888.
5. Chi, S., Kitanaka, C., Noguchi, K., Mochizuki, T., Nagashima, Y., Shirouzu, M., Fujita, H., Yoshida, M., Chen, W., Asai, A., Himeno, M., Yokoyama, S. & Kuchino, Y. (1999) Oncogenic Ras triggers cell suicide through the activation of a caspase-independent cell death program in human cancer cells. Oncogene 18, 2281-2290.
6. Cliby, W.A., Roberts, C.J., Cimprich, K.A., Stringer, C.M., Lamb, J.R., Schreiber, S.L. & Friend, S.H. (1998) Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. EMBO J. 17, 159-169.
7. Cortez, D., Guntuku, S., Qin, J. & Elledge, S.J. (2001) ATR and ATRIP: partners in checkpoint signaling. Science 294, 1713-1716.
8. Elgendy, M., Sheridan, C., Brumatti, G. & Martin, S.J. (2011) Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival. Mol. Cell 42, 23-35.
9. Furuta, S., Hidaka, E., Ogata, A., Yokota, S. & Kamata, T. (2004) Ras is involved in the negative control of autophagy through the class I PI3-kinase. Oncogene 23, 3898-3904.
10. Furuya, N., Yu, J., Byfield, M., Pattingre, S. & Levine, B. (2005) The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function. Autophagy 1, 46-52.
11. He, H., Dang, Y., Dai, F., Guo, Z., Wu, J., She, X., Pei, Y., Chen, Y., Ling, W., Wu, C., Zhao, S., Liu, J.O. & Yu, L. (2003) Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B. J. Biol. Chem. 278, 29278-29287.
12. Hetz, C.A., Torres, V. & Quest, A.F. (2005) Beyond apoptosis: nonapoptotic cell death in physiology and disease. Biochem. Cell Biol. 83, 579-588.
13. Jung, C.H., Ro, S.H., Cao, J., Otto, N.M. & Kim, D.H. (2010) mTOR regulation of autophagy. FEBS Lett. 584, 1287-1295.
14. Kitanaka, C. & Kuchino, Y. (1999) Caspase-independent programmed cell death with necrotic morphology. Cell Death Differ. 6, 508-515.
15. Kumamoto-Yonezawa, Y., Sasaki, R., Ota, Y., Suzuki, Y., Fukushima, S., Hada, T., Uryu, K., Sugimura, K., Yoshida, H. & Mizushina, Y. (2009) Cell cycle arrest triggered by conjugated eicosapentaenoic acid occurs through several mechanisms including G1 checkpoint activation by induced RPA and ATR expression. Biochim. Biophys. Acta 1790, 339-346.
16. Li, J., Han, Y.R., Plummer, M.R. & Herrup, K. (2009) Cytoplasmic ATM in neurons modulates synaptic function. Curr. Biol. 19, 2091-2096.
17. Liang, X.H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H. & Levine, B. (1999) Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 402, 672-676.
18. Lossaint, G., Besnard, E., Fisher, D., Piette, J. & Dulić, V. (2011) Chk1 is dispensable for G2 arrest in response to sustained DNA damage when the ATM/p53/p21 pathway is functional. Oncogene 30, 4261-4274.
19. Ma, Y., Pannicke, U., Schwarz, K. & Lieber, M.R. (2002) Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell 108, 781-794.
20. Marom, M., Haklai, R., Ben-Baruch, G., Marciano, D., Egozi, a Y. & Kloog, Y. (1995) Selective inhibition of Ras-dependent cell growth by farnesylthiosalicylic acid. J. Biol. Chem. 270, 22263-22270.
21. Miller, T.M., Moulder, K.L., Knudson, C.M., Creedon, D.J., Deshmukh, M., Korsmeyer, S.J. & Johnson, E.M. Jr (1997) Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death. J. Cell Biol. 139, 205-217.
22. Murga, M., Bunting, S., Montana, M.F., Soria, R., Mulero, F., Canamero, M., Lee, Y., McKinnon, P.J., Nussenzweig, A. & Fernandez-Capetillo, O. (2009) A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging. Nat. Genet. 41, 891-898.
23. O'Driscoll, M. (2009) Mouse models for ATR deficiency. DNA Repair 8, 1333-1337.
24. O'Driscoll, M., Ruiz-Perez, V.L., Woods, C.G., Jeggo, P.A. & Goodship, J.A. (2003) A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. Nat. Genet. 33, 497-501.
25. Perry, J. & Kleckner, N. (2003) The ATRs, ATMs, and TORs are giant HEAT repeat proteins. Cell 112, 151-155.
26. Schmelzle, T. & Hall, M.N. (2000) TOR, a central controller of cell growth. Cell 103, 253-262.
27. Sibanda, B.L., Chirgadze, D.Y. & Blundell, T.L. (2010) Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats. Nature 463, 118-121.
28. Tait, S.W. & Green, D.R. (2010) Mitochondria and cell death: outer membrane permeabilization and beyond. Nat. Rev. Mol. Cell Biol. 11, 621-632.
29. Takai, H., Wang, R.C., Takai, K.K., Yang, H. & de Lange, T. (2007) Tel2 regulates the stability of PI3K-related protein kinases. Cell 131, 1248-1259.
30. Takai, H., Xie, Y., de Lange, T. & Pavletich, N.P. (2010) Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes. Genes Dev. 24, 2019-2030.
31. Taylor, R.C., Cullen, S.P. & Martin, S.J. (2008) Apoptosis: controlled demolition at the cellular level. Nat. Rev. Mol. Cell Biol. 9, 231-241.
32. Thoreen, C.C., Kang, S.A., Chang, J.W., Liu, Q., Zhang, J., Gao, Y., Reichling, L.J., Sim, T., Sabatini, D.M. & Gray, N.S. (2009) An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J. Biol. Chem. 284, 8023-8032.
33. Wang, Y., Singh, R., Massey, A.C., Kane, S.S., Kaushik, S., Grant, T., Xiang, Y., Cuervo, A.M. & Czaja, M.J. (2008) Loss of macroautophagy promotes or prevents fibroblast apoptosis depending on the death stimulus. J. Biol. Chem. 283, 4766-4777.
34. Wright, J.A., Keegan, K.S., Herendeen, D.R., Bentley, N.J., Carr, A.M., Hoekstra, M.F. & Concannon, P. (1998) Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control. Proc. Natl Acad. Sci. USA 95, 7445-7450.
35. Yamashita, A., Ohnishi, T., Kashima, I., Taya, Y. & Ohno, S. (2001) Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay. Genes Dev. 15, 2215-2228.