메뉴 건너뛰기




Volumn 33, Issue 5, 2013, Pages 364-369

The effects of onion (Allium cepa) extract on doxorubicin-induced apoptosis in aortic endothelial cells

Author keywords

Allium cepa; Antioxidants; Aortic endothelial cells; Doxorubicin; Rat; TUNEL

Indexed keywords

DOXORUBICIN; GLUTATHIONE; MALONALDEHYDE; ONION EXTRACT;

EID: 84875589104     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1750     Document Type: Article
Times cited : (11)

References (37)
  • 1
    • 84873059182 scopus 로고    scopus 로고
    • Antioxidant and anti-apoptotic effects of onion (Allium cepa) extract on doxorubicin-induced cardiotoxicity in rats
    • DOI: 10.1002/jat.1738
    • Alpsoy S, Aktas C, Uygur R, Topcu B, Kanter M, Erboga M, Karakaya O, Gedikbasi A. 2011. Antioxidant and anti-apoptotic effects of onion (Allium cepa) extract on doxorubicin-induced cardiotoxicity in rats. J. Appl. Toxicol. DOI: 10.1002/jat.1738
    • (2011) J. Appl. Toxicol.
    • Alpsoy, S.1    Aktas, C.2    Uygur, R.3    Topcu, B.4    Kanter, M.5    Erboga, M.6    Karakaya, O.7    Gedikbasi, A.8
  • 2
    • 0017703085 scopus 로고
    • Anthracycline antibiotic augmentation of microsomal electron transport and free radical formation
    • Bachur NR, Gordon SL, Gee MV. 1977. Anthracycline antibiotic augmentation of microsomal electron transport and free radical formation. Mol. Pharmacol. 13(5): 901-910.
    • (1977) Mol. Pharmacol. , vol.13 , Issue.5 , pp. 901-910
    • Bachur, N.R.1    Gordon, S.L.2    Gee, M.V.3
  • 4
    • 73649194769 scopus 로고
    • Improved method for the determination of blood glutathione
    • Beutler E, Duron O, Kelly BM. 1963. Improved method for the determination of blood glutathione. J. Lab. Clin. Med. 61: 882-888.
    • (1963) J. Lab. Clin. Med. , vol.61 , pp. 882-888
    • Beutler, E.1    Duron, O.2    Kelly, B.M.3
  • 5
    • 0017872475 scopus 로고
    • Microsomallipid peroxidation
    • Buage JA, Aust SD. 1978. Microsomallipid peroxidation. Meth. Enzymol. 12: 302-310.
    • (1978) Meth. Enzymol. , vol.12 , pp. 302-310
    • Buage, J.A.1    Aust, S.D.2
  • 6
    • 33646030654 scopus 로고    scopus 로고
    • The superoxide dismutase inhibitor diethyldithiocarbamate has antagonistic effects on apoptosis by triggering both cytochrome c release and caspase inhibition
    • Dumay A, Rincheval V, Trotot P, Mignotte B, Vayssiere JL. 2006. The superoxide dismutase inhibitor diethyldithiocarbamate has antagonistic effects on apoptosis by triggering both cytochrome c release and caspase inhibition. Free Radic. Biol. Med. 40: 1377-1390.
    • (2006) Free Radic. Biol. Med. , vol.40 , pp. 1377-1390
    • Dumay, A.1    Rincheval, V.2    Trotot, P.3    Mignotte, B.4    Vayssiere, J.L.5
  • 8
    • 0033938716 scopus 로고    scopus 로고
    • Antioxidant effect of onion oil (Allium cepa. Linn) on the damages induced by nicotine in rats as compared to alpha-tocopherol
    • Helen A, Krishnakumar K, Vijayammal PL, Augusti KT. 2000. Antioxidant effect of onion oil (Allium cepa. Linn) on the damages induced by nicotine in rats as compared to alpha-tocopherol. Toxicol. Lett. 116: 61-68.
    • (2000) Toxicol. Lett. , vol.116 , pp. 61-68
    • Helen, A.1    Krishnakumar, K.2    Vijayammal, P.L.3    Augusti, K.T.4
