PI3Ks and small GTPases in neutrophil migration: Two sides of the same coin

Molecular Immunology

Volumn 55, Issue 1, 2013, Pages 83-86

  Germena, Giulia ^a   Hirsch, Emilio ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

Actin; Leukocyte; PI3Ks; Small GTPases

Indexed keywords

ADENOSINE TRIPHOSPHATE; CHEMOATTRACTANT; GUANOSINE TRIPHOSPHATASE; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 3 KINASE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

BINDING AFFINITY; CELL INTERACTION; CELL MEMBRANE; CELL POLARITY; CYTOSKELETON; ENZYME ACTIVATION; LEUKOCYTE MIGRATION; NEUTROPHIL; POLARIZATION; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CELL MOVEMENT; CHEMOTACTIC FACTORS; HUMANS; IMMUNE SYSTEM DISEASES; LEUKOCYTE DISORDERS; MODELS, BIOLOGICAL; MONOMERIC GTP-BINDING PROTEINS; PHOSPHATIDYLINOSITOL 3-KINASES; RECEPTORS, CHEMOKINE; SIGNAL TRANSDUCTION;

EID: 84875611051     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2012.10.004     Document Type: Review

References (42)

1. Albertinazzi C., Za L., Paris S., de Curtis I. ADP-ribosylation factor 6 and a functional PIX/p95-APP1 complex are required for Rac1B-mediated neurite outgrowth. Molecular Biology of the Cell 2003, 14:1295-1307.
2. Andrew N., Insall R.H. Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions. Nature Cell Biology 2007, 9:193-200.
3. Balasubramanian N., Scott D.W., Castle J.D., Casanova J.E., Schwartz M.A. Arf6 and microtubules in adhesion-dependent trafficking of lipid rafts. Nature Cell Biology 2007, 9:1381-1391.
4. Bosgraaf L., Keizer-Gunnink I., Van Haastert P.J. PI3-kinase signaling contributes to orientation in shallow gradients and enhances speed in steep chemoattractant gradients. Journal of Cell Science 2008, 121:3589-3597.
5. Costa C., Barberis L., Ambrogio C., Manazza A.D., Patrucco E., Azzolino O., Neilsen P.O., Ciraolo E., Altruda F., Prestwich G.D., Chiarle R., Wymann M., Ridley A., Hirsch E. Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase gamma. Proceedings of the National Academy of Sciences of the United States of America 2007, 104:14354-14359.
6. Costa C., Germena G., Martin-Conte E.L., Molineris I., Bosco E., Marengo S., Azzolino O., Altruda F., Ranieri V.M., Hirsch E. The RacGAP ArhGAP15 is a master negative regulator of neutrophil functions. Blood 2011, 118:1099-1108.
7. Cote J.F., Motoyama A.B., Bush J.A., Vuori K. A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling. Nature Cell Biology 2005, 7:797-807.
8. DeWire S.M., Ahn S., Lefkowitz R.J., Shenoy S.K. Beta-arrestins and cell signaling. Annual Review of Physiology 2007, 69:483-510.
9. Engelman J.A., Luo J., Cantley L.C. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nature Reviews Genetics 2006, 7:606-619.
10. Ferguson G.J., Milne L., Kulkarni S., Sasaki T., Walker S., Andrews S., Crabbe T., Finan P., Jones G., Jackson S., Camps M., Rommel C., Wymann M., Hirsch E., Hawkins P., Stephens L. PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis. Nature Cell Biology 2007, 9:86-91.
11. Gakidis M.A., Cullere X., Olson T., Wilsbacher J.L., Zhang B., Moores S.L., Ley K., Swat W., Mayadas T., Brugge J.S. Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. Journal of Cell Biology 2004, 166:273-282.
12. Gambardella L., Anderson K.E., Nussbaum C., Segonds-Pichon A., Margarido T., Norton L., Ludwig T., Sperandio M., Hawkins P.T., Stephens L., Vermeren S. The GTPase-activating protein ARAP3 regulates chemotaxis and adhesion-dependent processes in neutrophils. Blood 2011, 118:1087-1098.
13. Gomez-Mouton C., Manes S. Establishment and maintenance of cell polarity during leukocyte chemotaxis. Cell Adhesion and Migration 2007, 1:69-76.
14. Heit B., Liu L., Colarusso P., Puri K.D., Kubes P. PI3K accelerates, but is not required for, neutrophil chemotaxis to fMLP. Journal of Cell Science 2008, 121:205-214.
15. Heit B., Robbins S.M., Downey C.M., Guan Z., Colarusso P., Miller B.J., Jirik F.R., Kubes P. PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils. Nature Immunology 2008, 9:743-752.
16. Hirsch E., Katanaev V.L., Garlanda C., Azzolino O., Pirola L., Silengo L., Sozzani S., Mantovani A., Altruda F., Wymann M.P. Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Science 2000, 287:1049-1053.
17. Hoeller O., Kay R.R. Chemotaxis in the absence of PIP3 gradients. Current Biology 2007, 17:813-817.
18. Insall R.H., Weiner O.D. PIP3, PIP2, and cell movement - similar messages, different meanings?. Developmental Cell 2001, 1:743-747.