  • 9
    • 0027504187 scopus 로고
    • Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study
    • Hertog MG, Feskens EJ, Hollman PC, Katan MB, Kromhout D. 1993. Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 342: 1007-1011.
    • (1993) Lancet , vol.342 , pp. 1007-1011
    • Hertog, M.G.1    Feskens, E.J.2    Hollman, P.C.3    Katan, M.B.4    Kromhout, D.5
  • 10
    • 0028960826 scopus 로고
    • Nitric oxide and endothelin in pathophysiological settings
    • Hunley TE, Iwasaki S, Homma T, Kon V. 1995. Nitric oxide and endothelin in pathophysiological settings. Pediatr. Nephrol. 9: 235-244.
    • (1995) Pediatr. Nephrol. , vol.9 , pp. 235-244
    • Hunley, T.E.1    Iwasaki, S.2    Homma, T.3    Kon, V.4
  • 12
    • 0034625535 scopus 로고    scopus 로고
    • Apoptosis and heart failure: a critical review of the literature
    • Kang PM, Izumo S. 2000. Apoptosis and heart failure: a critical review of the literature. Circul. Res. 86: 1107-1120.
    • (2000) Circul. Res. , vol.86 , pp. 1107-1120
    • Kang, P.M.1    Izumo, S.2
  • 13
    • 0023205079 scopus 로고
    • Garlic (Allium sativum) and onion (Allium cepa): a review of their relationship to cardiovascular disease
    • Kendler BS. 1987. Garlic (Allium sativum) and onion (Allium cepa): a review of their relationship to cardiovascular disease. Prev. Med. 16: 670-685.
    • (1987) Prev. Med. , vol.16 , pp. 670-685
    • Kendler, B.S.1
  • 14
    • 0023819810 scopus 로고
    • G2 block induced by DNA crosslinking agents and its possible consequences
    • Konopa J. 1988. G2 block induced by DNA crosslinking agents and its possible consequences. Biochem. Pharmacol. 37: 2303-2309.
    • (1988) Biochem. Pharmacol. , vol.37 , pp. 2303-2309
    • Konopa, J.1
  • 15
    • 0037053406 scopus 로고    scopus 로고
    • Transferrin receptor-dependent iron uptake is responsible for doxorubicin-mediated apoptosis in endothelial cells: role of oxidant-induced iron signaling in apoptosis
    • Kotamraju S, Chitambar CR, Kalivendi SV, Joseph J, Kalyanaraman B. 2002. Transferrin receptor-dependent iron uptake is responsible for doxorubicin-mediated apoptosis in endothelial cells: role of oxidant-induced iron signaling in apoptosis. J. Biol. Chem. 277(19): 17179-17187.
    • (2002) J. Biol. Chem. , vol.277 , Issue.19 , pp. 17179-17187
    • Kotamraju, S.1    Chitambar, C.R.2    Kalivendi, S.V.3    Joseph, J.4    Kalyanaraman, B.5
  • 16
    • 0033067354 scopus 로고    scopus 로고
    • Regulation of hepatic glutathione synthesis: current concepts and controversies
    • Lu SC. 1999. Regulation of hepatic glutathione synthesis: current concepts and controversies. FASEB J. 13(10): 1169-1183.
    • (1999) FASEB J. , vol.13 , Issue.10 , pp. 1169-1183
    • Lu, S.C.1
  • 18
    • 2642586567 scopus 로고    scopus 로고
    • Protection against acute adriamycin-induced cardiotoxicity by garlic: role of endogenous antioxidants and inhibition of TNF-α expression
    • Mukherjee S, Banerjee SK, Maulik M, Dinda AK, Maulik KS. 2003. Protection against acute adriamycin-induced cardiotoxicity by garlic: role of endogenous antioxidants and inhibition of TNF-α expression. BMC Pharmacol. 3(16): 1-9.
    • (2003) BMC Pharmacol. , vol.3 , Issue.16 , pp. 1-9
    • Mukherjee, S.1    Banerjee, S.K.2    Maulik, M.3    Dinda, A.K.4    Maulik, K.S.5
  • 19
    • 0035914164 scopus 로고    scopus 로고
    • Chronic effect of doxorubicin on vascular endothelium assessed by organ culture study
    • Murata T, Yamawaki H, Yoshimoto R, Hori M, Sato K, Ozaki H, Karaki H. 2001. Chronic effect of doxorubicin on vascular endothelium assessed by organ culture study. Life Sci. 69(22): 2685-2695.
    • (2001) Life Sci. , vol.69 , Issue.22 , pp. 2685-2695
    • Murata, T.1    Yamawaki, H.2    Yoshimoto, R.3    Hori, M.4    Sato, K.5    Ozaki, H.6    Karaki, H.7
  • 20
    • 0017656527 scopus 로고
    • Adriamycin: the role of lipid peroxidation in cardiac toxicity and tumor response
    • Myers CE, McGuire WP, Liss RH, Ifrim I, Grotzinger K, Young RC. 1977. Adriamycin: the role of lipid peroxidation in cardiac toxicity and tumor response. Science 197(4299): 165-167.
    • (1977) Science , vol.197 , Issue.4299 , pp. 165-167
    • Myers, C.E.1    McGuire, W.P.2    Liss, R.H.3    Ifrim, I.4    Grotzinger, K.5    Young, R.C.6
  • 22
    • 69749114647 scopus 로고    scopus 로고
    • Antibacterial activity of Allium cepa (Onions) and Zingiber officinale (Ginger) on Staphylococcus aureus and Pseudomonas aeruginosa isolated from high vaginal swab
    • Nelson CA, Reginald AO, Okoro N, Janet K. 2007. Antibacterial activity of Allium cepa (Onions) and Zingiber officinale (Ginger) on Staphylococcus aureus and Pseudomonas aeruginosa isolated from high vaginal swab. Int. J. Trop. Med. 3(2): 1-5.
    • (2007) Int. J. Trop. Med. , vol.3 , Issue.2 , pp. 1-5
    • Nelson, C.A.1    Reginald, A.O.2    Okoro, N.3    Janet, K.4
  • 23
    • 0037409586 scopus 로고    scopus 로고
    • Comparison of antioxidant activities of onion and garlic and extracts by inhibition of lipid peroxidation and radical scavenging activity
    • Nuutila AM, Puuponen-Pimia R, Aarni M, Oksman-Caldentey K. 2003. Comparison of antioxidant activities of onion and garlic and extracts by inhibition of lipid peroxidation and radical scavenging activity. Food Chem. 81: 485-493.
    • (2003) Food Chem. , vol.81 , pp. 485-493
    • Nuutila, A.M.1    Puuponen-Pimia, R.2    Aarni, M.3    Oksman-Caldentey, K.4
  • 25
    • 70349394453 scopus 로고    scopus 로고
    • Reversal of doxorubicin-induced vascular dysfunction by resveratrol in rat thoracic aorta: is there a possible role of nitric oxide synthase inhibition?
    • Olukman M, Can C, Erol A, Oktem G, Oral O, Cinar MG. 2009. Reversal of doxorubicin-induced vascular dysfunction by resveratrol in rat thoracic aorta: is there a possible role of nitric oxide synthase inhibition? Anadolu Kardiyol. Derg. 9(4): 260-266.
    • (2009) Anadolu Kardiyol. Derg. , vol.9 , Issue.4 , pp. 260-266
    • Olukman, M.1    Can, C.2    Erol, A.3    Oktem, G.4    Oral, O.5    Cinar, M.G.6
  • 26
    • 67650863482 scopus 로고    scopus 로고
    • Methanolic extract of onion (Allium cepa) attenuates ischemia/hypoxia-induced apoptosis in cardiomyocytes via antioxidant effect
    • Park S, Kim MY, Lee DH, Lee SH, Baik EJ, Moon CH, Park SW, Ko EY, Oh SR, Jung YS. 2009. Methanolic extract of onion (Allium cepa) attenuates ischemia/hypoxia-induced apoptosis in cardiomyocytes via antioxidant effect. Eur. J. Nutr. 48(4): 235-242.