19. Janetopoulos C., Firtel R.A. Directional sensing during chemotaxis. FEBS Letters 2008, 582:2075-2085.
20. King J.S., Insall R.H. Chemotaxis: finding the way forward with Dictyostelium. Trends in Cell Biology 2009, 19:523-530.
21. Koronakis V., Hume P.J., Humphreys D., Liu T., Horning O., Jensen O.N., McGhie E.J. WAVE regulatory complex activation by cooperating GTPases Arf and Rac1. Proceedings of the National Academy of Sciences of the United States of America 2011, 108:14449-14454.
22. Kunisaki Y., Nishikimi A., Tanaka Y., Takii R., Noda M., Inayoshi A., Watanabe K., Sanematsu F., Sasazuki T., Sasaki T., Fukui Y. DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis. Journal of Cell Biology 2006, 174:647-652.
23. Leevers S.J., Vanhaesebroeck B., Waterfield M.D. Signalling through phosphoinositide 3-kinases: the lipids take centre stage. Current Opinion in Cell Biology 1999, 11:219-225.
24. Li Z., Hannigan M., Mo Z., Liu B., Lu W., Wu Y., Smrcka A.V., Wu G., Li L., Liu M., Huang C.K., Wu D. Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42. Cell 2003, 114:215-227.
25. Li Z., Jiang H., Xie W., Zhang Z., Smrcka A.V., Wu D. Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction. Science 2000, 287:1046-1049.
26. Magalhaes M.A., Zhu F., Sarantis H., Gray-Owen S.D., Ellen R.P., Glogauer M. Expression and translocation of fluorescent-tagged p21-activated kinase-binding domain and PH domain of protein kinase B during murine neutrophil chemotaxis. Journal of Leukocyte Biology 2007, 82:559-566.
27. Manes S., Gomez-Mouton C., Lacalle R.A., Jimenez-Baranda S., Mira E., Martinez A.C. Mastering time and space: immune cell polarization and chemotaxis. Seminars in Immunology 2005, 17:77-86.
28. Mazaki Y., Hashimoto S., Tsujimura T., Morishige M., Hashimoto A., Aritake K., Yamada A., Nam J.M., Kiyonari H., Nakao K., Sabe H. Neutrophil direction sensing and superoxide production linked by the GTPase-activating protein GIT2. Nature Immunology 2006, 7:724-731.
29. Min J., Defea K. Beta-arrestin-dependent actin reorganization: bringing the right players together at the leading edge. Molecular Pharmacology 2011, 80:760-768.
30. Neer E.J. Heterotrimeric G proteins: organizers of transmembrane signals. Cell 1995, 80:249-257.
31. Nishio M., Watanabe K., Sasaki J., Taya C., Takasuga S., Iizuka R., Balla T., Yamazaki M., Watanabe H., Itoh R., Kuroda S., Horie Y., Forster I., Mak T.W., Yonekawa H., Penninger J.M., Kanaho Y., Suzuki A., Sasaki T. Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nature Cell Biology 2007, 9:36-44.
32. Palamidessi A., Frittoli E., Garre M., Faretta M., Mione M., Testa I., Diaspro A., Lanzetti L., Scita G., Di Fiore P.P. Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration. Cell 2008, 134:135-147.
33. Pestonjamasp K.N., Forster C., Sun C., Gardiner E.M., Bohl B., Weiner O., Bokoch G.M., Glogauer M. Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis. Blood 2006, 108:2814-2820.
34. Premont R.T., Claing A., Vitale N., Perry S.J., Lefkowitz R.J. The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing. Journal of Biological Chemistry 2000, 275:22373-22380.
35. Ridley A.J., Schwartz M.A., Burridge K., Firtel R.A., Ginsberg M.H., Borisy G., Parsons J.T., Horwitz A.R. Cell migration: integrating signals from front to back. Science 2003, 302:1704-1709.
36. Santy L.C., Ravichandran K.S., Casanova J.E. The DOCK180/Elmo complex couples ARNO-mediated Arf6 activation to the downstream activation of Rac1. Current Biology 2005, 15:1749-1754.
37. Sasaki T., Irie-Sasaki J., Jones R.G., Oliveira-dos-Santos A.J., Stanford W.L., Bolon B., Wakeham A., Itie A., Bouchard D., Kozieradzki I., Joza N., Mak T.W., Ohashi P.S., Suzuki A., Penninger J.M. Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. Science 2000, 287:1040-1046.
38. Srinivasan S., Wang F., Glavas S., Ott A., Hofmann F., Aktories K., Kalman D., Bourne H.R. Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis. Journal of Cell Biology 2003, 160:375-385.
39. Subramanian K.K., Jia Y., Zhu D., Simms B.T., Jo H., Hattori H., You J., Mizgerd J.P., Luo H.R. Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions. Blood 2007, 109:4028-4037.
40. Wang F., Herzmark P., Weiner O.D., Srinivasan S., Servant G., Bourne H.R. Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils. Nature Cell Biology 2002, 4:513-518.
41. Welch H.C., Coadwell W.J., Stephens L.R., Hawkins P.T. Phosphoinositide 3-kinase-dependent activation of Rac. FEBS Letters 2003, 546:93-97.
42. Wong W. Focus issue: moving in the right direction. Science Signaling 2011, 4:eg4.