    • (2009) Eur. J. Nutr. , vol.48 , Issue.4 , pp. 235-242
    • Park, S.1    Kim, M.Y.2    Lee, D.H.3    Lee, S.H.4    Baik, E.J.5    Moon, C.H.6    Park, S.W.7    Ko, E.Y.8    Oh, S.R.9    Jung, Y.S.10
  • 27
    • 40449086665 scopus 로고    scopus 로고
    • Dose translation from animal to human studies revisited
    • Reagan-Shaw S, Nihal M, Ahmad N. 2008. Dose translation from animal to human studies revisited. FASEB J. 22: 659-661.
    • (2008) FASEB J. , vol.22 , pp. 659-661
    • Reagan-Shaw, S.1    Nihal, M.2    Ahmad, N.3
  • 28
    • 0033014821 scopus 로고    scopus 로고
    • Daunorubicin-induced apoptosis in rat cardiac myocytes is inhibited by dexrazoxane
    • Sawyer DB, Fukazawa R, Arstall MA, Kelly RA. 1999. Daunorubicin-induced apoptosis in rat cardiac myocytes is inhibited by dexrazoxane. Circul. Res. 84: 257-265.
    • (1999) Circul. Res. , vol.84 , pp. 257-265
    • Sawyer, D.B.1    Fukazawa, R.2    Arstall, M.A.3    Kelly, R.A.4
  • 31
    • 1542316326 scopus 로고    scopus 로고
    • Antimutagenic, antioxidant and free radical scavenging activity of ethyl acetate extracts from white, yellow and red onions
    • Shon MY, Choi SD, Kahng GG, Nam SH, Sung NJ. 2004. Antimutagenic, antioxidant and free radical scavenging activity of ethyl acetate extracts from white, yellow and red onions. Food Chem. Toxicol. 42: 659-666.
    • (2004) Food Chem. Toxicol. , vol.42 , pp. 659-666
    • Shon, M.Y.1    Choi, S.D.2    Kahng, G.G.3    Nam, S.H.4    Sung, N.J.5
  • 32
    • 0032563825 scopus 로고    scopus 로고
    • Doxorubicin-induced cardiomyopathy
    • Singal PK, Iliskovic N. 1998. Doxorubicin-induced cardiomyopathy. New Engl. J. Med. 339(13): 900-905.
    • (1998) New Engl. J. Med. , vol.339 , Issue.13 , pp. 900-905
    • Singal, P.K.1    Iliskovic, N.2
  • 34
    • 0019794806 scopus 로고
    • Pulse radiolysis studies of antitumor quinones: radical lifetimes, reactivity with oxygen, and one-electron reduction potentials
    • Svingen BA, Powis G. 1981. Pulse radiolysis studies of antitumor quinones: radical lifetimes, reactivity with oxygen, and one-electron reduction potentials. Arch. Biochem. Biophys. 209(1): 119-126.
    • (1981) Arch. Biochem. Biophys. , vol.209 , Issue.1 , pp. 119-126
    • Svingen, B.A.1    Powis, G.2
  • 35
    • 84875635343 scopus 로고    scopus 로고
    • The Patent Website. Use of an Onion Extract For Making a Composition to Control Weight Gain. Available from: [16 June, 2011].
    • The Patent Website. 2011. Use of an Onion Extract For Making a Composition to Control Weight Gain. Available from: http://patents.com/us-20110142971.html [16 June, 2011].
    • (2011)
  • 37
    • 0032103818 scopus 로고    scopus 로고
    • Free radical involvement in doxorubucin-induced electrophysiological alterations in rat papillary muscle fibres
    • Venditti P, Balestrieri M, De Leo T, Di Meo S. 1998. Free radical involvement in doxorubucin-induced electrophysiological alterations in rat papillary muscle fibres. Cardiovasc. Res. 38: 695-702.
    • (1998) Cardiovasc. Res. , vol.38 , pp. 695-702
    • Venditti, P.1    Balestrieri, M.2    De Leo, T.3    Di Meo, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.